PE121599A1 - Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos - Google Patents
Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidosInfo
- Publication number
- PE121599A1 PE121599A1 PE1998000955A PE00095598A PE121599A1 PE 121599 A1 PE121599 A1 PE 121599A1 PE 1998000955 A PE1998000955 A PE 1998000955A PE 00095598 A PE00095598 A PE 00095598A PE 121599 A1 PE121599 A1 PE 121599A1
- Authority
- PE
- Peru
- Prior art keywords
- cr4r5
- alkyl
- precipitate
- compound
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN METODO PARA SINTETIZAR UN COMPUESTO I, DONDE R1 ES -C(R4R5)nC(O)O(CR4R5)mR6, -(CR4R5)nC(O)NR4(CR4R5)mR6, -(CR4R5)nO(CR4R5)mR6 O -(CR4R5)rR6; m ES 0-2; n ES 1-4; r ES 0-6; R4 Y R5 SON H O ALQUILO C1-C2; R6 ES H, METILO, OH, ARILO; CUANDO R6 ES OH, ENTONCES m ES 2, r ES 2-6; CUANDO R6 ES 2-TETRAHIDROPIRANILO, 2-TETRAHIDROTIOPIRANILO, 2-TETRAHIDROFURANILO, 2-TETRAHIDROTIENILO, ENTONCES m ES 1 o 2; r ES 1-6; CUANDO n ES 1 Y m ES CERO, ENTONCES R6 ES DISTINTO DE H; X ES YR2, HALO, NITRO, NH2 O FORMILAMINA; X2 ES O o NR8; Y ES O o S(O)m`; m' ES 0-2; R2 ES -CH3 o -CH2CH3; R3 ES H, HALO, ALQUILO C1-C4, ENTRE OTROS, R8 ES H o ALQUILO C1-C4; R8' ES R8 o FLUOR; R10 ES OR8 o R11; R11 ES H O ALQUILO C1-C4; Z' ES O, NR9, NOR8, ENTRE OTROS; R' Y R'' SON H o C(O)OX; X ES H o -C(O)OX; X ES H, CATION METALICO o NH4; QUE COMPRENDE a)COMBINAR UN HALURO DE UN METAL DEL GRUPO Ia o IIa (BROMURO DE LITIO O DE MAGNESIO) CON UN COMPUESTO IIa o IIb EN UN DISOLVENTE APROTICO DIPOLAR AMIDICO (DIMETILFORMAMIDA), AGUA; b)CALENTAR LA COMBINACION A 60°C DURANTE VARIAS HORAS, OPCIONALMENTE EN UNA ATMOSFERA INERTE; c)PRECIPITAR UN COMPUESTO I POR ADICION DE UNA BASE FUERTE (HIDROXIDO DE LITIO); d)RETIRAR EL DISOLVENTE AMIDICO Y PURIFICAR EL PRECIPITADO O ACIDULAR EL PRECIPITADO PARA OBTENER EL ACIDO LIBRE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6161397P | 1997-10-10 | 1997-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE121599A1 true PE121599A1 (es) | 2000-02-19 |
Family
ID=22036929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998000955A PE121599A1 (es) | 1997-10-10 | 1998-10-09 | Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1043930A4 (es) |
| JP (1) | JP2001519363A (es) |
| KR (1) | KR100560038B1 (es) |
| CN (1) | CN1192025C (es) |
| AP (1) | AP1335A (es) |
| AR (1) | AR015952A1 (es) |
| AU (1) | AU741832B2 (es) |
| BG (1) | BG104302A (es) |
| BR (1) | BR9814064A (es) |
| CA (1) | CA2305614A1 (es) |
| DZ (1) | DZ2619A1 (es) |
| EA (1) | EA003609B1 (es) |
| HU (1) | HUP0003905A3 (es) |
| ID (1) | ID25536A (es) |
| IL (1) | IL135434A (es) |
| MA (1) | MA24670A1 (es) |
| MY (1) | MY122105A (es) |
| NO (1) | NO20001777L (es) |
| NZ (1) | NZ503759A (es) |
| OA (1) | OA11347A (es) |
| PE (1) | PE121599A1 (es) |
| PL (1) | PL191974B1 (es) |
| SA (1) | SA99191000A (es) |
| SK (1) | SK4902000A3 (es) |
| TR (1) | TR200000945T2 (es) |
| TW (1) | TW440557B (es) |
| UA (1) | UA67753C2 (es) |
| UY (2) | UY25201A1 (es) |
| WO (1) | WO1999018793A1 (es) |
| ZA (1) | ZA989228B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9920152D0 (en) * | 1999-08-25 | 1999-10-27 | Smithkline Beecham Plc | Novel process |
