CA2833962A1 - Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor - Google Patents

Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor Download PDF

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Publication number
CA2833962A1
CA2833962A1 CA2833962A CA2833962A CA2833962A1 CA 2833962 A1 CA2833962 A1 CA 2833962A1 CA 2833962 A CA2833962 A CA 2833962A CA 2833962 A CA2833962 A CA 2833962A CA 2833962 A1 CA2833962 A1 CA 2833962A1
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CA
Canada
Prior art keywords
compound
rad001
everolimus
pharmaceutically acceptable
syndrome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2833962A
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English (en)
French (fr)
Inventor
Christine Fritsch
Carlos Garcia-Echeverria
Xizhong Huang
Sauveur-Michel Maira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46018130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2833962(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA2833962A1 publication Critical patent/CA2833962A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
CA2833962A 2011-04-25 2012-04-23 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor Abandoned CA2833962A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161478572P 2011-04-25 2011-04-25
US61/478,572 2011-04-25
PCT/US2012/034647 WO2012148846A1 (en) 2011-04-25 2012-04-23 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Publications (1)

Publication Number Publication Date
CA2833962A1 true CA2833962A1 (en) 2012-11-01

Family

ID=46018130

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2833962A Abandoned CA2833962A1 (en) 2011-04-25 2012-04-23 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Country Status (26)

Country Link
US (3) US20140066474A1 (enExample)
EP (1) EP2701703A1 (enExample)
JP (2) JP6086902B2 (enExample)
KR (1) KR101925656B1 (enExample)
CN (1) CN103491955B (enExample)
AR (1) AR086481A1 (enExample)
AU (2) AU2012250010A1 (enExample)
BR (1) BR112013027486A2 (enExample)
CA (1) CA2833962A1 (enExample)
CL (1) CL2013003078A1 (enExample)
CO (1) CO6801759A2 (enExample)
EA (1) EA025948B1 (enExample)
EC (1) ECSP13012994A (enExample)
GT (1) GT201300263A (enExample)
IL (1) IL229008A (enExample)
MA (1) MA35038B1 (enExample)
MX (1) MX2013012385A (enExample)
NZ (1) NZ615593A (enExample)
PE (1) PE20140601A1 (enExample)
PH (1) PH12013502077A1 (enExample)
SG (1) SG193919A1 (enExample)
TN (1) TN2013000392A1 (enExample)
TW (1) TWI602567B (enExample)
UA (1) UA110961C2 (enExample)
WO (1) WO2012148846A1 (enExample)
ZA (1) ZA201306973B (enExample)

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MX2014005414A (es) * 2011-11-02 2014-09-22 Novartis Ag Derivados de 2-carboxamida-cicloamino-urea para su uso en el tratamiento de las enfermedades dependientes del factor de crecimiento endotelial vascular (vegf).
HK1219421A1 (zh) * 2013-03-15 2017-04-07 因特利凯有限责任公司 激酶抑制剂的组合及其用途
EA201690987A1 (ru) * 2013-11-13 2016-10-31 Новартис Аг Низкодозовые иммуностимулирующие ингибиторы mtor и их применения
AU2015216590A1 (en) * 2014-02-11 2016-06-30 Novartis Ag Pharmaceutical combinations comprising a PI3K inhibitor for the treatment of cancer
WO2015148626A1 (en) * 2014-03-26 2015-10-01 Millennium Pharmaceuticals, Inc. Treatment of fibrotic disorders
EP3200772B1 (en) * 2014-10-03 2022-08-03 Novartis AG Pharmaceutical compositions comprising alpelisib
US20160339030A1 (en) * 2015-05-19 2016-11-24 University Of Maryland, Baltimore Treatment agents for inhibiting hiv and cancer in hiv infected patients
JP6691337B2 (ja) * 2016-02-29 2020-04-28 学校法人北里研究所 膀胱癌患者の予後を予測するための方法
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

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US5120842A (en) 1991-04-01 1992-06-09 American Home Products Corporation Silyl ethers of rapamycin
US5100883A (en) 1991-04-08 1992-03-31 American Home Products Corporation Fluorinated esters of rapamycin
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US5151413A (en) 1991-11-06 1992-09-29 American Home Products Corporation Rapamycin acetals as immunosuppressant and antifungal agents
GB9125660D0 (en) 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compound
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EP0729471A1 (en) 1993-11-19 1996-09-04 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
BR9408323A (pt) 1993-12-17 1997-08-19 Sandoz Ag Derivados de rapamicina
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AR044519A1 (es) * 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
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UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
CA2736361C (en) * 2008-10-31 2017-10-10 Novartis Ag Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

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CN103491955B (zh) 2015-12-23
ZA201306973B (en) 2014-06-25
PH12013502077A1 (en) 2013-12-16
BR112013027486A2 (pt) 2017-02-14
MX2013012385A (es) 2013-11-04
SG193919A1 (en) 2013-11-29
US20170095463A1 (en) 2017-04-06
AU2016202372B2 (en) 2017-07-20
MA35038B1 (fr) 2014-04-03
UA110961C2 (uk) 2016-03-10
AR086481A1 (es) 2013-12-18
ECSP13012994A (es) 2013-12-31
WO2012148846A1 (en) 2012-11-01
AU2012250010A1 (en) 2013-10-10
IL229008A0 (en) 2013-12-31
JP2014513097A (ja) 2014-05-29
TWI602567B (zh) 2017-10-21
EA025948B1 (ru) 2017-02-28
US20180085362A1 (en) 2018-03-29
EA201391565A1 (ru) 2014-02-28
JP2017061527A (ja) 2017-03-30
PE20140601A1 (es) 2014-05-24
GT201300263A (es) 2015-11-24
US20140066474A1 (en) 2014-03-06
TN2013000392A1 (en) 2015-01-20
CO6801759A2 (es) 2013-11-29
JP6086902B2 (ja) 2017-03-01
IL229008A (en) 2017-11-30
NZ615593A (en) 2015-05-29
KR20140012147A (ko) 2014-01-29
AU2016202372A1 (en) 2016-05-05
EP2701703A1 (en) 2014-03-05
CL2013003078A1 (es) 2014-05-30
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