ECSP13012994A - COMBINACIÓN DE UN INHIBIDOR DE CINASA DE FOSFATIDIL-INOSITOL-3 (PI3K) Y UN INHIBIDOR DE mTOR - Google Patents

COMBINACIÓN DE UN INHIBIDOR DE CINASA DE FOSFATIDIL-INOSITOL-3 (PI3K) Y UN INHIBIDOR DE mTOR

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Publication number
ECSP13012994A
ECSP13012994A ECSP13012994A ECSP13012994A EC SP13012994 A ECSP13012994 A EC SP13012994A EC SP13012994 A ECSP13012994 A EC SP13012994A EC SP13012994 A ECSP13012994 A EC SP13012994A
Authority
EC
Ecuador
Prior art keywords
inhibitor
combination
pi3k
mtor
inositol
Prior art date
Application number
Other languages
English (en)
Inventor
Xizhong Huang
Christine Fritsch
Carlos Garcia-Echeverria
Sauveur Michel Maira
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46018130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP13012994(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP13012994A publication Critical patent/ECSP13012994A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Pulmonology (AREA)

Abstract

La presente invención se refiere a una combinación farmacéutica que comprende un compuesto inhibidor de cinasa de fosfatidil-inositol-3 (PI3K), el cual es un derivado de 2-carboxamida-cicloamino-urea, o una sal farmacéuticamente aceptable del mismo, y cuando menos un inhibidor del objetivo de rapamicina de mamífero (mTOR), o una sal farmacéuticamente aceptable del mismo; a una composición farmacéutica, la cual comprende dicha combinación; y a los usos de esta combinación en el tratamiento de las enfermedades proliferativas, más específicamente de las enfermedades dependientes de la cinasa del objetivo de rapamicina de mamífero (mTOR).
ECSP13012994 2011-04-25 2013-10-25 COMBINACIÓN DE UN INHIBIDOR DE CINASA DE FOSFATIDIL-INOSITOL-3 (PI3K) Y UN INHIBIDOR DE mTOR ECSP13012994A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161478572P 2011-04-25 2011-04-25

Publications (1)

Publication Number Publication Date
ECSP13012994A true ECSP13012994A (es) 2013-12-31

Family

ID=46018130

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012994 ECSP13012994A (es) 2011-04-25 2013-10-25 COMBINACIÓN DE UN INHIBIDOR DE CINASA DE FOSFATIDIL-INOSITOL-3 (PI3K) Y UN INHIBIDOR DE mTOR

Country Status (25)

Country Link
US (3) US20140066474A1 (es)
EP (1) EP2701703A1 (es)
JP (2) JP6086902B2 (es)
KR (1) KR101925656B1 (es)
CN (1) CN103491955B (es)
AR (1) AR086481A1 (es)
AU (2) AU2012250010A1 (es)
BR (1) BR112013027486A2 (es)
CA (1) CA2833962A1 (es)
CL (1) CL2013003078A1 (es)
CO (1) CO6801759A2 (es)
EA (1) EA025948B1 (es)
EC (1) ECSP13012994A (es)
GT (1) GT201300263A (es)
IL (1) IL229008A (es)
MA (1) MA35038B1 (es)
MX (1) MX2013012385A (es)
NZ (1) NZ615593A (es)
PE (1) PE20140601A1 (es)
SG (1) SG193919A1 (es)
TN (1) TN2013000392A1 (es)
TW (1) TWI602567B (es)
UA (1) UA110961C2 (es)
WO (1) WO2012148846A1 (es)
ZA (1) ZA201306973B (es)

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CN105246482A (zh) * 2013-03-15 2016-01-13 因特利凯有限责任公司 激酶抑制剂的组合及其用途
EP3068435A1 (en) * 2013-11-13 2016-09-21 Novartis AG Mtor inhibitors for enhancing the immune response
KR20160110963A (ko) * 2014-02-11 2016-09-23 노파르티스 아게 암 치료를 위한 pi3k 억제제를 포함하는 제약 조합물
WO2015148626A1 (en) * 2014-03-26 2015-10-01 Millennium Pharmaceuticals, Inc. Treatment of fibrotic disorders
MX2017004359A (es) * 2014-10-03 2017-06-23 Novartis Ag Composiciones farmaceuticas que comprenden alpelisib.
US20160339030A1 (en) 2015-05-19 2016-11-24 University Of Maryland, Baltimore Treatment agents for inhibiting hiv and cancer in hiv infected patients
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

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US20140066474A1 (en) 2014-03-06
TN2013000392A1 (en) 2015-01-20
US20170095463A1 (en) 2017-04-06
AU2012250010A1 (en) 2013-10-10
CA2833962A1 (en) 2012-11-01
AU2016202372B2 (en) 2017-07-20
EP2701703A1 (en) 2014-03-05
MA35038B1 (fr) 2014-04-03
IL229008A (en) 2017-11-30
JP2014513097A (ja) 2014-05-29
TW201244716A (en) 2012-11-16
KR101925656B1 (ko) 2018-12-05
IL229008A0 (en) 2013-12-31
BR112013027486A2 (pt) 2017-02-14
SG193919A1 (en) 2013-11-29
WO2012148846A1 (en) 2012-11-01
NZ615593A (en) 2015-05-29
US20180085362A1 (en) 2018-03-29
UA110961C2 (uk) 2016-03-10
MX2013012385A (es) 2013-11-04
CO6801759A2 (es) 2013-11-29
CL2013003078A1 (es) 2014-05-30
AR086481A1 (es) 2013-12-18
CN103491955A (zh) 2014-01-01
KR20140012147A (ko) 2014-01-29
EA025948B1 (ru) 2017-02-28
TWI602567B (zh) 2017-10-21
JP6086902B2 (ja) 2017-03-01
PE20140601A1 (es) 2014-05-24
JP2017061527A (ja) 2017-03-30
AU2016202372A1 (en) 2016-05-05
ZA201306973B (en) 2014-06-25
CN103491955B (zh) 2015-12-23
EA201391565A1 (ru) 2014-02-28
GT201300263A (es) 2015-11-24

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