| JP2003534238A (ja) * | 1999-12-15 | 2003-11-18 | スミスクライン・ビーチャム・コーポレイション | シス−４−シアノ−４−［３−（シクロペンチルオキシ）−４−メトキシフェニル］シクロヘキサン−１−カルボン酸の塩。 |
| KR20020073183A (ko) * | 2000-01-26 | 2002-09-19 | 스미스클라인 비참 코포레이션 | 시스-리튬시아노-4-[3-(시클로펜틸옥시)-4-메톡시페닐]시클로헥산카르복실레이트의 일수화물 |
| EP2258689A1 (en) | 2000-03-16 | 2010-12-08 | Biolipox AB | Benzylated PDE4 inhibitors |
| US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| CA2436535A1 (en) | 2001-01-31 | 2002-08-08 | Prizer Products Inc. | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
| DE60113731T2 (de) | 2001-01-31 | 2006-06-29 | Pfizer Products Inc., Groton | Als inhibitoren von pde4-isozymen geeignete etherderivate |
| KR20030072614A (ko) | 2001-01-31 | 2003-09-15 | 화이자 프로덕츠 인크. | Ｐｄｅ４ 이소자임 억제제로 유용한 티아졸릴-,옥사졸릴-, 피롤릴- 및 이미다졸릴-산 아미드 유도체 |
| CN102491959B (zh) * | 2011-12-19 | 2015-03-25 | 江苏澄扬作物科技有限公司 | 一种环氧乙烷衍生物的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4021478A (en) * | 1972-07-13 | 1977-05-03 | The Upjohn Company | Preparation of carboxylic acids from glycidonitriles with ionic lewis acids |
| SK279958B6 (sk) * | 1992-04-02 | 1999-06-11 | Smithkline Beecham Corporation | Zlúčeniny s protialergickým a protizápalovým účink |
| US5524438A (en) * | 1994-12-15 | 1996-06-11 | United Technologies Corporation | Segmented bulkhead liner for a gas turbine combustor |
| MY118813A (en) * | 1997-02-12 | 2005-01-31 | Smithkline Beecham Corp | Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids |
| US6452022B1 (en) * | 1997-10-10 | 2002-09-17 | Smithkline Beecham Corporation | Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids |
-
1998
- 1998-07-10 UA UA2000041944A patent/UA67753C2/uk unknown
- 1998-10-02 MA MA25278A patent/MA24670A1/fr unknown
- 1998-10-07 UY UY25201A patent/UY25201A1/es not_active IP Right Cessation
- 1998-10-07 EA EA200000406A patent/EA003609B1/ru not_active IP Right Cessation
- 1998-10-07 DZ DZ980229A patent/DZ2619A1/xx active
- 1998-10-07 ID IDW20000614A patent/ID25536A/id unknown
- 1998-10-07 PL PL339759A patent/PL191974B1/pl not_active IP Right Cessation
- 1998-10-07 JP JP2000515437A patent/JP2001519363A/ja active Pending
- 1998-10-07 NZ NZ503759A patent/NZ503759A/en unknown
- 1998-10-07 TR TR2000/00945T patent/TR200000945T2/xx unknown
- 1998-10-07 BR BR9814064-7A patent/BR9814064A/pt not_active IP Right Cessation
- 1998-10-07 SK SK490-2000A patent/SK4902000A3/sk unknown
- 1998-10-07 IL IL13543498A patent/IL135434A/en not_active IP Right Cessation
- 1998-10-07 CA CA002305614A patent/CA2305614A1/en not_active Abandoned
- 1998-10-07 AR ARP980105002A patent/AR015952A1/es unknown
- 1998-10-07 CN CNB988100304A patent/CN1192025C/zh not_active Expired - Fee Related
- 1998-10-07 AP APAP/P/2000/001782A patent/AP1335A/en active
- 1998-10-07 KR KR1020007003742A patent/KR100560038B1/ko not_active IP Right Cessation
- 1998-10-07 EP EP98950965A patent/EP1043930A4/en not_active Withdrawn
- 1998-10-07 WO PCT/US1998/021061 patent/WO1999018793A1/en not_active Application Discontinuation
- 1998-10-07 HU HU0003905A patent/HUP0003905A3/hu not_active Application Discontinuation
- 1998-10-07 AU AU96874/98A patent/AU741832B2/en not_active Ceased
