NZ540161A - Compositions useful as inhibitors of rock and other protein kinases - Google Patents
Compositions useful as inhibitors of rock and other protein kinasesInfo
- Publication number
- NZ540161A NZ540161A NZ540161A NZ54016103A NZ540161A NZ 540161 A NZ540161 A NZ 540161A NZ 540161 A NZ540161 A NZ 540161A NZ 54016103 A NZ54016103 A NZ 54016103A NZ 540161 A NZ540161 A NZ 540161A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- occurrence
- optionally substituted
- hydrogen
- chr6
- Prior art date
Links
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- 239000003112 inhibitor Substances 0.000 title abstract description 36
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- -1 -OH Chemical group 0.000 claims description 75
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 75
- 101100244083 Arabidopsis thaliana PKL gene Proteins 0.000 claims description 71
- 229910052736 halogen Inorganic materials 0.000 claims description 63
- 150000002367 halogens Chemical group 0.000 claims description 56
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 49
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 46
- 238000006243 chemical reaction Methods 0.000 claims description 44
- 229910052757 nitrogen Inorganic materials 0.000 claims description 43
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- 229910052717 sulfur Chemical group 0.000 claims description 27
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 25
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- 239000011593 sulfur Chemical group 0.000 claims description 24
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 23
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 23
- 239000001301 oxygen Chemical group 0.000 claims description 23
- 125000005842 heteroatom Chemical group 0.000 claims description 22
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 21
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- 102000020233 phosphotransferase Human genes 0.000 claims description 21
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 20
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- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 18
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 7
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- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims description 5
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- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims description 4
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- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 claims description 4
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| US47643303P | 2003-06-06 | 2003-06-06 | |
| US47990303P | 2003-06-19 | 2003-06-19 | |
| PCT/US2003/034319 WO2004041813A1 (en) | 2002-10-30 | 2003-10-30 | Compositions useful as inhibitors of rock and other protein kinases |
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| US7196106B2 (en) * | 2002-11-05 | 2007-03-27 | Merck & Co., Inc | Cyanothiophene derivatives, compositions containing such compounds and methods of use |
| TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| JP2007512230A (ja) * | 2003-08-20 | 2007-05-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼ阻害剤として有用な（４−アミノ−１，２，５−オキサジアゾール−４−イル）−ヘテロ芳香族化合物 |
| CN1898221A (zh) * | 2003-09-06 | 2007-01-17 | 沃泰克斯药物股份有限公司 | Atp－结合弹夹转运蛋白的调控剂 |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| ES2629414T3 (es) * | 2003-12-26 | 2017-08-09 | Kyowa Hakko Kirin Co., Ltd. | Derivados de tiazol |
| EP1716122B1 (en) * | 2004-01-30 | 2017-04-19 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| WO2005095386A1 (en) * | 2004-03-30 | 2005-10-13 | Chiron Corporation | Substituted thiophene derivatives as anti-cancer agents |
| ATE464303T1 (de) * | 2004-04-28 | 2010-04-15 | Vertex Pharma | Als inhibitoren von rock und anderen proteinkinasen geeignete zusammensetzungen |
| JP2007538063A (ja) * | 2004-05-20 | 2007-12-27 | スージェン， インク． | チオフェンヘテロアリールアミン |
| AU2005272815A1 (en) * | 2004-08-13 | 2006-02-23 | Genentech, Inc. | Thiazole based inhibitors of ATP-utilizing enzymes |
