FI935019A - Menetelmä klodronaattivalmisteen valmistamiseksi - Google Patents

Menetelmä klodronaattivalmisteen valmistamiseksi Download PDF

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Publication number
FI935019A
FI935019A FI935019A FI935019A FI935019A FI 935019 A FI935019 A FI 935019A FI 935019 A FI935019 A FI 935019A FI 935019 A FI935019 A FI 935019A FI 935019 A FI935019 A FI 935019A
Authority
FI
Finland
Prior art keywords
clodronate
pct
preparation
tetrahydrate
disodium
Prior art date
Application number
FI935019A
Other languages
English (en)
Swedish (sv)
Other versions
FI94926B (fi
FI935019A0 (fi
FI94926C (fi
Inventor
Esko Pohjala
Heikki Nupponen
Kari Lehmussaari
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of FI935019A0 publication Critical patent/FI935019A0/fi
Priority to FI935019A priority Critical patent/FI94926C/fi
Priority to IL11159694A priority patent/IL111596A/en
Priority to JP7513620A priority patent/JPH09504800A/ja
Priority to PT95900155T priority patent/PT727983E/pt
Priority to PCT/FI1994/000509 priority patent/WO1995013054A1/en
Priority to CN94194083A priority patent/CN1040945C/zh
Priority to HU9601257A priority patent/HU220633B1/hu
Priority to DE69427648T priority patent/DE69427648T2/de
Priority to KR1019960702481A priority patent/KR100352155B1/ko
Priority to CA002175994A priority patent/CA2175994A1/en
Priority to NZ275833A priority patent/NZ275833A/en
Priority to AT95900155T priority patent/ATE202700T1/de
Priority to SI9430385T priority patent/SI0727983T1/xx
Priority to ZA948974A priority patent/ZA948974B/xx
Priority to RU96113106A priority patent/RU2141323C1/ru
Priority to PL94314299A priority patent/PL176658B1/pl
Priority to DK95900155T priority patent/DK0727983T3/da
Priority to SK606-96A priority patent/SK280552B6/sk
Priority to EP95900155A priority patent/EP0727983B1/en
Priority to US08/646,359 priority patent/US5776499A/en
Priority to ES95900155T priority patent/ES2160688T3/es
Priority to CZ19961327A priority patent/CZ286132B6/cs
Priority to AU81087/94A priority patent/AU679586B2/en
Priority to TW083110664A priority patent/TW436297B/zh
Publication of FI935019A publication Critical patent/FI935019A/fi
Publication of FI94926B publication Critical patent/FI94926B/fi
Application granted granted Critical
Publication of FI94926C publication Critical patent/FI94926C/fi
Priority to NO19961906A priority patent/NO312938B1/no
Priority to GR20010401329T priority patent/GR3036470T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ceramic Products (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Glass Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Glanulating (AREA)
FI935019A 1993-11-11 1993-11-12 Menetelmä klodronaattivalmisteen valmistamiseksi FI94926C (fi)

Priority Applications (26)

