NO863176L - Fremgangsmaate og blanding ved fremstilling av liposomer. - Google Patents
Fremgangsmaate og blanding ved fremstilling av liposomer. Download PDFInfo
- Publication number
- NO863176L NO863176L NO863176A NO863176A NO863176L NO 863176 L NO863176 L NO 863176L NO 863176 A NO863176 A NO 863176A NO 863176 A NO863176 A NO 863176A NO 863176 L NO863176 L NO 863176L
- Authority
- NO
- Norway
- Prior art keywords
- liposome
- liposomes
- acid
- gel
- arginine
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title claims abstract description 113
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title claims description 34
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000000463 material Substances 0.000 claims abstract description 47
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 46
- 230000000887 hydrating effect Effects 0.000 claims abstract description 39
- 239000004475 Arginine Substances 0.000 claims abstract description 37
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 37
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 33
- 239000007864 aqueous solution Substances 0.000 claims abstract description 18
- 239000004220 glutamic acid Substances 0.000 claims abstract description 16
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims abstract description 15
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims abstract description 15
- 235000013922 glutamic acid Nutrition 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 17
- 229960002989 glutamic acid Drugs 0.000 claims description 14
- -1 amino, guanidino group Chemical group 0.000 claims description 13
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 12
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 11
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 10
- 239000004472 Lysine Substances 0.000 claims description 10
- 229960003646 lysine Drugs 0.000 claims description 10
- 235000018977 lysine Nutrition 0.000 claims description 10
- QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 claims description 9
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 9
- QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 claims description 9
- 235000003704 aspartic acid Nutrition 0.000 claims description 9
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
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- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 7
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims description 7
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- 230000036571 hydration Effects 0.000 claims description 7
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- 235000008206 alpha-amino acids Nutrition 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 150000007942 carboxylates Chemical class 0.000 claims description 4
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- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 3
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- 150000001767 cationic compounds Chemical class 0.000 claims description 3
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
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- 238000004519 manufacturing process Methods 0.000 claims description 2
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- 150000001370 alpha-amino acid derivatives Chemical group 0.000 claims 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 description 37
- 239000005642 Oleic acid Substances 0.000 description 29
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 28
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 28
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 18
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- 238000005538 encapsulation Methods 0.000 description 8
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- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 150000001412 amines Chemical class 0.000 description 6
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- 235000001014 amino acid Nutrition 0.000 description 6
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- 150000001483 arginine derivatives Chemical class 0.000 description 5
