NZ522773A - 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof - Google Patents

1,2-dihydropyridine compounds, manufacturing method thereof and use thereof

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Publication number
NZ522773A
NZ522773A NZ522773A NZ52277301A NZ522773A NZ 522773 A NZ522773 A NZ 522773A NZ 522773 A NZ522773 A NZ 522773A NZ 52277301 A NZ52277301 A NZ 52277301A NZ 522773 A NZ522773 A NZ 522773A
Authority
NZ
New Zealand
Prior art keywords
group
pyridyl
dihydropyridin
cyanophenyl
salt
Prior art date
Application number
NZ522773A
Other languages
English (en)
Inventor
Satoshi Nagato
Kohshi Ueno
Koki Kawano
Yoshihiko Norimine
Koichi Ito
Takahisa Hanada
Masataka Ueno
Hiroyuki Amino
Makoto Ogo
Shinji Hatakeyama
Yoshio Urawa
Hiroyuki Naka
Anthony John Groom
Leanne Rivers
Terence Smith
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0022483A external-priority patent/GB0022483D0/en
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NZ522773A publication Critical patent/NZ522773A/en

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Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2320973T3 (es) 2000-06-12 2009-06-01 EISAI R&D MANAGEMENT CO., LTD. Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos.
EP1343763A1 (en) * 2000-11-20 2003-09-17 Bristol-Myers Squibb Company Pyrodone derivatives as ap2 inhibitors
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
JP4119114B2 (ja) * 2001-11-28 2008-07-16 広栄化学工業株式会社 新規なジヒドロキシ(3−ピリジル)ボラン類
GB0129260D0 (en) * 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
EP1465869B1 (en) 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US7101883B2 (en) 2002-03-18 2006-09-05 Bristol-Myers Squibb Company Uracil derivatives as inhibitors of TNF-α converting enzyme (TACE) and matrix metalloproteinases
EP1497265B1 (en) * 2002-04-19 2009-02-18 Glaxo Group Limited Compounds having affinity at 5ht2c receptor and use thereof in therapy
JP4208512B2 (ja) 2002-07-23 2009-01-14 株式会社クラレ 5−(2’−ピリジル)−2−ピリドン誘導体の製造方法
WO2004035563A1 (en) * 2002-10-17 2004-04-29 Syngenta Participations Ag 3-heterocyclylpyridine derivatives useful as herbicides
KR100956052B1 (ko) * 2002-12-16 2010-05-06 미쓰비시 타나베 파마 코퍼레이션 3-치환-4-피리미돈 유도체
EP1581539A4 (en) 2003-01-03 2007-09-19 Bristol Myers Squibb Co NEW TYROSINE KINASE HEMMER
GB0305024D0 (en) * 2003-03-05 2003-04-09 Glaxo Group Ltd Compounds
SE0302323D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302324D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
WO2005099688A2 (en) 2004-04-07 2005-10-27 Takeda Pharmaceutical Company Limited Cyclic compounds
JP2007099781A (ja) * 2004-07-06 2007-04-19 Eisai R & D Management Co Ltd 1,2−ジヒドロピリジン化合物の結晶の製造方法
MY148809A (en) * 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
US20060069260A1 (en) * 2004-09-28 2006-03-30 Huiping Zhang Preparation of N-aryl pyridones
MX2007007330A (es) * 2004-12-16 2007-10-04 Vertex Pharma Piridonas de utilidad como inhibidores de quinasas .
