MA35038B1 - Association d'un inhibiteur de phosphatidylinositol-3-kinase (pi3k) et d'un inhibiteur de mtor - Google Patents

Association d'un inhibiteur de phosphatidylinositol-3-kinase (pi3k) et d'un inhibiteur de mtor

Info

Publication number
MA35038B1
MA35038B1 MA36325A MA36325A MA35038B1 MA 35038 B1 MA35038 B1 MA 35038B1 MA 36325 A MA36325 A MA 36325A MA 36325 A MA36325 A MA 36325A MA 35038 B1 MA35038 B1 MA 35038B1
Authority
MA
Morocco
Prior art keywords
pi3k
phosphatidylinositol
inhibitor
mtor
association
Prior art date
Application number
MA36325A
Other languages
English (en)
Inventor
Christine Fritsch
Carlos Garcia-Echeverria
Xizhong Huang
Sauveur-Michel Maira
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46018130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35038(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA35038B1 publication Critical patent/MA35038B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12—Antihypertensives

Abstract

L'invention concerne une association pharmaceutique contenant un composé inhibiteur de phosphatidylinositol-3-kinase (PI3K) qui est un dérivé de 2-carboxamide cycloamino urée ou un sel pharmaceutiquement acceptable de celui-ci, et au moins un inhibiteur de la cible de rapamycine chez les mammifères (mTOR) ou un sel pharmaceutiquement acceptable de celui-ci ; une composition pharmaceutique contenant ladite association ; ainsi que les utilisations de cette association dans le traitement des maladies prolifératives, et plus particulièrement des maladies dépendant de la kinase de la cible de rapamycine chez les mammifères (mTOR).
MA36325A 2011-04-25 2012-04-23 Association d'un inhibiteur de phosphatidylinositol-3-kinase (pi3k) et d'un inhibiteur de mtor MA35038B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478572P 2011-04-25 2011-04-25
PCT/US2012/034647 WO2012148846A1 (fr) 2011-04-25 2012-04-23 Association d'un inhibiteur de phosphatidylinositol-3-kinase (pi3k) et d'un inhibiteur de mtor

Publications (1)

Publication Number Publication Date
MA35038B1 true MA35038B1 (fr) 2014-04-03

Family

ID=46018130

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36325A MA35038B1 (fr) 2011-04-25 2012-04-23 Association d'un inhibiteur de phosphatidylinositol-3-kinase (pi3k) et d'un inhibiteur de mtor

Country Status (25)

Country Link
US (3) US20140066474A1 (fr)
EP (1) EP2701703A1 (fr)
JP (2) JP6086902B2 (fr)
KR (1) KR101925656B1 (fr)
CN (1) CN103491955B (fr)
AR (1) AR086481A1 (fr)
AU (2) AU2012250010A1 (fr)
BR (1) BR112013027486A2 (fr)
CA (1) CA2833962A1 (fr)
CL (1) CL2013003078A1 (fr)
CO (1) CO6801759A2 (fr)
EA (1) EA025948B1 (fr)
EC (1) ECSP13012994A (fr)
GT (1) GT201300263A (fr)
IL (1) IL229008A (fr)
MA (1) MA35038B1 (fr)
MX (1) MX2013012385A (fr)
NZ (1) NZ615593A (fr)
PE (1) PE20140601A1 (fr)
SG (1) SG193919A1 (fr)
TN (1) TN2013000392A1 (fr)
TW (1) TWI602567B (fr)
UA (1) UA110961C2 (fr)
WO (1) WO2012148846A1 (fr)
ZA (1) ZA201306973B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2776026A1 (fr) * 2011-11-02 2014-09-17 Novartis AG Dérivés de 2-carboxamide-cycloamino-urée destinés à être utilisés dans le traitement de maladies dépendant du vegf
WO2014151147A1 (fr) * 2013-03-15 2014-09-25 Intellikine, Llc Combinaison d'inhibiteurs de kinase et ses utilisations
CA2929181A1 (fr) * 2013-11-13 2015-05-21 Novartis Ag Inhibiteurs de mtor ameliorant la reponse immunitaire
US20170165246A1 (en) * 2014-02-11 2017-06-15 Novartis Ag Pharmaceutical combinations comprising a pi3k inhibitor for the treatment of cancer
WO2015148626A1 (fr) * 2014-03-26 2015-10-01 Millennium Pharmaceuticals, Inc. Traitement d'affections fibrotiques
AU2015326392B2 (en) * 2014-10-03 2018-10-04 Novartis Ag Pharmaceutical compositions comprising alpelisib
US20160339030A1 (en) * 2015-05-19 2016-11-24 University Of Maryland, Baltimore Treatment agents for inhibiting hiv and cancer in hiv infected patients
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

