PE121599A1 - Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos - Google Patents

Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos

Info

Publication number
PE121599A1
PE121599A1 PE1998000955A PE00095598A PE121599A1 PE 121599 A1 PE121599 A1 PE 121599A1 PE 1998000955 A PE1998000955 A PE 1998000955A PE 00095598 A PE00095598 A PE 00095598A PE 121599 A1 PE121599 A1 PE 121599A1
Authority
PE
Peru
Prior art keywords
cr4r5
alkyl
precipitate
compound
halo
Prior art date
Application number
PE1998000955A
Other languages
English (en)
Spanish (es)
Inventor
Wilford Mendelson
Kevin Webb
Jianhao Chen
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE121599A1 publication Critical patent/PE121599A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PE1998000955A 1997-10-10 1998-10-09 Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos PE121599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10

Publications (1)

Publication Number Publication Date
PE121599A1 true PE121599A1 (es) 2000-02-19

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000955A PE121599A1 (es) 1997-10-10 1998-10-09 Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos

Country Status (30)

Country Link
EP (1) EP1043930A4 (zh)
JP (1) JP2001519363A (zh)
KR (1) KR100560038B1 (zh)
CN (1) CN1192025C (zh)
AP (1) AP1335A (zh)
AR (1) AR015952A1 (zh)
AU (1) AU741832B2 (zh)
BG (1) BG104302A (zh)
BR (1) BR9814064A (zh)
CA (1) CA2305614A1 (zh)
DZ (1) DZ2619A1 (zh)
EA (1) EA003609B1 (zh)
HU (1) HUP0003905A3 (zh)
ID (1) ID25536A (zh)
IL (1) IL135434A (zh)
MA (1) MA24670A1 (zh)
MY (1) MY122105A (zh)
NO (1) NO20001777L (zh)
NZ (1) NZ503759A (zh)
OA (1) OA11347A (zh)
PE (1) PE121599A1 (zh)
PL (1) PL191974B1 (zh)
SA (1) SA99191000A (zh)
SK (1) SK4902000A3 (zh)
TR (1) TR200000945T2 (zh)
TW (1) TW440557B (zh)
UA (1) UA67753C2 (zh)
UY (2) UY25201A1 (zh)
WO (1) WO1999018793A1 (zh)
ZA (1) ZA989228B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
JP2003534238A (ja) * 1999-12-15 2003-11-18 スミスクライン・ビーチャム・コーポレイション シス−４−シアノ−４−［３−（シクロペンチルオキシ）−４−メトキシフェニル］シクロヘキサン−１−カルボン酸の塩。
KR20020073183A (ko) * 2000-01-26 2002-09-19 스미스클라인 비참 코포레이션 시스-리튬시아노-4-[3-(시클로펜틸옥시)-4-메톡시페닐]시클로헥산카르복실레이트의 일수화물
EP2258689A1 (en) 2000-03-16 2010-12-08 Biolipox AB Benzylated PDE4 inhibitors
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
CA2436535A1 (en) 2001-01-31 2002-08-08 Prizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
DE60113731T2 (de) 2001-01-31 2006-06-29 Pfizer Products Inc., Groton Als inhibitoren von pde4-isozymen geeignete etherderivate
KR20030072614A (ko) 2001-01-31 2003-09-15 화이자 프로덕츠 인크. Ｐｄｅ４ 이소자임 억제제로 유용한 티아졸릴-,옥사졸릴-, 피롤릴- 및 이미다졸릴-산 아미드 유도체
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
SK279958B6 (sk) * 1992-04-02 1999-06-11 Smithkline Beecham Corporation Zlúčeniny s protialergickým a protizápalovým účink
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
MY118813A (en) * 1997-02-12 2005-01-31 Smithkline Beecham Corp Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
TW440557B (en) 2001-06-16
AP1335A (en) 2004-11-29
PL191974B1 (pl) 2006-07-31
MA24670A1 (fr) 1999-07-01
OA11347A (en) 2003-12-17
SK4902000A3 (en) 2000-11-07
KR20010015709A (ko) 2001-02-26
UA67753C2 (uk) 2004-07-15
ID25536A (id) 2000-10-12
EP1043930A1 (en) 2000-10-18
IL135434A0 (en) 2001-05-20
TR200000945T2 (tr) 2000-10-23
EP1043930A4 (en) 2004-09-15
CN1192025C (zh) 2005-03-09
AR015952A1 (es) 2001-05-30
UY25201A1 (es) 2001-08-27
AU9687498A (en) 1999-05-03
HUP0003905A2 (en) 2001-03-28
JP2001519363A (ja) 2001-10-23
EA003609B1 (ru) 2003-06-26
WO1999018793A1 (en) 1999-04-22
UY25524A1 (es) 2000-02-23
AU741832B2 (en) 2001-12-13
MY122105A (en) 2006-03-31
DZ2619A1 (fr) 2003-03-08
CA2305614A1 (en) 1999-04-22
NO20001777L (no) 2000-05-03
PL339759A1 (en) 2001-01-02
ZA989228B (en) 1999-04-12
BG104302A (en) 2001-08-31
SA99191000A (ar) 2005-12-03
CN1275052A (zh) 2000-11-29
EA200000406A1 (ru) 2000-10-30
KR100560038B1 (ko) 2006-03-13
HUP0003905A3 (en) 2002-01-28
BR9814064A (pt) 2000-09-26
IL135434A (en) 2004-12-15
NO20001777D0 (no) 2000-04-06
AP2000001782A0 (en) 2000-06-30
NZ503759A (en) 2002-03-01

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