NO333750B1 - Granuler basert pa stivelse og laktose - Google Patents
Granuler basert pa stivelse og laktose Download PDFInfo
- Publication number
- NO333750B1 NO333750B1 NO20021424A NO20021424A NO333750B1 NO 333750 B1 NO333750 B1 NO 333750B1 NO 20021424 A NO20021424 A NO 20021424A NO 20021424 A NO20021424 A NO 20021424A NO 333750 B1 NO333750 B1 NO 333750B1
- Authority
- NO
- Norway
- Prior art keywords
- granules
- lactose
- starch
- equal
- tablets
- Prior art date
Links
- 239000008187 granular material Substances 0.000 title claims abstract description 60
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 title claims abstract description 53
- 239000008101 lactose Substances 0.000 title claims abstract description 53
- 229920002472 Starch Polymers 0.000 title claims abstract description 49
- 235000019698 starch Nutrition 0.000 title claims abstract description 49
- 239000008107 starch Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 claims abstract description 19
- 230000008569 process Effects 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims description 20
- 239000002245 particle Substances 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- 230000000717 retained effect Effects 0.000 claims description 4
- 229910000831 Steel Inorganic materials 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 235000019359 magnesium stearate Nutrition 0.000 claims description 3
- 239000010959 steel Substances 0.000 claims description 3
- 238000001493 electron microscopy Methods 0.000 claims description 2
- 230000035515 penetration Effects 0.000 claims description 2
- 239000002023 wood Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 5
- 235000013305 food Nutrition 0.000 abstract description 4
- 239000007787 solid Substances 0.000 abstract 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 51
- 229960001375 lactose Drugs 0.000 description 45
- 239000000203 mixture Substances 0.000 description 29
- 235000019589 hardness Nutrition 0.000 description 10
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 6
- 229920002261 Corn starch Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 4
- 229960001021 lactose monohydrate Drugs 0.000 description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000008120 corn starch Substances 0.000 description 3
- 239000003974 emollient agent Substances 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 235000019759 Maize starch Nutrition 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 229960004977 anhydrous lactose Drugs 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000011363 dried mixture Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001033 granulometry Methods 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000004682 monohydrates Chemical group 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229930195727 α-lactose Natural products 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Glanulating (AREA)
- Grain Derivatives (AREA)
- Jellies, Jams, And Syrups (AREA)
- Formation And Processing Of Food Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00402159A EP1175899B1 (fr) | 2000-07-27 | 2000-07-27 | Granules à base d'amidon et de lactose |
| PCT/FR2001/002432 WO2002009673A1 (fr) | 2000-07-27 | 2001-07-25 | Granules a base d'amidon et de lactose |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20021424D0 NO20021424D0 (no) | 2002-03-21 |
| NO20021424L NO20021424L (no) | 2002-03-21 |
| NO333750B1 true NO333750B1 (no) | 2013-09-09 |
Family
ID=8173789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20021424A NO333750B1 (no) | 2000-07-27 | 2002-03-21 | Granuler basert pa stivelse og laktose |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6770368B2 (pt) |
