AR053206A1 - Derivados de isoindoles, composiciones farmaceuticas que los contienen, sus utilizaciones terapeuticas como inhibidores de la actividad de la proteina chaperona hsp90 y su empleo en la preparacion de medicamentos para el tratamiento de diversos tipos de cancer. - Google Patents
Derivados de isoindoles, composiciones farmaceuticas que los contienen, sus utilizaciones terapeuticas como inhibidores de la actividad de la proteina chaperona hsp90 y su empleo en la preparacion de medicamentos para el tratamiento de diversos tipos de cancer.Info
- Publication number
- AR053206A1 AR053206A1 ARP060101366A ARP060101366A AR053206A1 AR 053206 A1 AR053206 A1 AR 053206A1 AR P060101366 A ARP060101366 A AR P060101366A AR P060101366 A ARP060101366 A AR P060101366A AR 053206 A1 AR053206 A1 AR 053206A1
- Authority
- AR
- Argentina
- Prior art keywords
- heteroaryl
- aryl
- radicals
- pharmaceutical compositions
- contain
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 101710113864 Heat shock protein 90 Proteins 0.000 title 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 nitro, cyano, methyl Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 150000003254 radicals Chemical class 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- SOWBFZRMHSNYGE-UHFFFAOYSA-N Monoamide-Oxalic acid Natural products NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Abstract
Composiciones farmacéuticas que los contienen. Uso de estos compuestos para medicamentos utilizados en el tratamiento de enfermedades proliferativas. Reivindicacion 1: Productos de formula (1) en la que: A1, A2, A3 y A4, iguales o diferentes representan CRa o N; n representa el numero entero 1 o 2; R1 representa un átomo de O o de S o un radical NRb; R2 independientemente seleccionado en el grupo constituido por H, halogeno, CF3, nitro, ciano, metilo, etilo, hidroxi, mercapto, amino, metoxi, tiometoxi, metilamino, dimetilamino, acetilamino, carboxi y carboxamido; Ra se selecciona del grupo constituido por H, halogeno, CF3, hidroxi, mercapto, nitro, amino, OR3, SR3, NR3R4, NH-OH, NH-CO-H, NH-CO-OH, NH-CO-NH2, carboxi, ciano, carboxamido, Y-(CH2)p-alquilo, Y-(CH2)p-cicloalquilo, Y-(CH2)p-heterocicloalquilo, Y-(CH2)p-arilo o Y-(CH2)p-heteroarilo, con Y = O, S, NH, O-C(O), C(O)-NH, NH-C(O), NH-S(O) o NH-S(O)2, con p = 1, 2 o 3, y en el que el radical arilo, contiene de 6 a 10 miembros, el radical cicloalquilo contiene de 3 a 10 miembros y el radical heteroarilo o heterocicloalquilo, contiene de 4 a10 miembros de los cuales 1 a 3 heteroátomos se eligen entre O, N, o S; estando todos estos radicales opcionalmente sustituidos; R3 y R4 se eligen independientemente entre el átomo de H o los radicales alquilos, alquenilos, alquinilos, arilos o heteroarilo, aralquilo o heteroaralquilos, todos los radicales alquilos, alquenilos, alquinilo, arilos, heteroarilos, aralquilos o heteroaralquilos anteriores están opcionalmente sustituidos; Rb se selecciona del grupo constituido por H, (CH2)m-cicloalquilo, (CH2)m-heterocicloalquilo, (CH2)m-arilo o (CH2)m-heteroarilo, con m = 0, 1, 2, estando todos estos radicales opcionalmente sustituidos, estando dichos productos de formula (1) en todas las formas isoméricas posibles racémicas, enantiomeras y diastereoisomeras, así como las sales de adicion con ácidos minerales y orgánicos o con bases minerales y orgánicas de dichos productos de formula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0503511A FR2884252B1 (fr) | 2005-04-08 | 2005-04-08 | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053206A1 true AR053206A1 (es) | 2007-04-25 |
Family
ID=35539484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101366A AR053206A1 (es) | 2005-04-08 | 2006-04-06 | Derivados de isoindoles, composiciones farmaceuticas que los contienen, sus utilizaciones terapeuticas como inhibidores de la actividad de la proteina chaperona hsp90 y su empleo en la preparacion de medicamentos para el tratamiento de diversos tipos de cancer. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8034939B2 (es) |
