OA10515A - Utilisation du fumagillol et ses dérivés pour préparer des médicaments destinés à combattre les infections intestinales - Google Patents

Utilisation du fumagillol et ses dérivés pour préparer des médicaments destinés à combattre les infections intestinales Download PDF

Info

Publication number
OA10515A
OA10515A OA70088A OA70088A OA10515A OA 10515 A OA10515 A OA 10515A OA 70088 A OA70088 A OA 70088A OA 70088 A OA70088 A OA 70088A OA 10515 A OA10515 A OA 10515A
Authority
OA
OAPI
Prior art keywords
fumagillol
fumagillin
preparation
ester
patients
Prior art date
Application number
OA70088A
Other languages
English (en)
French (fr)
Inventor
Jean-Michel Molina
Francis Derouin
Original Assignee
Sanofi Sa
Assist Publ Hopitaux De Paris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa, Assist Publ Hopitaux De Paris filed Critical Sanofi Sa
Publication of OA10515A publication Critical patent/OA10515A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
OA70088A 1995-03-27 1997-09-26 Utilisation du fumagillol et ses dérivés pour préparer des médicaments destinés à combattre les infections intestinales OA10515A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9503549 1995-03-27

Publications (1)

Publication Number Publication Date
OA10515A true OA10515A (fr) 2002-04-24

Family

ID=9477436

Family Applications (1)

Application Number Title Priority Date Filing Date
OA70088A OA10515A (fr) 1995-03-27 1997-09-26 Utilisation du fumagillol et ses dérivés pour préparer des médicaments destinés à combattre les infections intestinales

Country Status (25)