| MX2007004551A (es) * | 2004-10-18 | 2007-05-23 | Amgen Inc | Compuestos tiadiazol y metodos de uso. |
| CN101098872B (zh) * | 2004-11-22 | 2012-09-05 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的吡咯并吡嗪和吡唑并吡嗪 |
| US8148412B2 (en) * | 2004-12-03 | 2012-04-03 | Novo Nordisk A/S | Heteroaromatic glucokinase activators |
| WO2006137527A1 (ja) | 2005-06-23 | 2006-12-28 | Kyowa Hakko Kogyo Co., Ltd. | チアゾール誘導体 |
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| JP2009513704A (ja) * | 2005-11-01 | 2009-04-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | グルコキナーゼのアロステリックモジュレーターとしての置換ジヒドロイソインドロン |
| EP1951706A1 (en) * | 2005-11-01 | 2008-08-06 | Janssen Pharmaceutica N.V. | Dihydroisoindolones as allosteric modulators of glucokinase |
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| BRPI0706621A2 (pt) * | 2006-01-18 | 2011-04-05 | Amgen Inc | composto, composição farmacêutica, métodos para tratar um distúrbio mediado por quinase em um mamìfero e para tratar um distúrbio relacionado com a proliferação em um mamìfero, e , uso do composto |
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| AU2007249891A1 (en) | 2006-05-12 | 2007-11-22 | Vertex Pharmaceuticals Incorporated | Selective inhibitors of ROCK protein kinase and uses thereof |
| JP5448164B2 (ja) * | 2006-07-28 | 2014-03-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を変調する化合物 |
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| SG187396A1 (en) | 2007-07-19 | 2013-02-28 | Lundbeck & Co As H | 5-membered heterocyclic amides and related compounds |
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| CA2709879A1 (en) * | 2007-12-19 | 2009-06-25 | The Scripps Research Institute | Anilides and analogs as rho kinase inhibitors |
| CA2709883A1 (en) * | 2007-12-19 | 2009-06-25 | The Scripps Research Institute | Benzimidazoles and analogs as rho kinase inhibitors |
| US8940771B2 (en) | 2007-12-20 | 2015-01-27 | Novartis Ag | Organic compounds |
| JP2011507848A (ja) * | 2007-12-21 | 2011-03-10 | ザ スクリプス リサーチ インスティチュート | Ｒｈｏキナーゼインヒビターとしてのベンゾピランおよびアナログ |
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| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
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| AR040123A1 (es) * | 2002-05-31 | 2005-03-16 | Upjohn Co | Compuestos tiofeno, antihelminticos e insecticidas |
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2003
- 2003-10-30 CA CA002504320A patent/CA2504320A1/en not_active Abandoned
- 2003-10-30 TW TW092130255A patent/TW200416221A/zh unknown
- 2003-10-30 NZ NZ540161A patent/NZ540161A/en unknown
- 2003-10-30 MX MXPA05004689A patent/MXPA05004689A/es unknown
- 2003-10-30 AT AT03781448T patent/ATE466855T1/de not_active IP Right Cessation
- 2003-10-30 EP EP03781448A patent/EP1558607B1/en not_active Expired - Lifetime
- 2003-10-30 JP JP2005502202A patent/JP2006514684A/ja not_active Withdrawn
- 2003-10-30 DE DE60332475T patent/DE60332475D1/de not_active Expired - Lifetime
- 2003-10-30 WO PCT/US2003/034319 patent/WO2004041813A1/en not_active Ceased
- 2003-10-30 US US10/696,862 patent/US20040122016A1/en not_active Abandoned
- 2003-10-30 AU AU2003288956A patent/AU2003288956A1/en not_active Abandoned
- 2003-10-30 KR KR1020057007702A patent/KR20050088283A/ko not_active Withdrawn
- 2003-10-30 AR ARP030103973A patent/AR043057A1/es unknown
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- 2005-05-30 NO NO20052595A patent/NO20052595L/no not_active Application Discontinuation
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| KR20050088283A (ko) | 2005-09-05 |
| AU2003288956A1 (en) | 2004-06-07 |
| TW200416221A (en) | 2004-09-01 |
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| EP1558607A1 (en) | 2005-08-03 |
| ATE466855T1 (de) | 2010-05-15 |
| CA2504320A1 (en) | 2004-05-21 |
| AR043057A1 (es) | 2005-07-13 |
| JP2006514684A (ja) | 2006-05-11 |
| NO20052595L (no) | 2005-06-27 |
| EP1558607B1 (en) | 2010-05-05 |
| US20040122016A1 (en) | 2004-06-24 |
| DE60332475D1 (de) | 2010-06-17 |
| MXPA05004689A (es) | 2005-12-05 |
| WO2004041813A1 (en) | 2004-05-21 |
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