NO328418B1 - Pentacykliske taksanforbindelser, anvendelser derav, og medikamenter omfattende slike forbindelser. - Google Patents
Pentacykliske taksanforbindelser, anvendelser derav, og medikamenter omfattende slike forbindelser. Download PDFInfo
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- NO328418B1 NO328418B1 NO20021753A NO20021753A NO328418B1 NO 328418 B1 NO328418 B1 NO 328418B1 NO 20021753 A NO20021753 A NO 20021753A NO 20021753 A NO20021753 A NO 20021753A NO 328418 B1 NO328418 B1 NO 328418B1
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- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical compound [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 210000004276 hyalin Anatomy 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000006241 metabolic reaction Methods 0.000 description 1
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 1
- 230000003228 microsomal effect Effects 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229950006238 nadide Drugs 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 208000025189 neoplasm of testis Diseases 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012285 osmium tetroxide Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940063683 taxotere Drugs 0.000 description 1
- XCLDDMCNFANFBG-DLBZAZTESA-N tert-butyl (2s,3r)-2-(3-fluoropyridin-2-yl)-4-oxo-3-phenylmethoxyazetidine-1-carboxylate Chemical compound O([C@@H]1[C@@H](N(C1=O)C(=O)OC(C)(C)C)C=1C(=CC=CN=1)F)CC1=CC=CC=C1 XCLDDMCNFANFBG-DLBZAZTESA-N 0.000 description 1
- GZSZOHPUGGDAGX-RBUKOAKNSA-N tert-butyl (2s,3r)-2-(5-chloropyridin-2-yl)-4-oxo-3-tri(propan-2-yl)silyloxyazetidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1C(=O)[C@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]1C1=CC=C(Cl)C=N1 GZSZOHPUGGDAGX-RBUKOAKNSA-N 0.000 description 1
- YULDFNCBIJHTRW-RBUKOAKNSA-N tert-butyl (2s,3r)-2-(5-fluoropyridin-2-yl)-4-oxo-3-tri(propan-2-yl)silyloxyazetidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1C(=O)[C@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]1C1=CC=C(F)C=N1 YULDFNCBIJHTRW-RBUKOAKNSA-N 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000005233 tubule cell Anatomy 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29335699 | 1999-10-15 | ||
| PCT/JP2000/007087 WO2001027115A1 (fr) | 1999-10-15 | 2000-10-12 | Composes pentacycliques au taxane |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20021753D0 NO20021753D0 (no) | 2002-04-12 |
| NO20021753L NO20021753L (no) | 2002-06-12 |
| NO328418B1 true NO328418B1 (no) | 2010-02-15 |
Family
ID=17793741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20021753A NO328418B1 (no) | 1999-10-15 | 2002-04-12 | Pentacykliske taksanforbindelser, anvendelser derav, og medikamenter omfattende slike forbindelser. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1221445B1 (de) |
| JP (1) | JP3776799B2 (de) |
| KR (1) | KR100706566B1 (de) |
| CN (1) | CN1203074C (de) |
| AR (1) | AR026026A1 (de) |
| AT (1) | ATE405569T1 (de) |
| AU (1) | AU774787B2 (de) |
| BR (1) | BR0014687A (de) |
| CA (1) | CA2386772C (de) |
| DE (1) | DE60039998D1 (de) |
| DK (1) | DK1221445T3 (de) |
| ES (1) | ES2311473T3 (de) |
| HK (1) | HK1044000B (de) |
| IL (2) | IL149007A0 (de) |
| MX (1) | MXPA02003797A (de) |
| MY (1) | MY125378A (de) |
| NO (1) | NO328418B1 (de) |
| PT (1) | PT1221445E (de) |
| RU (1) | RU2257387C2 (de) |
| TW (1) | TWI225062B (de) |
| WO (1) | WO2001027115A1 (de) |
| ZA (1) | ZA200202696B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2299612T3 (es) * | 2001-11-29 | 2008-06-01 | Daiichi Sankyo Company, Limited | Cristales de un derivado de taxano y procedimiento de obtencion. |
| TW200533339A (en) | 2004-03-16 | 2005-10-16 | Bristol Myers Squibb Co | Therapeutic synergy of anti-cancer compounds |
