NO961906L - Fremgangsmåte ved fremstilling av et klodronatpreparat - Google Patents

Fremgangsmåte ved fremstilling av et klodronatpreparat

Info

Publication number
NO961906L
NO961906L NO961906A NO961906A NO961906L NO 961906 L NO961906 L NO 961906L NO 961906 A NO961906 A NO 961906A NO 961906 A NO961906 A NO 961906A NO 961906 L NO961906 L NO 961906L
Authority
NO
Norway
Prior art keywords
clodronate
pct
preparation
tetrahydrate
disodium
Prior art date
Application number
NO961906A
Other languages
English (en)
Other versions
NO312938B1 (no
NO961906D0 (no
Inventor
Esko Pohjala
Heikki Nupponen
Kari Lehmussaari
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of NO961906D0 publication Critical patent/NO961906D0/no
Publication of NO961906L publication Critical patent/NO961906L/no
Publication of NO312938B1 publication Critical patent/NO312938B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ceramic Products (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Glass Compositions (AREA)
  • Seasonings (AREA)
  • Glanulating (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
NO19961906A 1993-11-12 1996-05-10 Fremgangsmåte ved fremstilling av et klodronatpreparat NO312938B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI935019A FI94926C (fi) 1993-11-12 1993-11-12 Menetelmä klodronaattivalmisteen valmistamiseksi
PCT/FI1994/000509 WO1995013054A1 (en) 1993-11-12 1994-11-11 Process for preparing a clodronate preparation

Publications (3)

Publication Number Publication Date
NO961906D0 NO961906D0 (no) 1996-05-10
NO961906L true NO961906L (no) 1996-05-23
NO312938B1 NO312938B1 (no) 2002-07-22

Family

ID=8538945

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19961906A NO312938B1 (no) 1993-11-12 1996-05-10 Fremgangsmåte ved fremstilling av et klodronatpreparat

Country Status (25)

Country Link
US (1) US5776499A (no)
EP (1) EP0727983B1 (no)
JP (1) JPH09504800A (no)
KR (1) KR100352155B1 (no)
CN (1) CN1040945C (no)
AT (1) ATE202700T1 (no)
AU (1) AU679586B2 (no)
CA (1) CA2175994A1 (no)
CZ (1) CZ286132B6 (no)
DE (1) DE69427648T2 (no)
DK (1) DK0727983T3 (no)
ES (1) ES2160688T3 (no)
FI (1) FI94926C (no)
GR (1) GR3036470T3 (no)
HU (1) HU220633B1 (no)
IL (1) IL111596A (no)
NO (1) NO312938B1 (no)
NZ (1) NZ275833A (no)
PL (1) PL176658B1 (no)
PT (1) PT727983E (no)
RU (1) RU2141323C1 (no)
SK (1) SK280552B6 (no)
TW (1) TW436297B (no)
WO (1) WO1995013054A1 (no)
ZA (1) ZA948974B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI109088B (fi) * 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
DE19808634A1 (de) * 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
AR021347A1 (es) 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
RO121891B1 (ro) 2001-07-04 2008-07-30 Sindan S.R.L. Compoziţie farmaceutică pentru profilaxia şi tratamentul dereglărilor metabolismului calciului şi procedeu de preparare
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
GB0616794D0 (en) 2006-08-24 2006-10-04 Arrow Int Ltd Solid dosage form
CA3009962C (en) * 2015-12-22 2021-11-09 Stock Company "Chepetsky Mechanical Plant" (Sc Cmp) A method of manufacturing rods from titanium alloys
CA3082728A1 (en) 2017-11-22 2019-05-31 Inbiomotion S.L. Therapeutic treatment of breast cancer based on c-maf status
TWI806467B (zh) 2022-03-03 2023-06-21 金兆豐數位科技股份有限公司 金融商品提昇報酬率多維度決策方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE60711T1 (de) * 1986-12-20 1991-02-15 Boehringer Mannheim Gmbh Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
SE501389C2 (sv) * 1992-04-24 1995-01-30 Leiras Oy Farmaceutiskt preparat och förfarande för dess framställning
AU687744B2 (en) * 1993-05-15 1998-03-05 Riemser Arzneimittel Ag More easily biologically absorbed tablet containing dichloromethylene diphosphonic acid as the active agent

