KR100560038B1 - 치환된 4-페닐-4-시아노시클로헥사노산의 제조 방법 - Google Patents

치환된 4-페닐-4-시아노시클로헥사노산의 제조 방법 Download PDF

Info

Publication number
KR100560038B1
KR100560038B1 KR1020007003742A KR20007003742A KR100560038B1 KR 100560038 B1 KR100560038 B1 KR 100560038B1 KR 1020007003742 A KR1020007003742 A KR 1020007003742A KR 20007003742 A KR20007003742 A KR 20007003742A KR 100560038 B1 KR100560038 B1 KR 100560038B1
Authority
KR
South Korea
Prior art keywords
substituted
compound
formula
alkyl
water
Prior art date
Application number
KR1020007003742A
Other languages
English (en)
Korean (ko)
Other versions
KR20010015709A (ko
Inventor
케빈 웹
윌포드 멘델손
지안하오 첸
Original Assignee
스미스클라인 비참 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스미스클라인 비참 코포레이션 filed Critical 스미스클라인 비참 코포레이션
Publication of KR20010015709A publication Critical patent/KR20010015709A/ko
Application granted granted Critical
Publication of KR100560038B1 publication Critical patent/KR100560038B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020007003742A 1997-10-10 1998-10-07 치환된 4-페닐-4-시아노시클로헥사노산의 제조 방법 KR100560038B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10
US60/061,613 1997-10-10
PCT/US1998/021061 WO1999018793A1 (en) 1997-10-10 1998-10-07 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (2)

Publication Number Publication Date
KR20010015709A KR20010015709A (ko) 2001-02-26
KR100560038B1 true KR100560038B1 (ko) 2006-03-13

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007003742A KR100560038B1 (ko) 1997-10-10 1998-10-07 치환된 4-페닐-4-시아노시클로헥사노산의 제조 방법

Country Status (30)

Country Link
EP (1) EP1043930A4 (zh)
JP (1) JP2001519363A (zh)
KR (1) KR100560038B1 (zh)
CN (1) CN1192025C (zh)
AP (1) AP1335A (zh)
AR (1) AR015952A1 (zh)
AU (1) AU741832B2 (zh)
BG (1) BG104302A (zh)
BR (1) BR9814064A (zh)
CA (1) CA2305614A1 (zh)
DZ (1) DZ2619A1 (zh)
EA (1) EA003609B1 (zh)
HU (1) HUP0003905A3 (zh)
ID (1) ID25536A (zh)
IL (1) IL135434A (zh)
MA (1) MA24670A1 (zh)
MY (1) MY122105A (zh)
NO (1) NO20001777L (zh)
NZ (1) NZ503759A (zh)
OA (1) OA11347A (zh)
PE (1) PE121599A1 (zh)
PL (1) PL191974B1 (zh)
SA (1) SA99191000A (zh)
SK (1) SK4902000A3 (zh)
TR (1) TR200000945T2 (zh)
TW (1) TW440557B (zh)
UA (1) UA67753C2 (zh)
UY (2) UY25201A1 (zh)
WO (1) WO1999018793A1 (zh)
ZA (1) ZA989228B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
JP2003534238A (ja) * 1999-12-15 2003-11-18 スミスクライン・ビーチャム・コーポレイション シス−４−シアノ−４−［３−（シクロペンチルオキシ）−４−メトキシフェニル］シクロヘキサン−１−カルボン酸の塩。
DZ3285A1 (fr) * 2000-01-26 2001-08-02 Smithkline Beecham Corp Monohydrate cis-lithium-4-cyano-4-(3-(cyclopentyloxy)-4methoxyphenyl) cyclohexanecarboxylate
WO2001068600A2 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Limited Benzylated pde4 inhibitors
JP2004520386A (ja) 2001-01-31 2004-07-08 ファイザー・プロダクツ・インク Ｐｄｅ４アイソザイムの阻害剤として有用なニコチンアミドビアリール誘導体
PL364910A1 (en) 2001-01-31 2004-12-27 Pfizer Products Inc. Ether derivatives useful as inhibitors of pde4 isozymes
HUP0401305A2 (hu) 2001-01-31 2004-10-28 Pfizer Products Inc. Tiazolil-, oxazolil-, pirrolil- és imidazolil-savamid-származékok, mint PDE4 izozimek inhibitorai és az ezeket tartalmazó gyógyszerkészítmények
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552438A (en) * 1992-04-02 1996-09-03 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
AR012550A1 (es) * 1997-02-12 2000-11-08 Smithkline Beecham Corp Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552438A (en) * 1992-04-02 1996-09-03 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases

Also Published As

Publication number Publication date
IL135434A (en) 2004-12-15
BR9814064A (pt) 2000-09-26
NO20001777L (no) 2000-05-03
MA24670A1 (fr) 1999-07-01
PL191974B1 (pl) 2006-07-31
NZ503759A (en) 2002-03-01
DZ2619A1 (fr) 2003-03-08
CN1275052A (zh) 2000-11-29
ZA989228B (en) 1999-04-12
CN1192025C (zh) 2005-03-09
IL135434A0 (en) 2001-05-20
PE121599A1 (es) 2000-02-19
TR200000945T2 (tr) 2000-10-23
EP1043930A4 (en) 2004-09-15
EA200000406A1 (ru) 2000-10-30
UY25524A1 (es) 2000-02-23
TW440557B (en) 2001-06-16
JP2001519363A (ja) 2001-10-23
SA99191000A (ar) 2005-12-03
BG104302A (en) 2001-08-31
NO20001777D0 (no) 2000-04-06
KR20010015709A (ko) 2001-02-26
UY25201A1 (es) 2001-08-27
OA11347A (en) 2003-12-17
UA67753C2 (uk) 2004-07-15
AR015952A1 (es) 2001-05-30
AP2000001782A0 (en) 2000-06-30
AP1335A (en) 2004-11-29
EA003609B1 (ru) 2003-06-26
MY122105A (en) 2006-03-31
AU9687498A (en) 1999-05-03
SK4902000A3 (en) 2000-11-07
PL339759A1 (en) 2001-01-02
WO1999018793A1 (en) 1999-04-22
EP1043930A1 (en) 2000-10-18
CA2305614A1 (en) 1999-04-22
AU741832B2 (en) 2001-12-13
HUP0003905A3 (en) 2002-01-28
HUP0003905A2 (en) 2001-03-28
ID25536A (id) 2000-10-12

Similar Documents

Publication Publication Date Title
KR100560038B1 (ko) 치환된 4-페닐-4-시아노시클로헥사노산의 제조 방법
JP4093967B2 (ja) 置換４−フェニル−４−シアノシクロヘキサン酸の中間体および製法
US6452022B1 (en) Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
CZ20001273A3 (cs) Způsob přípravy substituovaných 4-fenyl-4- kyancyklohexanových kyselin
MXPA00003405A (en) Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
EP1295869B1 (en) Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
EP1524268A1 (en) Compounds and method for preparing sustituted 4-phenyl-4-cyanocyclohexanoic acids
CZ283999A3 (cs) Sloučeniny a způsob přípravy substituovaných 4-fenyl-4-kyanocyklohexanových kyselin
MXPA99007441A (en) Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20100122

Year of fee payment: 5

LAPS Lapse due to unpaid annual fee