AU2006203819A1 (en) * 2005-01-07 2006-07-13 Roskamp Research Llc Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
TW200700392A (en) * 2005-03-16 2007-01-01 Astrazeneca Ab Novel compounds
JP5180816B2 (ja) * 2005-04-04 2013-04-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 神経変性疾患および認知症のためのジヒドロピリジン化合物
US20090030017A1 (en) * 2005-04-08 2009-01-29 Eisai R & D Management Co., Ltd Therapeutic agent for dyskinesia
PH12012502411A1 (en) * 2005-05-10 2019-07-17 Intermune Inc Method of modulating stress-activated protein kinase system
GB0510141D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
JP2009503103A (ja) * 2005-08-02 2009-01-29 レキシコン・ファーマシューティカルズ・インコーポレーテッド アリールピリジン及びその使用方法
ES2361338T3 (es) * 2005-08-29 2011-06-16 Vertex Pharmaceuticals Incorporated Pirid-2-onas 3,5-disustituidas útiles como inhibidores de la familia tec de tirosina quinasas no ligadas a receptor.
CA2620269A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
CA2620352A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
US7968572B2 (en) * 2005-10-03 2011-06-28 Ono Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
WO2007072868A1 (ja) * 2005-12-21 2007-06-28 Eisai R & D Management Co., Ltd. 1,2-ジヒドロピリジン化合物の結晶(iv型)
CN101304970A (zh) * 2005-12-21 2008-11-12 卫材R&D管理有限公司 1,2-二氢吡啶化合物的无定形物
JP4865337B2 (ja) * 2006-01-24 2012-02-01 富士フイルムファインケミカルズ株式会社 2,3’−ビピリジル−6’−オンの製造方法
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途
WO2007126060A1 (ja) * 2006-04-28 2007-11-08 Eisai R & D Management Co., Ltd 1,2-ジヒドロピリジン化合物の塩
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
TW200808771A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
US20080108622A1 (en) * 2006-10-19 2008-05-08 Eisenach James C Combination therapy for the treatment of pain
US20080108603A1 (en) * 2006-10-19 2008-05-08 Eisenach James C Combination therapy for the treatment of pain
EP2131828A2 (en) * 2007-03-05 2009-12-16 Eisai R&D Management Co., Ltd. Ampa and nmda receptor antagonists for neurodegenerative diseases
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
WO2008139984A1 (en) * 2007-04-26 2008-11-20 Eisai R & D Management Co., Ltd. Cinnamide compounds for dementia
CA2690110A1 (en) * 2007-07-13 2009-01-22 Eisai R&D Management Co., Ltd. Ampa receptor antagonists for neuropathic pain
JP2010533127A (ja) * 2007-07-13 2010-10-21 コミッサリア ア レネルジー アトミーク エ オ ゼネルジ ザルタナテイヴ 神経因性疼痛のためのampa受容体アンタゴニストおよびアルドースレダクターゼ阻害剤
PL2200985T3 (pl) 2007-09-14 2011-12-30 Ortho Mcneil Janssen Pharmaceuticals Inc 1,3-Dipodstawione-4-(arylo-X-fenylo)-1H-pirydyn-2-ony
WO2009033703A1 (en) 2007-09-14 2009-03-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
TWI475995B (zh) 2007-09-14 2015-03-11 詹森藥物公司 1’,3’-二取代-4-苯基-3,4,5,6-四氫-2h,1’h-〔1,4’〕聯吡啶基-2’-酮化物
WO2009054544A1 (en) * 2007-10-26 2009-04-30 Eisai R & D Management Co., Ltd. Ampa receptor antagonists for parkinson's disease and movement disorders
AR069206A1 (es) 2007-11-06 2010-01-06 Astrazeneca Ab Derivados de 2-pirazinona, proceso para preparalos, composiciones farmaceuticas que los comprenden, proceso de preparacion de las mismas y usos en el tratamiento de trastornos osteoarticularesy del aparato respiratorio, entre otros.
