NZ540050A - Pyrrolobenzodiazepines having activity against cancer cell lines - Google Patents

Info

Publication number

NZ540050A

NZ540050A NZ540050A NZ54005003A NZ540050A NZ 540050 A NZ540050 A NZ 540050A NZ 540050 A NZ540050 A NZ 540050A NZ 54005003 A NZ54005003 A NZ 54005003A NZ 540050 A NZ540050 A NZ 540050A

Authority

NZ

New Zealand

Prior art keywords

group

compound

groups

substituent

mmol

Prior art date

2002-11-14

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• 206010028980 Neoplasm Diseases 0.000 title abstract description 11
• 230000000694 effects Effects 0.000 title abstract description 11
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• 201000011510 cancer Diseases 0.000 title abstract description 5
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 21
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 18
• 150000003839 salts Chemical class 0.000 claims abstract description 15
• 125000001309 chloro group Chemical group Cl* 0.000 claims abstract description 14
• 239000012453 solvate Substances 0.000 claims abstract description 14
• 125000001153 fluoro group Chemical group F* 0.000 claims abstract description 13
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• 229940002612 prodrug Drugs 0.000 claims abstract description 12
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• 125000002541 furyl group Chemical group 0.000 claims abstract description 9
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• 150000001875 compounds Chemical class 0.000 claims description 117
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• 238000000338 in vitro Methods 0.000 description 8
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• 229910000029 sodium carbonate Inorganic materials 0.000 description 8
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 8
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 7
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 7
• 206010006187 Breast cancer Diseases 0.000 description 6
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