ATE192486T1 - Chondroitinase, herstellungsverfahren und pharmazeutische zusammensetzung - Google Patents
Chondroitinase, herstellungsverfahren und pharmazeutische zusammensetzungInfo
- Publication number
- ATE192486T1 ATE192486T1 AT93304979T AT93304979T ATE192486T1 AT E192486 T1 ATE192486 T1 AT E192486T1 AT 93304979 T AT93304979 T AT 93304979T AT 93304979 T AT93304979 T AT 93304979T AT E192486 T1 ATE192486 T1 AT E192486T1
- Authority
- AT
- Austria
- Prior art keywords
- chondroitinase
- chondroitinase abc
- crystallizable
- sds
- measurement
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02004—Chondroitin ABC lyase (4.2.2.4), i.e. chondroitinase
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C1/00—Photosensitive materials
- G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
- G03C1/04—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein with macromolecular additives; with layer-forming substances
- G03C1/047—Proteins, e.g. gelatine derivatives; Hydrolysis or extraction products of proteins
- G03C2001/0471—Isoelectric point of gelatine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/873—Proteus
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19288292 | 1992-06-26 | ||
JP31098092A JP3895782B2 (ja) | 1992-10-26 | 1992-10-26 | コンドロイチナーゼ組成物およびそれを含有する注射用製剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE192486T1 true ATE192486T1 (de) | 2000-05-15 |
Family
ID=26507572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93304979T ATE192486T1 (de) | 1992-06-26 | 1993-06-25 | Chondroitinase, herstellungsverfahren und pharmazeutische zusammensetzung |
Country Status (10)
Country | Link |
---|---|
US (3) | US5496718A (de) |
EP (1) | EP0576294B1 (de) |
KR (1) | KR100280779B1 (de) |
AT (1) | ATE192486T1 (de) |
CA (1) | CA2099138C (de) |
DE (1) | DE69328519T2 (de) |
DK (1) | DK0576294T3 (de) |
ES (1) | ES2146600T3 (de) |
RU (1) | RU2144833C1 (de) |
SG (1) | SG50677A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5496718A (en) * | 1992-06-26 | 1996-03-05 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Chondroitinase ABC isolated from proteus vulgaris ATCC 6896 |
US7008783B1 (en) | 1992-09-22 | 2006-03-07 | Maruha Corporation | Gene encoding chondroitinase ABC and uses therefor |
JP3419811B2 (ja) * | 1993-02-24 | 2003-06-23 | マルハ株式会社 | コンドロイチナーゼ遺伝子 |
JPH09500011A (ja) * | 1993-04-23 | 1997-01-07 | アメリカン サイアナミド カンパニー | P.ブルガリスからのコンドロイチナーゼi及びii遺伝子のクローニング及び発現 |
WO1995013091A1 (en) * | 1993-11-12 | 1995-05-18 | International Technology Management Associates, Ltd. | Methods of repairing connective tissues |
US5525500A (en) * | 1994-04-22 | 1996-06-11 | American Cyanamid Company | Chromatographic process for the copurification of chondroitinase I and II proteins from Proteus vulgaris |
US5498536A (en) * | 1994-04-22 | 1996-03-12 | American Cyanamid Company | Chondroitinase II from Proteus vulgaris |
AU2428195A (en) * | 1994-04-22 | 1995-11-16 | American Cyanamid Company | Chondroitinases i and ii, methods of preparation, and use thereof |
US5888798A (en) * | 1995-06-07 | 1999-03-30 | American Cyanamid Company | Chondroitinase I and chondroitinase II producing mutants of P. vulgaris |