| EP (1) | EP1175899B1 (pt) |
| JP (1) | JP4394313B2 (pt) |
| KR (1) | KR100869171B1 (pt) |
| CN (1) | CN1253148C (pt) |
| AT (1) | ATE371439T1 (pt) |
| AU (1) | AU785135B2 (pt) |
| BR (1) | BR0107036A (pt) |
| CA (1) | CA2353363C (pt) |
| CZ (1) | CZ303682B6 (pt) |
| DE (1) | DE60036205T2 (pt) |
| ES (1) | ES2292414T3 (pt) |
| HU (1) | HU229277B1 (pt) |
| IL (1) | IL148752A0 (pt) |
| MX (1) | MXPA01007666A (pt) |
| NO (1) | NO333750B1 (pt) |
| NZ (1) | NZ517931A (pt) |
| PL (1) | PL203778B1 (pt) |
| RS (1) | RS49931B (pt) |
| RU (1) | RU2286142C2 (pt) |
| SK (1) | SK286951B6 (pt) |
| WO (1) | WO2002009673A1 (pt) |
| ZA (1) | ZA200202178B (pt) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2826549A1 (fr) * | 2001-06-28 | 2003-01-03 | Roquette Freres | Procede de preparation d'un comprime edulcorant et comprime edulcorant ainsi obtenu. |
| FR2834889B1 (fr) * | 2002-01-18 | 2004-04-02 | Roquette Freres | Forme pharmaceutique solide orodispersible |
| FR2834894B1 (fr) * | 2002-01-21 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de piribedil |
| FR2834890B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible d'agomelatine |
| FR2834896B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible d'ivabradine |
| FR2834897B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de testosterone |
| FR2834892B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de mitiglinide |
| FR2834891B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de 2-({2-methoxy-2-[3(trifluoromethyl)phenyl]ethyl}amino)ethyl4 -(2-(9h-fluoren-9-yl)acetyl]amino}ethyl)benzoate |
| FR2834893B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de perindopril |
| US20030228370A1 (en) * | 2002-06-11 | 2003-12-11 | Michel Serpelloni | Orodispersible solid pharmaceutical form |
| FR2857593B1 (fr) * | 2003-07-18 | 2005-10-14 | Servier Lab | Composition pharmaceutique orodispersible d'un compose antithrombotique |
| GB0329208D0 (en) * | 2003-12-17 | 2004-01-21 | Ici Plc | Particulate materials |
| GB0523810D0 (en) * | 2005-11-23 | 2006-01-04 | Astrazeneca Ab | Pharmaceutical compositions |
| FR2894475B1 (fr) * | 2005-12-14 | 2008-05-16 | Servier Lab | Composition pharmaceutique orodispersible pour administra- -tion oromucosale ou sublinguale d'agomelatine |
| KR101665705B1 (ko) * | 2006-12-07 | 2016-10-12 | 다이이찌 산쿄 가부시키가이샤 | 안정성이 개선된 필름 코팅 제제 |
| TWI482641B (zh) * | 2006-12-07 | 2015-05-01 | Daiichi Sankyo Co Ltd | 含有低取代度羥丙基纖維素之醫藥組成物 |
| CN101600430A (zh) * | 2006-12-07 | 2009-12-09 | 第一三共株式会社 | 含有甘露糖醇或乳糖的固体药物制剂 |
| CA2672154C (en) * | 2006-12-07 | 2014-11-18 | Daiichi Sankyo Company, Limited | Pharmaceutical composition having improved storage stability |
| FR2933299B1 (fr) | 2008-07-04 | 2012-02-03 | Roquette Freres | Mannitol orodispersible |
| DE102008047910A1 (de) | 2008-09-19 | 2010-03-25 | Molkerei Meggle Wasserburg Gmbh & Co. Kg | Tablettierhilfsstoff auf Laktose- und Cellulosebasis |
| EP2397161B1 (en) * | 2009-02-12 | 2019-09-25 | Fuji Chemical Industry Co., Ltd. | Disintegrating particle composition and rapidly disintegrating compression-molded material comprising same |
| FR2944971B1 (fr) * | 2009-04-30 | 2012-09-07 | Roquette Freres | Coagglomerats de mannitol et d'amidon granulaire comprimables et a ecoulement libre |
| CN103140207A (zh) * | 2010-06-23 | 2013-06-05 | 高露洁-棕榄公司 | 形成活性包囊物的乳糖基质中成分的包囊作用 |
| FR2966828B1 (fr) * | 2010-11-02 | 2012-12-28 | Roquette Freres | Poudre de polysaccharide et de polyol, comprimable et de haute viscosite |
| JP5483482B2 (ja) * | 2011-05-23 | 2014-05-07 | 三井製糖株式会社 | 糖液から固形物を製造する方法及び固形物 |
| CN102516321A (zh) * | 2011-12-08 | 2012-06-27 | 上海天伟生物制药有限公司 | 一种药用乳糖及其制备方法和用途 |
| JP5276199B1 (ja) * | 2012-03-23 | 2013-08-28 | 池田食研株式会社 | 多孔質顆粒の製造方法 |
