CA1246447A - Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use - Google Patents

Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use

Info

Publication number
CA1246447A
CA1246447A CA000481011A CA481011A CA1246447A CA 1246447 A CA1246447 A CA 1246447A CA 000481011 A CA000481011 A CA 000481011A CA 481011 A CA481011 A CA 481011A CA 1246447 A CA1246447 A CA 1246447A
Authority
CA
Canada
Prior art keywords
active agent
hydrogel
swollen
release
bead
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000481011A
Other languages
English (en)
French (fr)
Inventor
Ping I. Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Participations AG
Original Assignee
Ciba Geigy Investments Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Investments Ltd filed Critical Ciba Geigy Investments Ltd
Application granted granted Critical
Publication of CA1246447A publication Critical patent/CA1246447A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Colloid Chemistry (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
CA000481011A 1984-05-10 1985-05-08 Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use Expired CA1246447A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US608,756 1984-05-10
US06/608,756 US4624848A (en) 1984-05-10 1984-05-10 Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use

Publications (1)

Publication Number Publication Date
CA1246447A true CA1246447A (en) 1988-12-13

Family

ID=24437841

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000481011A Expired CA1246447A (en) 1984-05-10 1985-05-08 Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use

Country Status (16)

Country Link
US (1) US4624848A (OSRAM)
EP (1) EP0164311B1 (OSRAM)
JP (1) JPS619A (OSRAM)
AT (1) ATE61731T1 (OSRAM)
AU (1) AU583507B2 (OSRAM)
CA (1) CA1246447A (OSRAM)
DE (1) DE3582193D1 (OSRAM)
DK (1) DK205185A (OSRAM)
ES (1) ES542948A0 (OSRAM)
FI (1) FI851801A7 (OSRAM)
GR (1) GR851114B (OSRAM)
IL (1) IL75129A (OSRAM)
NZ (1) NZ212030A (OSRAM)
PH (1) PH24100A (OSRAM)
PT (1) PT80416B (OSRAM)
ZA (1) ZA853511B (OSRAM)

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AU583507B2 (en) 1989-05-04
DK205185D0 (da) 1985-05-09
PT80416A (en) 1985-06-01
DE3582193D1 (de) 1991-04-25
IL75129A0 (en) 1985-09-29
FI851801L (fi) 1985-11-11
PT80416B (en) 1987-04-16
EP0164311A2 (en) 1985-12-11
EP0164311A3 (en) 1987-06-03
ATE61731T1 (de) 1991-04-15
NZ212030A (en) 1988-01-08
PH24100A (en) 1990-03-05
IL75129A (en) 1989-08-15
EP0164311B1 (en) 1991-03-20
ES8603273A1 (es) 1986-01-01
AU4221685A (en) 1985-11-14
JPS619A (ja) 1986-01-06
FI851801A7 (fi) 1985-11-11
DK205185A (da) 1985-11-11
ES542948A0 (es) 1986-01-01
ZA853511B (en) 1985-12-24
US4624848A (en) 1986-11-25
FI851801A0 (fi) 1985-05-08
GR851114B (OSRAM) 1985-11-25

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