UY25201A1 - Método para tratar ácido 4-fenil-4-cianociclohexanoicos sustituidos - Google Patents

Método para tratar ácido 4-fenil-4-cianociclohexanoicos sustituidos

Info

Publication number
UY25201A1
UY25201A1 UY25201A UY25201A UY25201A1 UY 25201 A1 UY25201 A1 UY 25201A1 UY 25201 A UY25201 A UY 25201A UY 25201 A UY25201 A UY 25201A UY 25201 A1 UY25201 A1 UY 25201A1
Authority
UY
Uruguay
Prior art keywords
cr4r5
cyanociclohexanoic
phenyl
acid
alkyl
Prior art date
Application number
UY25201A
Other languages
English (en)
Inventor
Jian-Hoa Chen
Wilford Mendelson
Kevin Webb
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of UY25201A1 publication Critical patent/UY25201A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invención se refiere a un método para preparar un compuesto de fórmula l, en la que R1 es (CR4R5)nC(O)O(CR4R5)mR6; (CR4R5)rR6, en que los restos alquilo pueden estar opcionalmente sustituidos con uno o más halogenos; X es YR2, halogeno, nitro, NH2, o formilamina; X2 es O o NR8; R3 es H, halogeno, alquilo, CH2NHC(O)C(O)NH2, alquilo sustituido con halo, ciclopropilo, etc; R' y R'' son independientemente H o C(O)OX, en que X es H o un catión metálico o amonio. Una composición de materia que comprende cis-4-ciano-4-3-ciclopentilloxi-4-metoxifenil)-r-1-ciclohexano-carboxilato de litio esencialmente puro.
UY25201A 1997-10-10 1998-10-07 Método para tratar ácido 4-fenil-4-cianociclohexanoicos sustituidos UY25201A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10

Publications (1)

Publication Number Publication Date
UY25201A1 true UY25201A1 (es) 2001-08-27

Family

ID=22036929

Family Applications (2)

Application Number Title Priority Date Filing Date
UY25201A UY25201A1 (es) 1997-10-10 1998-10-07 Método para tratar ácido 4-fenil-4-cianociclohexanoicos sustituidos
UY25524A UY25524A1 (es) 1997-10-10 1999-05-25 Método para preparar ácidos 4-fenil4-cianociclohexanoicos sustituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
UY25524A UY25524A1 (es) 1997-10-10 1999-05-25 Método para preparar ácidos 4-fenil4-cianociclohexanoicos sustituidos

Country Status (30)

Country Link
EP (1) EP1043930A4 (es)
JP (1) JP2001519363A (es)
KR (1) KR100560038B1 (es)
CN (1) CN1192025C (es)
AP (1) AP1335A (es)
AR (1) AR015952A1 (es)
AU (1) AU741832B2 (es)
BG (1) BG104302A (es)
BR (1) BR9814064A (es)
CA (1) CA2305614A1 (es)
DZ (1) DZ2619A1 (es)
EA (1) EA003609B1 (es)
HU (1) HUP0003905A3 (es)
ID (1) ID25536A (es)
IL (1) IL135434A (es)
MA (1) MA24670A1 (es)
MY (1) MY122105A (es)
NO (1) NO20001777L (es)
NZ (1) NZ503759A (es)
OA (1) OA11347A (es)
PE (1) PE121599A1 (es)
PL (1) PL191974B1 (es)
SA (1) SA99191000A (es)
SK (1) SK4902000A3 (es)
TR (1) TR200000945T2 (es)
TW (1) TW440557B (es)
UA (1) UA67753C2 (es)
UY (2) UY25201A1 (es)
WO (1) WO1999018793A1 (es)
ZA (1) ZA989228B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
WO2001043692A2 (en) * 1999-12-15 2001-06-21 Smithkline Beecham Corporation SALTS OF Cis-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANE-1-CARBOXYLIC ACID
KR20020073183A (ko) * 2000-01-26 2002-09-19 스미스클라인 비참 코포레이션 시스-리튬시아노-4-[3-(시클로펜틸옥시)-4-메톡시페닐]시클로헥산카르복실레이트의 일수화물
US6555572B2 (en) 2000-03-16 2003-04-29 Inflazyme Pharmaceuticals Ltd. Benzylated PDE4 inhibitors
IL156412A0 (en) 2001-01-31 2004-01-04 Pfizer Prod Inc Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
IL156413A0 (en) 2001-01-31 2004-01-04 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
OA12541A (en) 2001-01-31 2006-06-05 Pfizer Prod Inc Ether derivatives useful as inhibitors of PDE4 isozymes.
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
CZ283425B6 (cs) * 1992-04-02 1998-04-15 Smithkline Beecham Corporation Fenylové deriváty a farmaceutické prostředky s jejich obsahem
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
AR012550A1 (es) * 1997-02-12 2000-11-08 Smithkline Beecham Corp Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
HUP0003905A2 (en) 2001-03-28
OA11347A (en) 2003-12-17
CN1275052A (zh) 2000-11-29
CN1192025C (zh) 2005-03-09
NZ503759A (en) 2002-03-01
CA2305614A1 (en) 1999-04-22
ID25536A (id) 2000-10-12
DZ2619A1 (fr) 2003-03-08
MA24670A1 (fr) 1999-07-01
EP1043930A4 (en) 2004-09-15
BG104302A (en) 2001-08-31
EA003609B1 (ru) 2003-06-26
TW440557B (en) 2001-06-16
TR200000945T2 (tr) 2000-10-23
MY122105A (en) 2006-03-31
AP1335A (en) 2004-11-29
UA67753C2 (uk) 2004-07-15
IL135434A (en) 2004-12-15
PE121599A1 (es) 2000-02-19
SK4902000A3 (en) 2000-11-07
KR20010015709A (ko) 2001-02-26
PL191974B1 (pl) 2006-07-31
AU9687498A (en) 1999-05-03
EP1043930A1 (en) 2000-10-18
SA99191000A (ar) 2005-12-03
NO20001777D0 (no) 2000-04-06
NO20001777L (no) 2000-05-03
WO1999018793A1 (en) 1999-04-22
JP2001519363A (ja) 2001-10-23
EA200000406A1 (ru) 2000-10-30
AP2000001782A0 (en) 2000-06-30
ZA989228B (en) 1999-04-12
KR100560038B1 (ko) 2006-03-13
UY25524A1 (es) 2000-02-23
PL339759A1 (en) 2001-01-02
AU741832B2 (en) 2001-12-13
AR015952A1 (es) 2001-05-30
HUP0003905A3 (en) 2002-01-28
IL135434A0 (en) 2001-05-20
BR9814064A (pt) 2000-09-26