RU2492170C9 (ru) 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
EP2223912A4 (en) 2007-12-21 2012-04-25 Kuraray Co PROCESS FOR THE PREPARATION OF A 6-HALOGENO-3-ARYLPYRIDINE DERIVATIVE
US20100256191A1 (en) * 2007-12-26 2010-10-07 Eisai R&D Management Co., Ltd. Ampa receptor antagonists and zonisamide for epilepsy
US20100297181A1 (en) * 2007-12-26 2010-11-25 Eisai R&D Management Co., Ltd. AMPA Receptor Antagonists for Epilepsy, Mental Disorders or Deficits in Sensory Organ
JP2011520809A (ja) * 2008-05-05 2011-07-21 アムジエン・インコーポレーテツド γセクレターゼモジュレーターとしての尿素化合物
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
US8859760B2 (en) 2008-07-29 2014-10-14 Frontier Scientific, Inc. Compositions for killing or preventing the growth of microbes
MX2011002042A (es) 2008-09-02 2011-06-20 Ortho Mcneil Janssen Pharm Derivados de 3-azabiciclo[3.1.o]hexilo como moduladores de los receptores del glutamato metabotropico.
MX2011003691A (es) 2008-10-16 2011-09-06 Ortho Mcneil Janssen Pharm Derivados de indol y benzomorfolina como moduladores de los receptores de glutamato metabotropico.
ES2534199T3 (es) * 2008-10-31 2015-04-20 Merck Sharp & Dohme Corp. Antagonistas del receptor P2X3 para el tratamiento del dolor
RU2512283C2 (ru) 2008-11-28 2014-04-10 Янссен Фармасьютикалз, Инк. Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов
WO2010072599A1 (en) 2008-12-23 2010-07-01 F. Hoffmann-La Roche Ag Dihydropyridone ureas as p2x7 modulators
BRPI0923498A2 (pt) 2008-12-23 2019-09-24 Hoffmann La Roche amidos de diidropiridona como moduladores de p2x7
US8153808B2 (en) 2008-12-23 2012-04-10 Roche Palo Alto Llc Dihydropyridone amides as P2X7 modulators
MX2011006843A (es) 2008-12-23 2011-08-04 Hoffmann La Roche Dihidropiridona-amidas como moduladores de p2x7.
BRPI0923488A2 (pt) 2008-12-23 2019-09-24 Hoffmann La Roche amidas de didropiridona como modulares p2x7
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
CA2756870A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted indolo-pyridinone compounds
AR076859A1 (es) 2009-05-12 2011-07-13 Ortho Mcneil Janssen Pharm Derivados de 1,2,4-triazolo[4,3-a]piridina moduladores alostericos positivos de receptores mglur2 , composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de trastornos neurologicos y siquiatricos.
NZ596078A (en) 2009-05-12 2013-06-28 Janssen Pharmaceuticals Inc 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
KR20120099639A (ko) 2009-10-02 2012-09-11 아스트라제네카 아베 호중구 엘라스타제의 억제제로서 사용되는 2-피리돈 화합물
JP2013234123A (ja) * 2010-09-03 2013-11-21 Taisho Pharmaceutical Co Ltd 3−ピラゾリル−2−ピリドン誘導体
JP5852666B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
CN103298810B (zh) 2010-11-08 2016-03-16 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
WO2012062751A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
PL2648516T3 (pl) * 2010-12-06 2019-04-30 Aclaris Therapeutics Inc Podstawione związki pirydynono-pirydynylowe
