MD20140135A2 - Inhibitori macrociclici ai viruşilor din familia Flaviviridae - Google Patents

Inhibitori macrociclici ai viruşilor din familia Flaviviridae

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Publication number
MD20140135A2
MD20140135A2 MDA20140135A MD20140135A MD20140135A2 MD 20140135 A2 MD20140135 A2 MD 20140135A2 MD A20140135 A MDA20140135 A MD A20140135A MD 20140135 A MD20140135 A MD 20140135A MD 20140135 A2 MD20140135 A2 MD 20140135A2
Authority
MD
Moldova
Prior art keywords
flaviviridae viruses
macrocyclic inhibitors
compounds
formula
macrocyclic
Prior art date
Application number
MDA20140135A
Other languages
English (en)
Russian (ru)
Inventor
Виктория Александра Стедман
Карин Г. Пулленнек
Линос Лазаридес
Кэролайн АСИРО
Дэвид Кеннет Дин
Эндрю Джон Китс
Дастин Скот СИДЖЕЛ
Адам Джеймс ШРАЙЕР
Ричард Макман
Пётр ЯНСА
Грегори ВАТТ
Адриан Джон ХАЙТОН
Джин Ивес ЧИВА
Original Assignee
Gilead Sciences, Inc.
Selcia Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc., Selcia Limited filed Critical Gilead Sciences, Inc.
Publication of MD20140135A2 publication Critical patent/MD20140135A2/ro

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    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
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    • A61K38/15—Depsipeptides; Derivatives thereof
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    • A61K39/12—Viral antigens
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

Sunt propuşi compuşii cu Formula I :Formula Işi sărurile acceptabile farmaceutic şi esterii acestora. Compuşii, compoziţiile şi metodele propuse sunt utile pentru tratamentul infecţiilor virale, în mod special al infecţiilor cu virusul hepatitei C.
MDA20140135A 2012-06-08 2013-06-07 Inhibitori macrociclici ai viruşilor din familia Flaviviridae MD20140135A2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261657562P 2012-06-08 2012-06-08
PCT/US2013/044812 WO2013185093A1 (en) 2012-06-08 2013-06-07 Macrocyclic inhibitors of flaviviridae viruses

Publications (1)

Publication Number Publication Date
MD20140135A2 true MD20140135A2 (ro) 2015-05-31

Family

ID=48626704

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20140135A MD20140135A2 (ro) 2012-06-08 2013-06-07 Inhibitori macrociclici ai viruşilor din familia Flaviviridae

Country Status (34)

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US (4) US9062092B2 (ro)
EP (2) EP3392253B1 (ro)
JP (1) JP6273268B2 (ro)
KR (1) KR102185152B1 (ro)
CN (1) CN104781261B (ro)
AP (1) AP2015008189A0 (ro)
AR (1) AR091279A1 (ro)
AU (1) AU2013270670B2 (ro)
BR (1) BR112014030639A2 (ro)
CA (1) CA2875690C (ro)
CL (1) CL2014003337A1 (ro)
CR (1) CR20150018A (ro)
EA (1) EA027134B1 (ro)
EC (1) ECSP15000435A (ro)
ES (2) ES2672480T3 (ro)
HK (2) HK1209731A1 (ro)
IL (1) IL236007B (ro)
IN (1) IN2014MN02657A (ro)
MA (1) MA37712B1 (ro)
MD (1) MD20140135A2 (ro)
MX (1) MX358372B (ro)
NO (1) NO2885641T3 (ro)
NZ (1) NZ703062A (ro)
PE (1) PE20150862A1 (ro)
PH (1) PH12014502739A1 (ro)
PL (1) PL2861601T3 (ro)
PT (1) PT2861601T (ro)
SG (2) SG11201408064PA (ro)
SI (1) SI2861601T1 (ro)
TW (1) TWI616448B (ro)
UA (1) UA115664C2 (ro)
UY (1) UY34851A (ro)
WO (1) WO2013185093A1 (ro)
ZA (1) ZA201409215B (ro)

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