BR9714183A - Processo para a preparação de dìmero purificado de fator obtido a partir do osso - Google Patents

Processo para a preparação de dìmero purificado de fator obtido a partir do osso

Info

Publication number
BR9714183A
BR9714183A BR9714183-6A BR9714183A BR9714183A BR 9714183 A BR9714183 A BR 9714183A BR 9714183 A BR9714183 A BR 9714183A BR 9714183 A BR9714183 A BR 9714183A
Authority
BR
Brazil
Prior art keywords
bone
dimer
preparation
subjecting
factor obtained
Prior art date
Application number
BR9714183-6A
Other languages
English (en)
Inventor
Jun Honda
Hidetoshi Andou
Shunjiro Sugimoto
Original Assignee
Hoechst Marion Roussel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18445882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9714183(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Marion Roussel Ltd filed Critical Hoechst Marion Roussel Ltd
Publication of BR9714183A publication Critical patent/BR9714183A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA A PREPARAçãO DE DìMERO PURIFICADO DE FATOR OBTIDO A PARTIR DO OSSO"<D>. Um processo para a preparação de um dímero purificado de um fator obtido a partir do osso, que compreende sujeitar um corpo de inclusão de um fator obtido a partir do osso produzido por engenharia genética às seguintes etapas a) a e) em seq³ência: a) a etapa de tratamento de um corpo de inclusão de um fator obtido a partir do osso com um agente de redobramento para preparar um monómero solubilizado; b) a etapa de tratamento do monómero solubilizado com uma solução de redobramento para preparar um dímero; c) a etapa de sujeitar o dímero redobrado a ultrafiltração e substituição de solvente, d) a etapa de sujeitar a solução do dímero preparado acima a precipitação isoelétrica; e e) a etapa de sujeitar o dímero precipitado isoeletricamente a cromatografia em fase reversa.
BR9714183-6A 1996-12-25 1997-12-24 Processo para a preparação de dìmero purificado de fator obtido a partir do osso BR9714183A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP35581296 1996-12-25
PCT/JP1997/004784 WO1998029559A1 (fr) 1996-12-25 1997-12-24 Procede de preparation de dimeres purifies a partir de facteur derive de l'os

Publications (1)

Publication Number Publication Date
BR9714183A true BR9714183A (pt) 2000-02-29

Family

ID=18445882

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9714183-6A BR9714183A (pt) 1996-12-25 1997-12-24 Processo para a preparação de dìmero purificado de fator obtido a partir do osso

Country Status (21)

Country Link
US (1) US6551801B1 (pt)
EP (1) EP0949335B2 (pt)
KR (1) KR20000062328A (pt)
AP (1) AP9901539A0 (pt)
AT (1) ATE266095T1 (pt)
AU (1) AU5339598A (pt)
BR (1) BR9714183A (pt)
CA (1) CA2275464A1 (pt)
DE (1) DE69728997T3 (pt)
DK (1) DK0949335T4 (pt)
EA (1) EA199900596A1 (pt)
ES (1) ES2216181T5 (pt)
HU (1) HUP0002573A2 (pt)
IL (1) IL130641A0 (pt)
NO (1) NO993151D0 (pt)
PL (1) PL334303A1 (pt)
PT (1) PT949335E (pt)
SI (1) SI0949335T2 (pt)
TR (1) TR199901479T2 (pt)
WO (1) WO1998029559A1 (pt)
ZA (1) ZA9711580B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7811793B2 (en) * 1996-12-25 2010-10-12 Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Process for preparing purified active monomer of bone-derived factor
US20040019185A1 (en) * 1996-12-25 2004-01-29 Hidetoshi Andou Process for preparing purified active monomer of bone-derived factor
EP1273655A4 (en) * 2000-03-30 2004-08-04 Takeda Chemical Industries Ltd METHOD FOR PRODUCING A RECOMBINANT PROTEIN
AU2003209071B2 (en) * 2002-02-08 2008-08-14 The University Of Erlangen-Nuremberg Formulation comprising bioactive agents and method of using same
EP1542711A4 (en) * 2002-08-13 2009-07-01 Wyeth Corp PEPTIDES AS SOLUBILIZING AUXILIARIES FOR THE CONVERSION OF GROWTH FACTOR PROTEINS
JP4800739B2 (ja) * 2005-10-20 2011-10-26 デンカ生研株式会社 アッセイ用媒体及びアッセイ方法
JP5386354B2 (ja) * 2006-09-08 2014-01-15 ワイス・エルエルシー アフィニティークロマトグラフィーを使用するタンパク質精製におけるアルギニン洗浄
AU2007234612B2 (en) * 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
JP5323832B2 (ja) 2007-08-07 2013-10-23 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー 酸性水溶液中にｇｄｆ−５を含むタンパク質製剤
US7947649B2 (en) * 2008-04-14 2011-05-24 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered GDF-5 formulations
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1225225A3 (en) * 1988-04-08 2003-01-08 Stryker Corporation Osteogenic devices
ATE287949T1 (de) * 1992-07-31 2005-02-15 Stryker Corp Löslicher komplex morphogener proteine und zusammensetzungen davon
JP3570558B2 (ja) * 1993-05-01 2004-09-29 持田製薬株式会社 Ｄｎａ断片およびそれを含むベクター、該ベクターによって形質転換された形質転換体、該ベクターを用いる蛋白質の産生方法
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
US5702637A (en) 1995-04-19 1997-12-30 Minnesota Mining And Manufacturing Company Liquid crystal compounds having a chiral fluorinated terminal portion
PL186518B1 (pl) * 1995-04-19 2004-01-30 Bioph Biotech Entw Pharm Gmbh Białko, kompozycja farmaceutyczna i sposób wytwarzania białka

Also Published As

Publication number Publication date
KR20000062328A (ko) 2000-10-25
DK0949335T4 (da) 2009-03-23
SI0949335T1 (en) 2004-10-31
ATE266095T1 (de) 2004-05-15
EP0949335B2 (en) 2008-11-19
PT949335E (pt) 2004-09-30
DE69728997T2 (de) 2004-09-02
EP0949335A4 (en) 2003-01-22
ZA9711580B (en) 1999-09-23
TR199901479T2 (xx) 1999-09-21
HUP0002573A2 (hu) 2000-12-28
EP0949335A1 (en) 1999-10-13
NO993151L (no) 1999-06-24
DE69728997T3 (de) 2009-07-09
DE69728997D1 (de) 2004-06-09
CA2275464A1 (en) 1998-07-09
ES2216181T3 (es) 2004-10-16
AP9901539A0 (en) 1999-06-30
NO993151D0 (no) 1999-06-24
EA199900596A1 (ru) 2000-02-28
DK0949335T3 (da) 2004-08-30
SI0949335T2 (sl) 2009-04-30
AU5339598A (en) 1998-07-31
US6551801B1 (en) 2003-04-22
ES2216181T5 (es) 2009-03-01
IL130641A0 (en) 2000-06-01
WO1998029559A1 (fr) 1998-07-09
EP0949335B1 (en) 2004-05-06
PL334303A1 (en) 2000-02-14

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A,7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1836 DE 14/03/2006.