|
US4749576A
(en)
*
|
1984-05-10 |
1988-06-07 |
Ciba-Geigy Corporation |
Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
|
|
JPS61218517A
(ja)
*
|
1985-03-25 |
1986-09-29 |
Bio Materiaru Yunibaasu:Kk |
経皮吸収製剤
|
|
FR2585246A1
(fr)
*
|
1985-07-26 |
1987-01-30 |
Cortial |
Procede d'obtention de formes pharmaceutiques solides a liberation prolongee
|
|
US4794002A
(en)
*
|
1985-11-01 |
1988-12-27 |
Monsanto Company |
Modified polymeric surfaces and process for preparing same
|
|
JPH0643851B2
(ja)
*
|
1986-03-13 |
1994-06-08 |
大同メタル工業株式会社 |
軸受ユニット
|
|
US4983400A
(en)
*
|
1986-06-16 |
1991-01-08 |
Merck & Co., Inc. |
Controlled release combination of carbidopa/levodopa
|
|
US4780236A
(en)
*
|
1986-06-20 |
1988-10-25 |
Kiwi Brands, Inc. |
Lavoratory cleansing block containing polyethylene gycol disteatrate, guar gum and sodium chloride
|
|
US4743248A
(en)
*
|
1986-08-11 |
1988-05-10 |
Alza Corporation |
Dosage form for delivering acid sensitive beneficial agent
|
|
GB8620845D0
(en)
*
|
1986-08-28 |
1986-10-08 |
Reckitt & Colmann Prod Ltd |
Treatment of textile surfaces
|
|
US5219575A
(en)
*
|
1987-06-26 |
1993-06-15 |
Duphar International Research B.V. |
Compositions with controlled zero-order delivery rate and method of preparing these compositions
|
|
EP0297650A1
(en)
*
|
1987-06-26 |
1989-01-04 |
Duphar International Research B.V |
Compositions with controlled zero-order delivery rate and method of preparing these compositions
|
|
US4910015A
(en)
*
|
1987-10-19 |
1990-03-20 |
Massachusetts Institute Of Technology |
Surface-active polysiloxanes and drug releasing materials thereof
|
|
GB8801863D0
(en)
*
|
1988-01-28 |
1988-02-24 |
Fulmer Yarsley Ltd |
Pharmaceutical formulations with controlled drug release
|
|
US6440457B1
(en)
*
|
1993-05-27 |
2002-08-27 |
Alza Corporation |
Method of administering antidepressant dosage form
|
|
DE69603577T2
(de)
|
1995-02-10 |
1999-11-25 |
Medtronic, Inc. |
Verfahren und vorrichtung zur verabreichung von analgetika
|
|
US5945125A
(en)
*
|
1995-02-28 |
1999-08-31 |
Temple University |
Controlled release tablet
|
|
US20030203036A1
(en)
|
2000-03-17 |
2003-10-30 |
Gordon Marc S. |
Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
|
|
GB9703673D0
(en)
*
|
1997-02-21 |
1997-04-09 |
Bradford Particle Design Ltd |
Method and apparatus for the formation of particles
|
|
US6039968A
(en)
*
|
1997-06-24 |
2000-03-21 |
Hoechst Marion Roussel |
Intravaginal drug delivery device
|
|
DE19843904A1
(de)
*
|
1998-09-24 |
2000-03-30 |
Basf Ag |
Feste Dosierungsform mit polymerem Bindemittel
|
|
DE19843903A1
(de)
*
|
1998-09-24 |
2000-03-30 |
Basf Ag |
Feste Dosierungsform mit copolymerem Bindemittel
|
|
US6706283B1
(en)
*
|
1999-02-10 |
2004-03-16 |
Pfizer Inc |
Controlled release by extrusion of solid amorphous dispersions of drugs
|
|
US7943162B2
(en)
*
|
1999-10-21 |
2011-05-17 |
Alcon, Inc. |
Drug delivery device
|
|
KR100523127B1
(ko)
*
|
1999-12-23 |
2005-10-20 |
화이자 프로덕츠 인코포레이티드 |
하이드로겔계 약물 투여 형태
|
|
US20030086972A1
(en)
*
|
2000-08-09 |
2003-05-08 |
Appel Leah E. |
Hydrogel-driven drug dosage form
|
|
GB0027357D0
(en)
*
|
2000-11-09 |
2000-12-27 |
Bradford Particle Design Plc |
Particle formation methods and their products
|
|
PL204645B1
(pl)
*
|
2001-07-23 |
2010-01-29 |
Alcon |
Okulistyczne urządzenie do podawania leków
|
|
PT1409065E
(pt)
|
2001-07-23 |
2007-03-30 |
Alcon Inc |
Dispositivo de administração de fármacos oftálmicos
|
|
US7300668B2
(en)
*
|
2001-10-29 |
