DK0727983T3 - Fremgangsmåde til fremstilling af et clodronat-præparat - Google Patents

Fremgangsmåde til fremstilling af et clodronat-præparat

Info

Publication number
DK0727983T3
DK0727983T3 DK95900155T DK95900155T DK0727983T3 DK 0727983 T3 DK0727983 T3 DK 0727983T3 DK 95900155 T DK95900155 T DK 95900155T DK 95900155 T DK95900155 T DK 95900155T DK 0727983 T3 DK0727983 T3 DK 0727983T3
Authority
DK
Denmark
Prior art keywords
clodronate
pct
preparation
tetrahydrate
disodium
Prior art date
Application number
DK95900155T
Other languages
Danish (da)
English (en)
Inventor
Esko Pohjala
Kari Lehmussaari
Heikki Nupponen
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Application granted granted Critical
Publication of DK0727983T3 publication Critical patent/DK0727983T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ceramic Products (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Seasonings (AREA)
  • Glanulating (AREA)
  • Glass Compositions (AREA)
DK95900155T 1993-11-12 1994-11-11 Fremgangsmåde til fremstilling af et clodronat-præparat DK0727983T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI935019A FI94926C (fi) 1993-11-12 1993-11-12 Menetelmä klodronaattivalmisteen valmistamiseksi
PCT/FI1994/000509 WO1995013054A1 (en) 1993-11-12 1994-11-11 Process for preparing a clodronate preparation

Publications (1)

Publication Number Publication Date
DK0727983T3 true DK0727983T3 (da) 2001-09-24

Family

ID=8538945

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95900155T DK0727983T3 (da) 1993-11-12 1994-11-11 Fremgangsmåde til fremstilling af et clodronat-præparat

Country Status (25)

Country Link
US (1) US5776499A (no)
EP (1) EP0727983B1 (no)
JP (1) JPH09504800A (no)
KR (1) KR100352155B1 (no)
CN (1) CN1040945C (no)
AT (1) ATE202700T1 (no)
AU (1) AU679586B2 (no)
CA (1) CA2175994A1 (no)
CZ (1) CZ286132B6 (no)
DE (1) DE69427648T2 (no)
DK (1) DK0727983T3 (no)
ES (1) ES2160688T3 (no)
FI (1) FI94926C (no)
GR (1) GR3036470T3 (no)
HU (1) HU220633B1 (no)
IL (1) IL111596A (no)
NO (1) NO312938B1 (no)
NZ (1) NZ275833A (no)
PL (1) PL176658B1 (no)
PT (1) PT727983E (no)
RU (1) RU2141323C1 (no)
SK (1) SK280552B6 (no)
TW (1) TW436297B (no)
WO (1) WO1995013054A1 (no)
ZA (1) ZA948974B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI109088B (fi) * 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
DE19808634A1 (de) * 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
AR021347A1 (es) 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
RO121891B1 (ro) 2001-07-04 2008-07-30 Sindan S.R.L. Compoziţie farmaceutică pentru profilaxia şi tratamentul dereglărilor metabolismului calciului şi procedeu de preparare
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
GB0616794D0 (en) 2006-08-24 2006-10-04 Arrow Int Ltd Solid dosage form
CN108472703B (zh) * 2015-12-22 2021-01-01 切佩茨基机械厂股份公司 使用钛合金制造棒材的方法
US11654153B2 (en) 2017-11-22 2023-05-23 Inbiomotion S.L. Therapeutic treatment of breast cancer based on c-MAF status
TWI806467B (zh) 2022-03-03 2023-06-21 金兆豐數位科技股份有限公司 金融商品提昇報酬率多維度決策方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE60711T1 (de) 1986-12-20 1991-02-15 Boehringer Mannheim Gmbh Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
SE501389C2 (sv) * 1992-04-24 1995-01-30 Leiras Oy Farmaceutiskt preparat och förfarande för dess framställning
US5650168A (en) 1993-05-15 1997-07-22 Boehringer Mannheim Gmbh Tablet with improved bioavailability containing dichloromethylenediphosphonic acid as the active substance

Also Published As

Publication number Publication date
CA2175994A1 (en) 1995-05-18
NZ275833A (en) 1997-10-24
HU220633B1 (hu) 2002-03-28
SK280552B6 (sk) 2000-03-13
CZ286132B6 (cs) 2000-01-12
IL111596A0 (en) 1995-01-24
ZA948974B (en) 1995-11-21
JPH09504800A (ja) 1997-05-13
HUT75228A (en) 1997-04-28
FI935019A (fi) 1995-05-13
WO1995013054A1 (en) 1995-05-18
NO961906L (no) 1996-05-23
PT727983E (pt) 2001-11-30
ATE202700T1 (de) 2001-07-15
AU679586B2 (en) 1997-07-03
SK60696A3 (en) 1997-02-05
DE69427648D1 (de) 2001-08-09
EP0727983A1 (en) 1996-08-28
GR3036470T3 (en) 2001-11-30
FI935019A0 (fi) 1993-11-12
PL176658B1 (pl) 1999-07-30
FI94926B (fi) 1995-08-15
US5776499A (en) 1998-07-07
PL314299A1 (en) 1996-09-02
NO312938B1 (no) 2002-07-22
DE69427648T2 (de) 2002-04-18
FI94926C (fi) 1995-11-27
CZ132796A3 (en) 1996-10-16
HU9601257D0 (en) 1996-07-29
KR100352155B1 (ko) 2002-12-31
ES2160688T3 (es) 2001-11-16
NO961906D0 (no) 1996-05-10
KR960705548A (ko) 1996-11-08
CN1134664A (zh) 1996-10-30
TW436297B (en) 2001-05-28
CN1040945C (zh) 1998-12-02
AU8108794A (en) 1995-05-29
RU2141323C1 (ru) 1999-11-20
EP0727983B1 (en) 2001-07-04
IL111596A (en) 1998-12-06

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