Application Number Priority Date Filing Date Title
FI935019A FI94926C (fi) 1993-11-12 1993-11-12 Menetelmä klodronaattivalmisteen valmistamiseksi
IL11159694A IL111596A (en) 1993-11-12 1994-11-10 Process for the preparation of Claudront and pharmaceutical preparations containing it
RU96113106A RU2141323C1 (ru) 1993-11-12 1994-11-11 Способ получения препарата клодроната
PL94314299A PL176658B1 (pl) 1993-11-12 1994-11-11 Sposób wytwarzania preparatu farmaceutycznego zawierającego klodronian
PCT/FI1994/000509 WO1995013054A1 (en) 1993-11-12 1994-11-11 Process for preparing a clodronate preparation
CN94194083A CN1040945C (zh) 1993-11-12 1994-11-11 制备氯甲双磷酸盐制剂的方法
HU9601257A HU220633B1 (hu) 1993-11-12 1994-11-11 Eljárás dinátriumklodronát-tetrahidrátot tartalmazó gyógyszerkészítmény előállítására, és maga a készítmény
DE69427648T DE69427648T2 (de) 1993-11-12 1994-11-11 Verfahren zur herstellung einer clodronat-zubereitung
KR1019960702481A KR100352155B1 (ko) 1993-11-12 1994-11-11 클로드로네이트제제의제조방법
CA002175994A CA2175994A1 (en) 1993-11-12 1994-11-11 Process for preparing a clodronate preparation
NZ275833A NZ275833A (en) 1993-11-12 1994-11-11 Clodronate granule preparation (dichloromethylene bisphosphonic acid derivative); medicament
AT95900155T ATE202700T1 (de) 1993-11-12 1994-11-11 Verfahren zur herstellung einer clodronat- zubereitung
SI9430385T SI0727983T1 (en) 1993-11-12 1994-11-11 Process for preparing a clodronate preparation
ZA948974A ZA948974B (en) 1993-11-12 1994-11-11 Process for preparing a clodronate preparation
JP7513620A JPH09504800A (ja) 1993-11-12 1994-11-11 クロドロネート製剤の製造方法
PT95900155T PT727983E (pt) 1993-11-12 1994-11-11 Processo para a preparacao de um clodronato
DK95900155T DK0727983T3 (da) 1993-11-12 1994-11-11 Fremgangsmåde til fremstilling af et clodronat-præparat
SK606-96A SK280552B6 (sk) 1993-11-12 1994-11-11 Spôsob prípravy klodronátových prípravkov
EP95900155A EP0727983B1 (en) 1993-11-12 1994-11-11 Process for preparing a clodronate preparation
US08/646,359 US5776499A (en) 1993-11-11 1994-11-11 Process for preparing a clodronate preparation
ES95900155T ES2160688T3 (es) 1993-11-12 1994-11-11 Procedimiento para obtener una preparacion de clodronato.
CZ19961327A CZ286132B6 (cs) 1993-11-12 1994-11-11 Způsob přípravy klodronátového přípravku
AU81087/94A AU679586B2 (en) 1993-11-12 1994-11-11 Process for preparing a clodronate preparation
TW083110664A TW436297B (en) 1993-11-12 1994-11-17 Process for preparing disodium clodronate tetrahydrate granules
NO19961906A NO312938B1 (no) 1993-11-12 1996-05-10 Fremgangsmåte ved fremstilling av et klodronatpreparat
GR20010401329T GR3036470T3 (en) 1993-11-12 2001-08-30 Process for preparing a clodronate preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI935019A FI94926C (fi) 1993-11-12 1993-11-12 Menetelmä klodronaattivalmisteen valmistamiseksi
FI935019 1993-11-12

Publications (4)

Publication Number Publication Date
FI935019A0 FI935019A0 (fi) 1993-11-12
FI935019A true FI935019A (fi) 1995-05-13
FI94926B FI94926B (fi) 1995-08-15
FI94926C FI94926C (fi) 1995-11-27

Family

ID=8538945

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935019A FI94926C (fi) 1993-11-11 1993-11-12 Menetelmä klodronaattivalmisteen valmistamiseksi

Country Status (25)

