ATE403671T1 - Methoden zur aufreinigung von rekombinatem humanem erythropoietin aus zellkulturüberständen - Google Patents
Methoden zur aufreinigung von rekombinatem humanem erythropoietin aus zellkulturüberständenInfo
- Publication number
- ATE403671T1 ATE403671T1 AT99958811T AT99958811T ATE403671T1 AT E403671 T1 ATE403671 T1 AT E403671T1 AT 99958811 T AT99958811 T AT 99958811T AT 99958811 T AT99958811 T AT 99958811T AT E403671 T1 ATE403671 T1 AT E403671T1
- Authority
- AT
- Austria
- Prior art keywords
- epo
- human erythropoietin
- supernatives
- purification
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP980105610 AR008359A1 (es) | 1998-11-06 | 1998-11-06 | PROCEDIMIENTO PARA LA PURIFICACIoN DE ERITROPOYETINA HUMANA RECOMBINANTE A PARTIR DE SOBRENADANTES DE CULTIVO DE CÉLULAS. |
| ARP990100680 AR008364A1 (es) | 1999-02-23 | 1999-02-23 | Procedimiento para la purificacion de eritropoyetina humana recombinante a partir de sobrenadantes de cultivo de celulas y eritropoyetina humanarecombinante obtenida con tal procedimiento |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE403671T1 true ATE403671T1 (de) | 2008-08-15 |
Family
ID=25590827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99958811T ATE403671T1 (de) | 1998-11-06 | 1999-11-08 | Methoden zur aufreinigung von rekombinatem humanem erythropoietin aus zellkulturüberständen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7012130B1 (de) |
| EP (1) | EP1127063B1 (de) |
| JP (1) | JP4516692B2 (de) |
| AT (1) | ATE403671T1 (de) |
| AU (1) | AU1610000A (de) |
| BR (1) | BR9917606A (de) |
| CA (2) | CA2350327C (de) |
| CO (1) | CO5241324A1 (de) |
| DE (1) | DE69939268D1 (de) |
| ES (1) | ES2312219T3 (de) |
| WO (1) | WO2000027869A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9917606A (pt) | 1998-11-06 | 2002-12-31 | Bio Sidus S A | Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento |
| BR9905868A (pt) | 1998-11-06 | 2001-01-23 | Bio Sidus S A | Procedimento de cultivo massivo de células de mamìfero para a obtenção de eritropoetina humana, recombinante e a eritropoetina humana recombinante obtida com tal procedimento |
| US6777205B1 (en) | 1998-11-06 | 2004-08-17 | Sterrenbeld Biotechnologie North America, Inc. | Host cells expressing recombinant human erythropoietin |
| CN1596268A (zh) | 2001-11-28 | 2005-03-16 | 桑多斯有限公司 | 重组人红细胞生成素的层析纯化 |
| KR100567448B1 (ko) * | 2003-11-05 | 2006-04-04 | 주식회사 인투젠 | 형질전환 동물의 유즙 전처리방법 및 이를 통한 인체단백질의 정제방법 |
| DE102004027816A1 (de) * | 2004-06-08 | 2006-01-05 | Bioceuticals Arzneimittel Ag | Verfahren zur Reinigung von Erythropoietin |
| AR053416A1 (es) * | 2005-11-10 | 2007-05-09 | Protech Pharma S A | Combinacion de glicoisoformas para el tratamiento o prevencion de la septicemia, linea celular transgenica productora de glicoformas de eritropoyetina, composicion farmaceutica que comprende a dicha combinacion, procedimientos para obtener la linea celular, procedimiento para producir dicha combinac |
| EP2120998B1 (de) | 2006-11-28 | 2013-08-07 | HanAll Biopharma Co., Ltd. | Modifizierte erythropoetin-polypeptide und ihre verwendungen zur behandlung |
| KR100988706B1 (ko) | 2007-03-07 | 2010-10-18 | 한미홀딩스 주식회사 | 재조합 에리트로포이에틴의 신규한 정제방법 |
| CL2008002053A1 (es) | 2007-07-17 | 2009-05-22 | Hoffmann La Roche | Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion. |
| CL2008002054A1 (es) * | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
| DE102008002210A1 (de) * | 2008-06-04 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von Erythropoietin |
| DE102008002209A1 (de) | 2008-06-04 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur Aufreinigung von Erythropoietin |
| JP5380743B2 (ja) * | 2008-06-19 | 2014-01-08 | 住友化学株式会社 | 光学活性な４−アミノ−３−置換フェニルブタン酸の製造方法 |
| US8779110B2 (en) | 2008-06-24 | 2014-07-15 | Dr. Reddy's Laboratories Limited | Purification of low isoelectric point isoforms of darbepoietin |
| EP2334699B1 (de) | 2008-09-23 | 2013-09-11 | F. Hoffmann-La Roche AG | Aufreinigung von erythropoietin |
| DE102008054716A1 (de) | 2008-12-16 | 2010-06-17 | Evonik Degussa Gmbh | Inprozesskontrolle in einem Verfahren zur Herstellung von EPO |
| EA022396B1 (ru) * | 2009-09-23 | 2015-12-30 | Ратиофарм Гмбх | Способ очистки рекомбинантного эритропоэтина человека (epo), эритропоэтин, очищенный данным способом, и фармацевтические композиции, содержащие такой эритропоэтин |