Also Published As

Publication number Publication date
DE69427648D1 (de) 2001-08-09
ZA948974B (en) 1995-11-21
RU2141323C1 (ru) 1999-11-20
KR960705548A (ko) 1996-11-08
CN1134664A (zh) 1996-10-30
HU220633B1 (hu) 2002-03-28
ES2160688T3 (es) 2001-11-16
CN1040945C (zh) 1998-12-02
EP0727983B1 (en) 2001-07-04
IL111596A0 (en) 1995-01-24
AU679586B2 (en) 1997-07-03
NO312938B1 (no) 2002-07-22
GR3036470T3 (en) 2001-11-30
CZ286132B6 (cs) 2000-01-12
WO1995013054A1 (en) 1995-05-18
PL314299A1 (en) 1996-09-02
AU8108794A (en) 1995-05-29
KR100352155B1 (ko) 2002-12-31
FI94926B (fi) 1995-08-15
IL111596A (en) 1998-12-06
HU9601257D0 (en) 1996-07-29
JPH09504800A (ja) 1997-05-13
PT727983E (pt) 2001-11-30
CA2175994A1 (en) 1995-05-18
NO961906D0 (no) 1996-05-10
DE69427648T2 (de) 2002-04-18
FI94926C (fi) 1995-11-27
FI935019A0 (fi) 1993-11-12
HUT75228A (en) 1997-04-28
FI935019A (fi) 1995-05-13
ATE202700T1 (de) 2001-07-15
DK0727983T3 (da) 2001-09-24
CZ132796A3 (en) 1996-10-16
PL176658B1 (pl) 1999-07-30
EP0727983A1 (en) 1996-08-28
SK60696A3 (en) 1997-02-05
TW436297B (en) 2001-05-28
NZ275833A (en) 1997-10-24
US5776499A (en) 1998-07-07
SK280552B6 (sk) 2000-03-13

Similar Documents

Publication Publication Date Title
GR3031936T3 (en) Process for preparing controlled release pharmaceutical forms and the forms thus obtained.
UA37214C2 (uk) Таблетки, що диспергуються у воді, та спосіб їх виготовлення
DK0777964T3 (da) Fremgangsmåde til fremstilling af et doseringssystem
ZA957670B (en) Pharmaceutical preparation containing metformin and processes for the production thereof
DK0789559T3 (da) Farmaceutisk præparat indeholdende en smeltelig bærer og en fremgangsmåde til fremstilling deraf
MY136231A (en) Slow release compositions
NO961906L (no) Fremgangsmåte ved fremstilling av et klodronatpreparat
MY113718A (en) Pharmaceutical formulation containing a hydrophobic active substance and an effervescent system, and process for the preparation of the formulation
ATE59960T1 (de) Theophyllintabletten mit verzoegerter freigabe.
FI103015B1 (fi) Menetelmä tabletti- tai raekoostumuksen valmistamiseksi, joka sisältää lämmölle, valolle ja kosteudelle herkkää aktiivista aineosaa, jolla on monokliininen kiderakenne
HUT49793A (en) Herbicide compositions containing n-aryl-tetrahydro-phtalimides as active components and process for producing the active components
JPS5296729A (en) Mixed vaccin for cyanomycosis
ES8500760A1 (es) Procedimiento de obtencion de un granulado adecuado para la fabricacion de tabletas.
GR1002034B (en) Process for the preparation of dry processed particles dry processed particles thus obtained and pharmaceutical compositions containing such particles.
HUT34344A (en) Process for producing tablets controlled dissolution of active ingredients
HUT52069A (en) Herbicide compositions containing sulfonanilide derivatives as active components and process for producing the active components
JPS57170165A (en) Active calcium fortifier
HUT48241A (en) Herbicide compositions containing halogenated cyclopropan derivatives as active components and process for producing the active components
HUT55604A (en) Fungicide and growth-controlling compositions containing n-oxo-azolyl-methyl-oxiranes as active components and process for producing the active components
JPS53122679A (en) Process for preparing forming tablets
NO170795C (no) Maleinnretning for en pastaformet masse
SU1791978A1 (ru) Кормовая добавка
JPS55160715A (en) Tablet having improved disintegrating property
RU94018502A (ru) Способ получения гербицидных гранулированных продуктов
JPS55105881A (en) Buffer memory system