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Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Peptides Or Proteins
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Abstract
Postupak za proizvodnju prečišćenog dimernog koštanog morfogenetskog faktora koji obuhvata podvrgavanje inkluzionih tela koštanog morfogenetskog faktora dobijenog pomoću tehnologije genetskog inženjeringa sledećim fazama a) - e) u nizu: a) faza tretiranja inkluzionog tela faktora dobijenog iz kosti sa nesastavljenim agensom radi dobijanja rastvorenog monomera, b) faza tretiranja rastvorenog monomera sa rastvorom ponovnog sastavljanja radi dobijanja dimera, c) faza podvrgavanja ponovo sastavljenog dimera ultrafiltriranju i zamene rastvarača, d) faza podvrgavanja rastvora dimera dobijenog gore izoelektričnom taloženju, i e) faza podvrgavanja izoelektrično staloženog dimera hromatografiji povratne faze.A process for the production of purified dimeric bone morphogenetic factor comprising subjecting the inclusion bodies of the bone morphogenetic factor obtained by genetic engineering to the following stages a) - e) in a sequence: a) a phase of treating the inclusion body of a factor obtained from bone with an unassembled agent to obtain a dissolved agent ) the phase of treatment of the dissolved monomer with the reassembly solution to obtain the dimer; c) the phase of subjecting the reassembled dimer to ultrafiltration and solvent replacement; d) the phase of the dimer solution obtained from isoelectric deposition above;
YU28799A1996-12-251997-12-24Process for preparing purified dimer of bone-derived factor
YU28799A
(en)
METHOD FOR PREPARING A HIGH SPECIFIC VOLUME ACTIVITY SOLUTION OF A TISSUE PLASMINOGEN ACTIVATOR (T-PA) ACTIVITY PROTEIN, SOLUTION CONTAINING T-PA ACTIVITY PROTEIN AND USE OF THE SOLUTION IN HUMAN AND VETERINARY MEDICINE.