EA201391565A1 - КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТ-3-КИНАЗЫ (PI3K) И ИНГИБИТОРА mTOR - Google Patents

КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТ-3-КИНАЗЫ (PI3K) И ИНГИБИТОРА mTOR

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Publication number
EA201391565A1
EA201391565A1 EA201391565A EA201391565A EA201391565A1 EA 201391565 A1 EA201391565 A1 EA 201391565A1 EA 201391565 A EA201391565 A EA 201391565A EA 201391565 A EA201391565 A EA 201391565A EA 201391565 A1 EA201391565 A1 EA 201391565A1
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EA
Eurasian Patent Office
Prior art keywords
combination
inhibitor
pi3k
mtor
phosphatidylinosite
Prior art date
Application number
EA201391565A
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English (en)
Other versions
EA025948B1 (ru
Inventor
Кристин ФРИТЧ
Карлос ГАРСИЯ-ЭЧЕВЕРРИЯ
Сичжун Хуан
Савер-Мишель МЕРА
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Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201391565A1 publication Critical patent/EA201391565A1/ru
Publication of EA025948B1 publication Critical patent/EA025948B1/ru

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

Настоящее изобретение относится к фармацевтической комбинации, включающей соединение-ингибитор фосфатидилинозит-3-киназы (PI3K), которое является производным 2-карбоксамидциклоаминомочевины, или его фармацевтически приемлемую соль и по меньшей мере один ингибитор мишени рапамицина (mTOR) у млекопитающих или его фармацевтически приемлемую соль; фармацевтической композиции, содержащей такую комбинацию; и к применению такой комбинации при лечении пролиферативных заболеваний, более предпочтительно заболеваний, зависимых от мишени рапамицина (mTOR) киназы у млекопитающих.
EA201391565A 2011-04-25 2012-04-23 КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТ-3-КИНАЗЫ (PI3K) И ИНГИБИТОРА mTOR EA025948B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478572P 2011-04-25 2011-04-25
PCT/US2012/034647 WO2012148846A1 (en) 2011-04-25 2012-04-23 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Publications (2)

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EA201391565A1 true EA201391565A1 (ru) 2014-02-28
EA025948B1 EA025948B1 (ru) 2017-02-28

Family

ID=46018130

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EA201391565A EA025948B1 (ru) 2011-04-25 2012-04-23 КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТ-3-КИНАЗЫ (PI3K) И ИНГИБИТОРА mTOR

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Country Link
US (3) US20140066474A1 (ru)
EP (1) EP2701703A1 (ru)
JP (2) JP6086902B2 (ru)
KR (1) KR101925656B1 (ru)
CN (1) CN103491955B (ru)
AR (1) AR086481A1 (ru)
AU (2) AU2012250010A1 (ru)
BR (1) BR112013027486A2 (ru)
CA (1) CA2833962A1 (ru)
CL (1) CL2013003078A1 (ru)
CO (1) CO6801759A2 (ru)
EA (1) EA025948B1 (ru)
EC (1) ECSP13012994A (ru)
GT (1) GT201300263A (ru)
IL (1) IL229008A (ru)
MA (1) MA35038B1 (ru)
MX (1) MX2013012385A (ru)
NZ (1) NZ615593A (ru)
PE (1) PE20140601A1 (ru)
SG (1) SG193919A1 (ru)
TN (1) TN2013000392A1 (ru)
TW (1) TWI602567B (ru)
UA (1) UA110961C2 (ru)
WO (1) WO2012148846A1 (ru)
ZA (1) ZA201306973B (ru)

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KR20110090911A (ko) * 2008-10-31 2011-08-10 노파르티스 아게 포스파티딜이노시톨-3-키나아제 (ｐｉ3ｋ) 억제제 및 ｍｔｏｒ 억제제의 조합물

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AU2012250010A1 (en) 2013-10-10
US20170095463A1 (en) 2017-04-06
US20180085362A1 (en) 2018-03-29
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