| JP4800205B2 (ja) * | 2004-04-30 | 2011-10-26 | 第一三共株式会社 | 五環性タキサンの製造方法 |
| JPWO2007049575A1 (ja) * | 2005-10-25 | 2009-04-30 | 第一三共株式会社 | アゼチジン環構造を有するタキサン化合物 |
| CN100516067C (zh) * | 2006-01-10 | 2009-07-22 | 上海恒瑞医药有限公司 | 具有抗肿瘤活性的紫杉酚衍生物 |
| US8785669B2 (en) * | 2010-06-30 | 2014-07-22 | Gfv, Llc | Taxane compounds, compositions and methods |
| TW201316990A (zh) | 2011-08-02 | 2013-05-01 | Astellas Pharma Inc | 藥劑併用之癌治療方法 |
| FR2986526A1 (fr) | 2012-02-03 | 2013-08-09 | Sanofi Sa | Procede de preparation de derives du taxol et certains composes intermediaires |
| CN104650109B (zh) * | 2013-11-22 | 2019-01-01 | 江苏天士力帝益药业有限公司 | 紫杉烷类化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2712289B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| BR9608040B1 (pt) * | 1995-04-28 | 2010-02-23 | composto taxàide pentacÍclico. | |
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
-
2000
- 2000-10-12 JP JP2001530333A patent/JP3776799B2/ja not_active Expired - Lifetime
- 2000-10-12 MX MXPA02003797A patent/MXPA02003797A/es active IP Right Grant
- 2000-10-12 WO PCT/JP2000/007087 patent/WO2001027115A1/ja active IP Right Grant
- 2000-10-12 RU RU2002109593/04A patent/RU2257387C2/ru active IP Right Revival
- 2000-10-12 DE DE60039998T patent/DE60039998D1/de not_active Expired - Lifetime
- 2000-10-12 BR BR0014687-0A patent/BR0014687A/pt not_active IP Right Cessation
- 2000-10-12 PT PT00966445T patent/PT1221445E/pt unknown
- 2000-10-12 KR KR1020027004826A patent/KR100706566B1/ko not_active IP Right Cessation
- 2000-10-12 ES ES00966445T patent/ES2311473T3/es not_active Expired - Lifetime
- 2000-10-12 CN CNB008169780A patent/CN1203074C/zh not_active Expired - Fee Related
- 2000-10-12 DK DK00966445T patent/DK1221445T3/da active
- 2000-10-12 CA CA002386772A patent/CA2386772C/en not_active Expired - Fee Related
- 2000-10-12 EP EP00966445A patent/EP1221445B1/de not_active Expired - Lifetime
- 2000-10-12 AT AT00966445T patent/ATE405569T1/de active
- 2000-10-12 AU AU76851/00A patent/AU774787B2/en not_active Ceased
- 2000-10-12 IL IL14900700A patent/IL149007A0/xx active IP Right Grant
- 2000-10-12 MY MYPI20004781A patent/MY125378A/en unknown
- 2000-10-13 TW TW089121432A patent/TWI225062B/zh not_active IP Right Cessation
- 2000-10-13 AR ARP000105381A patent/AR026026A1/es active IP Right Grant
-
2002
- 2002-04-04 IL IL149007A patent/IL149007A/en unknown
- 2002-04-05 ZA ZA200202696A patent/ZA200202696B/en unknown
- 2002-04-12 NO NO20021753A patent/NO328418B1/no not_active IP Right Cessation
- 2002-08-01 HK HK02105667.9A patent/HK1044000B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60039998D1 (de) | 2008-10-02 |
| ES2311473T3 (es) | 2009-02-16 |
| IL149007A (en) | 2006-12-10 |
| IL149007A0 (en) | 2002-11-10 |
| HK1044000B (zh) | 2008-11-21 |
| NO20021753L (no) | 2002-06-12 |
| KR20020035901A (ko) | 2002-05-15 |
| NO20021753D0 (no) | 2002-04-12 |
| MY125378A (en) | 2006-07-31 |
| DK1221445T3 (da) | 2008-11-24 |
| CA2386772A1 (en) | 2001-04-19 |
| AU774787B2 (en) | 2004-07-08 |
| BR0014687A (pt) | 2002-11-19 |
| ZA200202696B (en) | 2003-09-23 |
| PT1221445E (pt) | 2008-10-08 |
| TWI225062B (en) | 2004-12-11 |
| CN1203074C (zh) | 2005-05-25 |
| RU2257387C2 (ru) | 2005-07-27 |
| CN1409714A (zh) | 2003-04-09 |
| MXPA02003797A (es) | 2002-12-13 |
| AR026026A1 (es) | 2002-12-26 |
| JP3776799B2 (ja) | 2006-05-17 |
| EP1221445B1 (de) | 2008-08-20 |
| EP1221445A4 (de) | 2003-05-28 |
| AU7685100A (en) | 2001-04-23 |
| EP1221445A1 (de) | 2002-07-10 |
| ATE405569T1 (de) | 2008-09-15 |
| CA2386772C (en) | 2009-01-13 |
| KR100706566B1 (ko) | 2007-04-13 |
| WO2001027115A1 (fr) | 2001-04-19 |
| HK1044000A1 (en) | 2002-10-04 |
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Legal Events
| Date | Code | Title | Description |
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| MK1K | Patent expired |