DE602006019953D1 - Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90 - Google Patents
Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90Info
- Publication number
- DE602006019953D1 DE602006019953D1 DE602006019953T DE602006019953T DE602006019953D1 DE 602006019953 D1 DE602006019953 D1 DE 602006019953D1 DE 602006019953 T DE602006019953 T DE 602006019953T DE 602006019953 T DE602006019953 T DE 602006019953T DE 602006019953 D1 DE602006019953 D1 DE 602006019953D1
- Authority
- DE
- Germany
- Prior art keywords
- chapterone
- inhibitors
- compositions
- activity
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- VHMICKWLTGFITH-UHFFFAOYSA-N 2H-isoindole Chemical class C1=CC=CC2=CNC=C21 VHMICKWLTGFITH-UHFFFAOYSA-N 0.000 title 1
- 101710113864 Heat shock protein 90 Proteins 0.000 title 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0503511A FR2884252B1 (fr) | 2005-04-08 | 2005-04-08 | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
PCT/FR2006/000750 WO2006108948A2 (fr) | 2005-04-08 | 2006-04-05 | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006019953D1 true DE602006019953D1 (de) | 2011-03-17 |
Family
ID=35539484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006019953T Active DE602006019953D1 (de) | 2005-04-08 | 2006-04-05 | Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90 |
Country Status (17)
Country | Link |
---|---|
US (1) | US8034939B2 (de) |
EP (1) | EP1869042B1 (de) |
JP (1) | JP5124443B2 (de) |
KR (1) | KR20080002809A (de) |
CN (1) | CN101287733A (de) |
AR (1) | AR053206A1 (de) |
AT (1) | ATE497501T1 (de) |
AU (1) | AU2006234396A1 (de) |
BR (1) | BRPI0609734A2 (de) |
CA (1) | CA2603634A1 (de) |
DE (1) | DE602006019953D1 (de) |
FR (1) | FR2884252B1 (de) |
IL (1) | IL186050A0 (de) |
RU (1) | RU2375361C2 (de) |
TW (1) | TW200718700A (de) |
UY (1) | UY29468A1 (de) |
WO (1) | WO2006108948A2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2885904B1 (fr) * | 2005-05-19 | 2007-07-06 | Aventis Pharma Sa | Nouveaux derives du fluorene, compositions les contenant et utilisation |
WO2008045529A1 (en) * | 2006-10-12 | 2008-04-17 | Serenex, Inc. | Purine and pyrimidine derivatives for treatment of cancer and inflammatory diseases |
FR2932484B1 (fr) | 2008-06-16 | 2010-06-18 | Sanofi Aventis | Nouveaux derives de pyrroloindole inhibiteurs d'hsp90, compositions les contenant et utilisation |
AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
PL2560645T3 (pl) * | 2010-04-21 | 2017-01-31 | Syntarga B.V. | Koniugaty analogów CC-1065 i łączników dwufunkcyjnych |
UY36629A (es) | 2015-04-17 | 2016-11-30 | Abbvie Inc | Indazolonas como moduladores de la señalización de tnf |
EP3288939A1 (de) | 2015-04-17 | 2018-03-07 | AbbVie Inc. | Tricyclische modulatoren des tnf-signalwegs |
WO2016168638A1 (en) | 2015-04-17 | 2016-10-20 | Abbvie Inc. | Indazolones as modulators of tnf signaling |
KR101925395B1 (ko) | 2016-01-29 | 2019-02-27 | 계명대학교 산학협력단 | Hsp90 억제 활성을 갖는 신규 디히드록시페닐계 화합물 또는 이의 약제학적으로 허용가능한 염 및 이의 의학적 용도 |
US10131663B2 (en) | 2016-10-24 | 2018-11-20 | Astrazeneca Ab | Chemical compounds |