AU2012226251B2 (en) 2011-03-04 2017-05-04 Yale University (--)- huperzine A processes and related compositions and methods of treatment
ITMI20111952A1 (it) * 2011-10-27 2013-04-28 Italiana Sint Spa Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel
EP2800747A4 (en) * 2012-01-03 2015-12-09 Mapi Pharma Ltd POLYMORPHY OF PERAMPANEL
US9650360B2 (en) 2012-03-31 2017-05-16 University Of Georgia Research Foundation, Inc. Anti-mycobacterial drugs against tuberculosis
KR102057877B1 (ko) * 2012-07-18 2019-12-20 노스 앤드 사우스 브라더 파마시 인베스트먼트 컴파니 리미티드 질소함유 헤테로고리 유도체 및 그의 약물에서의 용도
ITMI20121390A1 (it) 2012-08-06 2014-02-07 F I S Fabbrica Italiana Sint P A Procedimento per la preparazione di acido 2-cianofenilboronico e suoi esteri, intermedi del perampanel o di e2040
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
JO3225B1 (ar) * 2012-11-27 2018-03-08 Lilly Co Eli 6-((s)-1-{1-[5-(2-هيدروكسي-إيثوكسي)-بيريدين-2-يل]-1h-بيرازول-3-يل}إيثيل)-3h-1 ، 3-بنزو ثيازول-2- أون باعتباره مضاد مستقبل ampa يعتمد على tarp- جاما 8
TW201441193A (zh) 2012-12-06 2014-11-01 Kyowa Hakko Kirin Co Ltd 吡啶酮化合物
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
US20160045625A1 (en) * 2013-04-04 2016-02-18 Eisai R&D Management Co., Ltd. [11c] and [18f] labeled 1,3-diphenyl-5-(pyrimidin-2-yl)-pyridin-2(1h)-one derivatives and their use for pet imaging of the ampa receptor
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
CN103274993A (zh) * 2013-06-13 2013-09-04 南京工业大学 二氢吡啶和吡咯类杂环的新合成方法
EP3024821B1 (en) * 2013-07-25 2017-09-27 Teva Pharmaceuticals International GmbH Process for the preparation of perampanel
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
SI3063139T1 (sl) 2013-10-29 2019-03-29 Takeda Pharmaceutical Company Limited Heterociklična spojina
CN103664756A (zh) * 2013-11-26 2014-03-26 苏州晶云药物科技有限公司 吡仑帕奈新晶型a及其制备方法
CN104706604A (zh) * 2013-12-12 2015-06-17 北京星昊医药股份有限公司 一种吡仑帕奈冻干口崩片及其制备方法
CN104725301A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 一种1,2-二氢吡啶-2-酮衍生物的制备方法
IL279202B2 (en) 2014-01-21 2023-09-01 Janssen Pharmaceutica Nv Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
CN109999025A (zh) 2014-01-21 2019-07-12 詹森药业有限公司 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途
KR102373700B1 (ko) 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논
CN105085382B (zh) * 2014-05-14 2019-10-18 江苏豪森药业集团有限公司 吡仑帕奈异构体晶型及其制备方法和用途
TW201609719A (zh) 2014-05-28 2016-03-16 美國禮來大藥廠 作為TARP-γ8依賴性AMPA受體拮抗劑之6-經取代-3H-1,3-苯并噻唑-2-酮化合物
CN103980188B (zh) * 2014-05-30 2016-01-27 浙江永宁药业股份有限公司 一种吡仑帕奈的合成方法及其中间体和中间体的合成方法
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
SG11201705952SA (en) 2015-02-04 2017-09-28 Beyondbio Inc Heterocyclic compound and pharmaceutical composition comprising same
EP3259262A4 (en) * 2015-02-17 2018-08-01 Mapi Pharma Limited Process and intermediates for the preparation of perampanel
AR104259A1 (es) * 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
WO2016172333A1 (en) 2015-04-21 2016-10-27 Teva Pharmaceuticals International Gmbh A solid state form of perampanel
