MY122105A - Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids. - Google Patents

Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids.

Info

Publication number
MY122105A
MY122105A MYPI98004606A MYPI9804606A MY122105A MY 122105 A MY122105 A MY 122105A MY PI98004606 A MYPI98004606 A MY PI98004606A MY PI9804606 A MYPI9804606 A MY PI9804606A MY 122105 A MY122105 A MY 122105A
Authority
MY
Malaysia
Prior art keywords
phenyl
preparing substituted
group
cyanocyclohexanoic
acids
Prior art date
Application number
MYPI98004606A
Inventor
Kevin Webb
Wilford Mendelson
Jian-Hoa Chen
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MY122105A publication Critical patent/MY122105A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

THIS INVENTION RELATES TO A METHOD OF PREPARING A COMPOUND OF THE FOLLOWING TYPE WHERE AT LEAST ONE OF R' OR R" IS A CARBOXYL GROUP BY TREATING A COMPOUND OF FORMULA (11) WITH A GROUP I(A) OR GROUP II(A) METAL HALIDE, WITH AN APROTIC DIPOLAR AMIDEBASED SOLVENT AND WATER.
MYPI98004606A 1997-10-10 1998-10-08 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids. MY122105A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10

Publications (1)

Publication Number Publication Date
MY122105A true MY122105A (en) 2006-03-31

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI98004606A MY122105A (en) 1997-10-10 1998-10-08 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids.

Country Status (30)

Country Link
EP (1) EP1043930A4 (en)
JP (1) JP2001519363A (en)
KR (1) KR100560038B1 (en)
CN (1) CN1192025C (en)
AP (1) AP1335A (en)
AR (1) AR015952A1 (en)
AU (1) AU741832B2 (en)
BG (1) BG104302A (en)
BR (1) BR9814064A (en)
CA (1) CA2305614A1 (en)
DZ (1) DZ2619A1 (en)
EA (1) EA003609B1 (en)
HU (1) HUP0003905A3 (en)
ID (1) ID25536A (en)
IL (1) IL135434A (en)
MA (1) MA24670A1 (en)
MY (1) MY122105A (en)
NO (1) NO20001777L (en)
NZ (1) NZ503759A (en)
OA (1) OA11347A (en)
PE (1) PE121599A1 (en)
PL (1) PL191974B1 (en)
SA (1) SA99191000A (en)
SK (1) SK4902000A3 (en)
TR (1) TR200000945T2 (en)
TW (1) TW440557B (en)
UA (1) UA67753C2 (en)
UY (2) UY25201A1 (en)
WO (1) WO1999018793A1 (en)
ZA (1) ZA989228B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
JP2003534238A (en) * 1999-12-15 2003-11-18 スミスクライン・ビーチャム・コーポレイション Salt of cis-4-cyano-4- [3- (cyclopentyloxy) -4-methoxyphenyl] cyclohexane-1-carboxylic acid.
CN1157371C (en) * 2000-01-26 2004-07-14 史密丝克莱恩比彻姆公司 Monohydrate of cis-lithium-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl] cyclohexanecarboxylate
EP1265861A2 (en) 2000-03-16 2002-12-18 Inflazyme Pharmaceuticals, Ltd. Benzylated pde4 inhibitors
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
EP1355907A1 (en) 2001-01-31 2003-10-29 Pfizer Products Inc. Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
KR20030070150A (en) 2001-01-31 2003-08-27 화이자 프로덕츠 인크. Ether Derivatives Useful as Inhibitors of PDE4 Isozymes
EE200300360A (en) 2001-01-31 2003-12-15 Pfizer Products Inc. Biaryl derivatives of nicotinamide used as inhibitors of PDE4 isozymes
CN102491959B (en) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 Preparation method of oxirane derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
AU677776B2 (en) * 1992-04-02 1997-05-08 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
UY24882A1 (en) * 1997-02-12 2001-08-27 Smithkline Beecham Corp SUBSTITUTED 4-PHENYL-4-CIANO-CYCLOHEXANOIC ACIDS
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
PL339759A1 (en) 2001-01-02
DZ2619A1 (en) 2003-03-08
WO1999018793A1 (en) 1999-04-22
EP1043930A4 (en) 2004-09-15
KR20010015709A (en) 2001-02-26
PE121599A1 (en) 2000-02-19
SK4902000A3 (en) 2000-11-07
EA200000406A1 (en) 2000-10-30
UA67753C2 (en) 2004-07-15
NO20001777L (en) 2000-05-03
JP2001519363A (en) 2001-10-23
HUP0003905A2 (en) 2001-03-28
CA2305614A1 (en) 1999-04-22
AU741832B2 (en) 2001-12-13
NZ503759A (en) 2002-03-01
UY25524A1 (en) 2000-02-23
PL191974B1 (en) 2006-07-31
CN1275052A (en) 2000-11-29
BG104302A (en) 2001-08-31
BR9814064A (en) 2000-09-26
MA24670A1 (en) 1999-07-01
EP1043930A1 (en) 2000-10-18
ID25536A (en) 2000-10-12
AR015952A1 (en) 2001-05-30
EA003609B1 (en) 2003-06-26
AU9687498A (en) 1999-05-03
SA99191000A (en) 2005-12-03
AP1335A (en) 2004-11-29
AP2000001782A0 (en) 2000-06-30
CN1192025C (en) 2005-03-09
NO20001777D0 (en) 2000-04-06
IL135434A (en) 2004-12-15
IL135434A0 (en) 2001-05-20
UY25201A1 (en) 2001-08-27
HUP0003905A3 (en) 2002-01-28
OA11347A (en) 2003-12-17
TR200000945T2 (en) 2000-10-23
ZA989228B (en) 1999-04-12
TW440557B (en) 2001-06-16
KR100560038B1 (en) 2006-03-13

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