Similar Documents

Publication Publication Date Title
BR9200317A (pt) Composto termoconformavel e processo para a preparacao do mesmo
UY25201A1 (es) Método para tratar ácido 4-fenil-4-cianociclohexanoicos sustituidos
MY100100A (en) N-[(4,6-dimethoxypyrimidin-2-y1) aminocarbonyl]-3- trifluoromethylpyridine-2- sulfonamide or salts thereof, herbicidal composition containing the same, and process for the production of the compound
PT99261A (pt) Processo para a preparacao de herbicidas a base de aril-haloalquilpirazoles substituidos
DK97890D0 (da) Fremgangsmaade til fremstilling af mevalolactonanaloge
AU540707B2 (en) N-methyl-3-(2methyl phenoxy)-o-phenylpropyl amine
UA26972A1 (uk) Гербіцидhа композиція та спосіб приглушеhhя бур'яhів
DE69419263D1 (de) Herbizide zusammensetzungen in form einer diphenylether- und stickstofflösung und verfahren
DE69523159T2 (de) Sulfonamidderivate von azolonen als anti-helicobacter-mittel
ES2028101T3 (es) Una composicion que comprende un acido carboxilico y una amina.
GB8306351D0 (en) Azole fungicides
ES8601311A1 (es) Un procedimiento para el curtido de piel
DK0760870T3 (da) Jernphosphatering under anvendelse af substituerede monocarboxylsyrer
BR8402999A (pt) Processo para preparacao de um composto de ureia,composicao herbicida e composicao algicida
DK432286D0 (da) Vandig sur aluminiumphosphatoploesning og dennes anvendelse ved fremstilling af hurtighaerdende cement
BR8207050A (pt) Composicao herbicidas a base de derivados de ureia,e,processo para preparacao destes derivados
BR8504580A (pt) Composto de benzoil-ureia,composicao inseticida,processo para controlar insetos e processo para a preparacao de um composto inseticida
PT858429E (pt) Composicao que contem pelo menos bicarbonato de sodio, processo de obtencao e utilizacoes
BR9812997A (pt) Processo para tratar uma solução contendo sal (is) de ferro contaminados com sal (is) de manganês solúvel
BR8503860A (pt) Composto,composicao herbicida e processo para a preparacao de tal composto
UY25338A1 (es) Método para tratar copd
BR8402998A (pt) Processo para a preparacao de um composto de ureia,composicao algicida aquatica e composicoes herbicida terrestre e aquatica
SI0679646T1 (en) Sulfonyl ureas as herbicidal compounds
ATE233731T1 (de) Verfahren zur herstellung von arylvinylsulfonen
DE59008367D1 (de) Kobaltgebundene Diamantwerkzeuge, Verfahren zu ihrer Herstellung sowie deren Verwendung.

Legal Events

Date Code Title Description
110 Patent granted

Effective date: 20100625

VENC Patent expired

Effective date: 20181007