DE602005026395D1 - Neue zyklische harnstoffderivate, deren herstellung und pharmazeutische verwendung damit als kinase-inhibitoren - Google Patents
Neue zyklische harnstoffderivate, deren herstellung und pharmazeutische verwendung damit als kinase-inhibitorenInfo
- Publication number
- DE602005026395D1 DE602005026395D1 DE602005026395T DE602005026395T DE602005026395D1 DE 602005026395 D1 DE602005026395 D1 DE 602005026395D1 DE 602005026395 T DE602005026395 T DE 602005026395T DE 602005026395 T DE602005026395 T DE 602005026395T DE 602005026395 D1 DE602005026395 D1 DE 602005026395D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- kinase inhibitors
- pharmaceutical use
- urea derivatives
- cyclic urea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04291904A EP1621536A1 (de) | 2004-07-27 | 2004-07-27 | Amino zyklische Urea-Derivaten, ihre Herstellung und deren pharmazeutische Verwendungen als Kinase Inhibitoren |
PCT/EP2005/008720 WO2006010641A2 (en) | 2004-07-27 | 2005-07-25 | Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005026395D1 true DE602005026395D1 (de) | 2011-03-31 |
Family
ID=34931289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005026395T Active DE602005026395D1 (de) | 2004-07-27 | 2005-07-25 | Neue zyklische harnstoffderivate, deren herstellung und pharmazeutische verwendung damit als kinase-inhibitoren |
Country Status (20)
Country | Link |
---|---|
US (1) | US7759379B2 (de) |
EP (2) | EP1621536A1 (de) |
JP (1) | JP2008508228A (de) |
KR (1) | KR20070038529A (de) |
CN (1) | CN101031559A (de) |
AR (1) | AR050269A1 (de) |
AT (1) | ATE498618T1 (de) |
AU (1) | AU2005266460A1 (de) |
BR (1) | BRPI0512681A (de) |
CA (1) | CA2571323A1 (de) |
DE (1) | DE602005026395D1 (de) |
EA (1) | EA011088B1 (de) |
IL (1) | IL180286A0 (de) |
MA (1) | MA28732B1 (de) |
MX (1) | MX2007001024A (de) |
NO (1) | NO20071067L (de) |
PE (1) | PE20060383A1 (de) |
TW (1) | TW200616973A (de) |
UY (1) | UY29039A1 (de) |
WO (1) | WO2006010641A2 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7354933B2 (en) * | 2003-01-31 | 2008-04-08 | Aventis Pharma Sa | Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
EP1621539A1 (de) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Heterocyclische-substituirte cyclische Harnstoffderivate, Verfaren zu ihrer Herstellung, und ihre pharmaceutische Verwendung als Kinase Inhibitoren |
EP1621535A1 (de) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Cyclische Substituirte Harnstoffderivate, Verfahren zu ihrer Herstellung, und ihre pharmazeutische Verwendung als Kinase Inhibitoren |
FR2896504B1 (fr) | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
FR2896503B1 (fr) | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
US8445507B2 (en) | 2006-03-27 | 2013-05-21 | The Regents Of The University Of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
US8835426B2 (en) * | 2007-02-26 | 2014-09-16 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
CL2008002199A1 (es) * | 2007-07-26 | 2009-10-23 | Vitae Pharmaceuticals Inc | Compuestos derivados de 1,3-oxazin-2-ona; composicion farmaceutica que comprende a dichos compuestos; y uso para tratar una enfermedad asociada con la actividad de la 11beta-hidroxiesteroide deshidrogenasa tipo 1 (11beta-hsd1) tales como dislipidemia, hiperlipidemia, hipertension, obesidad y enfermedad cardiovascular, entre otras. |
AR069207A1 (es) * | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
EP2229368A1 (de) | 2007-12-11 | 2010-09-22 | Vitae Pharmaceuticals, Inc. | Cyclische harnstoffe als inhibitoren von 11beta-hydroxysteroiddehydrogenase 1 |
TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
CA2712500A1 (en) * | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
EP2252598A2 (de) * | 2008-02-11 | 2010-11-24 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-on und 1,3-diazepan-2-on als inhibitoren von 11beta-hydroxysteroiddehydrogenase 1 |
WO2009102460A2 (en) * | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
EP2274287B1 (de) * | 2008-03-18 | 2016-03-09 | Vitae Pharmaceuticals, Inc. | Inhibitoren der 11beta-hydroxysteroiddehydrogenase vom typ 1 |
EP2291370B1 (de) | 2008-05-01 | 2013-11-27 | Vitae Pharmaceuticals, Inc. | Cyclische inhibitoren von 11beta-hydroxysteroiddehydrogenase 1 |
PL2300461T3 (pl) * | 2008-05-01 | 2013-09-30 | Vitae Pharmaceuticals Inc | Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1 |
CA2723039A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
EP2291373B1 (de) * | 2008-05-01 | 2013-09-11 | Vitae Pharmaceuticals, Inc. | Cyclische inhibitoren von 11beta-hydroxysteroiddehydrogenase 1 |
NZ590495A (en) | 2008-07-25 | 2012-10-26 | Vitae Pharmaceuticals Inc | Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
EP2324017B1 (de) | 2008-07-25 | 2014-12-31 | Boehringer Ingelheim International GmbH | 11-beta-HYDROXYSTEROID-DEHYDROGENASE-1-HEMMER |
US8637505B2 (en) | 2009-02-04 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
TW201039034A (en) * | 2009-04-27 | 2010-11-01 | Chunghwa Picture Tubes Ltd | Pixel structure and the method of forming the same |
KR20120061771A (ko) * | 2009-04-30 | 2012-06-13 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
JP5656986B2 (ja) | 2009-06-11 | 2015-01-21 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 1,3−オキサジナン−2−オン構造に基づく11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤 |
US8883778B2 (en) | 2009-07-01 | 2014-11-11 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
EP2483407A2 (de) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Verfahren zur autophagie-modulation durch modulation autophagie-verstärkender genprodukte |
JP5860042B2 (ja) | 2010-06-16 | 2016-02-16 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 置換5、6及び7員複素環、そのような化合物を含有する医薬及びそれらの使用 |
WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
EA201300522A1 (ru) | 2010-11-02 | 2013-11-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические комбинации для лечения метаболических нарушений |
UA117663C2 (uk) | 2012-09-26 | 2018-09-10 | Арагон Фармасьютікалз, Інк. | Антиандроген для лікування неметастатичного кастраційно-резистентного раку передміхурової залози |
EP3200791B1 (de) * | 2014-09-29 | 2020-04-22 | ChemoCentryx, Inc. | Verfahren und zwischenprodukte bei der herstellung von c5ar antagonisten |
EP3886853A4 (de) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Diarylhydantoiverbindungen und verfahren zur verwendung davon |
WO2021057696A1 (zh) * | 2019-09-27 | 2021-04-01 | 隆泰申医药科技(南京)有限公司 | 一种杂芳基类化合物及其应用 |
CN114591335B (zh) * | 2021-03-29 | 2023-06-27 | 浙江大学 | 吲唑类化合物及其制备方法和应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2476087A1 (fr) | 1980-02-18 | 1981-08-21 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR2671348B1 (fr) | 1991-01-09 | 1993-03-26 | Roussel Uclaf | Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
US5411981A (en) * | 1991-01-09 | 1995-05-02 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
DE19540027A1 (de) * | 1995-10-27 | 1997-04-30 | Gruenenthal Gmbh | Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe |
DE19732928C2 (de) * | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
FR2796945B1 (fr) * | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments |
US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
AU2002951247A0 (en) * | 2002-09-06 | 2002-09-19 | Alchemia Limited | Compounds that interact with kinases |
FR2850652B1 (fr) * | 2003-01-31 | 2008-05-30 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
US7354933B2 (en) * | 2003-01-31 | 2008-04-08 | Aventis Pharma Sa | Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
US7256208B2 (en) | 2003-11-13 | 2007-08-14 | Bristol-Myers Squibb Company | Monocyclic N-Aryl hydantoin modulators of androgen receptor function |
EP1621535A1 (de) | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Cyclische Substituirte Harnstoffderivate, Verfahren zu ihrer Herstellung, und ihre pharmazeutische Verwendung als Kinase Inhibitoren |
EP1621539A1 (de) | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Heterocyclische-substituirte cyclische Harnstoffderivate, Verfaren zu ihrer Herstellung, und ihre pharmaceutische Verwendung als Kinase Inhibitoren |
-
2004
- 2004-07-27 EP EP04291904A patent/EP1621536A1/de not_active Withdrawn
-
2005
- 2005-07-25 MX MX2007001024A patent/MX2007001024A/es not_active Application Discontinuation
- 2005-07-25 BR BRPI0512681-9A patent/BRPI0512681A/pt not_active IP Right Cessation
- 2005-07-25 EA EA200700141A patent/EA011088B1/ru not_active IP Right Cessation
- 2005-07-25 CA CA002571323A patent/CA2571323A1/en not_active Abandoned
- 2005-07-25 PE PE2005000866A patent/PE20060383A1/es not_active Application Discontinuation
- 2005-07-25 WO PCT/EP2005/008720 patent/WO2006010641A2/en active Application Filing
- 2005-07-25 KR KR1020077002102A patent/KR20070038529A/ko not_active Application Discontinuation
- 2005-07-25 AR ARP050103075A patent/AR050269A1/es unknown
- 2005-07-25 DE DE602005026395T patent/DE602005026395D1/de active Active
- 2005-07-25 JP JP2007523038A patent/JP2008508228A/ja active Pending
- 2005-07-25 AU AU2005266460A patent/AU2005266460A1/en not_active Abandoned
- 2005-07-25 EP EP05771072A patent/EP1773808B1/de active Active
- 2005-07-25 CN CNA2005800250805A patent/CN101031559A/zh active Pending
- 2005-07-25 AT AT05771072T patent/ATE498618T1/de not_active IP Right Cessation
- 2005-07-26 TW TW094125192A patent/TW200616973A/zh unknown
- 2005-07-27 UY UY29039A patent/UY29039A1/es unknown
-
2006
- 2006-12-24 IL IL180286A patent/IL180286A0/en unknown
-
2007
- 2007-01-02 MA MA29602A patent/MA28732B1/fr unknown
- 2007-01-26 US US11/627,518 patent/US7759379B2/en not_active Expired - Fee Related
- 2007-02-26 NO NO20071067A patent/NO20071067L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
UY29039A1 (es) | 2006-02-24 |
TW200616973A (en) | 2006-06-01 |
JP2008508228A (ja) | 2008-03-21 |
WO2006010641A3 (en) | 2006-10-26 |
AR050269A1 (es) | 2006-10-11 |
WO2006010641A2 (en) | 2006-02-02 |
PE20060383A1 (es) | 2006-06-06 |
EP1773808A2 (de) | 2007-04-18 |
EA200700141A1 (ru) | 2007-08-31 |
ATE498618T1 (de) | 2011-03-15 |
BRPI0512681A (pt) | 2008-04-01 |
US7759379B2 (en) | 2010-07-20 |
MX2007001024A (es) | 2007-04-16 |
IL180286A0 (en) | 2007-07-04 |
US20080004300A1 (en) | 2008-01-03 |
EA011088B1 (ru) | 2008-12-30 |
NO20071067L (no) | 2007-04-26 |
EP1621536A1 (de) | 2006-02-01 |
KR20070038529A (ko) | 2007-04-10 |
CA2571323A1 (en) | 2006-01-02 |
AU2005266460A1 (en) | 2006-02-02 |
EP1773808B1 (de) | 2011-02-16 |
MA28732B1 (fr) | 2007-07-02 |
CN101031559A (zh) | 2007-09-05 |
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