EP0747469A1 (de) * | 1995-06-08 | 1996-12-11 | The Procter & Gamble Company | Chondroitinase enthaltende Reinigungszusammensetzungen |
EP0875253B1 (de) * | 1997-05-02 | 2005-04-06 | Seikagaku Corporation | Chondroitinase enthaltende Zusammensetzungen |
JPH1149698A (ja) | 1997-07-31 | 1999-02-23 | Santen Pharmaceut Co Ltd | 安定性を向上させたラクトフェリンの水性製剤 |
ATE225184T1 (de) * | 1997-08-22 | 2002-10-15 | Seikagaku Kogyo Co Ltd | Arzneimittel zur behandlung von durch hernie gestörter intervertebraler bandscheibe |
AU6875900A (en) | 1999-09-08 | 2001-04-10 | Chugai Seiyaku Kabushiki Kaisha | Protein solution preparation and method of stabilizing the same |
EP2312051B1 (de) | 2001-06-01 | 2017-07-12 | Mitsubishi Paper Mills Limited | Gesamtwärmetauschelementpapier |
US6972168B2 (en) | 2001-08-13 | 2005-12-06 | University Of Florida Research Foundation, Incorporated | Materials and methods for nerve grafting, selection of nerve grafts, and in vitro nerve tissue culture |
GB0205022D0 (en) | 2002-03-04 | 2002-04-17 | Univ Cambridge Tech | Materials and methods for the treatment of cns damage |
EP1575548B1 (de) | 2002-05-04 | 2011-03-09 | Acorda Therapeutics, Inc. | Zusammensetzungen und verfahren zur förderung des neuronalen wachstums |
US6962699B2 (en) * | 2002-06-03 | 2005-11-08 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from chondroitinase B |
AU2003265561A1 (en) * | 2002-08-15 | 2004-03-03 | Acorda Therapeutics, Inc. | Chimeric protein |
AU2003297199A1 (en) * | 2002-12-16 | 2004-07-22 | Halozyme, Inc. | Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
US20060104968A1 (en) * | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
US20090123367A1 (en) * | 2003-03-05 | 2009-05-14 | Delfmems | Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases |
CA2517145C (en) | 2003-03-05 | 2017-08-01 | Halozyme, Inc. | Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
US7959914B2 (en) * | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
MXPA05012307A (es) * | 2003-05-16 | 2006-07-03 | Acorda Therapeutics Inc | Mutantes que degradan proteoglicanos para tratamiento del snc. |
MXPA05012305A (es) * | 2003-05-16 | 2006-04-18 | Acorda Therapeutics Inc | Composiciones y metodos para el tratamiento de lesiones del snc. |
GB0403247D0 (en) | 2004-02-13 | 2004-03-17 | Tillotts Pharma Ag | A pharmaceutical composition |
WO2005087920A2 (en) * | 2004-03-10 | 2005-09-22 | Massachusetts Institute Of Technology | Recombinant chondroitinase abc i and uses thereof |
AU2005244933B2 (en) * | 2004-05-18 | 2011-08-04 | Acorda Therapeutics, Inc. | Methods of purifying chondroitinase and stable formulations thereof |
WO2005122734A2 (en) * | 2004-06-14 | 2005-12-29 | The Research Foundation Of State University Of New York | Nanosphere/microsphere delivery system for the treatment of spinal cord injury |
EP1848812A4 (de) * | 2004-10-01 | 2011-11-09 | Life Technologies Corp | Zufuhrpuffer, systeme und verfahren zur in-vitro-synthese von biomolekülen |
EP1928490B8 (de) | 2005-09-26 | 2012-10-03 | Acorda Therapeutics, Inc. | Zusammensetzungen und verfahren zur verwendung von chondroitinase-abci-mutanten |
US8003369B2 (en) | 2005-11-29 | 2011-08-23 | Sanyo Chemical Industries, Ltd. | Bacteriolytic agent |
