DOP2010000013A - Derivados de pirimidina trisustituida para el tratamiento de enfermedades proliferativas - Google Patents

Derivados de pirimidina trisustituida para el tratamiento de enfermedades proliferativas

Info

Publication number
DOP2010000013A
DOP2010000013A DO2010000013A DO2010000013A DOP2010000013A DO P2010000013 A DOP2010000013 A DO P2010000013A DO 2010000013 A DO2010000013 A DO 2010000013A DO 2010000013 A DO2010000013 A DO 2010000013A DO P2010000013 A DOP2010000013 A DO P2010000013A
Authority
DO
Dominican Republic
Prior art keywords
treatment
proliferative diseases
trisustituida
pirimidine
derivatives
Prior art date
Application number
DO2010000013A
Other languages
English (en)
Inventor
Maurice Raymond Verschoyle Finlay
Kurt Gordon Pike
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of DOP2010000013A publication Critical patent/DOP2010000013A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de formula (I) o una de sus sales farmaceuticamente aceptables, procesos para su preparacion, composiciones farmaceuticas que los contienen y su use en terapia, por ejemplo en el tratamiento de enfermedades proliferativas como el cancer y en particular en enfermedades mediadas por una quinasa mTOR y una o mas enzimas P13K.
DO2010000013A 2007-07-09 2010-01-08 Derivados de pirimidina trisustituida para el tratamiento de enfermedades proliferativas DOP2010000013A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94857007P 2007-07-09 2007-07-09

Publications (1)

Publication Number Publication Date
DOP2010000013A true DOP2010000013A (es) 2010-01-31

Family

ID=40029122

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2010000013A DOP2010000013A (es) 2007-07-09 2010-01-08 Derivados de pirimidina trisustituida para el tratamiento de enfermedades proliferativas

Country Status (17)

Country Link
US (1) US20100227858A1 (es)
EP (1) EP2176256A2 (es)
JP (1) JP2010533161A (es)
KR (1) KR20100042643A (es)
CN (1) CN101801963A (es)
AU (1) AU2008273892A1 (es)
BR (1) BRPI0814503A2 (es)
CA (1) CA2692725A1 (es)
CO (1) CO6251271A2 (es)
CR (1) CR11199A (es)
DO (1) DOP2010000013A (es)
EA (1) EA201000090A1 (es)
EC (1) ECSP109934A (es)
NI (1) NI201000003A (es)
SV (1) SV2010003451A (es)
WO (1) WO2009007751A2 (es)
ZA (1) ZA201000087B (es)

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Also Published As

Publication number Publication date
CN101801963A (zh) 2010-08-11
ZA201000087B (en) 2011-06-29
EP2176256A2 (en) 2010-04-21
WO2009007751A3 (en) 2009-04-23
CO6251271A2 (es) 2011-02-21
ECSP109934A (es) 2010-03-31
SV2010003451A (es) 2010-06-09
AU2008273892A1 (en) 2009-01-15
US20100227858A1 (en) 2010-09-09
WO2009007751A2 (en) 2009-01-15
KR20100042643A (ko) 2010-04-26
CR11199A (es) 2010-06-17
CA2692725A1 (en) 2009-01-15
EA201000090A1 (ru) 2010-06-30
NI201000003A (es) 2010-10-12
BRPI0814503A2 (pt) 2017-05-16
JP2010533161A (ja) 2010-10-21

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