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- IJFVSSZAOYLHEE-UHFFFAOYSA-N 2,3-di(dodecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCC IJFVSSZAOYLHEE-UHFFFAOYSA-N 0.000 description 3
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- 235000019197 fats Nutrition 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 150000002332 glycine derivatives Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229960001416 pilocarpine Drugs 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- GGHDAUPFEBTORZ-UHFFFAOYSA-N propane-1,1-diamine Chemical compound CCC(N)N GGHDAUPFEBTORZ-UHFFFAOYSA-N 0.000 description 1
- 230000007065 protein hydrolysis Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000003168 reconstitution method Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000001132 ultrasonic dispersion Methods 0.000 description 1
- 239000002691 unilamellar liposome Substances 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 230000007332 vesicle formation Effects 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76348485A | 1985-08-07 | 1985-08-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO863176D0 NO863176D0 (no) | 1986-08-06 |
| NO863176L true NO863176L (no) | 1987-02-09 |
Family
ID=25067952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO863176A NO863176L (no) | 1985-08-07 | 1986-08-06 | Fremgangsmaate og blanding ved fremstilling av liposomer. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0211647B1 (hu) |
| JP (1) | JP2511417B2 (hu) |
| KR (1) | KR900007185B1 (hu) |
| CN (1) | CN1027491C (hu) |
| AT (1) | ATE94754T1 (hu) |
| AU (1) | AU601154B2 (hu) |
| CA (1) | CA1280975C (hu) |
| DE (1) | DE3689056T2 (hu) |
| DK (1) | DK362786A (hu) |
| ES (1) | ES8801118A1 (hu) |
| FI (1) | FI863227A (hu) |
| GR (1) | GR862020B (hu) |
| HK (1) | HK1004530A1 (hu) |
| HU (1) | HU198836B (hu) |
| IE (1) | IE61445B1 (hu) |
| IL (1) | IL79114A (hu) |
| NO (1) | NO863176L (hu) |
| NZ (1) | NZ216768A (hu) |
| PT (1) | PT83130B (hu) |
| ZA (1) | ZA864541B (hu) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL79114A (en) * | 1985-08-07 | 1990-09-17 | Allergan Pharma | Method and composition for making liposomes |
| IT1214540B (it) * | 1986-10-23 | 1990-01-18 | Vincenzo Zappia Mario De Rosa | Formulazioni idrosolubili di ubidecarenoni, procedimento per laloro preparazione e composizioni farmaceutiche che li compongono. |
| JPH01501153A (ja) * | 1986-10-23 | 1989-04-20 | アルバル・エッセ・ピ・ア | ユビデカレノン類を含有する化粧品 |
| DE3851842T2 (de) * | 1987-10-19 | 1995-03-02 | Liposome Co Inc | Wässrige bereitung von liposomenzusammensetzungen. |
| FR2631234B1 (fr) * | 1988-05-10 | 1990-09-14 | Dior Christian Parfums | Composition cosmetique ou dermatologique, notamment a action amincissante ou anti-cellulitique contenant des extraits de cola sous forme libre ou sous forme liposomale |
| JP2786482B2 (ja) * | 1988-06-29 | 1998-08-13 | 第一製薬株式会社 | 脂質膜構造体 |
| BE1001869A3 (fr) * | 1988-10-12 | 1990-04-03 | Franz Legros | Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine. |
| US5741513A (en) * | 1990-02-08 | 1998-04-21 | A. Natterman & Cie. Gmbh | Alcoholic aqueous gel-like phospholipid composition, its use and topical preparations containing it |
| JP3218637B2 (ja) * | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
| US6165500A (en) * | 1990-08-24 | 2000-12-26 | Idea Ag | Preparation for the application of agents in mini-droplets |
| CA2067754C (en) * | 1990-08-24 | 2002-06-04 | Gregor Cevc | Preparation for the application of agents in mini-droplets |
| DE4038075C1 (en) * | 1990-11-29 | 1992-03-19 | B. Braun Melsungen Ag, 3508 Melsungen, De | Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium |
| CA2087691A1 (en) * | 1992-01-23 | 1993-07-24 | Peter Critchley | Cosmetic compositon |
| GB9224502D0 (en) * | 1992-11-23 | 1993-01-13 | New Roger R C | Method of preparing a lipid-containing formulation |
| CA2156525A1 (en) * | 1993-02-19 | 1994-09-01 | Susan Dillon | Influenza vaccine compositions containing 3-o-deacylated monophosphoryl lipid a |
| ES2147744T3 (es) * | 1993-03-24 | 2000-10-01 | Collaborative Lab Inc | Sistema de administracion cosmetico para acido salicilico y proceso para su preparacion. |
| CA2120197A1 (en) * | 1993-04-02 | 1994-10-03 | Kenji Endo | Stable aqueous dispersions containing liposomes |
| JPH0757826A (ja) * | 1993-08-18 | 1995-03-03 | Nec Corp | 端子台 |
| US6375980B1 (en) * | 1998-01-08 | 2002-04-23 | Research Development Foundation | Stabilization of lipid:DNA formulations during nebulization |
| TW520294B (en) * | 1998-01-08 | 2003-02-11 | Res Dev Foundation | Stabilization of lipid: DNA formulations during nebulization |
| CZ20012038A3 (cs) | 1998-12-23 | 2001-09-12 | Idea Ag | Zdokonalený přípravek pro topické, neinvazivní použití in vivo |
| ES2173678T3 (es) | 1999-01-27 | 2002-10-16 | Idea Ag | Vacunacion no invasiva a traves de la piel. |
| DK1031347T3 (da) | 1999-01-27 | 2002-07-08 | Idea Ag | Transnasal transport/immunisering med meget tilpasselige bærere |
| US6248353B1 (en) * | 1999-12-10 | 2001-06-19 | Dade Behring Inc. | Reconstitution of purified membrane proteins into preformed liposomes |
| EP1138310A1 (de) * | 2000-03-28 | 2001-10-04 | Primacare S.A. | Pro-liposomen |
| DK1347743T3 (da) | 2000-12-07 | 2006-07-03 | Univ Utrecht Holding Bv | Præparat til behandling af inflammatoriske lidelser |
| US6610322B1 (en) | 2000-12-20 | 2003-08-26 | Brian Charles Keller | Self forming, thermodynamically stable liposomes and their applications |
| GB0404993D0 (en) * | 2004-03-05 | 2004-04-07 | Univ Liverpool John Moores | Method and apparatus for producing carrier complexes |
| ES2613387T3 (es) * | 2005-03-31 | 2017-05-24 | Unilever N.V. | Administración mejorada de agentes de beneficio de la piel |
| EP2086507B1 (en) | 2006-10-06 | 2018-11-07 | BioNet Pharma GmbH | A spinal nucleus pulposus implant |
| JP5112673B2 (ja) * | 2006-10-16 | 2013-01-09 | 株式会社コーセー | セラミド含有組成物及びこれを配合する皮膚外用剤 |
| CA2825417A1 (en) | 2011-01-25 | 2012-08-02 | The Procter And Gamble Company | Liposome and personal care composition comprising thereof |
| US10159646B2 (en) * | 2013-08-12 | 2018-12-25 | Altum-Avro Pharma Partnership | Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery |
| US8986732B2 (en) | 2013-08-12 | 2015-03-24 | Helix Biopharma Corporation | Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery |
| IT201700086879A1 (it) * | 2017-07-28 | 2019-01-28 | Univ Degli Studi Cagliari | Vescicole lipidiche a doppio strato contenenti adrenalina, per uso nel trattamento delle emergenze cardiache |
| CN109224879B (zh) * | 2018-09-17 | 2021-04-27 | 南京工业大学 | 一种cha分子筛膜的制备方法 |
| CN113995852B (zh) * | 2021-11-08 | 2024-01-30 | 河北大学 | Arg-脂质体微囊、微囊包封的鱼精蛋白-siRNA复合体及其制备方法和应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK116528A (hu) * | 1966-09-30 | |||
| US3932657A (en) * | 1973-11-12 | 1976-01-13 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome encapsulation of chelating agents |
| US3957971A (en) * | 1974-07-29 | 1976-05-18 | Lever Brothers Company | Moisturizing units and moisturizing compositions containing the same |
| AT356278B (de) * | 1976-07-12 | 1980-04-25 | Hoffmann La Roche | Verfahren zur herstellung von injektions- loesungen |
| JPS5323872A (en) * | 1976-08-17 | 1978-03-04 | Takeda Chem Ind Ltd | Preparation of microcapsule |
| DE2656333C2 (de) * | 1976-12-13 | 1985-08-08 | Karl Prof. Dr.med. 7302 Ostfildern Theurer | Verfahren zur Herstellung von Liposomen, welche Arzneistoffe enthalten |
| IT1110989B (it) * | 1979-01-19 | 1986-01-13 | Erba Farmitalia | Forme farmaceutiche costitutite da liposomi e procedimenti relativi |
| DE2856333C2 (de) * | 1978-12-27 | 1983-09-22 | A. Nattermann & Cie GmbH, 5000 Köln | Oral einnehmbare Arzneimittel mit entzündungshemmender Wirkung |
| US4174296A (en) * | 1978-12-04 | 1979-11-13 | American Lecithin Company | Water soluble lecithin composition |
| US4528193A (en) * | 1978-12-27 | 1985-07-09 | A. Natterman & Cie. Gmbh | Inflammation-preventing pharmaceutical composition of oral administration |
| DE2914789A1 (de) * | 1979-04-11 | 1980-10-16 | Nattermann A & Cie | Injizierbare arzneimittel mit entzuendungshemmender wirkung |