| US9522964B2 (en) * | 2012-04-03 | 2016-12-20 | Development, Inc. | Micronized starch and methods for manufacturing same |
| WO2016012853A1 (en) | 2014-07-21 | 2016-01-28 | Roquette Freres | Sugar compositions for tableting by direct compression |
| EP3002005A1 (en) | 2014-09-30 | 2016-04-06 | Molkerei Meggle Wasserburg GmbH & Co. Kg | Direct compression excipient based on lactose, cellulose and starch |
| EP3034070A1 (en) * | 2014-12-18 | 2016-06-22 | Omya International AG | Method for the production of a pharmaceutical delivery system |
| JP6544564B2 (ja) * | 2015-04-20 | 2019-07-17 | 清水建設株式会社 | 模擬粉体、及び粉体飛散状態評価方法 |
| US10820608B1 (en) | 2015-10-26 | 2020-11-03 | The Hershey Company | Hard candy confections with low hygroscopicity |
| WO2018137644A1 (zh) | 2017-01-24 | 2018-08-02 | 南京明德新药研发股份有限公司 | Lsd1抑制剂及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE575343A (pt) * | 1955-09-09 | |||
| AT376147B (de) * | 1980-12-15 | 1984-10-10 | Gergely Gerhard | Verfahren und vorrichtung zum granulieren eines pulvergemisches |
| DE3505433A1 (de) * | 1985-02-16 | 1986-08-21 | Basf Ag, 6700 Ludwigshafen | Direkttablettierhilfsmittel |
| US5043170A (en) * | 1989-02-14 | 1991-08-27 | Hoffmann-La Roche Inc. | Animal feed composition containing a vitamin D metabolite |
| JPH0584054A (ja) * | 1991-09-27 | 1993-04-06 | Kunoole Shokuhin Kk | スープまたはソース粉末もしくは顆粒の製造法 |
| JP3349535B2 (ja) * | 1993-01-12 | 2002-11-25 | フロイント産業株式会社 | 球形顆粒の製造方法 |
| JPH08298956A (ja) * | 1995-05-10 | 1996-11-19 | Ajinomoto Co Inc | 顆粒状調味料の製造方法 |
| JPH0937737A (ja) * | 1995-05-25 | 1997-02-10 | Tokiwa Kanpo Seiyaku:Kk | 菊花含有健康食品 |
| JP3611652B2 (ja) * | 1995-10-30 | 2005-01-19 | 長谷川香料株式会社 | コーティング粉末の製造方法 |
| DE19603984A1 (de) * | 1996-02-05 | 1997-08-07 | Bayer Ag | Granulate von Triazinen |
| JP3934179B2 (ja) * | 1996-07-11 | 2007-06-20 | 不二製油株式会社 | 動物の体内へ摂取される物質からなる粉体を造粒する方法及び造粒物 |
| JP3447042B2 (ja) * | 1997-07-23 | 2003-09-16 | フロイント産業株式会社 | 単一物質球形粒の製造方法 |
-
2000
- 2000-07-27 DE DE60036205T patent/DE60036205T2/de not_active Expired - Lifetime
- 2000-07-27 ES ES00402159T patent/ES2292414T3/es not_active Expired - Lifetime
- 2000-07-27 AT AT00402159T patent/ATE371439T1/de not_active IP Right Cessation
- 2000-07-27 EP EP00402159A patent/EP1175899B1/fr not_active Expired - Lifetime
-
2001
- 2001-07-13 US US09/905,569 patent/US6770368B2/en not_active Expired - Lifetime
- 2001-07-23 CA CA2353363A patent/CA2353363C/fr not_active Expired - Lifetime
- 2001-07-25 RU RU2002111360/15A patent/RU2286142C2/ru active
- 2001-07-25 NZ NZ517931A patent/NZ517931A/en not_active IP Right Cessation
- 2001-07-25 PL PL353056A patent/PL203778B1/pl unknown
- 2001-07-25 CZ CZ20020978A patent/CZ303682B6/cs not_active IP Right Cessation
- 2001-07-25 WO PCT/FR2001/002432 patent/WO2002009673A1/fr active IP Right Grant
- 2001-07-25 BR BR0107036-3A patent/BR0107036A/pt not_active Application Discontinuation
- 2001-07-25 KR KR1020027003970A patent/KR100869171B1/ko active IP Right Grant
- 2001-07-25 CN CNB01802176XA patent/CN1253148C/zh not_active Expired - Lifetime
- 2001-07-25 RS YUP-220/02A patent/RS49931B/sr unknown
- 2001-07-25 SK SK370-2002A patent/SK286951B6/sk not_active IP Right Cessation
- 2001-07-25 HU HU0203064A patent/HU229277B1/hu unknown
- 2001-07-25 IL IL14875201A patent/IL148752A0/xx unknown
- 2001-07-25 AU AU79909/01A patent/AU785135B2/en not_active Expired
- 2001-07-26 JP JP2001226631A patent/JP4394313B2/ja not_active Expired - Lifetime
- 2001-07-27 MX MXPA01007666A patent/MXPA01007666A/es active IP Right Grant
-
2002
- 2002-03-18 ZA ZA200202178A patent/ZA200202178B/xx unknown
- 2002-03-21 NO NO20021424A patent/NO333750B1/no not_active IP Right Cessation
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