2007-11-27 |
Massachusetts Institute Of Technology |
System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing
|
|
GB0216562D0
(en)
|
2002-04-25 |
2002-08-28 |
Bradford Particle Design Ltd |
Particulate materials
|
|
US9339459B2
(en)
|
2003-04-24 |
2016-05-17 |
Nektar Therapeutics |
Particulate materials
|
|
BRPI0409962A
(pt)
|
2003-05-08 |
2006-04-25 |
Nektar Therapeutics Uk Ltd |
co-formulação particulada de uma substáncia ativa e um excipiente, composição farmacêutica ou nutricêutrica, produto farmacêutico ou nutricêutico, método para preparar uma co-formulação particulada de uma substáncia ativa e um excipiente, e, uso de uma substáncia ativa e um excipiente
|
|
GB0310636D0
(en)
*
|
2003-05-08 |
2003-06-11 |
Nektar Therapeutics Uk Ltd |
Particulate materials
|
|
CN1805719A
(zh)
*
|
2003-07-10 |
2006-07-19 |
爱尔康公司 |
眼药输送装置
|
|
US20060246109A1
(en)
*
|
2005-04-29 |
2006-11-02 |
Hossainy Syed F |
Concentration gradient profiles for control of agent release rates from polymer matrices
|
|
JP5505760B2
(ja)
*
|
2005-09-27 |
2014-05-28 |
ティッシュテク・インコーポレーテッド |
羊膜調製物及び精製組成物及びその使用方法
|
|
US8187639B2
(en)
*
|
2005-09-27 |
2012-05-29 |
Tissue Tech, Inc. |
Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
|
|
MX336930B
(es)
|
2005-11-28 |
2016-02-05 |
Marinus Pharmaceuticals |
Formulaciones de ganaxolona y metodos para la manufactura y el uso de las mismas.
|
|
US8246973B2
(en)
|
2006-06-21 |
2012-08-21 |
Advanced Cardiovascular Systems, Inc. |
Freeze-thaw method for modifying stent coating
|
|
CN101528830A
(zh)
|
2006-07-10 |
2009-09-09 |
麦德医像公司 |
超弹性环氧水凝胶
|
|
WO2008021368A2
(en)
|
2006-08-11 |
2008-02-21 |
The Johns Hopkins University |
Compositions and methods for neuroprotection
|
|
DK2529622T3
(en)
|
2006-09-22 |
2018-05-07 |
Pharmacyclics Llc |
INHIBITORS OF BRUTON-TYROSINKINASE
|
|
US8263641B2
(en)
|
2007-09-10 |
2012-09-11 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
JP2011505520A
(ja)
|
2007-12-03 |
2011-02-24 |
メディパックス インコーポレイテッド |
流体計量供給装置
|
|
CA2734500A1
(en)
|
2008-08-27 |
2010-03-11 |
Calcimedica Inc. |
Compounds that modulate intracellular calcium
|
|
ES2559029T3
(es)
|
2009-04-24 |
2016-02-10 |
Tissue Tech, Inc. |
Composiciones que contienen al complejo HC.HA y metodos de uso de las mismas
|
|
WO2011032011A1
(en)
|
2009-09-10 |
2011-03-17 |
Medipacs, Inc. |
Low profile actuator and improved method of caregiver controlled administration of therapeutics
|
|
US7718662B1
(en)
|
2009-10-12 |
2010-05-18 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
|
|
US9500186B2
(en)
|
2010-02-01 |
2016-11-22 |
Medipacs, Inc. |
High surface area polymer actuator with gas mitigating components
|
|
ES2602475T3
(es)
|
2010-04-15 |
2017-02-21 |
Tracon Pharmaceuticals, Inc. |
Potenciación de la actividad anticáncer por terapia de combinación con inhibidores de la vía BER
|
|
HUE029570T2
(en)
|
2010-04-27 |
2017-03-28 |
Calcimedica Inc |
Intracellular calcium modifying compounds
|
|
US8754219B2
(en)
|
2010-04-27 |
2014-06-17 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
KR101580714B1
(ko)
|
2010-06-03 |
2016-01-04 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 인산화효소(btk)의 억제제의 용도
|
|
CN114591311A
(zh)
|
2010-08-27 |
2022-06-07 |
钙医学公司 |
调节细胞内钙的化合物
|
|
WO2012061556A1
(en)
|
2010-11-03 |
2012-05-10 |
Flugen, Inc. |
Wearable drug delivery device having spring drive and sliding actuation mechanism
|
|
MX350838B
(es)
|
2011-02-11 |
2017-09-18 |
Grain Proc Corporation * |
Composicion de sal.