Country Link
US (1) US5900431A (forum.php)
EP (1) EP0817626B1 (forum.php)
JP (1) JP3260378B2 (forum.php)
KR (1) KR100286920B1 (forum.php)
CN (1) CN1072485C (forum.php)
AP (1) AP646A (forum.php)
AT (1) ATE172641T1 (forum.php)
AU (1) AU706161B2 (forum.php)
CA (1) CA2216623C (forum.php)
CZ (1) CZ286821B6 (forum.php)
DE (1) DE69600879T2 (forum.php)
DK (1) DK0817626T3 (forum.php)
EA (1) EA000150B1 (forum.php)
ES (1) ES2128846T3 (forum.php)
FR (1) FR06C0014I2 (forum.php)
HU (1) HU224028B1 (forum.php)
IS (1) IS2048B (forum.php)
NO (1) NO315968B1 (forum.php)
NZ (1) NZ304906A (forum.php)
OA (1) OA10515A (forum.php)
PL (1) PL183378B1 (forum.php)
SK (1) SK283883B6 (forum.php)
TR (1) TR199701048T1 (forum.php)
UA (1) UA41446C2 (forum.php)
WO (1) WO1996030010A2 (forum.php)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0817626T3 (da) * 1995-03-27 1999-07-12 Assist Publ Hopitaux De Paris Anvendelse af fumagillol og derivater deraf til fremstilling af lægemidler mod tarminfektioner
EP0799616A1 (en) * 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative
HU228857B1 (en) * 1999-02-26 2013-06-28 Sanofi Aventis Stable formulation containing fumagillin
JP3265394B1 (ja) * 2001-03-14 2002-03-11 泰三 矢野 アクリル系樹脂手袋
DE10341887A1 (de) * 2003-09-09 2005-03-31 Leopold Kostal Gmbh & Co. Kg Elektrisches Schaltermodul
FR2886855B1 (fr) * 2005-06-08 2009-07-17 Agronomique Inst Nat Rech Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
EA020251B1 (ru) * 2007-11-28 2014-09-30 Мерсана Терапьютикс, Инк. Биосовместимые и биоразлагаемые конъюгаты аналогов фумагиллина
CN102123586A (zh) * 2008-07-18 2011-07-13 法弗根股份有限公司 治疗超重或肥胖受试者的方法
WO2013055385A2 (en) 2011-10-03 2013-04-18 Zafgen Corporation Methods of treating age related disorders
WO2010065877A2 (en) 2008-12-04 2010-06-10 Zafgen Corporation Methods of treating an overweight or obese subject
WO2010065883A2 (en) 2008-12-04 2010-06-10 Zafgen Corporation Method of treating an overweight or obese subject
EP2486004B1 (en) 2009-10-09 2017-05-03 Zafgen, Inc. Sulphone compounds for use in the treatment of obesity
WO2011085198A1 (en) 2010-01-08 2011-07-14 Zafgen Corporation Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph)
US8772333B2 (en) 2010-01-08 2014-07-08 Zafgen, Inc. Fumigillol type compounds and methods of making and using same
WO2011127304A2 (en) 2010-04-07 2011-10-13 Zafgen Corporation Methods of treating an overweight subject
MX2013000836A (es) 2010-07-22 2013-09-26 Zafgen Inc Compuestos triciclicos y metodos para elaborar y usar los mismos.
PH12013500934A1 (en) 2010-11-09 2022-10-24 Zafgen Inc Crystalline solids of a metap-2 inhibitor and methods of making and using same
AU2011336785A1 (en) 2010-11-29 2013-06-20 Zafgen, Inc Treatment of obesity using non-daily administration of 6-0-(4 - dimethylaminoethoxy) cinnamoyl fumagillol
KR20140006888A (ko) 2011-01-26 2014-01-16 자프겐 인크. 테트라졸화합물, 그리고, 이를 제조하는 방법 및 이를 이용하는 방법
EP2683706B1 (en) 2011-03-08 2018-02-21 Zafgen, Inc. Oxaspiro [2.5]octane derivatives and analogs
EP2705030B1 (en) 2011-05-06 2016-07-27 Zafgen, Inc. Partially saturated tricyclic compounds and methods of making and using same
CN103764652B (zh) 2011-05-06 2016-03-23 扎夫根股份有限公司 三环吡唑磺酰胺化合物及其制备和使用方法
BR112013028665A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos
WO2013109739A1 (en) 2012-01-18 2013-07-25 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
US9440943B2 (en) 2012-01-18 2016-09-13 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
BR112014027808A2 (pt) 2012-05-07 2017-06-27 Zafgen Inc sal polimórfico do sal de oxalato de 6-o-(4-dimetilaminoetoxi) cinaroil fumagilol e métodos de produção e utilização do mesmo
CN104363905A (zh) 2012-05-08 2015-02-18 扎夫根股份有限公司 用metap2抑制剂治疗下丘脑性肥胖
EP2850079B1 (en) 2012-05-09 2018-05-02 Zafgen, Inc. Fumigillol type compounds and methods of making and using same
EP2917197B1 (en) 2012-11-05 2019-06-05 Zafgen, Inc. Tricyclic compounds and methods of making and using same
WO2014071368A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Methods of treating liver diseases
AU2013337288A1 (en) 2012-11-05 2015-05-21 Zafgen, Inc. Tricyclic compounds for use in the treatment and/or control of obesity
AU2014236528A1 (en) 2013-03-14 2015-09-24 Zafgen, Inc. Methods of treating renal disease and other disorders
AR105671A1 (es) 2015-08-11 2017-10-25 Zafgen Inc Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法
CN106591389B (zh) * 2015-10-15 2019-10-11 中国科学院微生物研究所 一种利用烟曲霉菌生产烟曲霉素的方法
CN105622593B (zh) * 2016-02-25 2018-06-26 中国农业科学院蜜蜂研究所 一种烟曲霉素的提取方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2791530A (en) * 1953-08-31 1957-05-07 Abbott Lab Stabilized fumagillin compositions
JPH0629278B2 (ja) * 1985-06-26 1994-04-20 藤沢薬品工業株式会社 オキサスピロオクタン化合物
US5135920A (en) * 1988-11-16 1992-08-04 Takeda Chemical Industries, Ltd. Angiostatic agents
JPH06504262A (ja) * 1990-07-27 1994-05-19 レブリゲン　コーポレーション 脈管形成性の病気の処置用の新規な方法と組成物
US5328930A (en) * 1993-03-01 1994-07-12 Emory University Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin
DK0817626T3 (da) * 1995-03-27 1999-07-12 Assist Publ Hopitaux De Paris Anvendelse af fumagillol og derivater deraf til fremstilling af lægemidler mod tarminfektioner
EP0799616A1 (en) * 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative
CA2210600A1 (en) * 1996-07-17 1998-01-17 Takashi Houkan Inhibitor of tumor metastasis or recurrence
WO1998005293A2 (en) * 1996-08-02 1998-02-12 The Children's Medical Center Corporation Method of regulating the female reproductive system through angiogenesis inhibitors