CN107922328B (zh) 2015-07-06 2020-05-19 公立大学法人横滨市立大学 和ampa受体特异性结合的新颖化合物
CN105085383B (zh) * 2015-08-19 2017-09-01 四川大学 5‑甲基‑2(1h)吡啶酮衍生物及其制备方法和用途
JP6353173B2 (ja) * 2015-11-13 2018-07-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラノジピリジン化合物
KR101652750B1 (ko) * 2015-12-03 2016-08-31 김종선 피리딘 및 그 유도체의 정제방법
EP3515446B1 (en) 2016-09-19 2023-12-20 Novartis AG Therapeutic combinations comprising a raf inhibitor and a erk inhibitor
WO2018081167A1 (en) 2016-10-24 2018-05-03 Yumanity Therapeutics Compounds and uses thereof
WO2018094128A1 (en) * 2016-11-18 2018-05-24 Vps-3, Inc. 4-((6-bromopyridin-3-yl)oxy)benzonitrile and processes of preparation
US20190358369A1 (en) * 2016-12-22 2019-11-28 Biotronik Ag Drug releasing coatings for medical devices and methods of making same
EA201991650A1 (ru) 2017-01-06 2020-01-20 Юманити Терапьютикс, Инк. Способы лечения неврологических расстройств
JP6241974B1 (ja) 2017-01-11 2017-12-06 公立大学法人横浜市立大学 霊長類生体の脳内ampa受容体のイメージング方法、プログラム、及びスクリーニング方法
GB201702221D0 (en) 2017-02-10 2017-03-29 Univ Of Sussex Compounds
CA3057969A1 (en) 2017-05-02 2018-11-08 Novartis Ag Combination therapy
WO2019028062A1 (en) 2017-07-31 2019-02-07 Washington University PIRFENIDONE DERIVATIVES FOR MODULATION OF B-LYMPHOCYTE ACTIVITY AND PROTECTION OF ORGANS
WO2019084157A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. COMPOUNDS AND USES THEREOF
CN110028442B (zh) * 2018-01-11 2020-07-17 新发药业有限公司 一种吡仑帕奈的简便制备方法
GB201803340D0 (en) * 2018-03-01 2018-04-18 Univ Of Sussex Compounds
ES3043183T3 (en) 2018-03-23 2025-11-25 Janssen Pharmaceutica Nv Compounds and uses thereof
EP3560934A1 (en) 2018-04-26 2019-10-30 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of pure 2-cyanophenylboronic acid and esters thereof, intermediates of perampanel or of e2040
BR112021010953A2 (pt) 2018-12-14 2021-08-24 Eisai R&D Management Co., Ltd. Formulações farmacêuticas de base aquosa de compostos de 1,2-di-hidropiridina
SG11202108079RA (en) 2019-01-24 2021-08-30 Yumanity Therapeutics Inc Compounds and uses thereof
AU2020276695B2 (en) 2019-05-13 2025-12-18 Novartis Ag New crystalline forms of N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2 (trifluoromethyl)isonicotinamide as RAF inhibitors for the treatment of cancer
CN110483563B (zh) * 2019-09-06 2021-12-28 山西医科大学 一种新型离子型β-萘酚醛席夫碱锆配合物的制备方法及应用
EP4037770A1 (en) * 2019-10-04 2022-08-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Novel pyridin-2(1h)one derivatives, their preparation and their use for the treatment of pain
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
KR102392825B1 (ko) 2020-02-18 2022-04-29 명인제약주식회사 2-(2-옥소-1-페닐-5-피리딘-2-일피리딘-3-일)벤조니트릴과 l-말릭산의 공결정 화합물 및 이의 제조 방법
CN111362930B (zh) * 2020-04-15 2023-02-03 安徽医科大学 一种1,2,4-噁二唑-吡啶类化合物及其应用
WO2022150584A1 (en) * 2021-01-08 2022-07-14 Yale University Non-covalent inhibitors of the main protease of sars-cov-2 and methods of use
MX2023009059A (es) 2021-02-02 2023-09-15 Liminal Biosciences Ltd Antagonistas de gpr84 y usos de estos.