| CA1173360A (en) * | 1979-06-22 | 1984-08-28 | Jurg Schrank | Pharmaceutical preparations |
| JPS574913A (en) * | 1980-06-11 | 1982-01-11 | Green Cross Corp:The | Urokinase preparation for oral administration |
| JPS5746921A (en) * | 1980-09-02 | 1982-03-17 | Green Cross Corp:The | Oral preparation of human blood coagulation factor |
| IL64397A0 (en) * | 1981-01-07 | 1982-02-28 | Weder Hans G | Process for the preparation of liposomal medicaments |
| FR2521565B1 (fr) * | 1982-02-17 | 1985-07-05 | Dior Sa Parfums Christian | Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees |
| AU564876B2 (en) * | 1982-03-29 | 1987-08-27 | Liposome Company, Inc., The | Stable plurilamellar vesicles |
| EP0102324A3 (de) * | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
| SE8206744D0 (sv) * | 1982-11-26 | 1982-11-26 | Fluidcarbon International Ab | Preparat for kontrollerad avgivning av substanser |
| FR2540381B1 (fr) * | 1983-02-08 | 1986-05-30 | Dior Sa Parfums Christian | Procede pour stimuler la croissance des cellules; composition cosmetique, pharmaceutique et composition complementaire pour milieu de culture cellulaire appliquant ce procede |
| JPS607932A (ja) * | 1983-06-29 | 1985-01-16 | Dai Ichi Seiyaku Co Ltd | リポソーム懸濁液およびその製法 |
| JPS607934A (ja) * | 1983-06-29 | 1985-01-16 | Dai Ichi Seiyaku Co Ltd | リポソ−ムの製造方法 |
| IL79114A (en) * | 1985-08-07 | 1990-09-17 | Allergan Pharma | Method and composition for making liposomes |
-
1986
- 1986-06-16 IL IL79114A patent/IL79114A/xx not_active IP Right Cessation
- 1986-06-17 CA CA000511751A patent/CA1280975C/en not_active Expired - Fee Related
- 1986-06-18 ZA ZA864541A patent/ZA864541B/xx unknown
- 1986-06-24 AU AU59141/86A patent/AU601154B2/en not_active Ceased
- 1986-06-25 ES ES556651A patent/ES8801118A1/es not_active Expired
- 1986-07-07 NZ NZ216768A patent/NZ216768A/xx unknown
- 1986-07-30 GR GR862020A patent/GR862020B/el unknown
- 1986-07-30 DK DK362786A patent/DK362786A/da not_active Application Discontinuation
- 1986-08-01 PT PT83130A patent/PT83130B/pt not_active IP Right Cessation
- 1986-08-05 DE DE86306014T patent/DE3689056T2/de not_active Expired - Fee Related
- 1986-08-05 EP EP86306014A patent/EP0211647B1/en not_active Expired - Lifetime
- 1986-08-05 KR KR1019860006446A patent/KR900007185B1/ko not_active IP Right Cessation
- 1986-08-05 AT AT86306014T patent/ATE94754T1/de not_active IP Right Cessation
- 1986-08-06 FI FI863227A patent/FI863227A/fi not_active Application Discontinuation
- 1986-08-06 HU HU863431A patent/HU198836B/hu not_active IP Right Cessation
- 1986-08-06 IE IE210386A patent/IE61445B1/en not_active IP Right Cessation
- 1986-08-06 NO NO863176A patent/NO863176L/no unknown
- 1986-08-07 CN CN86104874A patent/CN1027491C/zh not_active Expired - Fee Related
- 1986-08-07 JP JP61186682A patent/JP2511417B2/ja not_active Expired - Lifetime
-
1998
- 1998-04-29 HK HK98103674A patent/HK1004530A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0211647A1 (en) | 1987-02-25 |
| JPS6242733A (ja) | 1987-02-24 |
| HU198836B (en) | 1989-12-28 |
| DK362786A (da) | 1987-02-08 |
| GR862020B (en) | 1986-12-24 |
| AU5914186A (en) | 1987-12-24 |
| IL79114A0 (en) | 1986-09-30 |
| HUT43487A (en) | 1987-11-30 |
| HK1004530A1 (en) | 1998-11-27 |
| EP0211647B1 (en) | 1993-09-22 |
| PT83130B (pt) | 1989-03-30 |
| IE862103L (en) | 1987-02-07 |
| CA1280975C (en) | 1991-03-05 |
| DE3689056D1 (de) | 1993-10-28 |
| ES8801118A1 (es) | 1987-12-16 |
| FI863227A (fi) | 1987-02-08 |
| ZA864541B (en) | 1987-02-25 |
| FI863227A0 (fi) | 1986-08-06 |
| IL79114A (en) | 1990-09-17 |
| ATE94754T1 (de) | 1993-10-15 |
| DE3689056T2 (de) | 1994-01-27 |
| ES556651A0 (es) | 1987-12-16 |
| DK362786D0 (da) | 1986-07-30 |
| PT83130A (en) | 1986-09-01 |
| KR900007185B1 (ko) | 1990-09-29 |
| KR880002508A (ko) | 1988-05-09 |
| NO863176D0 (no) | 1986-08-06 |
| IE61445B1 (en) | 1994-11-02 |
| JP2511417B2 (ja) | 1996-06-26 |
| CN86104874A (zh) | 1987-02-04 |
| CN1027491C (zh) | 1995-01-25 |
| AU601154B2 (en) | 1990-09-06 |
| NZ216768A (en) | 1989-11-28 |
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