Country Link
US (1) US5776499A (fi)
EP (1) EP0727983B1 (fi)
JP (1) JPH09504800A (fi)
KR (1) KR100352155B1 (fi)
CN (1) CN1040945C (fi)
AT (1) ATE202700T1 (fi)
AU (1) AU679586B2 (fi)
CA (1) CA2175994A1 (fi)
CZ (1) CZ286132B6 (fi)
DE (1) DE69427648T2 (fi)
DK (1) DK0727983T3 (fi)
ES (1) ES2160688T3 (fi)
FI (1) FI94926C (fi)
GR (1) GR3036470T3 (fi)
HU (1) HU220633B1 (fi)
IL (1) IL111596A (fi)
NO (1) NO312938B1 (fi)
NZ (1) NZ275833A (fi)
PL (1) PL176658B1 (fi)
PT (1) PT727983E (fi)
RU (1) RU2141323C1 (fi)
SK (1) SK280552B6 (fi)
TW (1) TW436297B (fi)
WO (1) WO1995013054A1 (fi)
ZA (1) ZA948974B (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI109088B (fi) * 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
DE19808634A1 (de) * 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
AR021347A1 (es) * 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
RO121891B1 (ro) 2001-07-04 2008-07-30 Sindan S.R.L. Compoziţie farmaceutică pentru profilaxia şi tratamentul dereglărilor metabolismului calciului şi procedeu de preparare
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
GB0616794D0 (en) * 2006-08-24 2006-10-04 Arrow Int Ltd Solid dosage form
US10815558B2 (en) * 2015-12-22 2020-10-27 Stock Company “Chepetsky Mechanical Plant” (SC CMP) Method for preparing rods from titanium-based alloys
CN111565725A (zh) 2017-11-22 2020-08-21 生物运动有限公司 基于c-maf状态的乳腺癌的治疗性处理
TWI806467B (zh) 2022-03-03 2023-06-21 金兆豐數位科技股份有限公司 金融商品提昇報酬率多維度決策方法
EP4445909A1 (en) 2023-04-14 2024-10-16 Università Degli Studi Magna Graecia Catanzaro Pharmaceutical formulation consisting of c-peptide combined with a bisphosphonate in a single form and its use in the treatment of osteosarcopenia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3767998D1 (de) * 1986-12-20 1991-03-14 Boehringer Mannheim Gmbh Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
SE501389C2 (sv) * 1992-04-24 1995-01-30 Leiras Oy Farmaceutiskt preparat och förfarande för dess framställning
SK281193B6 (sk) * 1993-05-15 2001-01-18 Roche Diagnostics Gmbh Tableta so zlepšenou biodostupnosťou účinnej látky, kyseliny klodrónovej, spôsob jej výroby a použitie mikrokryštalickej celulózy

Also Published As

Publication number Publication date
HU220633B1 (hu) 2002-03-28
FI94926B (fi) 1995-08-15
EP0727983B1 (en) 2001-07-04
CN1134664A (zh) 1996-10-30
FI935019A0 (fi) 1993-11-12
GR3036470T3 (en) 2001-11-30
FI94926C (fi) 1995-11-27
US5776499A (en) 1998-07-07
IL111596A (en) 1998-12-06
CN1040945C (zh) 1998-12-02
PL176658B1 (pl) 1999-07-30
HU9601257D0 (en) 1996-07-29
KR100352155B1 (ko) 2002-12-31
PT727983E (pt) 2001-11-30
NO961906D0 (no) 1996-05-10
NO312938B1 (no) 2002-07-22
PL314299A1 (en) 1996-09-02
ATE202700T1 (de) 2001-07-15
AU679586B2 (en) 1997-07-03
RU2141323C1 (ru) 1999-11-20
DE69427648T2 (de) 2002-04-18
CZ286132B6 (cs) 2000-01-12
KR960705548A (ko) 1996-11-08
NO961906L (no) 1996-05-23
TW436297B (en) 2001-05-28
SK60696A3 (en) 1997-02-05
DE69427648D1 (de) 2001-08-09
ES2160688T3 (es) 2001-11-16
HUT75228A (en) 1997-04-28
IL111596A0 (en) 1995-01-24
EP0727983A1 (en) 1996-08-28
JPH09504800A (ja) 1997-05-13
SK280552B6 (sk) 2000-03-13
CA2175994A1 (en) 1995-05-18
NZ275833A (en) 1997-10-24
DK0727983T3 (da) 2001-09-24
AU8108794A (en) 1995-05-29
CZ132796A3 (en) 1996-10-16
WO1995013054A1 (en) 1995-05-18
ZA948974B (en) 1995-11-21

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FG Patent granted

Owner name: LEIRAS OY

BB Publication of examined application
MA Patent expired