Family Cites Families (21)

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PT98990A (pt) 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5120842A (en) 1991-04-01 1992-06-09 American Home Products Corporation Silyl ethers of rapamycin
US5100883A (en) 1991-04-08 1992-03-31 American Home Products Corporation Fluorinated esters of rapamycin
US5118678A (en) 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5118677A (en) 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
US5151413A (en) 1991-11-06 1992-09-29 American Home Products Corporation Rapamycin acetals as immunosuppressant and antifungal agents
GB9125660D0 (en) 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compound
ZA935111B (en) 1992-07-17 1994-02-04 Smithkline Beecham Corp Rapamycin derivatives
ZA935112B (en) 1992-07-17 1994-02-08 Smithkline Beecham Corp Rapamycin derivatives
US5256790A (en) 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5258389A (en) 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
CA2175215C (fr) 1993-11-19 2008-06-03 Yat Sun Or Analogues semi-synthetiques de rapamycine (macrolides) utilises comme immunomodulateurs
NZ277498A (en) 1993-12-17 1998-03-25 Novartis Ag Rapamycin derivatives
PT833828E (pt) 1995-06-09 2003-02-28 Novartis Ag Derivados de rapamicina
EP0937082A2 (fr) 1996-07-12 1999-08-25 Ariad Pharmaceuticals, Inc. Elements et procedes pour traiter ou prevenir les mycoses pathog nes
AU783158B2 (en) 1999-08-24 2005-09-29 Ariad Pharmaceuticals, Inc. 28-epirapalogs
TW200519106A (en) * 2003-05-02 2005-06-16 Novartis Ag Organic compounds
CN101360495B (zh) * 2005-11-14 2012-03-14 阿里亚德医药股份有限公司 对癌症病人给药mTOR抑制剂
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
AU2009309616B2 (en) * 2008-10-31 2014-02-13 Novartis Ag Combination of a phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibitor

Also Published As

Publication number Publication date
CO6801759A2 (es) 2013-11-29
KR20140012147A (ko) 2014-01-29
TWI602567B (zh) 2017-10-21
JP2014513097A (ja) 2014-05-29
UA110961C2 (uk) 2016-03-10
MX2013012385A (es) 2013-11-04
NZ615593A (en) 2015-05-29
EA025948B1 (ru) 2017-02-28
ZA201306973B (en) 2014-06-25
JP6086902B2 (ja) 2017-03-01
AU2012250010A1 (en) 2013-10-10
SG193919A1 (en) 2013-11-29
US20180085362A1 (en) 2018-03-29
IL229008A (en) 2017-11-30
JP2017061527A (ja) 2017-03-30
ECSP13012994A (es) 2013-12-31
EA201391565A1 (ru) 2014-02-28
US20170095463A1 (en) 2017-04-06
GT201300263A (es) 2015-11-24
CN103491955A (zh) 2014-01-01
TN2013000392A1 (en) 2015-01-20
CL2013003078A1 (es) 2014-05-30
CA2833962A1 (fr) 2012-11-01
TW201244716A (en) 2012-11-16
WO2012148846A1 (fr) 2012-11-01
AR086481A1 (es) 2013-12-18
CN103491955B (zh) 2015-12-23
AU2016202372B2 (en) 2017-07-20
KR101925656B1 (ko) 2018-12-05
AU2016202372A1 (en) 2016-05-05
EP2701703A1 (fr) 2014-03-05
BR112013027486A2 (pt) 2017-02-14
IL229008A0 (en) 2013-12-31
PE20140601A1 (es) 2014-05-24
US20140066474A1 (en) 2014-03-06

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