NZ615593A - Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor - Google Patents

Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor Download PDF

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Publication number
NZ615593A
NZ615593A NZ615593A NZ61559312A NZ615593A NZ 615593 A NZ615593 A NZ 615593A NZ 615593 A NZ615593 A NZ 615593A NZ 61559312 A NZ61559312 A NZ 61559312A NZ 615593 A NZ615593 A NZ 615593A
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NZ
New Zealand
Prior art keywords
inhibitor
kinase
combination
pi3k
phosphatidylinositol
Prior art date
Application number
NZ615593A
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English (en)
Inventor
Christine Fritsch
Carlos Garcia-Echeverria
Xizhong Huang
Sauveur-Michel Maira
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46018130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ615593(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NZ615593A publication Critical patent/NZ615593A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Immunology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
NZ615593A 2011-04-25 2012-04-23 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor NZ615593A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478572P 2011-04-25 2011-04-25
PCT/US2012/034647 WO2012148846A1 (en) 2011-04-25 2012-04-23 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Publications (1)

Publication Number Publication Date
NZ615593A true NZ615593A (en) 2015-05-29

Family

ID=46018130

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ615593A NZ615593A (en) 2011-04-25 2012-04-23 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Country Status (26)

Country Link
US (3) US20140066474A1 (enExample)
EP (1) EP2701703A1 (enExample)
JP (2) JP6086902B2 (enExample)
KR (1) KR101925656B1 (enExample)
CN (1) CN103491955B (enExample)
AR (1) AR086481A1 (enExample)
AU (2) AU2012250010A1 (enExample)
BR (1) BR112013027486A2 (enExample)
CA (1) CA2833962A1 (enExample)
CL (1) CL2013003078A1 (enExample)
CO (1) CO6801759A2 (enExample)
EA (1) EA025948B1 (enExample)
EC (1) ECSP13012994A (enExample)
GT (1) GT201300263A (enExample)
IL (1) IL229008A (enExample)
MA (1) MA35038B1 (enExample)
MX (1) MX2013012385A (enExample)
NZ (1) NZ615593A (enExample)
PE (1) PE20140601A1 (enExample)
PH (1) PH12013502077A1 (enExample)
SG (1) SG193919A1 (enExample)
TN (1) TN2013000392A1 (enExample)
TW (1) TWI602567B (enExample)
UA (1) UA110961C2 (enExample)
WO (1) WO2012148846A1 (enExample)
ZA (1) ZA201306973B (enExample)

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MX2014005414A (es) * 2011-11-02 2014-09-22 Novartis Ag Derivados de 2-carboxamida-cicloamino-urea para su uso en el tratamiento de las enfermedades dependientes del factor de crecimiento endotelial vascular (vegf).
HK1219421A1 (zh) * 2013-03-15 2017-04-07 因特利凯有限责任公司 激酶抑制剂的组合及其用途
EA201690987A1 (ru) * 2013-11-13 2016-10-31 Новартис Аг Низкодозовые иммуностимулирующие ингибиторы mtor и их применения
AU2015216590A1 (en) * 2014-02-11 2016-06-30 Novartis Ag Pharmaceutical combinations comprising a PI3K inhibitor for the treatment of cancer
WO2015148626A1 (en) * 2014-03-26 2015-10-01 Millennium Pharmaceuticals, Inc. Treatment of fibrotic disorders
EP3200772B1 (en) * 2014-10-03 2022-08-03 Novartis AG Pharmaceutical compositions comprising alpelisib
US20160339030A1 (en) * 2015-05-19 2016-11-24 University Of Maryland, Baltimore Treatment agents for inhibiting hiv and cancer in hiv infected patients
JP6691337B2 (ja) * 2016-02-29 2020-04-28 学校法人北里研究所 膀胱癌患者の予後を予測するための方法
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

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US5120842A (en) 1991-04-01 1992-06-09 American Home Products Corporation Silyl ethers of rapamycin
US5100883A (en) 1991-04-08 1992-03-31 American Home Products Corporation Fluorinated esters of rapamycin
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US5151413A (en) 1991-11-06 1992-09-29 American Home Products Corporation Rapamycin acetals as immunosuppressant and antifungal agents
GB9125660D0 (en) 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compound
ZA935111B (en) 1992-07-17 1994-02-04 Smithkline Beecham Corp Rapamycin derivatives
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US5256790A (en) 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5258389A (en) 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
EP0729471A1 (en) 1993-11-19 1996-09-04 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
BR9408323A (pt) 1993-12-17 1997-08-19 Sandoz Ag Derivados de rapamicina
DE69624921T2 (de) 1995-06-09 2003-09-11 Novartis Ag, Basel Rapamycinderivate
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AR044519A1 (es) * 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
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UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
CA2736361C (en) * 2008-10-31 2017-10-10 Novartis Ag Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

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CN103491955B (zh) 2015-12-23
ZA201306973B (en) 2014-06-25
PH12013502077A1 (en) 2013-12-16
BR112013027486A2 (pt) 2017-02-14
MX2013012385A (es) 2013-11-04
SG193919A1 (en) 2013-11-29
US20170095463A1 (en) 2017-04-06
AU2016202372B2 (en) 2017-07-20
MA35038B1 (fr) 2014-04-03
CA2833962A1 (en) 2012-11-01
UA110961C2 (uk) 2016-03-10
AR086481A1 (es) 2013-12-18
ECSP13012994A (es) 2013-12-31
WO2012148846A1 (en) 2012-11-01
AU2012250010A1 (en) 2013-10-10
IL229008A0 (en) 2013-12-31
JP2014513097A (ja) 2014-05-29
TWI602567B (zh) 2017-10-21
EA025948B1 (ru) 2017-02-28
US20180085362A1 (en) 2018-03-29
EA201391565A1 (ru) 2014-02-28
JP2017061527A (ja) 2017-03-30
PE20140601A1 (es) 2014-05-24
GT201300263A (es) 2015-11-24
US20140066474A1 (en) 2014-03-06
TN2013000392A1 (en) 2015-01-20
CO6801759A2 (es) 2013-11-29
JP6086902B2 (ja) 2017-03-01
IL229008A (en) 2017-11-30
KR20140012147A (ko) 2014-01-29
AU2016202372A1 (en) 2016-05-05
EP2701703A1 (en) 2014-03-05
CL2013003078A1 (es) 2014-05-30
CN103491955A (zh) 2014-01-01
KR101925656B1 (ko) 2018-12-05
TW201244716A (en) 2012-11-16

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