| KR101443257B1 (ko) * | 2011-10-18 | 2014-09-19 | 주식회사 종근당 | 낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법 |
| US20150065689A1 (en) | 2012-04-10 | 2015-03-05 | Dr. Reddy's Laboratories Limited | Single step fractionation method |
| KR101414897B1 (ko) | 2013-11-29 | 2014-07-04 | 씨제이헬스케어 주식회사 | 다베포에틴 알파의 정제 방법 |
| CN107001411B (zh) | 2014-12-15 | 2021-07-23 | 默克专利股份公司 | 从粗溶液捕获靶分子 |
| WO2016144658A1 (en) * | 2015-03-10 | 2016-09-15 | Merck Sharp & Dohme Corp. | Process for preparing recombinant insulin using microfiltration |
| JP6906497B2 (ja) * | 2016-03-09 | 2021-07-21 | Ｊｃｒファーマ株式会社 | 変異型ヒトエリスロポエチンの製造方法 |
| JP6920280B2 (ja) * | 2016-03-31 | 2021-08-18 | 株式会社カネカ | 精製されたネコ由来エリスロポエチンの製造方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5010002A (en) | 1983-01-19 | 1991-04-23 | Genentech, Inc. | Human t-PA production using vectors coding DHFR protein |
| US4667195A (en) | 1983-04-26 | 1987-05-19 | Nippon Soken, Inc. | Rear monitor system triggered by occupant leaving the vehicle |
| KR850004274A (ko) | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| JPS6197229A (ja) | 1984-10-18 | 1986-05-15 | Chugai Pharmaceut Co Ltd | 安定なエリトロポエチン製剤 |
| IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin |
| IL79176A (en) * | 1985-06-20 | 1992-06-21 | Kirin Amgen Inc | Process for the recovery of erythropoietin from a fluid |
| US4667016A (en) * | 1985-06-20 | 1987-05-19 | Kirin-Amgen, Inc. | Erythropoietin purification |
| DK173067B1 (da) | 1986-06-27 | 1999-12-13 | Univ Washington | Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa |
| DE4014654A1 (de) * | 1990-05-08 | 1991-11-14 | Behringwerke Ag | Galenische waessrige formulierungen von erythropoietin und ihre verwendung |
| JPH05502463A (ja) * | 1990-09-28 | 1993-04-28 | オーソ・フアーマシユーチカル・コーポレーシヨン | ハイブリツド成長因子 |
| SE9300105D0 (sv) | 1993-01-15 | 1993-01-15 | Kabi Pharmacia Ab | Stable protein solution |
| IL118201A (en) * | 1995-05-11 | 2004-12-15 | Roche Diagnostics Gmbh | Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof |
| US5876992A (en) | 1996-07-03 | 1999-03-02 | Molecular Biology Resources, Inc. | Method and formulation for stabilization of enzymes |
| BR9917606A (pt) | 1998-11-06 | 2002-12-31 | Bio Sidus S A | Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento |
| UY25790A1 (es) | 1998-11-06 | 2000-08-21 | Bio Sidus S A | Formas farmaceuticas de eritropoyetina humana recombinante estables a temperatura ambiente y apropiadas para su uso en humanos, formulaciones y procedimientos de liofilizacion para su obtencion. |
| BR9905868A (pt) | 1998-11-06 | 2001-01-23 | Bio Sidus S A | Procedimento de cultivo massivo de células de mamìfero para a obtenção de eritropoetina humana, recombinante e a eritropoetina humana recombinante obtida com tal procedimento |
| BR9905867A (pt) * | 1998-11-06 | 2001-01-23 | Bio Sidus S A | Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula |
-
1999
- 1999-07-07 BR BR9917606-8A patent/BR9917606A/pt not_active Application Discontinuation
- 1999-11-05 CO CO99069965A patent/CO5241324A1/es not_active Application Discontinuation
- 1999-11-08 WO PCT/US1999/026241 patent/WO2000027869A1/en not_active Ceased
- 1999-11-08 DE DE69939268T patent/DE69939268D1/de not_active Expired - Lifetime
- 1999-11-08 CA CA2350327A patent/CA2350327C/en not_active Expired - Fee Related
- 1999-11-08 EP EP99958811A patent/EP1127063B1/de not_active Expired - Lifetime
- 1999-11-08 AT AT99958811T patent/ATE403671T1/de not_active IP Right Cessation
- 1999-11-08 US US09/830,964 patent/US7012130B1/en not_active Expired - Fee Related
- 1999-11-08 CA CA2704598A patent/CA2704598A1/en not_active Abandoned
- 1999-11-08 JP JP2000581046A patent/JP4516692B2/ja not_active Expired - Fee Related
- 1999-11-08 ES ES99958811T patent/ES2312219T3/es not_active Expired - Lifetime
- 1999-11-08 AU AU16100/00A patent/AU1610000A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP4516692B2 (ja) | 2010-08-04 |
| JP2002529475A (ja) | 2002-09-10 |
| EP1127063A1 (de) | 2001-08-29 |
| DE69939268D1 (de) | 2008-09-18 |
| BR9917606A (pt) | 2002-12-31 |
| CO5241324A1 (es) | 2003-01-31 |
| CA2350327A1 (en) | 2000-05-18 |
| AU1610000A (en) | 2000-05-29 |
| CA2350327C (en) | 2010-05-18 |
| EP1127063B1 (de) | 2008-08-06 |
| ES2312219T3 (es) | 2009-02-16 |
| US7012130B1 (en) | 2006-03-14 |
| WO2000027869A1 (en) | 2000-05-18 |
| CA2704598A1 (en) | 2000-05-18 |
| EP1127063A4 (de) | 2005-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |