CO6801759A2 - Combinación de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor - Google Patents

Combinación de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor

Info

Publication number
CO6801759A2
CO6801759A2 CO13252726A CO13252726A CO6801759A2 CO 6801759 A2 CO6801759 A2 CO 6801759A2 CO 13252726 A CO13252726 A CO 13252726A CO 13252726 A CO13252726 A CO 13252726A CO 6801759 A2 CO6801759 A2 CO 6801759A2
Authority
CO
Colombia
Prior art keywords
inhibitor
pi3k
combination
phosphatidyl inositol
kinase inhibitor
Prior art date
Application number
CO13252726A
Other languages
English (en)
Spanish (es)
Inventor
Christine Fritsch
Carlos Garcia-Echeverria
Xizhong Huang
Sauveur-Michel Maira
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46018130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6801759(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO6801759A2 publication Critical patent/CO6801759A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
CO13252726A 2011-04-25 2013-10-24 Combinación de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor CO6801759A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161478572P 2011-04-25 2011-04-25

Publications (1)

Publication Number Publication Date
CO6801759A2 true CO6801759A2 (es) 2013-11-29

Family

ID=46018130

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13252726A CO6801759A2 (es) 2011-04-25 2013-10-24 Combinación de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor

Country Status (26)

Country Link
US (3) US20140066474A1 (enExample)
EP (1) EP2701703A1 (enExample)
JP (2) JP6086902B2 (enExample)
KR (1) KR101925656B1 (enExample)
CN (1) CN103491955B (enExample)
AR (1) AR086481A1 (enExample)
AU (2) AU2012250010A1 (enExample)
BR (1) BR112013027486A2 (enExample)
CA (1) CA2833962A1 (enExample)
CL (1) CL2013003078A1 (enExample)
CO (1) CO6801759A2 (enExample)
EA (1) EA025948B1 (enExample)
EC (1) ECSP13012994A (enExample)
GT (1) GT201300263A (enExample)
IL (1) IL229008A (enExample)
MA (1) MA35038B1 (enExample)
MX (1) MX2013012385A (enExample)
NZ (1) NZ615593A (enExample)
PE (1) PE20140601A1 (enExample)
PH (1) PH12013502077A1 (enExample)
SG (1) SG193919A1 (enExample)
TN (1) TN2013000392A1 (enExample)
TW (1) TWI602567B (enExample)
UA (1) UA110961C2 (enExample)
WO (1) WO2012148846A1 (enExample)
ZA (1) ZA201306973B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2014005414A (es) * 2011-11-02 2014-09-22 Novartis Ag Derivados de 2-carboxamida-cicloamino-urea para su uso en el tratamiento de las enfermedades dependientes del factor de crecimiento endotelial vascular (vegf).
EP2968340A4 (en) * 2013-03-15 2016-08-10 Intellikine Llc COMBINING KINASE INHIBITORS AND USES THEREOF
US20150140036A1 (en) * 2013-11-13 2015-05-21 Novartis Institutes For Biomedical Research, Inc. Low, immune enhancing, dose mtor inhibitors and uses thereof
CA2937504A1 (en) * 2014-02-11 2015-08-20 Novartis Ag Pharmaceutical combinations comprising a pi3k inhibitor for the treatment of cancer
WO2015148626A1 (en) * 2014-03-26 2015-10-01 Millennium Pharmaceuticals, Inc. Treatment of fibrotic disorders
CN107106497A (zh) * 2014-10-03 2017-08-29 诺华股份有限公司 含alpelisib的药物组合物
US20160339030A1 (en) 2015-05-19 2016-11-24 University Of Maryland, Baltimore Treatment agents for inhibiting hiv and cancer in hiv infected patients
JP6691337B2 (ja) * 2016-02-29 2020-04-28 学校法人北里研究所 膀胱癌患者の予後を予測するための方法
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT98990A (pt) 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5120842A (en) 1991-04-01 1992-06-09 American Home Products Corporation Silyl ethers of rapamycin
US5100883A (en) 1991-04-08 1992-03-31 American Home Products Corporation Fluorinated esters of rapamycin
US5118678A (en) 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5118677A (en) 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
US5151413A (en) 1991-11-06 1992-09-29 American Home Products Corporation Rapamycin acetals as immunosuppressant and antifungal agents
GB9125660D0 (en) 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compound
ZA935112B (en) 1992-07-17 1994-02-08 Smithkline Beecham Corp Rapamycin derivatives
ZA935111B (en) 1992-07-17 1994-02-04 Smithkline Beecham Corp Rapamycin derivatives
US5256790A (en) 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5258389A (en) 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
CA2175215C (en) 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
PL314238A1 (en) 1993-12-17 1996-09-02 Sandoz Ltd Rapamycin derivatives
ATE228135T1 (de) 1995-06-09 2002-12-15 Novartis Erfind Verwalt Gmbh Rapamycinderivate
AU735648B2 (en) 1996-07-12 2001-07-12 Ariad Pharmaceuticals, Inc. Materials and method for treating or preventing pathogenic fungal infection
IL147803A0 (en) 1999-08-24 2002-08-14 Ariad Gene Therapeutics Inc 28-epirapalogs
TW200519106A (en) * 2003-05-02 2005-06-16 Novartis Ag Organic compounds
CN101360495B (zh) * 2005-11-14 2012-03-14 阿里亚德医药股份有限公司 对癌症病人给药mTOR抑制剂
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
US20110195966A1 (en) * 2008-10-31 2011-08-11 Novartis Ag Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

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EA025948B1 (ru) 2017-02-28
CN103491955B (zh) 2015-12-23
AU2016202372B2 (en) 2017-07-20
JP2014513097A (ja) 2014-05-29
NZ615593A (en) 2015-05-29
CA2833962A1 (en) 2012-11-01
TW201244716A (en) 2012-11-16
MX2013012385A (es) 2013-11-04
EP2701703A1 (en) 2014-03-05
TN2013000392A1 (en) 2015-01-20
AR086481A1 (es) 2013-12-18
AU2012250010A1 (en) 2013-10-10
PE20140601A1 (es) 2014-05-24
KR101925656B1 (ko) 2018-12-05
EA201391565A1 (ru) 2014-02-28
BR112013027486A2 (pt) 2017-02-14
IL229008A (en) 2017-11-30
SG193919A1 (en) 2013-11-29
JP2017061527A (ja) 2017-03-30
MA35038B1 (fr) 2014-04-03
KR20140012147A (ko) 2014-01-29
CL2013003078A1 (es) 2014-05-30
AU2016202372A1 (en) 2016-05-05
TWI602567B (zh) 2017-10-21
WO2012148846A1 (en) 2012-11-01
US20140066474A1 (en) 2014-03-06
ECSP13012994A (es) 2013-12-31
ZA201306973B (en) 2014-06-25
PH12013502077A1 (en) 2013-12-16
IL229008A0 (en) 2013-12-31
GT201300263A (es) 2015-11-24
US20170095463A1 (en) 2017-04-06
US20180085362A1 (en) 2018-03-29
CN103491955A (zh) 2014-01-01
JP6086902B2 (ja) 2017-03-01
UA110961C2 (uk) 2016-03-10

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