ATE497501T1 - Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90 - Google Patents

Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90

Info

Publication number
ATE497501T1
ATE497501T1 AT06743635T AT06743635T ATE497501T1 AT E497501 T1 ATE497501 T1 AT E497501T1 AT 06743635 T AT06743635 T AT 06743635T AT 06743635 T AT06743635 T AT 06743635T AT E497501 T1 ATE497501 T1 AT E497501T1
Authority
AT
Austria
Prior art keywords
inhibiters
compositions
activity
preparation
pharmaceutical use
Prior art date
Application number
AT06743635T
Other languages
English (en)
Inventor
Patrick Mailliet
Luc Bertin
Didier Benard
Chantal Carrez
Francois Vallee
Eric Bacque
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE497501T1 publication Critical patent/ATE497501T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT06743635T 2005-04-08 2006-04-05 Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90 ATE497501T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0503511A FR2884252B1 (fr) 2005-04-08 2005-04-08 Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90
PCT/FR2006/000750 WO2006108948A2 (fr) 2005-04-08 2006-04-05 Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90

Publications (1)

Publication Number Publication Date
ATE497501T1 true ATE497501T1 (de) 2011-02-15

Family

ID=35539484

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06743635T ATE497501T1 (de) 2005-04-08 2006-04-05 Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90

Country Status (17)

Country Link
US (1) US8034939B2 (de)
EP (1) EP1869042B1 (de)
JP (1) JP5124443B2 (de)
KR (1) KR20080002809A (de)
CN (1) CN101287733A (de)
AR (1) AR053206A1 (de)
AT (1) ATE497501T1 (de)
AU (1) AU2006234396A1 (de)
BR (1) BRPI0609734A2 (de)
CA (1) CA2603634A1 (de)
DE (1) DE602006019953D1 (de)
FR (1) FR2884252B1 (de)
IL (1) IL186050A0 (de)
RU (1) RU2375361C2 (de)
TW (1) TW200718700A (de)
UY (1) UY29468A1 (de)
WO (1) WO2006108948A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2885904B1 (fr) * 2005-05-19 2007-07-06 Aventis Pharma Sa Nouveaux derives du fluorene, compositions les contenant et utilisation
WO2008045529A1 (en) * 2006-10-12 2008-04-17 Serenex, Inc. Purine and pyrimidine derivatives for treatment of cancer and inflammatory diseases
FR2932484B1 (fr) * 2008-06-16 2010-06-18 Sanofi Aventis Nouveaux derives de pyrroloindole inhibiteurs d'hsp90, compositions les contenant et utilisation
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
KR101901555B1 (ko) * 2010-04-21 2018-09-21 신타가 비.브이. Ｃｃ―１０６５ 유사체와 2작용성 링커의 신규한 콘쥬게이트
EP3286195A1 (de) 2015-04-17 2018-02-28 AbbVie Inc. Indazolone als modulatoren der tnf-signalisierung
UY36629A (es) 2015-04-17 2016-11-30 Abbvie Inc Indazolonas como moduladores de la señalización de tnf
UY36630A (es) 2015-04-17 2016-11-30 Abbvie Inc Moduladores tricíclicos de la señalización por tnf
KR101925395B1 (ko) 2016-01-29 2019-02-27 계명대학교 산학협력단 Ｈｓｐ９０ 억제 활성을 갖는 신규 디히드록시페닐계 화합물 또는 이의 약제학적으로 허용가능한 염 및 이의 의학적 용도
HRP20220255T1 (hr) 2016-10-24 2022-04-29 Astrazeneca Ab Derivati 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]izokinolina koji su korisni u liječenju raka
LT3494116T (lt) 2017-01-30 2020-01-10 Astrazeneca Ab Estrogeno receptorių moduliatoriai
KR20190014474A (ko) 2017-08-02 2019-02-12 계명대학교 산학협력단 Ｈｓｐ９０ 억제 활성을 갖는 디히드록시페닐계 입체이성질체 및 이의 의학적 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001106673A (ja) * 1999-07-26 2001-04-17 Banyu Pharmaceut Co Ltd ビアリールウレア誘導体
GB0228417D0 (en) 2002-12-05 2003-01-08 Cancer Rec Tech Ltd Pyrazole compounds
GB0229618D0 (en) * 2002-12-19 2003-01-22 Cancer Rec Tech Ltd Pyrazole compounds
WO2004072081A1 (en) * 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
NZ541479A (en) 2003-02-11 2008-11-28 Vernalis Cambridge Liimited Isoxazole compounds as inhibitors of heat shock proteins
GB0309637D0 (en) * 2003-04-28 2003-06-04 Cancer Rec Tech Ltd Pyrazole compounds
AU2004251949B2 (en) 2003-06-27 2009-05-07 Kyowa Hakko Kirin Co., Ltd. Hsp90 family protein inhibitors
GB0315111D0 (en) 2003-06-27 2003-07-30 Cancer Rec Tech Ltd Substituted 5-membered ring compounds and their use

Also Published As

Publication number Publication date
CA2603634A1 (fr) 2006-10-19
EP1869042A2 (de) 2007-12-26
FR2884252A1 (fr) 2006-10-13
AU2006234396A1 (en) 2006-10-19
FR2884252B1 (fr) 2007-05-18
BRPI0609734A2 (pt) 2010-04-27
KR20080002809A (ko) 2008-01-04
RU2375361C2 (ru) 2009-12-10
RU2007141398A (ru) 2009-05-20
JP5124443B2 (ja) 2013-01-23
JP2008534660A (ja) 2008-08-28
EP1869042B1 (de) 2011-02-02
US8034939B2 (en) 2011-10-11
AR053206A1 (es) 2007-04-25
UY29468A1 (es) 2006-11-30
WO2006108948A2 (fr) 2006-10-19
US20080119507A1 (en) 2008-05-22
CN101287733A (zh) 2008-10-15
DE602006019953D1 (de) 2011-03-17
WO2006108948A3 (fr) 2007-10-11
IL186050A0 (en) 2008-06-05
TW200718700A (en) 2007-05-16

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