Also Published As

Publication number Publication date
MX9707150A (es) 1998-07-31
EP0817626A2 (fr) 1998-01-14
UA41446C2 (uk) 2001-09-17
PL183378B1 (pl) 2002-06-28
HUP9801220A2 (hu) 1999-09-28
CA2216623C (en) 2005-05-31
CN1179715A (zh) 1998-04-22
KR19980703271A (ko) 1998-10-15
CZ286821B6 (en) 2000-07-12
CZ304997A3 (en) 1997-12-17
DE69600879T2 (de) 1999-06-02
NO974466L (no) 1997-09-26
WO1996030010A2 (fr) 1996-10-03
CA2216623A1 (en) 1996-10-03
JP3260378B2 (ja) 2002-02-25
DK0817626T3 (da) 1999-07-12
WO1996030010A3 (fr) 1996-11-28
CN1072485C (zh) 2001-10-10
US5900431A (en) 1999-05-04
HU224028B1 (hu) 2005-05-30
IS4557A (is) 1997-09-11
ATE172641T1 (de) 1998-11-15
DE69600879D1 (de) 1998-12-03
PL322470A1 (en) 1998-02-02
TR199701048T1 (xx) 1998-01-21
KR100286920B1 (ko) 2001-04-16
AU706161B2 (en) 1999-06-10
IS2048B (is) 2005-09-15
FR06C0014I1 (forum.php) 2006-11-17
SK130797A3 (en) 1998-03-04
EA199700267A1 (ru) 1998-04-30
SK283883B6 (sk) 2004-04-06
AU5278696A (en) 1996-10-16
NO974466D0 (no) 1997-09-26
EA000150B1 (ru) 1998-10-29
AP9701092A0 (en) 1997-10-31
HUP9801220A3 (en) 2001-10-29
FR06C0014I2 (forum.php) 2006-12-29
EP0817626B1 (fr) 1998-10-28
AP646A (en) 1998-04-27
JPH11506421A (ja) 1999-06-08
NO315968B1 (no) 2003-11-24
ES2128846T3 (es) 1999-05-16
NZ304906A (en) 1999-06-29

Similar Documents

Publication Publication Date Title
EP0817626B1 (fr) Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales
EP0385846B1 (fr) Composition pharmaceutique à libération prolongée d'acide valproîque
FR2774591A1 (fr) Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie
EP0237538B1 (fr) Preparation d'un medicament retard
EP0437128B1 (fr) Utilisation des dérivés des fluoroquinolones pour le traitement de la pneumonie à Pneumocystis carinii
JPH0232093A (ja) 抗レトロウィルスジフルオロ化ヌクレオシド類
US4880742A (en) Prostaglandin biosynthesis inhibitors
WO1991007960A1 (fr) Compositions pharmaceutiques destinees au traitement de l'ataxie et les troubles de l'equilibre
KR20000057628A (ko) 당뇨병환자의 혈관 기능부전 예방을 위한 약제 제조에 있어서카테콜-오-메틸전이효소 억제제의 용도
US6593329B1 (en) Method for the treatment or prevention of coronary graft vasospasm
WO1992007564A2 (en) Method of treating demyelinating disease
FR2675384A1 (fr) Complexes de l'acide polyadenylique avec l'acide polyuridylique.
FR2566664A1 (fr) Composition utile au traitement de la diarrhee contenant du dextromethorphan
EA007488B1 (ru) Фармацевтические композиции с контролируемым высвобождением, содержащие альгинат натрия и альгинат натрия-кальция
FR2618676A1 (fr) Compositions pharmaceutiques antivirales
FR2585573A1 (fr) Medicament pour prevenir l'abus d'alcool
CH679982A5 (en) Anti-retroviral compsn. contg. 2-methyl-9-hydroxy-ellipticine acetate - esp. for treatment or prevention of AIDS with greater activity than AZT
EP0818997A1 (fr) Compositions comprenant l'amiodarone et le betaxolol
FR2684297A1 (fr) Utilisation d'un acide amine soufre pour la preparation d'un medicament destine au traitement de l'eczema.
JPS58210010A (ja) 抗腫瘍剤
FR2740343A1 (fr) Utilisation de la 1-(2-napht-2-yl-ethyl)-4- (3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de la sclerose laterale amyotrophique
FR2527077A1 (fr) Nouveau medicament a base d'un anti-depresseur et d'un alcaloide ergopeptidique