NZ206338A - L -(indol-2-yl)- b , w -dihydroxyalkanoates and pharmaceutical compositions - Google Patents

L -(indol-2-yl)- b , w -dihydroxyalkanoates and pharmaceutical compositions

Info

Publication number
NZ206338A
NZ206338A NZ206338A NZ20633883A NZ206338A NZ 206338 A NZ206338 A NZ 206338A NZ 206338 A NZ206338 A NZ 206338A NZ 20633883 A NZ20633883 A NZ 20633883A NZ 206338 A NZ206338 A NZ 206338A
Authority
NZ
New Zealand
Prior art keywords
hydrogen
fluoro
chloro
benzyloxy
compound according
Prior art date
Application number
NZ206338A
Other languages
English (en)
Inventor
F G Kathawala
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of NZ206338A publication Critical patent/NZ206338A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NZ206338A 1982-11-22 1983-11-21 L -(indol-2-yl)- b , w -dihydroxyalkanoates and pharmaceutical compositions NZ206338A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44366882A 1982-11-22 1982-11-22
US54885083A 1983-11-04 1983-11-04

Publications (1)

Publication Number Publication Date
NZ206338A true NZ206338A (en) 1987-08-31

Family

ID=27033614

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ206338A NZ206338A (en) 1982-11-22 1983-11-21 L -(indol-2-yl)- b , w -dihydroxyalkanoates and pharmaceutical compositions

Country Status (18)

Country Link
EP (1) EP0114027B1 (cg-RX-API-DMAC7.html)
JP (1) JPH0347167A (cg-RX-API-DMAC7.html)
AT (1) ATE31718T1 (cg-RX-API-DMAC7.html)
AU (1) AU570021B2 (cg-RX-API-DMAC7.html)
CA (1) CA1210405A (cg-RX-API-DMAC7.html)
CY (1) CY1579A (cg-RX-API-DMAC7.html)
DE (2) DE19475017I2 (cg-RX-API-DMAC7.html)
DK (2) DK359284D0 (cg-RX-API-DMAC7.html)
FI (1) FI77228C (cg-RX-API-DMAC7.html)
GR (1) GR79042B (cg-RX-API-DMAC7.html)
HK (1) HK11191A (cg-RX-API-DMAC7.html)
HU (1) HU204253B (cg-RX-API-DMAC7.html)
IE (1) IE56262B1 (cg-RX-API-DMAC7.html)
IL (1) IL70286A (cg-RX-API-DMAC7.html)
LU (1) LU88670I2 (cg-RX-API-DMAC7.html)
NL (1) NL950022I2 (cg-RX-API-DMAC7.html)
NZ (1) NZ206338A (cg-RX-API-DMAC7.html)
WO (1) WO1984002131A1 (cg-RX-API-DMAC7.html)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
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ATE60571T1 (de) * 1984-12-04 1991-02-15 Sandoz Ag Inden-analoga von mevalonolakton und ihre derivate.
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US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
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US5185328A (en) * 1987-08-20 1993-02-09 Nissan Chemical Industries Ltd. Quinoline type mevalonolactones useful for treating hyperlipidemia, hyperlipoproteinemia or atherosclerosis
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Also Published As

Publication number Publication date
JPH0440343B2 (cg-RX-API-DMAC7.html) 1992-07-02
CA1210405A (en) 1986-08-26
DK165244B (da) 1992-10-26
IE832713L (en) 1984-05-22
IE56262B1 (en) 1991-06-05
DE19475017I2 (de) 2003-02-20
FI77228C (fi) 1989-02-10
HUT35642A (en) 1985-07-29
DK359284A (da) 1984-07-20
IL70286A (en) 1987-08-31
DK359284D0 (da) 1984-07-20
FI842615A7 (fi) 1984-06-28
CY1579A (en) 1991-12-20
NL950022I1 (cg-RX-API-DMAC7.html) 1996-01-02
DE3375137D1 (en) 1988-02-11
FI842615A0 (fi) 1984-06-28
EP0114027B1 (en) 1988-01-07
AU2261283A (en) 1984-06-18
HK11191A (en) 1991-02-13
LU88670I2 (fr) 1996-04-29
DK97890D0 (da) 1990-04-19
FI77228B (fi) 1988-10-31
ATE31718T1 (de) 1988-01-15
AU570021B2 (en) 1988-03-03
NL950022I2 (nl) 1996-12-02
WO1984002131A1 (fr) 1984-06-07
DK165244C (da) 1993-03-22
IL70286A0 (en) 1984-02-29
DK97890A (da) 1990-04-19
EP0114027A1 (en) 1984-07-25
GR79042B (cg-RX-API-DMAC7.html) 1984-10-02
JPH0347167A (ja) 1991-02-28
HU204253B (en) 1991-12-30

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