TN2013000392A1 - Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor - Google Patents

Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Info

Publication number
TN2013000392A1
TN2013000392A1 TNP2013000392A TN2013000392A TN2013000392A1 TN 2013000392 A1 TN2013000392 A1 TN 2013000392A1 TN P2013000392 A TNP2013000392 A TN P2013000392A TN 2013000392 A TN2013000392 A TN 2013000392A TN 2013000392 A1 TN2013000392 A1 TN 2013000392A1
Authority
TN
Tunisia
Prior art keywords
inhibitor
combination
kinase
pi3k
phosphatidylinositol
Prior art date
Application number
TNP2013000392A
Other languages
English (en)
Inventor
Christine Fritsch
Carlos Garcia-Echeverria
Xizhong Huang
Sauveur-Michel Maira
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46018130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2013000392(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TN2013000392A1 publication Critical patent/TN2013000392A1/fr

Links

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
TNP2013000392A 2011-04-25 2013-09-27 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor TN2013000392A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478572P 2011-04-25 2011-04-25
PCT/US2012/034647 WO2012148846A1 (fr) 2011-04-25 2012-04-23 Association d'un inhibiteur de phosphatidylinositol-3-kinase (pi3k) et d'un inhibiteur de mtor

Publications (1)

Publication Number Publication Date
TN2013000392A1 true TN2013000392A1 (en) 2015-01-20

Family

ID=46018130

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2013000392A TN2013000392A1 (en) 2011-04-25 2013-09-27 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Country Status (25)

Country Link
US (3) US20140066474A1 (fr)
EP (1) EP2701703A1 (fr)
JP (2) JP6086902B2 (fr)
KR (1) KR101925656B1 (fr)
CN (1) CN103491955B (fr)
AR (1) AR086481A1 (fr)
AU (2) AU2012250010A1 (fr)
BR (1) BR112013027486A2 (fr)
CA (1) CA2833962A1 (fr)
CL (1) CL2013003078A1 (fr)
CO (1) CO6801759A2 (fr)
EA (1) EA025948B1 (fr)
EC (1) ECSP13012994A (fr)
GT (1) GT201300263A (fr)
IL (1) IL229008A (fr)
MA (1) MA35038B1 (fr)
MX (1) MX2013012385A (fr)
NZ (1) NZ615593A (fr)
PE (1) PE20140601A1 (fr)
SG (1) SG193919A1 (fr)
TN (1) TN2013000392A1 (fr)
TW (1) TWI602567B (fr)
UA (1) UA110961C2 (fr)
WO (1) WO2012148846A1 (fr)
ZA (1) ZA201306973B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2014122198A (ru) * 2011-11-02 2015-12-10 Новартис Аг Производные 2-карбоксамид циклоамино мочевины для применения в лечении vegf-зависимых заболеваний
WO2014151147A1 (fr) * 2013-03-15 2014-09-25 Intellikine, Llc Combinaison d'inhibiteurs de kinase et ses utilisations
US20150140036A1 (en) * 2013-11-13 2015-05-21 Novartis Institutes For Biomedical Research, Inc. Low, immune enhancing, dose mtor inhibitors and uses thereof
KR20160110963A (ko) * 2014-02-11 2016-09-23 노파르티스 아게 암 치료를 위한 pi3k 억제제를 포함하는 제약 조합물
WO2015148626A1 (fr) * 2014-03-26 2015-10-01 Millennium Pharmaceuticals, Inc. Traitement d'affections fibrotiques
EP3200772B1 (fr) * 2014-10-03 2022-08-03 Novartis AG Compositions pharmaceutiques contenant de l'alpélisib
US20160339030A1 (en) * 2015-05-19 2016-11-24 University Of Maryland, Baltimore Treatment agents for inhibiting hiv and cancer in hiv infected patients
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT98990A (pt) 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5120842A (en) 1991-04-01 1992-06-09 American Home Products Corporation Silyl ethers of rapamycin
US5100883A (en) 1991-04-08 1992-03-31 American Home Products Corporation Fluorinated esters of rapamycin
US5118678A (en) 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5118677A (en) 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
US5151413A (en) 1991-11-06 1992-09-29 American Home Products Corporation Rapamycin acetals as immunosuppressant and antifungal agents
GB9125660D0 (en) 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compound
ZA935112B (en) 1992-07-17 1994-02-08 Smithkline Beecham Corp Rapamycin derivatives
ZA935111B (en) 1992-07-17 1994-02-04 Smithkline Beecham Corp Rapamycin derivatives
US5256790A (en) 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5258389A (en) 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
WO1995014023A1 (fr) 1993-11-19 1995-05-26 Abbott Laboratories Analogues semi-synthetiques de rapamycine (macrolides) utilises comme immunomodulateurs
JP3745772B2 (ja) 1993-12-17 2006-02-15 ノバルティス アクチエンゲゼルシャフト 免疫抑制剤として有用なラパマイシン誘導体
DK0833828T3 (da) 1995-06-09 2003-03-17 Novartis Ag Rapamycinderivater
EP0937082A2 (fr) 1996-07-12 1999-08-25 Ariad Pharmaceuticals, Inc. Elements et procedes pour traiter ou prevenir les mycoses pathog nes
ES2219388T3 (es) 1999-08-24 2004-12-01 Ariad Gene Therapeutics, Inc. 28-epi-rapalogos.
AR044519A1 (es) * 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
EA015922B1 (ru) * 2005-11-14 2011-12-30 Ариад Фармасьютикалз, Инк. ВВЕДЕНИЕ ИНГИБИТОРА mTOR ДЛЯ ЛЕЧЕНИЯ ПАЦИЕНТОВ СО ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛЬЮ
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
RU2538683C2 (ru) * 2008-10-31 2015-01-10 Новартис Аг КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR

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MX2013012385A (es) 2013-11-04
JP2017061527A (ja) 2017-03-30
KR20140012147A (ko) 2014-01-29
TW201244716A (en) 2012-11-16
CA2833962A1 (fr) 2012-11-01
US20140066474A1 (en) 2014-03-06
ECSP13012994A (es) 2013-12-31
GT201300263A (es) 2015-11-24
KR101925656B1 (ko) 2018-12-05
SG193919A1 (en) 2013-11-29
AU2012250010A1 (en) 2013-10-10
PE20140601A1 (es) 2014-05-24
JP6086902B2 (ja) 2017-03-01
BR112013027486A2 (pt) 2017-02-14
NZ615593A (en) 2015-05-29
AR086481A1 (es) 2013-12-18
MA35038B1 (fr) 2014-04-03
WO2012148846A1 (fr) 2012-11-01
ZA201306973B (en) 2014-06-25
AU2016202372B2 (en) 2017-07-20
TWI602567B (zh) 2017-10-21
CL2013003078A1 (es) 2014-05-30
EA025948B1 (ru) 2017-02-28
CN103491955A (zh) 2014-01-01
EP2701703A1 (fr) 2014-03-05
UA110961C2 (uk) 2016-03-10
JP2014513097A (ja) 2014-05-29
CO6801759A2 (es) 2013-11-29
US20180085362A1 (en) 2018-03-29
AU2016202372A1 (en) 2016-05-05
EA201391565A1 (ru) 2014-02-28
US20170095463A1 (en) 2017-04-06
IL229008A (en) 2017-11-30
IL229008A0 (en) 2013-12-31
CN103491955B (zh) 2015-12-23

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