- 1998-10-08 MY MYPI98004606A patent/MY122105A/en unknown
- 1998-10-09 ZA ZA989228A patent/ZA989228B/xx unknown
- 1998-10-09 PE PE1998000955A patent/PE121599A1/es not_active Application Discontinuation
- 1998-12-01 TW TW087116680A patent/TW440557B/zh not_active IP Right Cessation
-
1999
- 1999-01-26 SA SA99191000A patent/SA99191000A/ar unknown
- 1999-05-25 UY UY25524A patent/UY25524A1/es not_active Application Discontinuation
-
2000
- 2000-04-05 BG BG104302A patent/BG104302A/xx unknown
- 2000-04-06 NO NO20001777A patent/NO20001777L/no not_active Application Discontinuation
- 2000-04-07 OA OA1200000100A patent/OA11347A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2000603A6 (es) | Un procedimiento para preparar aril-piperidino carbinoles | |
| PE121599A1 (es) | Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos | |
| TW356415B (en) | 2-Amino-1,3,5-triazines, processes for their preparation, and their use as herbicides | |
| AR247402A1 (es) | Un procedimiento para preparar antibioticos macrolidos c-20 aminosustituidos | |
| DK160309C (da) | Analogifremgangsmaade til fremstilling af 8-substituerede pyrrolizidinderivater | |
| KR890009950A (ko) | 부동액중의 규산염을 안정화시키는 신규의 유기실란 및 그 제조방법 | |
| ES8304916A1 (es) | Procedimiento para preparar esteres de 2-nitro-5(fenoxi sus-tituido-benzoato de alfa-hidroxialcanoatos) | |
| NO924617D0 (no) | Fremgangsmaate for fremstilling av 10beta-h-steroider | |
| ES438234A1 (es) | Un procedimiento para la preparacion de derivados de oxici- clohexano. | |
| ES448629A1 (es) | Procedimiento para la preparacion de nuevos derivados de 1,4-bis-(carboxil-alcohil-benzoxazolil)-naftaleno. | |
| GB1506021A (en) | Process for the preparation of 5-triazolo(3,4-b)-benzothiazoles | |
| DK148804C (da) | Fremgangsmaade til fremstilling af 1,2,3,4-tetrahydroquinolin-4-oner | |
| KR840006975A (ko) | 스피로-3-헤테로-아졸론의 제조방법 | |
| ES437599A1 (es) | Un procedimiento para la preparacion de compuestos 3-(5-ni- troimidazol-2-il) pirazolo (3, 4-d) pirimidina. | |
| PE52699A1 (es) | Compuestos y metodos para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos | |
| ES2184628A1 (es) | Procedimiento estereoselectivo para la produccion de 6 -fluorpregnanos e intermedios. | |
| ES8403891A1 (es) | Un procedimiento para la preparacion de un derivado del acido furiloxazolila-cetico | |
| HK1078876A1 (en) | Method for producing formylphenylboronic acids | |
| GB937183A (en) | 3,8-diazabicyclo-[3,2,1]-octanes | |
| ES8506606A1 (es) | Procedimiento de preparacion de eteres oximas basicos y de sus sales de adicion acidas | |
| DK0406790T3 (da) | Fremgangsmåde til fremstilling af penemer | |
| HUP9902967A2 (hu) | Új eljárás trovafloxacinsav savaddíciós sóinak előállítására és intermedierek | |
| ES8203381A1 (es) | Un procedimiento para la preparacion de un compuesto que contiene una b-lactama biciclica fusionada | |
| ES444180A1 (es) | Un procedimiento para la preparacion de 6-amino-2, 2-dimetil-3-(5-tetrazolil) penam. | |
| GB1178133A (en) | Preparation of 1-Aminoalkyl-1-Arylindenes, Intermediates therefor, and Compounds thus prepared |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |