BR9814064A - Processo para preparação de ácidos 4-fenil-4-cianociclo-hexanóicos substituìdos - Google Patents

Processo para preparação de ácidos 4-fenil-4-cianociclo-hexanóicos substituìdos

Info

Publication number
BR9814064A
BR9814064A BR9814064-7A BR9814064A BR9814064A BR 9814064 A BR9814064 A BR 9814064A BR 9814064 A BR9814064 A BR 9814064A BR 9814064 A BR9814064 A BR 9814064A
Authority
BR
Brazil
Prior art keywords
phenyl
substituted
preparation
acids
group
Prior art date
Application number
BR9814064-7A
Other languages
English (en)
Inventor
Kevin Webb
Wilford Mendelson
Jian-Hoa Chen
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR9814064A publication Critical patent/BR9814064A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE áCIDOS 4-FENIL-4-CIANOCICLOHEXANóICOS SUBSTITUìDOS" Esta invenção refere-se a um processo para preparação de um composto do tipo onde pelo menos um de R' ou R" é um grupo carboxila (I), por tratamento do composto da fórmula (II) com um haleto metálico do Grupo I (a) ou Grupo II(a), com um solvente a base de amida dipolar aprótico e água.
BR9814064-7A 1997-10-10 1998-10-07 Processo para preparação de ácidos 4-fenil-4-cianociclo-hexanóicos substituìdos BR9814064A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10
PCT/US1998/021061 WO1999018793A1 (en) 1997-10-10 1998-10-07 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (1)

Publication Number Publication Date
BR9814064A true BR9814064A (pt) 2000-09-26

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814064-7A BR9814064A (pt) 1997-10-10 1998-10-07 Processo para preparação de ácidos 4-fenil-4-cianociclo-hexanóicos substituìdos

Country Status (30)

Country Link
EP (1) EP1043930A4 (pt)
JP (1) JP2001519363A (pt)
KR (1) KR100560038B1 (pt)
CN (1) CN1192025C (pt)
AP (1) AP1335A (pt)
AR (1) AR015952A1 (pt)
AU (1) AU741832B2 (pt)
BG (1) BG104302A (pt)
BR (1) BR9814064A (pt)
CA (1) CA2305614A1 (pt)
DZ (1) DZ2619A1 (pt)
EA (1) EA003609B1 (pt)
HU (1) HUP0003905A3 (pt)
ID (1) ID25536A (pt)
IL (1) IL135434A (pt)
MA (1) MA24670A1 (pt)
MY (1) MY122105A (pt)
NO (1) NO20001777L (pt)
NZ (1) NZ503759A (pt)
OA (1) OA11347A (pt)
PE (1) PE121599A1 (pt)
PL (1) PL191974B1 (pt)
SA (1) SA99191000A (pt)
SK (1) SK4902000A3 (pt)
TR (1) TR200000945T2 (pt)
TW (1) TW440557B (pt)
UA (1) UA67753C2 (pt)
UY (2) UY25201A1 (pt)
WO (1) WO1999018793A1 (pt)
ZA (1) ZA989228B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
JP2003534238A (ja) * 1999-12-15 2003-11-18 スミスクライン・ビーチャム・コーポレイション シス−４−シアノ−４−［３−（シクロペンチルオキシ）−４−メトキシフェニル］シクロヘキサン−１−カルボン酸の塩。
DZ3285A1 (fr) * 2000-01-26 2001-08-02 Smithkline Beecham Corp Monohydrate cis-lithium-4-cyano-4-(3-(cyclopentyloxy)-4methoxyphenyl) cyclohexanecarboxylate
WO2001068600A2 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Limited Benzylated pde4 inhibitors
JP2004520386A (ja) 2001-01-31 2004-07-08 ファイザー・プロダクツ・インク Ｐｄｅ４アイソザイムの阻害剤として有用なニコチンアミドビアリール誘導体
PL364910A1 (en) 2001-01-31 2004-12-27 Pfizer Products Inc. Ether derivatives useful as inhibitors of pde4 isozymes
HUP0401305A2 (hu) 2001-01-31 2004-10-28 Pfizer Products Inc. Tiazolil-, oxazolil-, pirrolil- és imidazolil-savamid-származékok, mint PDE4 izozimek inhibitorai és az ezeket tartalmazó gyógyszerkészítmények
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
NZ251092A (en) * 1992-04-02 1996-12-20 Smithkline Beecham Corp 4-cyano-cyclohexane derivatives; medicaments; used in treating asthma
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
AR012550A1 (es) * 1997-02-12 2000-11-08 Smithkline Beecham Corp Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
IL135434A (en) 2004-12-15
NO20001777L (no) 2000-05-03
MA24670A1 (fr) 1999-07-01
PL191974B1 (pl) 2006-07-31
NZ503759A (en) 2002-03-01
DZ2619A1 (fr) 2003-03-08
CN1275052A (zh) 2000-11-29
ZA989228B (en) 1999-04-12
CN1192025C (zh) 2005-03-09
IL135434A0 (en) 2001-05-20
PE121599A1 (es) 2000-02-19
TR200000945T2 (tr) 2000-10-23
EP1043930A4 (en) 2004-09-15
EA200000406A1 (ru) 2000-10-30
UY25524A1 (es) 2000-02-23
TW440557B (en) 2001-06-16
JP2001519363A (ja) 2001-10-23
SA99191000A (ar) 2005-12-03
BG104302A (en) 2001-08-31
KR100560038B1 (ko) 2006-03-13
NO20001777D0 (no) 2000-04-06
KR20010015709A (ko) 2001-02-26
UY25201A1 (es) 2001-08-27
OA11347A (en) 2003-12-17
UA67753C2 (uk) 2004-07-15
AR015952A1 (es) 2001-05-30
AP2000001782A0 (en) 2000-06-30
AP1335A (en) 2004-11-29
EA003609B1 (ru) 2003-06-26
MY122105A (en) 2006-03-31
AU9687498A (en) 1999-05-03
SK4902000A3 (en) 2000-11-07
PL339759A1 (en) 2001-01-02
WO1999018793A1 (en) 1999-04-22
EP1043930A1 (en) 2000-10-18
CA2305614A1 (en) 1999-04-22
AU741832B2 (en) 2001-12-13
HUP0003905A3 (en) 2002-01-28
HUP0003905A2 (en) 2001-03-28
ID25536A (id) 2000-10-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO 1976 DE 18/11/2008.