NZ229234A - Thiazole derivatives: antitumour treatment and pharmaceutical compositions - Google Patents

Thiazole derivatives: antitumour treatment and pharmaceutical compositions

Info

Publication number
NZ229234A
NZ229234A NZ229234A NZ22923489A NZ229234A NZ 229234 A NZ229234 A NZ 229234A NZ 229234 A NZ229234 A NZ 229234A NZ 22923489 A NZ22923489 A NZ 22923489A NZ 229234 A NZ229234 A NZ 229234A
Authority
NZ
New Zealand
Prior art keywords
hydrogen
compound
fluoro
chloro
methyl
Prior art date
Application number
NZ229234A
Other languages
English (en)
Inventor
Anton Franz Josef Fliri
Rodney Caughren Schnur
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NZ229234A publication Critical patent/NZ229234A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Graft Or Block Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NZ229234A 1988-05-24 1989-05-23 Thiazole derivatives: antitumour treatment and pharmaceutical compositions NZ229234A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24

Publications (1)

Publication Number Publication Date
NZ229234A true NZ229234A (en) 1990-09-26

Family

ID=22731735

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ229234A NZ229234A (en) 1988-05-24 1989-05-23 Thiazole derivatives: antitumour treatment and pharmaceutical compositions

Country Status (25)

Country Link
EP (1) EP0343893B1 (OSRAM)
JP (1) JPH0678331B2 (OSRAM)
KR (1) KR910006864B1 (OSRAM)
CN (1) CN1023700C (OSRAM)
AT (1) ATE79114T1 (OSRAM)
AU (1) AU601905B2 (OSRAM)
CA (1) CA1328871C (OSRAM)
DD (1) DD283815A5 (OSRAM)
DE (1) DE68902358T2 (OSRAM)
DK (1) DK249389A (OSRAM)
ES (1) ES2043012T3 (OSRAM)
FI (1) FI892498A7 (OSRAM)
GR (1) GR3005844T3 (OSRAM)
HU (1) HU202507B (OSRAM)
IE (1) IE891667L (OSRAM)
IL (1) IL90337A0 (OSRAM)
MX (1) MX173140B (OSRAM)
MY (1) MY106035A (OSRAM)
NO (1) NO172389C (OSRAM)
NZ (1) NZ229234A (OSRAM)
PL (1) PL154875B1 (OSRAM)
PT (1) PT90622B (OSRAM)
SU (1) SU1681728A3 (OSRAM)
YU (1) YU47019B (OSRAM)
ZA (1) ZA893862B (OSRAM)

Families Citing this family (38)

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JP2790299B2 (ja) * 1989-02-01 1998-08-27 保土谷化学工業株式会社 ペンゾチアゾール誘導体
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
BR9610422A (pt) 1995-08-30 1999-07-13 Searle & Co Derivados de meta-guanidina uréia tiouréia ou ácido aminobenzóico azacíclico como antagonistas de integrina
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
RU2212407C2 (ru) 1997-11-10 2003-09-20 Бристол-Маерс Сквибб Компани Бензотиазольные ингибиторы протеинтирозинкиназ
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
KR100526487B1 (ko) 2000-06-21 2005-11-08 에프. 호프만-라 로슈 아게 벤조티아졸 유도체
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6599901B1 (en) * 2001-11-19 2003-07-29 Hoffman-La Roche Inc. Pyridone substituted benzothiazole derivatives
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
WO2004101558A1 (en) * 2003-05-13 2004-11-25 F. Hoffmann-La Roche Ag 2-imidazo-benzothiazoles as adenosine receptor ligands
AU2004251814B2 (en) * 2003-05-19 2009-07-23 F. Hoffmann-La Roche Ag Benzothiazole derivatives as adenosine receptor ligands
CN1791405A (zh) * 2003-05-21 2006-06-21 弗·哈夫曼-拉罗切有限公司 苯并噻唑衍生物及其在治疗涉及腺苷a 2a受体的疾病中的应用
DE602004014138D1 (de) * 2003-05-30 2008-07-10 Hoffmann La Roche Benzothiazole derivate und ihre anwendung in der behandlung von adenosine a2a rezeptor vermittelte krankheiten
HRP20060041B1 (hr) * 2003-07-28 2014-06-06 Janssen Pharmaceutica N.V. Derivati benzoimidazola, benzotiazola i benzooksazola i njihova uporaba kao modulatora lta4h
WO2005116026A1 (en) 2004-05-24 2005-12-08 F. Hoffmann-La Roche Ag 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide
RU2382782C2 (ru) * 2004-07-22 2010-02-27 Ф. Хоффманн-Ля Рош Аг Производные бензотиазола
BRPI0513510A (pt) * 2004-07-22 2008-05-06 Hoffmann La Roche benzotiazóis substituìdos
US7459563B2 (en) 2004-11-05 2008-12-02 Hoffmann-La Roche Inc. Process for the preparation of isonicotinic acid derivatives
AU2006226669B2 (en) 2005-03-23 2011-12-08 F. Hoffmann-La Roche Ag Acetylenyl-pyrazolo-pvrimidine derivatives as mGluR2 antagonists
AU2006298829B2 (en) 2005-09-27 2011-03-03 F. Hoffmann-La Roche Ag Oxadiazolyl pyrazolo-pyrimidines as mGluR2 antagonists
EP1994017A2 (en) * 2006-03-15 2008-11-26 4Sc Ag Novel heterocyclic nf-kb inhibitors
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
WO2010008847A2 (en) * 2008-06-24 2010-01-21 Takeda Pharmaceutical Company Limited Pi3k/m tor inhibitors
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
WO2013049407A2 (en) * 2011-09-30 2013-04-04 Kineta, Inc Anti-viral compounds
JP6274510B2 (ja) 2012-01-27 2018-02-07 国立大学法人京都大学 多能性幹細胞の心筋分化誘導法
WO2014136519A1 (ja) 2013-03-08 2014-09-12 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
EP3045451B1 (en) * 2013-09-13 2018-03-28 Kyoto University Compound promoting differentiation of pluripotent stem cells into cardiomyocytes
EP3150705B1 (en) 2014-05-30 2019-05-15 Kyoto University Method for inducing myocardial differentiation of pluripotent stem cells using low-molecular compound
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN110590735B (zh) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 一种环状硫酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61225168A (ja) * 1985-03-30 1986-10-06 Nippon Tokushu Noyaku Seizo Kk 新規ベンズアミド、その製法及び殺虫剤
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8611606D0 (en) * 1986-05-13 1986-06-18 Fbc Ltd Fungicides

Also Published As

Publication number Publication date
HU202507B (en) 1991-03-28
EP0343893B1 (en) 1992-08-05
KR890017248A (ko) 1989-12-15
CA1328871C (en) 1994-04-26
KR910006864B1 (ko) 1991-09-09
HUT51606A (en) 1990-05-28
NO892059D0 (no) 1989-05-23
IE891667L (en) 1989-11-24
PT90622B (pt) 1994-10-31
PL279613A1 (en) 1989-11-27
CN1037898A (zh) 1989-12-13
JPH0217181A (ja) 1990-01-22
FI892498A0 (fi) 1989-05-23
PL154875B1 (en) 1991-09-30
DE68902358D1 (de) 1992-09-10
MX16158A (es) 1993-06-01
AU601905B2 (en) 1990-09-20
NO172389B (no) 1993-04-05
DK249389D0 (da) 1989-05-23
GR3005844T3 (OSRAM) 1993-06-07
CN1023700C (zh) 1994-02-09
YU47019B (sh) 1994-11-15
FI892498A7 (fi) 1989-11-25
SU1681728A3 (ru) 1991-09-30
DE68902358T2 (de) 1992-12-10
MY106035A (en) 1995-03-31
NO892059L (no) 1989-11-27
ATE79114T1 (de) 1992-08-15
MX173140B (es) 1994-02-02
DD283815A5 (de) 1990-10-24
NO172389C (no) 1993-07-14
AU3509889A (en) 1989-11-30
ES2043012T3 (es) 1993-12-16
IL90337A0 (en) 1989-12-15
EP0343893A1 (en) 1989-11-29
ZA893862B (en) 1991-01-30
YU105989A (en) 1990-08-31
JPH0678331B2 (ja) 1994-10-05
PT90622A (pt) 1989-11-30
DK249389A (da) 1989-11-27

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