EP4403185A4 (en) 2021-09-15 2025-10-08 Univ Of The Ryukyus PHARMACEUTICAL COMPOSITION INTENDED FOR USE IN THE TREATMENT OF EITHER THE DECLINE OF COGNITIVE FUNCTIONS OR OVERWEIGHT OR OBESITY
EP4403184A4 (en) 2021-09-15 2025-09-24 Univ Of The Ryukyus PHARMACEUTICAL COMPOSITION INTENDED FOR USE IN THE TREATMENT OF EITHER THE DECLINE OF COGNITIVE FUNCTIONS OR OVERWEIGHT OR OBESITY
CN116265440B (zh) * 2021-12-16 2024-09-27 贵州大学 一种水杨酮拼接吡啶酮类化合物及其制备方法及应用
CN114057630B (zh) * 2021-12-23 2023-06-02 郑州大学 吡非尼酮衍生物及其合成方法和应用
EP4532470A1 (en) 2022-05-25 2025-04-09 Ikena Oncology, Inc. Mek inhibitors and uses thereof
US20250312345A1 (en) * 2022-07-07 2025-10-09 Yale University Non-covalent inhibitors of the main protease of sars-cov-2 and methods of use
KR102768044B1 (ko) * 2022-07-12 2025-02-17 이화여자대학교 산학협력단 연속 흐름 공정을 포함하는 페람파넬 유도체의 제조 방법
US11958832B1 (en) 2023-10-12 2024-04-16 King Faisal University 2-alkoxy[4,3:6,3-terpyridine]-3-carbonitriles as antimicrobial compounds
KR20250129557A (ko) 2024-02-22 2025-08-29 단국대학교 천안캠퍼스 산학협력단 독사조신을 유효성분으로 포함하는 신경질환 예방 또는 치료용 조성물

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5283761A (en) * 1976-01-01 1977-07-12 Yamanouchi Pharmaceut Co Ltd Novel pyridone derivative
JPS5531072A (en) * 1979-07-30 1980-03-05 Rikagaku Kenkyusho Preparation of 2-pyridone compound
DE4003541C1 (enExample) 1990-02-06 1991-08-08 Alter S.A., Madrid, Es
US5356902A (en) 1992-11-06 1994-10-18 Eli Lilly And Company Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists
IL109397A0 (en) 1993-04-28 1994-07-31 Schering Ag Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HU219777B (hu) 1993-07-02 2001-07-30 Gyógyszerkutató Intézet Kft. Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására
PT784054E (pt) 1994-09-27 2002-05-31 Yamanouchi Pharma Co Ltd Derivados de tetraidroquinoxalinadiona 1,2,3,4 e sua utilizacao como antagonistas do receptor glutamato
DE69634122D1 (de) * 1995-04-27 2005-02-03 Mitsubishi Pharma Corp Heterocyclische amidverbindungen und deren medizinische verwendung
AU1050597A (en) 1995-11-15 1997-06-05 California Institute Of Technology Synthesis of zeolites by hydrothermal reaction of zeolite p1
DE19604920A1 (de) 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5891871A (en) 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en) 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
PL330042A1 (en) 1996-05-15 1999-04-26 Pfizer Novel 2,3-disubstituted 4(3h)-quinazolynones
DE19643037A1 (de) 1996-10-18 1998-04-23 Boehringer Ingelheim Kg Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
JP2002514196A (ja) 1996-12-05 2002-05-14 アムジエン・インコーポレーテツド 置換ピリミジノンおよびピリドン化合物ならびに使用方法
CA2282277C (en) 1997-02-28 2005-10-11 Pfizer Products Inc. Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as ampa-receptor antagonists
GB9708945D0 (en) * 1997-05-01 1997-06-25 Merck Sharp & Dohme Therapeutic agents
GB9711753D0 (en) 1997-06-06 1997-08-06 Merck Sharp & Dohme Therapeutic agents
WO1999031062A1 (en) * 1997-12-17 1999-06-24 Shionogi & Co., Ltd. Novel pyridine compounds
EP1100504A2 (en) 1998-07-02 2001-05-23 Eisai Co., Ltd. Pharmaceutical compositions and their uses for treatment of demyelinating disorders
DE19835918A1 (de) 1998-08-07 2000-02-10 Dresden Arzneimittel Neue antikonvulsiv wirkende 4-Amino-1-aryl-pyridin-2-one und Verfahren zu deren Herstellung
ES2320973T3 (es) 2000-06-12 2009-06-01 EISAI R&D MANAGEMENT CO., LTD. Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos.
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses

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