OA11500A - Identification of chemical active agents for inhibiting the 1-desoxy-D-xylulose-5-phosphate biosynthetic pathway in parasites. - Google Patents

Identification of chemical active agents for inhibiting the 1-desoxy-D-xylulose-5-phosphate biosynthetic pathway in parasites. Download PDF

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Publication number
OA11500A
OA11500A OA1200000280A OA1200000280A OA11500A OA 11500 A OA11500 A OA 11500A OA 1200000280 A OA1200000280 A OA 1200000280A OA 1200000280 A OA1200000280 A OA 1200000280A OA 11500 A OA11500 A OA 11500A
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OA
OAPI
Prior art keywords
asn
ile
lys
leu
ser
Prior art date
Application number
OA1200000280A
Other languages
English (en)
Inventor
Hassan Jomaa
Original Assignee
Hassan Jomaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19825585A external-priority patent/DE19825585A1/de
Priority claimed from DE19828097A external-priority patent/DE19828097A1/de
Priority claimed from DE19831637A external-priority patent/DE19831637A1/de
Priority claimed from DE19831639A external-priority patent/DE19831639C1/de
Application filed by Hassan Jomaa filed Critical Hassan Jomaa
Publication of OA11500A publication Critical patent/OA11500A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
OA1200000280A 1998-04-14 2000-10-12 Identification of chemical active agents for inhibiting the 1-desoxy-D-xylulose-5-phosphate biosynthetic pathway in parasites. OA11500A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE19816196 1998-04-14
DE19825585A DE19825585A1 (de) 1998-04-14 1998-06-09 Verwendung von Aminohydrocarbylphosphonsäurederivaten zur therapeutischen und prophylaktischen Behandlung von Infektionen, die durch Parasiten, Pilze oder Viren hervorgerufen werden
DE19828097A DE19828097A1 (de) 1998-06-24 1998-06-24 Kombinationspräparat von Aminohydrocarbylphosphonsäurederivaten und Hemmern des Fettstoffwechsels
DE19831638 1998-07-15
DE19831637A DE19831637A1 (de) 1998-07-15 1998-07-15 Verwendung von phosphororganischen Verbindungen zur therapeutischen und prophylaktischen Behandlung von Infektionen, die durch Parasiten hervorgerufen werden
DE19831639A DE19831639C1 (de) 1998-07-15 1998-07-15 Phosphororganische Verbindungen und ihre Verwendung
DE19843279 1998-09-22

Publications (1)

Publication Number Publication Date
OA11500A true OA11500A (en) 2004-05-14

Family

ID=27561757

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200000280A OA11500A (en) 1998-04-14 2000-10-12 Identification of chemical active agents for inhibiting the 1-desoxy-D-xylulose-5-phosphate biosynthetic pathway in parasites.

Country Status (14)

Country Link
EP (1) EP1071959A2 (de)
JP (1) JP2002511486A (de)
CN (1) CN1297532A (de)
AP (1) AP2000001937A0 (de)
AU (1) AU753169B2 (de)
CA (1) CA2328157A1 (de)
HU (1) HUP0101711A2 (de)
IL (1) IL138721A0 (de)
MX (1) MXPA00010069A (de)
OA (1) OA11500A (de)
PL (1) PL358989A1 (de)
SK (1) SK15232000A3 (de)
TR (1) TR200002972T2 (de)
WO (1) WO1999052938A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1102852A1 (de) * 1998-08-05 2001-05-30 Sungene GmbH & Co. KgAA Dna-sequenz kodierend für eine 1-deoxy-d-xylulose-5-phosphat synthase und deren überproduktion in pflanzen
JP2002526061A (ja) * 1998-09-22 2002-08-20 ヨマー、ファルマカ、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング １−デオキシ−ｄ−キシルロース生合成経路の遺伝子
EP1141379A1 (de) * 1998-12-14 2001-10-10 Adelbert Bacher Screening für inhibitoren von terpenoiden-biosynthese
GB9901902D0 (en) * 1999-01-28 1999-03-17 New Royal Holloway & Bedford Manipulating isoprenoid expression
EP1179187A1 (de) * 1999-05-21 2002-02-13 Jomaa Pharmaka GmbH Verwendung von genen des desoxy-d-xylulose-phosphatbiosynthesewegs zur veränderung der isoprenoidkonzentration
AU6280300A (en) 1999-08-04 2001-03-05 Adelbert Bacher Isoprenoid biosynthesis
DE10021688A1 (de) * 2000-05-05 2001-11-15 Hassan Jomaa Gene des 1-Desoxy-D-xylulose-Biosynthesewegs
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
CN102860999B (zh) * 2012-10-12 2014-04-09 西北大学 1-脱氧-d-木酮糖5-磷酸还原异构化酶抑制剂及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19752700A1 (de) * 1997-11-28 1999-06-02 Hoechst Schering Agrevo Gmbh 1-Desoxy-D-xylulose-5-phosphat Synthase, Verfahren zur Identifizierung von Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase und Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase

Also Published As

Publication number Publication date
EP1071959A2 (de) 2001-01-31
SK15232000A3 (sk) 2001-05-10
WO1999052938A2 (de) 1999-10-21
CN1297532A (zh) 2001-05-30
CA2328157A1 (en) 1999-10-21
IL138721A0 (en) 2001-10-31
AP2000001937A0 (en) 2000-12-31
AU4481699A (en) 1999-11-01
PL358989A1 (en) 2004-08-23
MXPA00010069A (es) 2002-08-06
WO1999052938A3 (de) 1999-12-09
JP2002511486A (ja) 2002-04-16
TR200002972T2 (tr) 2001-01-22
AU753169B2 (en) 2002-10-10
HUP0101711A2 (hu) 2001-09-28

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