US7722864B2 (en) | 2006-10-10 | 2010-05-25 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase ABCI mutants |
US20110059508A1 (en) | 2007-06-29 | 2011-03-10 | National University Corporation Nagoya University | Improving agent for dysfunction due to neuropathy and rho kinase activation inhibitor |
US20090286289A1 (en) * | 2008-03-10 | 2009-11-19 | Pang Danny Z | Production of Hyaluronate Unsaturated Disaccharides and its Application |
PL2653168T3 (pl) | 2010-12-13 | 2015-07-31 | Seikagaku Kogyo Co Ltd | Chondroitynaza ABC do leczenia przepukliny dysku |
WO2016047797A1 (ja) | 2014-09-27 | 2016-03-31 | 大日本住友製薬株式会社 | 注射用医薬組成物 |
US9796970B1 (en) | 2017-04-24 | 2017-10-24 | Advantek Serum Laboratories Ltd. | Production of high purity chondroitinase ABC |
US11648299B2 (en) | 2018-02-28 | 2023-05-16 | Seikagaku Corporation | Pharmaceutical composition, package and method for producing the same |
CN114409731B (zh) * | 2022-01-05 | 2023-08-11 | 浙江省农业科学院 | 同时具有激活乙醇脱氢酶和乙醛脱氢酶活性的两种多肽 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3549500A (en) * | 1967-07-22 | 1970-12-22 | Seikagaku Kogyo Co Ltd | Novel chondroitinase and method of its recovery |
JPS4832351B1 (de) * | 1968-06-12 | 1973-10-05 | ||
JPS4713704Y1 (de) * | 1971-09-29 | 1972-05-18 | ||
JPS6031478B2 (ja) * | 1978-02-10 | 1985-07-22 | 生化学工業株式会社 | 純コンドロイチナ−ゼbの製造法 |
JPS6031479B2 (ja) * | 1978-02-10 | 1985-07-22 | 生化学工業株式会社 | 純コンドロイチナ−ゼcの製造法 |
DK151634C (da) * | 1978-09-29 | 1988-06-20 | Mitsubishi Chem Ind | Fremgangsmaade til rensning af langkaedet acyl-coenzym-a-syntetase |
JP2524573B2 (ja) * | 1983-04-21 | 1996-08-14 | ラ トローブ ユニバーシティ | 酵素の抽出および精製方法 |
US4696816A (en) * | 1985-11-07 | 1987-09-29 | Brown Mark D | Method for treating intervertebral disc displacement with enzymes |
JPS62122588A (ja) * | 1985-11-22 | 1987-06-03 | Taiyo Fishery Co Ltd | 純コンドロイチナ−ゼの製造法 |
JP2726275B2 (ja) * | 1988-08-24 | 1998-03-11 | 生化学工業株式会社 | グリコサミノグリカン分解酵素の精製法 |
JP2919496B2 (ja) * | 1989-08-24 | 1999-07-12 | 生化学工業株式会社 | 新規コンドロイチン硫酸分解酵素、それらを産生する微生物並びにそれらの製法 |
JP3140797B2 (ja) * | 1991-04-26 | 2001-03-05 | 生化学工業株式会社 | 安定化コンドロイチナーゼabc、その保存方法及び治療剤 |
US5496718A (en) * | 1992-06-26 | 1996-03-05 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Chondroitinase ABC isolated from proteus vulgaris ATCC 6896 |
-
1993
- 1993-06-23 US US08/082,853 patent/US5496718A/en not_active Expired - Lifetime
- 1993-06-25 DE DE69328519T patent/DE69328519T2/de not_active Expired - Lifetime
- 1993-06-25 AT AT93304979T patent/ATE192486T1/de active
- 1993-06-25 KR KR1019930011667A patent/KR100280779B1/ko not_active IP Right Cessation
- 1993-06-25 DK DK93304979T patent/DK0576294T3/da active
- 1993-06-25 RU RU93046317A patent/RU2144833C1/ru active
- 1993-06-25 EP EP93304979A patent/EP0576294B1/de not_active Expired - Lifetime
- 1993-06-25 CA CA002099138A patent/CA2099138C/en not_active Expired - Lifetime
- 1993-06-25 SG SG1996008458A patent/SG50677A1/en unknown
- 1993-06-25 ES ES93304979T patent/ES2146600T3/es not_active Expired - Lifetime
-
1995
- 1995-05-18 US US08/443,675 patent/US5763205A/en not_active Expired - Lifetime
-
1997
- 1997-07-07 US US08/888,530 patent/US6184023B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5763205A (en) | 1998-06-09 |
