DK97890D0 - Fremgangsmaade til fremstilling af mevalolactonanaloge - Google Patents

Fremgangsmaade til fremstilling af mevalolactonanaloge

Info

Publication number
DK97890D0
DK97890D0 DK097890A DK97890A DK97890D0 DK 97890 D0 DK97890 D0 DK 97890D0 DK 097890 A DK097890 A DK 097890A DK 97890 A DK97890 A DK 97890A DK 97890 D0 DK97890 D0 DK 97890D0
Authority
DK
Denmark
Prior art keywords
hydrogen
benzyloxy
phenoxy
trifluoromethyl
fluoro
Prior art date
Application number
DK097890A
Other languages
English (en)
Other versions
DK165244B (da
DK97890A (da
DK165244C (da
Inventor
Faizulla Gulamhusein Kathawala
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK97890A publication Critical patent/DK97890A/da
Publication of DK97890D0 publication Critical patent/DK97890D0/da
Publication of DK165244B publication Critical patent/DK165244B/da
Application granted granted Critical
Publication of DK165244C publication Critical patent/DK165244C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK097890A 1982-11-22 1990-04-19 Analogifremgangsmaade til fremstilling af 1,2,3-trisubstituerede indoler DK165244C (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US44366882A 1982-11-22 1982-11-22
US44366882 1982-11-22
US54885083A 1983-11-04 1983-11-04
US54885083 1983-11-04
PCT/EP1983/000308 WO1984002131A1 (en) 1982-11-22 1983-11-18 Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
EP8300308 1983-11-18

Publications (4)

Publication Number Publication Date
DK97890A DK97890A (da) 1990-04-19
DK97890D0 true DK97890D0 (da) 1990-04-19
DK165244B DK165244B (da) 1992-10-26
DK165244C DK165244C (da) 1993-03-22

Family

ID=27033614

Family Applications (2)

Application Number Title Priority Date Filing Date
DK359284A DK359284A (da) 1982-11-22 1984-07-20 Mevalolactonanaloge
DK097890A DK165244C (da) 1982-11-22 1990-04-19 Analogifremgangsmaade til fremstilling af 1,2,3-trisubstituerede indoler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK359284A DK359284A (da) 1982-11-22 1984-07-20 Mevalolactonanaloge

Country Status (18)

Country Link
EP (1) EP0114027B1 (da)
JP (1) JPH0347167A (da)
AT (1) ATE31718T1 (da)
AU (1) AU570021B2 (da)
CA (1) CA1210405A (da)
CY (1) CY1579A (da)
DE (2) DE3375137D1 (da)
DK (2) DK359284A (da)
FI (1) FI77228C (da)
GR (1) GR79042B (da)
HK (1) HK11191A (da)
HU (1) HU204253B (da)
IE (1) IE56262B1 (da)
IL (1) IL70286A (da)
LU (1) LU88670I2 (da)
NL (1) NL950022I2 (da)
NZ (1) NZ206338A (da)
WO (1) WO1984002131A1 (da)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
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Also Published As

Publication number Publication date
IE56262B1 (en) 1991-06-05
DK359284D0 (da) 1984-07-20
HU204253B (en) 1991-12-30
IL70286A (en) 1987-08-31
LU88670I2 (fr) 1996-04-29
HK11191A (en) 1991-02-13
FI77228C (fi) 1989-02-10
DK165244B (da) 1992-10-26
DK97890A (da) 1990-04-19
EP0114027B1 (en) 1988-01-07
DE19475017I2 (de) 2003-02-20
JPH0347167A (ja) 1991-02-28
NL950022I2 (nl) 1996-12-02
NL950022I1 (da) 1996-01-02
HUT35642A (en) 1985-07-29
FI842615A (fi) 1984-06-28
JPH0440343B2 (da) 1992-07-02
IE832713L (en) 1984-05-22
DE3375137D1 (en) 1988-02-11
CY1579A (en) 1991-12-20
GR79042B (da) 1984-10-02
FI77228B (fi) 1988-10-31
DK359284A (da) 1984-07-20
CA1210405A (en) 1986-08-26
NZ206338A (en) 1987-08-31
AU570021B2 (en) 1988-03-03
IL70286A0 (en) 1984-02-29
WO1984002131A1 (en) 1984-06-07
EP0114027A1 (en) 1984-07-25
AU2261283A (en) 1984-06-18
ATE31718T1 (de) 1988-01-15
DK165244C (da) 1993-03-22
FI842615A0 (fi) 1984-06-28

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