|
|
WO2012149486A1
(en)
|
2011-04-28 |
2012-11-01 |
Tissuetech, Inc. |
Methods of modulating bone remodeling
|
|
CA2837878A1
(en)
|
2011-06-10 |
2012-12-13 |
Tissuetech, Inc. |
Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
|
|
KR101892788B1
(ko)
|
2011-09-13 |
2018-08-28 |
파마싸이클릭스 엘엘씨 |
벤다무스틴과 조합된 히스톤 디아세틸라제 억제제의 제제 및 그의 용도
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
JP2015508407A
(ja)
|
2012-01-06 |
2015-03-19 |
アビデ セラピューティクス,インク. |
カルバメート化合物およびその製造および使用
|
|
CN104302689A
(zh)
|
2012-03-14 |
2015-01-21 |
麦德医像公司 |
含有过量活性分子的智能聚合物材料
|
|
KR20250151610A
(ko)
|
2012-06-04 |
2025-10-21 |
파마싸이클릭스 엘엘씨 |
브루톤 타이로신 키나아제 저해제의 결정 형태
|
|
JP2015528001A
(ja)
|
2012-07-11 |
2015-09-24 |
ティッシュテック,インク. |
Hc−ha/ptx3複合体を含む組成物およびその使用方法
|
|
US9416141B2
(en)
|
2012-09-28 |
2016-08-16 |
University Of Washington Through Its Center For Commercialization |
Compounds and methods for preventing, treating and/or protecting against sensory hair cell death
|
|
US9512116B2
(en)
|
2012-10-12 |
2016-12-06 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
US9611263B2
(en)
|
2013-10-08 |
2017-04-04 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
JP6345786B2
(ja)
|
2013-12-05 |
2018-06-20 |
ファーマサイクリックス エルエルシー |
ブルトン型チロシンキナーゼの阻害剤
|
|
EP3134418A4
(en)
|
2014-04-23 |
2018-01-03 |
The Research Foundation for The State University of New York |
A rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjuction therewith
|
|
TW201603818A
(zh)
|
2014-06-03 |
2016-02-01 |
組織科技股份有限公司 |
組成物及方法
|
|
US9775978B2
(en)
|
2014-07-25 |
2017-10-03 |
Warsaw Orthopedic, Inc. |
Drug delivery device and methods having a retaining member
|
|
US10080877B2
(en)
|
2014-07-25 |
2018-09-25 |
Warsaw Orthopedic, Inc. |
Drug delivery device and methods having a drug cartridge
|
|
US9839644B2
(en)
|
2014-09-09 |
2017-12-12 |
ARKAY Therapeutics, LLC |
Formulations and methods for treatment of metabolic syndrome
|
|
US9359316B1
(en)
|
2014-11-25 |
2016-06-07 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic TRPV1 agonists
|
|
ES2760373T3
(es)
|
2015-02-06 |
2020-05-13 |
Univ Washington |
Compuestos y procedimientos para prevenir o tratar la muerte de células ciliadas sensoriales
|
|
US10227333B2
(en)
|
2015-02-11 |
2019-03-12 |
Curtana Pharmaceuticals, Inc. |
Inhibition of OLIG2 activity
|
|
US20160243288A1
(en)
|
2015-02-23 |
2016-08-25 |
Tissuetech, Inc. |
Apparatuses and methods for treating ophthalmic diseases and disorders
|
|
BR112017018198A2
(pt)
|
2015-02-27 |
2018-04-10 |
Curtana Pharmaceuticals Inc |
inibição da atividade de olig2
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
MA41827A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
|
|
MA41828A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton
|
|
CN107849021A
(zh)
|
2015-05-11 |
2018-03-27 |
阿比德治疗公司 |
治疗炎症或神经性疼痛的方法
|
|
US10342831B2
(en)
|
2015-05-20 |
2019-07-09 |
Tissuetech, Inc. |
Composition and methods for preventing the proliferation and epithelial-mesenchymal transition of epithelial cells
|
|
MX2018002554A
(es)
|
2015-08-31 |
2018-08-14 |
Pharmacyclics Llc |
Combinaciones de inhibidores de btk para tratar mieloma multiple.
|
|
US10076650B2
(en)
|
2015-11-23 |
2018-09-18 |
Warsaw Orthopedic, Inc. |
Enhanced stylet for drug depot injector
|
|
EP3389695A4
(en)
|
2015-12-16 |
2019-10-09 |
The Walter and Eliza Hall Institute of Medical Research |
INHIBITION OF CYTOKININDUCED SH2 PROTEIN IN NK CELLS
|
|
HRP20251152T1
(hr)
|
2016-01-19 |
2025-12-05 |
Janssen Pharmaceutica Nv |
Formulacije/pripravci koji sadrže inhibitor btk-a
|
|
MX2018008771A
(es)
|
2016-01-19 |
2018-11-09 |
Janssen Pharmaceutica Nv |
Formulaciones/composiciones que comprenden un inhibidor de btk.
|
|
TW201733600A
(zh)
|
2016-01-29 |
2017-10-01 |
帝聖工業公司 |
胎兒扶持組織物及使用方法
|
|
WO2017147146A1
(en)
|
2016-02-23 |
2017-08-31 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic trpv1 agonists
|
|
AU2017246334C1
(en)
|
2016-04-04 |
2022-11-17 |
Sinopia Biosciences, Inc. |
Treating extrapyramidal syndrome using Trapidil
|
|
CA3025268A1
(en)
|
2016-05-25 |
2017-11-30 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
|
|
WO2017205769A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
WO2017205766A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
WO2017205762A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
USD802757S1
(en)
|
2016-06-23 |
2017-11-14 |
Warsaw Orthopedic, Inc. |
Drug pellet cartridge
|
|
WO2018005600A1
(en)
*
|
2016-06-28 |
2018-01-04 |
Trustees Of Tufts College |
Compositions and methods for delivery of active agents
|
|
PT3484862T
(pt)
|
2016-07-18 |
2021-11-17 |
Arthrosi Therapeutics Inc |
Compostos, composições e métodos para o tratamento ou a prevenção de um sintoma associado a gota ou hiperuricemia
|
|
SG11201901679XA
(en)
|
2016-08-26 |
2019-03-28 |
Curtana Pharmaceuticals Inc |
Inhibition of olig2 activity
|
|
US10434261B2
(en)
|
2016-11-08 |
2019-10-08 |
Warsaw Orthopedic, Inc. |
Drug pellet delivery system and method
|
|
WO2018093950A1
(en)
|
2016-11-16 |
2018-05-24 |
Abide Therapeutics, Inc. |
Pharmaceutical formulations
|
|
MA58133B1
(fr)
|
2016-11-16 |
2024-02-29 |
H Lundbeck As |
Une forme cristalline d'un inhibiteur de magl
|
|
WO2019046731A1
(en)
|
2017-09-01 |
2019-03-07 |
University Of Washington |
CRYSTALLINE FORMS OF COMPOUNDS FOR PREVENTING OR TREATING DEATH OF SENSORY CILIC CELLS
|
|
WO2019169112A1
(en)
|
2018-02-28 |
2019-09-06 |
Curtana Pharmaceuticals, Inc. |
Inhibition of olig2 activity
|
|
TW202019887A
(zh)
|
2018-07-27 |
2020-06-01 |
美商同心止痛劑股份有限公司 |
酚系trpv1促效劑之聚乙二醇化前藥
|
|
KR20210102933A
(ko)
|
2018-12-06 |
2021-08-20 |
아쓰로시 테라퓨틱스, 인크. |
통풍 또는 고뇨산혈증의 치료 또는 예방 방법
|
|
EP3890723A4
(en)
|
2018-12-06 |
2022-08-03 |
Arthrosi Therapeutics, Inc. |
CRYSTALLINE FORMS OF A COMPOUND FOR THE TREATMENT OR PREVENTION OF GOUT OR HYPERURICAEMIA
|
|
CN114040760B
(zh)
|
2018-12-31 |
2025-05-09 |
拜欧米富士恩公司 |
Menin-mll相互作用的不可逆抑制剂
|
|
BR112021018254A2
(pt)
|
2019-03-15 |
2022-03-15 |
Unicycive Therapeutics Inc |
Derivados de nicorandil
|
|
MX2022013224A
(es)
|
2020-04-21 |
2022-11-14 |
H Lundbeck As |
Sintesis de un inhibidor de la monoacilglicerol lipasa.
|
|
TW202208357A
(zh)
|
2020-05-11 |
2022-03-01 |
美商克立弗治療學股份有限公司 |
VCP/p97抑制劑之結晶型及調配物
|
|
CA3202151A1
(en)
|
2020-12-16 |
2022-06-23 |
Biomea Fusion, Inc. |
Fused pyrimidine compounds as inhibitors of menin-mll interaction
|
|
CA3204457A1
(en)
|
2021-01-06 |
2022-07-14 |
Ben SESSA |
Mdma in the treatment of alcohol use disorder
|
|
CA3218884A1
(en)
|
2021-05-11 |
2022-11-17 |
David Nutt |
Therapeutic aminoindane compounds and compositions
|
|
WO2022256720A2
(en)
|
2021-06-03 |
2022-12-08 |
Arcadia Medicine, Inc. |
Enantiomeric entactogen compositions and methods of their use
|
|
US12251385B2
(en)
|
2021-08-11 |
2025-03-18 |
Biomea Fusion, Inc. |
Covalent inhibitors of menin-MLL interaction for diabetes mellitus
|
|
WO2023022912A1
(en)
|
2021-08-20 |
2023-02-23 |
Biomea Fusion, Inc. |
Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cancer
|
|
EP4392028A4
(en)
|
2021-08-23 |
2025-09-24 |
Alexander Shulgin Res Institute Inc |
DEUTERATED EMPATHOGENS
|
|
US12180176B2
(en)
|
2021-08-23 |
2024-12-31 |
Alexander Shulgin Research Institute, Inc. |
Fluorinated empathogens
|
|
WO2023027966A1
(en)
|
2021-08-24 |
2023-03-02 |
Biomea Fusion, Inc. |
Pyrazine compounds as irreversible inhibitors of flt3
|
|
US12226408B2
(en)
|
2021-08-31 |
2025-02-18 |
Cerespir Incorporated |
Co-crystals
|
|
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(en)
|
2021-09-03 |
2025-11-12 |
Alexander Shulgin Res Institute Inc |
ASYMMETRIC ALLYL TRYPTAMINES
|
|
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(en)
|
2021-09-13 |
2023-03-16 |
Biomea Fusion, Inc. |
IRREVERSIBLE INHIBITORS OF KRas
|
|
EP4405318A4
(en)
|
2021-09-25 |
2025-11-05 |
Alexander Shulgin Res Institute Inc |
PHENYLAKYLAMINES SUBSTITUTED
|
|
WO2023086341A1
(en)
|
2021-11-09 |
2023-05-19 |
Biomea Fusion, Inc. |
Inhibitors of kras
|
|
KR20240128987A
(ko)
|
2021-12-30 |
2024-08-27 |
바이오메아 퓨전, 인크. |
Flt3의 억제제로서의 피라진 화합물
|
|
US20250100990A1
(en)
|
2022-01-19 |
2025-03-27 |
Awakn Ls Europe Holdings Limited |
1,3-benzodioxole esters and their therapeutic use
|
|
US20250179089A1
(en)
|
2022-02-16 |
2025-06-05 |
Awakn Ls Europe Holdings Limited |
Bridged ring compounds and their therapeutic use as cns agents
|
|
WO2023235618A1
(en)
|
2022-06-03 |
2023-12-07 |
Biomea Fusion, Inc. |
Fused pyrimidine compounds as inhibitors of menin
|
|
US20240010649A1
(en)
|
2022-07-06 |
2024-01-11 |
Oppilan Pharma Limited |
Crystalline forms of an s1p receptor modulator
|
|
WO2024155719A1
(en)
|
2023-01-18 |
2024-07-25 |
Biomea Fusion, Inc. |
Crystalline forms of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(l-oxo-2-propen-l-yl)amino]-l-piperidinyl]methyl]-2- pyridinecarboxamide as a covalentinhibitor of menin-mll interaction
|
|
US20250002458A1
(en)
|
2023-05-24 |
2025-01-02 |
Unicycive Therapeutics Inc. |
Salt forms of nicorandil derivative
|
|
WO2024249950A1
(en)
|
2023-06-02 |
2024-12-05 |
Biomea Fusion, Inc. |
Fused pyrimidine compounds as inhibitors of menin
|
|
WO2025072556A1
(en)
|
2023-09-26 |
2025-04-03 |
Unicycive Therapeutics, Inc. |
Amino acid prodrugs of nicorandil
|
|
WO2025194102A1
(en)
|
2024-03-15 |
2025-09-18 |
Unicycive Therapeutics, Inc. |
Pyridine modified nicorandil derivatives
|