KR940005793A (ko) | 1994-03-22 |
DE69328519D1 (de) | 2000-06-08 |
AU4146493A (en) | 1994-01-06 |
EP0576294A3 (en) | 1994-08-17 |
US6184023B1 (en) | 2001-02-06 |
KR100280779B1 (ko) | 2001-02-01 |
US5496718A (en) | 1996-03-05 |
RU2144833C1 (ru) | 2000-01-27 |
AU669528B2 (en) | 1996-06-13 |
EP0576294A2 (de) | 1993-12-29 |
ES2146600T3 (es) | 2000-08-16 |
DE69328519T2 (de) | 2000-09-14 |
CA2099138C (en) | 1998-09-22 |
EP0576294B1 (de) | 2000-05-03 |
DK0576294T3 (da) | 2000-10-09 |
SG50677A1 (en) | 1998-07-20 |
CA2099138A1 (en) | 1993-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE192486T1 (de) | Chondroitinase, herstellungsverfahren und pharmazeutische zusammensetzung | |
RU93046317A (ru) | Хиндроитиназа, способ ее получения и содержание ее фармацевтические композиции | |
Ruoslahti et al. | Novel human serum protein from fibroblast plasma membrane | |
Dimuzio et al. | Phosphophoryns—major noncollagenous proteins of rat incisor dentin | |
Feinstein et al. | A rapid method of purification of human granulocyte cationic neutral proteases: purification and further characterization of human granulocyte elastase | |
Dayton et al. | A Ca2+ ion-activated protease possibly involved in myofibrillar protein turnover. Purification from porcine muscle | |
Bennick et al. | Purification and partial characterization of four proteins from human parotid saliva | |
DK0447585T3 (da) | Fremgangsmåde til fremstilling af et intravenøst tolerant immunglobulin-G-præparat | |
ATE173478T1 (de) | Varianten des pankreatischen rinder- trypsininhibitors, deren herstellung und verwendung | |
Calvete et al. | A procedure for the large-scale isolation of major bovine seminal plasma proteins | |
DK426386D0 (da) | Fremgangsmaade til rensning og aktivering af proteiner fra uoploeselige inklusionslegemer | |
IE860305L (en) | Method for purifying antihemophilic factor | |
ATE68826T1 (de) | Verfahren zur herstellung von reifem, menschlichem serum-albumin. | |
Joubert | Snake venom toxins: the amino acid sequences of two toxins from Ophiophagus hannah (King Cobra) venom | |
KR880701246A (ko) | 재조합 페포 계면활성제 단백질 | |
JPS63503352A (ja) | タンパク質の精製 | |
OGILIVE et al. | Isolation and Characterization of Lactose-Binding Lectins from the Venoms of the Snakes Lachesis inuta and Dendroaspisjamesonii | |
ATE121754T1 (de) | Vakzine gegen bordetella. | |
CA2253246A1 (en) | Purified multimerase | |
IL76929A (en) | Preparation for the treatment of hemophilia a inhibitor patients and processes for producing such a preparation | |
DE58907555D1 (de) | Verfahren zur Anreicherung der Blutgerinnungsfaktoren II, VII, IX und X. | |
DE3853224D1 (de) | Produktion von Proteinen in aktiver Form. | |
Bajwa et al. | A new method for purification of the thrombin-like enzyme from the venom of the eastern diamondback rattlesnake | |
YUMOTO et al. | Comparison of tryptic peptides from the heavy and light subunits of calpain I and calpain II by high performance liquid chromatography | |
Roberts et al. | A structural comparison of the subunits of the Dolichos biflorus seed lectin by peptide mapping and carboxyl terminal amino acid analysis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |