NO993151L - Fremgangsmåte for fremstilling av renset dimer av benavledet faktor - Google Patents

Fremgangsmåte for fremstilling av renset dimer av benavledet faktor

Info

Publication number
NO993151L
NO993151L NO993151A NO993151A NO993151L NO 993151 L NO993151 L NO 993151L NO 993151 A NO993151 A NO 993151A NO 993151 A NO993151 A NO 993151A NO 993151 L NO993151 L NO 993151L
Authority
NO
Norway
Prior art keywords
dimer
derived factor
subjecting
bone
preparation
Prior art date
Application number
NO993151A
Other languages
English (en)
Other versions
NO993151D0 (no
Inventor
Hidetoshi Andou
Jun Honda
Shunjiro Sugimoto
Original Assignee
Hoechst Marion Roussel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18445882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO993151(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Marion Roussel Ltd filed Critical Hoechst Marion Roussel Ltd
Publication of NO993151D0 publication Critical patent/NO993151D0/no
Publication of NO993151L publication Critical patent/NO993151L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Fremgangsmåte for fremstilling av en renset dimer av en benavledet faktor, som omfatter underkastelse av et inklusjonslegeme av en benavledet faktor fremstilt ved hjelp av genetisk konstruksjon for følgende trinn a) til. e) i rekkefølge; a) trinnet med behandling av et inklusjonslegeme av en benavledet faktor med et denaturerende middel for å fremstille en oppløst monomer; b) trinnet med behandling av den oppløste monomer med en refoldende oppløsning for å fremstille en dimer; c) trinnet med underkastelse av den refoldende dimer for ultrafiltrering og utbytting av oppløsningsmiddel; d) trinnet med underkastelse av dimeroppløsningen fremstilt ovenfor for isoelektrisk utfelling; og e) trinnet med underkastelse av den isoelektrisk utfelte dimer for revers-fasekromatografi.
NO993151A 1996-12-25 1999-06-24 Fremgangsmåte for fremstilling av renset dimer av benavledet faktor NO993151L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP35581296 1996-12-25
PCT/JP1997/004784 WO1998029559A1 (fr) 1996-12-25 1997-12-24 Procede de preparation de dimeres purifies a partir de facteur derive de l'os

Publications (2)

Publication Number Publication Date
NO993151D0 NO993151D0 (no) 1999-06-24
NO993151L true NO993151L (no) 1999-06-24

Family

ID=18445882

Family Applications (1)

Application Number Title Priority Date Filing Date
NO993151A NO993151L (no) 1996-12-25 1999-06-24 Fremgangsmåte for fremstilling av renset dimer av benavledet faktor

Country Status (21)

Country Link
US (1) US6551801B1 (no)
EP (1) EP0949335B2 (no)
KR (1) KR20000062328A (no)
AP (1) AP9901539A0 (no)
AT (1) ATE266095T1 (no)
AU (1) AU5339598A (no)
BR (1) BR9714183A (no)
CA (1) CA2275464A1 (no)
DE (1) DE69728997T3 (no)
DK (1) DK0949335T4 (no)
EA (1) EA199900596A1 (no)
ES (1) ES2216181T5 (no)
HU (1) HUP0002573A2 (no)
IL (1) IL130641A0 (no)
NO (1) NO993151L (no)
PL (1) PL334303A1 (no)
PT (1) PT949335E (no)
SI (1) SI0949335T2 (no)
TR (1) TR199901479T2 (no)
WO (1) WO1998029559A1 (no)
ZA (1) ZA9711580B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7811793B2 (en) * 1996-12-25 2010-10-12 Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Process for preparing purified active monomer of bone-derived factor
US20040019185A1 (en) * 1996-12-25 2004-01-29 Hidetoshi Andou Process for preparing purified active monomer of bone-derived factor
US20030120042A1 (en) * 2000-03-30 2003-06-26 Takao Yamada Process for producing recombinant protein
AU2003209071B2 (en) * 2002-02-08 2008-08-14 The University Of Erlangen-Nuremberg Formulation comprising bioactive agents and method of using same
CN1735426A (zh) * 2002-08-13 2006-02-15 惠氏公司 用作转化生长因子β蛋白质的溶解赋形剂的肽
JP4800739B2 (ja) * 2005-10-20 2011-10-26 デンカ生研株式会社 アッセイ用媒体及びアッセイ方法
ES2764222T3 (es) * 2006-09-08 2020-06-02 Wyeth Llc Lavado con arginina en la purificación de proteínas mediante el uso de cromatografía de afinidad
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2187932B1 (en) 2007-08-07 2015-01-28 DePuy Synthes Products, LLC Protein formulations comprising gdf-5 in aqueous acidic solution
CN102026619A (zh) * 2008-04-14 2011-04-20 先进科技及再生医学有限责任公司 液体缓冲的gdf-5制剂
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338663C (en) * 1988-04-08 1996-10-22 Hermann Oppermann Biosynthetic osteogenic proteins and osteogenic devices containing them
CA2141555C (en) * 1992-07-31 2007-03-27 William K. Jones Morphogenic protein soluble complex and composition thereof
JP3570558B2 (ja) * 1993-05-01 2004-09-29 持田製薬株式会社 Ｄｎａ断片およびそれを含むベクター、該ベクターによって形質転換された形質転換体、該ベクターを用いる蛋白質の産生方法
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
BR9608019A (pt) * 1995-04-19 1999-11-30 Hoechst Japan Uma nova proteína e um processo para a preparação da mesma'
US5702637A (en) 1995-04-19 1997-12-30 Minnesota Mining And Manufacturing Company Liquid crystal compounds having a chiral fluorinated terminal portion

Also Published As

Publication number Publication date
HUP0002573A2 (hu) 2000-12-28
KR20000062328A (ko) 2000-10-25
AU5339598A (en) 1998-07-31
SI0949335T1 (en) 2004-10-31
ES2216181T3 (es) 2004-10-16
EP0949335A1 (en) 1999-10-13
TR199901479T2 (xx) 1999-09-21
ATE266095T1 (de) 2004-05-15
NO993151D0 (no) 1999-06-24
ES2216181T5 (es) 2009-03-01
PT949335E (pt) 2004-09-30
DE69728997D1 (de) 2004-06-09
DE69728997T3 (de) 2009-07-09
SI0949335T2 (sl) 2009-04-30
ZA9711580B (en) 1999-09-23
EP0949335B2 (en) 2008-11-19
US6551801B1 (en) 2003-04-22
DE69728997T2 (de) 2004-09-02
EP0949335A4 (en) 2003-01-22
EA199900596A1 (ru) 2000-02-28
IL130641A0 (en) 2000-06-01
DK0949335T3 (da) 2004-08-30
DK0949335T4 (da) 2009-03-23
EP0949335B1 (en) 2004-05-06
WO1998029559A1 (fr) 1998-07-09
BR9714183A (pt) 2000-02-29
CA2275464A1 (en) 1998-07-09
PL334303A1 (en) 2000-02-14
AP9901539A0 (en) 1999-06-30

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