CA3050337A1 (en) | 2017-01-30 | 2018-08-02 | Astrazeneca Ab | Estrogen receptor modulators |
KR20190014474A (ko) | 2017-08-02 | 2019-02-12 | 계명대학교 산학협력단 | Hsp90 억제 활성을 갖는 디히드록시페닐계 입체이성질체 및 이의 의학적 용도 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001106673A (ja) * | 1999-07-26 | 2001-04-17 | Banyu Pharmaceut Co Ltd | ビアリールウレア誘導体 |
GB0228417D0 (en) | 2002-12-05 | 2003-01-08 | Cancer Rec Tech Ltd | Pyrazole compounds |
GB0229618D0 (en) * | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
WO2004072081A1 (en) * | 2003-02-10 | 2004-08-26 | Cellular Genomics, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity |
CA2515726C (en) | 2003-02-11 | 2012-07-10 | Vernalis (Cambridge) Limited | Isoxazole compounds |
GB0309637D0 (en) * | 2003-04-28 | 2003-06-04 | Cancer Rec Tech Ltd | Pyrazole compounds |
GB0315111D0 (en) | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
CN100567242C (zh) | 2003-06-27 | 2009-12-09 | 协和发酵麒麟株式会社 | Hsp90家族蛋白质阻断剂 |
-
2005
- 2005-04-08 FR FR0503511A patent/FR2884252B1/fr not_active Expired - Fee Related
-
2006
- 2006-04-05 RU RU2007141398/04A patent/RU2375361C2/ru active
- 2006-04-05 AU AU2006234396A patent/AU2006234396A1/en not_active Abandoned
- 2006-04-05 JP JP2008504804A patent/JP5124443B2/ja not_active Expired - Fee Related
- 2006-04-05 EP EP06743635A patent/EP1869042B1/de active Active
- 2006-04-05 KR KR1020077022744A patent/KR20080002809A/ko not_active Application Discontinuation
- 2006-04-05 BR BRPI0609734-0A patent/BRPI0609734A2/pt not_active IP Right Cessation
- 2006-04-05 AT AT06743635T patent/ATE497501T1/de not_active IP Right Cessation
- 2006-04-05 DE DE602006019953T patent/DE602006019953D1/de active Active
- 2006-04-05 WO PCT/FR2006/000750 patent/WO2006108948A2/fr active Application Filing
- 2006-04-05 CN CNA2006800112231A patent/CN101287733A/zh active Pending
- 2006-04-05 CA CA002603634A patent/CA2603634A1/fr not_active Abandoned
- 2006-04-06 AR ARP060101366A patent/AR053206A1/es not_active Application Discontinuation
- 2006-04-07 TW TW095112562A patent/TW200718700A/zh unknown
- 2006-04-07 UY UY29468A patent/UY29468A1/es unknown
-
2007
- 2007-09-18 IL IL186050A patent/IL186050A0/en unknown
- 2007-09-28 US US11/864,105 patent/US8034939B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ATE497501T1 (de) | 2011-02-15 |
BRPI0609734A2 (pt) | 2010-04-27 |
AU2006234396A1 (en) | 2006-10-19 |
UY29468A1 (es) | 2006-11-30 |
WO2006108948A3 (fr) | 2007-10-11 |
RU2375361C2 (ru) | 2009-12-10 |
WO2006108948A2 (fr) | 2006-10-19 |
US8034939B2 (en) | 2011-10-11 |
RU2007141398A (ru) | 2009-05-20 |
EP1869042A2 (de) | 2007-12-26 |
FR2884252A1 (fr) | 2006-10-13 |
CA2603634A1 (fr) | 2006-10-19 |
TW200718700A (en) | 2007-05-16 |
JP5124443B2 (ja) | 2013-01-23 |
CN101287733A (zh) | 2008-10-15 |
IL186050A0 (en) | 2008-06-05 |
FR2884252B1 (fr) | 2007-05-18 |
US20080119507A1 (en) | 2008-05-22 |
JP2008534660A (ja) | 2008-08-28 |
KR20080002809A (ko) | 2008-01-04 |
EP1869042B1 (de) | 2011-02-02 |
AR053206A1 (es) | 2007-04-25 |
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