DE69635675D1 - Verkürzter aus einer gliazelllinie gewonnener neurotropher faktor - Google Patents

Verkürzter aus einer gliazelllinie gewonnener neurotropher faktor

Info

Publication number
DE69635675D1
DE69635675D1 DE69635675T DE69635675T DE69635675D1 DE 69635675 D1 DE69635675 D1 DE 69635675D1 DE 69635675 T DE69635675 T DE 69635675T DE 69635675 T DE69635675 T DE 69635675T DE 69635675 D1 DE69635675 D1 DE 69635675D1
Authority
DE
Germany
Prior art keywords
cell line
neurotrophic factor
factor obtained
proteins
glia cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69635675T
Other languages
English (en)
Other versions
DE69635675T2 (de
Inventor
Sylvia Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DE69635675D1 publication Critical patent/DE69635675D1/de
Publication of DE69635675T2 publication Critical patent/DE69635675T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69635675T 1995-09-28 1996-09-16 Verkürzter aus einer gliazelllinie gewonnener neurotropher faktor Expired - Lifetime DE69635675T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US535681 1995-09-28
US08/535,681 US6184200B1 (en) 1995-09-28 1995-09-28 Truncated glial cell line-derived neurotrophic factor
PCT/US1996/014915 WO1997011964A1 (en) 1995-09-28 1996-09-16 Truncated glial cell line-derived neurotrophic factor

Publications (2)

Publication Number Publication Date
DE69635675D1 true DE69635675D1 (de) 2006-02-02
DE69635675T2 DE69635675T2 (de) 2006-07-06

Family

ID=24135310

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69635675T Expired - Lifetime DE69635675T2 (de) 1995-09-28 1996-09-16 Verkürzter aus einer gliazelllinie gewonnener neurotropher faktor

Country Status (25)

Country Link
US (5) US6184200B1 (de)
EP (1) EP0920448B1 (de)
JP (3) JP4153036B2 (de)
KR (1) KR100334739B1 (de)
CN (1) CN1283659C (de)
AT (1) ATE314389T1 (de)
AU (1) AU707528B2 (de)
CA (1) CA2232749C (de)
CZ (1) CZ297326B6 (de)
DE (1) DE69635675T2 (de)
DK (1) DK0920448T3 (de)
EA (1) EA001204B1 (de)
ES (1) ES2255713T3 (de)
HK (1) HK1021823A1 (de)
HU (1) HU226220B1 (de)
IL (6) IL144488A0 (de)
MX (1) MX9802278A (de)
NO (1) NO322521B1 (de)
NZ (1) NZ318697A (de)
SI (1) SI0920448T1 (de)
SK (1) SK288094B6 (de)
TW (1) TW570926B (de)
UA (1) UA66339C2 (de)
WO (1) WO1997011964A1 (de)
ZA (1) ZA968087B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184200B1 (en) * 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US6677135B1 (en) 1996-05-08 2004-01-13 Biogen, Inc. Ret ligand (RetL) for stimulating neutral and renal growth
DE19816186A1 (de) * 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-kodierende DNA, Teile davon und GDNF-Varianten
US20020055467A1 (en) * 1998-07-06 2002-05-09 Johansen Teit E. Novel neurotrophic factors
US6507788B1 (en) * 1999-02-25 2003-01-14 Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) Rational selection of putative peptides from identified nucleotide, or peptide sequences, of unknown function
US6897061B1 (en) 2000-06-16 2005-05-24 Spinal Cord Society Transdifferentiation of glial cells
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
US8946151B2 (en) * 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
US7245117B1 (en) 2004-11-01 2007-07-17 Cardiomems, Inc. Communicating with implanted wireless sensor
CN1897977A (zh) * 2003-10-20 2007-01-17 Ns基因公司 帕金森氏病的体内基因治疗
AU2004283053A1 (en) 2003-10-20 2005-05-06 Nsgene A/S In vivo gene therapy of Parkinson's Disease
KR101241551B1 (ko) 2004-08-19 2013-03-11 바이오겐 아이덱 엠에이 인코포레이티드 전환 성장 인자 베타 패밀리 단백질의 리폴딩
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
JP5723528B2 (ja) * 2006-08-04 2015-05-27 プロロング ファーマシューティカルズ エルエルシー 修飾されたエリスロポエチン
US20090069230A1 (en) * 2007-02-12 2009-03-12 The Research Foundation Of State University Of New York Gdnf-derived peptides
NZ580947A (en) 2007-05-01 2012-05-25 Biogen Idec Inc Compositions and methods for increasing vascularization
US8446454B2 (en) 2007-05-21 2013-05-21 Polycom, Inc. Dynamic adaption of a continuous presence videoconferencing layout based on video content
FI20070808A0 (fi) * 2007-10-25 2007-10-25 Mart Saarma GDNF:n silmukointivariantit ja niiden käytöt
UA112981C2 (uk) * 2011-04-11 2016-11-25 Елі Ліллі Енд Компані Варіант людського gdnf
EP2968462B1 (de) 2013-03-15 2020-12-23 The Jackson Laboratory Verfahren zur förderung von wundheilung und haarwachstum
RU2561050C2 (ru) 2013-08-28 2015-08-20 Федеральное государственное бюджетное учреждение науки Институт биофизики клетки Российской академии наук (ИБК РАН) Применение белка yb-1 и его фрагментов для изготовления лекарственных средств при лечении болезни альцгеймера
US11912750B2 (en) 2016-11-10 2024-02-27 Keros Therapeutics, Inc. GDNF fusion polypeptides and methods of use thereof
JP2023515915A (ja) * 2019-12-19 2023-04-17 トランスフェルト・プラス・ソシエテ・アン・コマンディテ 腸のニューロパチーを治療するためのグリア細胞株由来神経栄養因子（ｇｄｎｆ）の使用
AU2022397707A1 (en) 2021-11-29 2024-06-13 Shanghai Regenelead Therapies Co., Ltd. Aadc/gdnf polynucleotide, and use thereof in treating parkinson's disease

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
EP0154316B1 (de) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemisch modifizierte Lymphokine und Verfahren zu ihrer Herstellung
US5158881A (en) 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5106627A (en) 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
CA2006596C (en) 1988-12-22 2000-09-05 Rika Ishikawa Chemically-modified g-csf
AU648505B2 (en) 1989-05-19 1994-04-28 Amgen, Inc. Metalloproteinase inhibitor
US5229500A (en) 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
CA1332433C (en) 1989-09-29 1994-10-11 Robert L. Sutherland Ski structure and binding therefor
DE69033584T2 (de) 1989-10-16 2001-03-08 Amgen Inc., Thousand Oaks Stammzellenfaktor
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
WO1991010470A1 (en) 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US5202428A (en) 1990-06-20 1993-04-13 The Salk Institute For Biological Studies DNA encoding neurotropic growth factor
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
KR100242093B1 (ko) 1991-09-20 2000-02-01 그레고리 아보트 신경교 유도 신경 영양성 인자
WO1995017203A1 (en) 1993-12-22 1995-06-29 The University Of Medicine And Dentistry Of New Jersey Novel nucleic acid sequences isolated from glial cells
FR2717824B1 (fr) * 1994-03-25 1996-04-26 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
US5733875A (en) * 1994-11-15 1998-03-31 Amgen Inc. Methods of using GDNF as a neuroprotective agent
US5739307A (en) 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US6184200B1 (en) * 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US5731284A (en) * 1995-09-28 1998-03-24 Amgen Inc. Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product
US5641750A (en) * 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US5929041A (en) * 1996-02-23 1999-07-27 Amgen Inc. Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
US5837681A (en) * 1996-02-23 1998-11-17 Amgen Inc. Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product
US5741778A (en) * 1996-03-19 1998-04-21 Amgen Inc. Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product

Also Published As

Publication number Publication date
US20110251267A1 (en) 2011-10-13
AU707528B2 (en) 1999-07-15
WO1997011964A1 (en) 1997-04-03
ATE314389T1 (de) 2006-01-15
IL123761A0 (en) 1998-10-30
EA199800301A1 (ru) 1998-10-29
IL144018A0 (en) 2002-04-21
EP0920448A1 (de) 1999-06-09
US7611865B2 (en) 2009-11-03
SI0920448T1 (sl) 2006-04-30
US20040127419A1 (en) 2004-07-01
IL218336A0 (en) 2012-04-30
IL144488A (en) 2006-12-31
EA001204B1 (ru) 2000-12-25
KR19990063825A (ko) 1999-07-26
CA2232749A1 (en) 1997-04-03
JP2008067699A (ja) 2008-03-27
US20040214776A1 (en) 2004-10-28
NO322521B1 (no) 2006-10-16
ZA968087B (en) 1997-06-12
CZ88298A3 (cs) 1999-02-17
IL123761A (en) 2005-12-18
US7390781B2 (en) 2008-06-24
CN1197461A (zh) 1998-10-28
EP0920448B1 (de) 2005-12-28
NO981430L (no) 1998-03-30
SK38998A3 (en) 1999-07-12
HK1021823A1 (en) 2000-07-07
JPH11512709A (ja) 1999-11-02
ES2255713T3 (es) 2006-07-01
UA66339C2 (uk) 2004-05-17
IL144488A0 (en) 2002-05-23
US6184200B1 (en) 2001-02-06
AU7074696A (en) 1997-04-17
CN1283659C (zh) 2006-11-08
MX9802278A (es) 1998-08-30
DE69635675T2 (de) 2006-07-06
NO981430D0 (no) 1998-03-30
NZ318697A (en) 1999-09-29
JP5241037B2 (ja) 2013-07-17
TW570926B (en) 2004-01-11
KR100334739B1 (ko) 2002-09-17
HUP9802262A3 (en) 2001-01-29
HUP9802262A2 (hu) 1999-01-28
HU226220B1 (hu) 2008-06-30
DK0920448T3 (da) 2006-04-10
US20040254114A1 (en) 2004-12-16
CA2232749C (en) 2003-03-25
IL144018A (en) 2012-04-30
CZ297326B6 (cs) 2006-11-15
JP2010279360A (ja) 2010-12-16
JP4909843B2 (ja) 2012-04-04
SK288094B6 (sk) 2013-07-02
JP4153036B2 (ja) 2008-09-17

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Legal Events

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8364 No opposition during term of opposition