| EP (1) | EP1869042B1 (es) |
| JP (1) | JP5124443B2 (es) |
| KR (1) | KR20080002809A (es) |
| CN (1) | CN101287733A (es) |
| AR (1) | AR053206A1 (es) |
| AT (1) | ATE497501T1 (es) |
| AU (1) | AU2006234396A1 (es) |
| BR (1) | BRPI0609734A2 (es) |
| CA (1) | CA2603634A1 (es) |
| DE (1) | DE602006019953D1 (es) |
| FR (1) | FR2884252B1 (es) |
| IL (1) | IL186050A0 (es) |
| RU (1) | RU2375361C2 (es) |
| TW (1) | TW200718700A (es) |
| UY (1) | UY29468A1 (es) |
| WO (1) | WO2006108948A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2885904B1 (fr) * | 2005-05-19 | 2007-07-06 | Aventis Pharma Sa | Nouveaux derives du fluorene, compositions les contenant et utilisation |
| WO2008045529A1 (en) * | 2006-10-12 | 2008-04-17 | Serenex, Inc. | Purine and pyrimidine derivatives for treatment of cancer and inflammatory diseases |
| FR2932484B1 (fr) | 2008-06-16 | 2010-06-18 | Sanofi Aventis | Nouveaux derives de pyrroloindole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| PL3056203T3 (pl) * | 2010-04-21 | 2018-06-29 | Syntarga B.V. | Koniugaty analogów CC-1065 i łączników dwufunkcyjnych |
| UY36630A (es) | 2015-04-17 | 2016-11-30 | Abbvie Inc | Moduladores tricíclicos de la señalización por tnf |
| WO2016168633A1 (en) | 2015-04-17 | 2016-10-20 | Abbvie Inc. | Indazolones as modulators of tnf signaling |
| WO2016168638A1 (en) | 2015-04-17 | 2016-10-20 | Abbvie Inc. | Indazolones as modulators of tnf signaling |
| KR101925395B1 (ko) | 2016-01-29 | 2019-02-27 | 계명대학교 산학협력단 | Ｈｓｐ９０ 억제 활성을 갖는 신규 디히드록시페닐계 화합물 또는 이의 약제학적으로 허용가능한 염 및 이의 의학적 용도 |
| US10131663B2 (en) | 2016-10-24 | 2018-11-20 | Astrazeneca Ab | Chemical compounds |
| DK3494116T3 (da) | 2017-01-30 | 2020-01-27 | Astrazeneca | Østrogenreceptormodulatorer |
| KR20190014474A (ko) | 2017-08-02 | 2019-02-12 | 계명대학교 산학협력단 | Ｈｓｐ９０ 억제 활성을 갖는 디히드록시페닐계 입체이성질체 및 이의 의학적 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001106673A (ja) * | 1999-07-26 | 2001-04-17 | Banyu Pharmaceut Co Ltd | ビアリールウレア誘導体 |
| GB0228417D0 (en) | 2002-12-05 | 2003-01-08 | Cancer Rec Tech Ltd | Pyrazole compounds |
| GB0229618D0 (en) * | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
| WO2004072081A1 (en) * | 2003-02-10 | 2004-08-26 | Cellular Genomics, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity |
| DK1611112T3 (da) | 2003-02-11 | 2012-11-19 | Cancer Res Inst | Isoxazolforbindelser som hæmmere af varmechokproteiner |
| GB0309637D0 (en) * | 2003-04-28 | 2003-06-04 | Cancer Rec Tech Ltd | Pyrazole compounds |
| GB0315111D0 (en) | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| US7538224B2 (en) * | 2003-06-27 | 2009-05-26 | Kyowa Hakko Kogyo Co., Ltd. | Hsp90 family protein inhibitors |
-
2005
- 2005-04-08 FR FR0503511A patent/FR2884252B1/fr not_active Expired - Fee Related
-
2006
- 2006-04-05 CA CA002603634A patent/CA2603634A1/fr not_active Abandoned
- 2006-04-05 BR BRPI0609734-0A patent/BRPI0609734A2/pt not_active IP Right Cessation
- 2006-04-05 EP EP06743635A patent/EP1869042B1/fr active Active
- 2006-04-05 AU AU2006234396A patent/AU2006234396A1/en not_active Abandoned
- 2006-04-05 DE DE602006019953T patent/DE602006019953D1/de active Active
- 2006-04-05 RU RU2007141398/04A patent/RU2375361C2/ru active
- 2006-04-05 CN CNA2006800112231A patent/CN101287733A/zh active Pending
- 2006-04-05 WO PCT/FR2006/000750 patent/WO2006108948A2/fr active Application Filing
- 2006-04-05 AT AT06743635T patent/ATE497501T1/de not_active IP Right Cessation
- 2006-04-05 JP JP2008504804A patent/JP5124443B2/ja not_active Expired - Fee Related
- 2006-04-05 KR KR1020077022744A patent/KR20080002809A/ko not_active Application Discontinuation
- 2006-04-06 AR ARP060101366A patent/AR053206A1/es not_active Application Discontinuation
- 2006-04-07 UY UY29468A patent/UY29468A1/es unknown
- 2006-04-07 TW TW095112562A patent/TW200718700A/zh unknown
-
2007
- 2007-09-18 IL IL186050A patent/IL186050A0/en unknown
- 2007-09-28 US US11/864,105 patent/US8034939B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR2884252B1 (fr) | 2007-05-18 |
| IL186050A0 (en) | 2008-06-05 |
| EP1869042A2 (fr) | 2007-12-26 |
| FR2884252A1 (fr) | 2006-10-13 |
| TW200718700A (en) | 2007-05-16 |
| WO2006108948A2 (fr) | 2006-10-19 |
| BRPI0609734A2 (pt) | 2010-04-27 |
| ATE497501T1 (de) | 2011-02-15 |
| KR20080002809A (ko) | 2008-01-04 |
| JP2008534660A (ja) | 2008-08-28 |
| UY29468A1 (es) | 2006-11-30 |
| DE602006019953D1 (de) | 2011-03-17 |
| CA2603634A1 (fr) | 2006-10-19 |
| RU2007141398A (ru) | 2009-05-20 |
| JP5124443B2 (ja) | 2013-01-23 |
| US20080119507A1 (en) | 2008-05-22 |
| EP1869042B1 (fr) | 2011-02-02 |
| RU2375361C2 (ru) | 2009-12-10 |
| AU2006234396A1 (en) | 2006-10-19 |
| WO2006108948A3 (fr) | 2007-10-11 |
| US8034939B2 (en) | 2011-10-11 |
| CN101287733A (zh) | 2008-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR053206A1 (es) | Derivados de isoindoles, composiciones farmaceuticas que los contienen, sus utilizaciones terapeuticas como inhibidores de la actividad de la proteina chaperona hsp90 y su empleo en la preparacion de medicamentos para el tratamiento de diversos tipos de cancer. | |
| UY38186A (es) | Sal sódica de n-((1,2,3,5,6,7-hexahidro-s-indacen-4-il)carbamoil)-1-isopropil-1h-pirazol-3-sulfonamida | |
| CY1118191T1 (el) | Αναλογα δεοξυνοζιριμυκινης και οι χρησεις τους ως αναστολεις γλυκοζυλοκεραμιδασης | |
| CY1115940T1 (el) | Παραγωγα υποκατεστημενου φαινυλαλκανοϊκου οξεος και η χρηση τους για τη θεραπευτικη αντιμετωπιση αναπνευστικων ασθενειων | |
| CR20190124A (es) | Inhibidores de ssao de aminopirimidina | |
| AR050261A2 (es) | Aminoacidos con afinidad por la proteina alfa-2-delta y composiciones farmaceuticas que los contienen y su uso para preparar un medicamento | |
| UY28376A1 (es) | Agentes terapéuticos | |
| HN2008000949A (es) | Derivados de pirimidinil- aril- urea que son inhibidores de fgf | |
| UY30314A1 (es) | Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmacéuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion | |
| CL2003002683A1 (es) | Enantiomeros s de compuestos derivados del acido (2s)-3-4(-{2-amino-2-oxoetoxi}fenil)-2-etoxipropanoico; proceso de preparacion; compuestos intermediarios; composicion farmaceutica; y su uso para el tratamiento o prevencion de trastornos de lipidos, | |
| UY27740A1 (es) | Nuevos compuestos | |
| AR077478A2 (es) | Derivados de oxindol sustituido medicamentos que los comprenden y uso de los mismos | |
| NO20080765L (no) | Prodrug av eksitasjonsaminosyrer | |
| AR060873A1 (es) | Derivados biciclicos como inhibidores de cetp | |
| AR053554A1 (es) | Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos | |
| AR024060A1 (es) | Nuevos compuestos farmaceuticamente activos | |
| AR047922A1 (es) | Nuevos derivados de pentafluorsulfanilo, su obtencion y su utilizacion como agentes farmaceuticos | |
| AR057162A1 (es) | Compuestos de benzamida como inhibidores de la enzima histona desacetilasa (hdac) | |
| ES2340502T3 (es) | Compuestos de 1,4,8-triazaespiro(4,5)decan-2-ona sustituidos para el tratamiento de la obesidad. | |
| AR039601A1 (es) | Derivados de nitrosodifenilamina y composiciones farmaceuticas que los comprenden como medicamentos que se pueden utilizar en el tratamiento de patologias que se caracterizan por estres oxidativo | |
| UY27969A1 (es) | Formulaciones que comprenden un compuesto de indolinona | |
| CL2004000732A1 (es) | Compuestos derivados de oximas sustituidas y sus sales farmaceuticamente aceptables; procedimiento de preparacion de dichos compuestos; composicion farmaceutica que los contiene; y uso de los compuestos para el tratamiento del cancer. | |
| AR013079A1 (es) | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios | |
| UY29741A1 (es) | Sales de 1,5- diaril pirazol-3-carboxamidas, procesos de preparación, composeciones farmacéuticas que las contienen, aplicaciones y métodos de uso. | |
| CY1111857T1 (el) | Κρυσταλλικη βαση trans-1-((1r,3s)-6-xλωpo-3-φαινυλινδαν-1-υλο)-3,3-διμεθυλοπιπεραζινης |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |