AR026026A1 - Compuesto de taxano pentaciclico. - Google Patents
Compuesto de taxano pentaciclico.Info
- Publication number
- AR026026A1 AR026026A1 ARP000105381A ARP000105381A AR026026A1 AR 026026 A1 AR026026 A1 AR 026026A1 AR P000105381 A ARP000105381 A AR P000105381A AR P000105381 A ARP000105381 A AR P000105381A AR 026026 A1 AR026026 A1 AR 026026A1
- Authority
- AR
- Argentina
- Prior art keywords
- action
- pentaciclic
- taxan
- compound
- antitumor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
Un nuevo derivado de taxol que tiene grupos sustituyentes respectivos, representado por la siguiente formula 1, que puede darse oralmente y que tiene unaactuacion antitumoral. Los valores de los sustituyentes de esta formula pueden ser consultados enla descripcion. Se sabe que el taxol es una sustancia de unaactuacion antitumoral considerándose que su mecanismo de actuacion se funda en su funcion inhibitoria de la despolimerizacion de microtubulos en la divisioncelular, y se espera que su aplicacion clínica sea debida a un mecanismo de accion diferente de los agentes antitumorales convencionales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP29335699 | 1999-10-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR026026A1 true AR026026A1 (es) | 2002-12-26 |
Family
ID=17793741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000105381A AR026026A1 (es) | 1999-10-15 | 2000-10-13 | Compuesto de taxano pentaciclico. |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1221445B1 (es) |
JP (1) | JP3776799B2 (es) |
KR (1) | KR100706566B1 (es) |
CN (1) | CN1203074C (es) |
AR (1) | AR026026A1 (es) |
AT (1) | ATE405569T1 (es) |
AU (1) | AU774787B2 (es) |
BR (1) | BR0014687A (es) |
CA (1) | CA2386772C (es) |
DE (1) | DE60039998D1 (es) |
DK (1) | DK1221445T3 (es) |
ES (1) | ES2311473T3 (es) |
HK (1) | HK1044000B (es) |
IL (2) | IL149007A0 (es) |
MX (1) | MXPA02003797A (es) |
MY (1) | MY125378A (es) |
NO (1) | NO328418B1 (es) |
PT (1) | PT1221445E (es) |
RU (1) | RU2257387C2 (es) |
TW (1) | TWI225062B (es) |
WO (1) | WO2001027115A1 (es) |
ZA (1) | ZA200202696B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100886805B1 (ko) * | 2001-11-29 | 2009-03-05 | 다이이찌 세이야꾸 가부시기가이샤 | 탁산 유도체 결정 및 그 제조방법 |
TW200533339A (en) | 2004-03-16 | 2005-10-16 | Bristol Myers Squibb Co | Therapeutic synergy of anti-cancer compounds |
JP4800205B2 (ja) * | 2004-04-30 | 2011-10-26 | 第一三共株式会社 | 五環性タキサンの製造方法 |
JPWO2007049575A1 (ja) * | 2005-10-25 | 2009-04-30 | 第一三共株式会社 | アゼチジン環構造を有するタキサン化合物 |
CN100516067C (zh) * | 2006-01-10 | 2009-07-22 | 上海恒瑞医药有限公司 | 具有抗肿瘤活性的紫杉酚衍生物 |
US8785669B2 (en) | 2010-06-30 | 2014-07-22 | Gfv, Llc | Taxane compounds, compositions and methods |
KR20140056238A (ko) | 2011-08-02 | 2014-05-09 | 아스텔라스세이야쿠 가부시키가이샤 | 약제의 병용에 의한 암 치료 방법 |
FR2986526A1 (fr) | 2012-02-03 | 2013-08-09 | Sanofi Sa | Procede de preparation de derives du taxol et certains composes intermediaires |
CN104650109B (zh) * | 2013-11-22 | 2019-01-01 | 江苏天士力帝益药业有限公司 | 紫杉烷类化合物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2712289B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent. |
EP0826688B1 (en) * | 1995-04-28 | 2001-09-05 | Daiichi Pharmaceutical Co., Ltd. | Pentacyclic compounds |
TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
-
2000
- 2000-10-12 PT PT00966445T patent/PT1221445E/pt unknown
- 2000-10-12 AT AT00966445T patent/ATE405569T1/de active
- 2000-10-12 ES ES00966445T patent/ES2311473T3/es not_active Expired - Lifetime
- 2000-10-12 CN CNB008169780A patent/CN1203074C/zh not_active Expired - Fee Related
- 2000-10-12 BR BR0014687-0A patent/BR0014687A/pt not_active IP Right Cessation
- 2000-10-12 MX MXPA02003797A patent/MXPA02003797A/es active IP Right Grant
- 2000-10-12 MY MYPI20004781A patent/MY125378A/en unknown
- 2000-10-12 DE DE60039998T patent/DE60039998D1/de not_active Expired - Lifetime
- 2000-10-12 RU RU2002109593/04A patent/RU2257387C2/ru active IP Right Revival
- 2000-10-12 WO PCT/JP2000/007087 patent/WO2001027115A1/ja active IP Right Grant
- 2000-10-12 CA CA002386772A patent/CA2386772C/en not_active Expired - Fee Related
- 2000-10-12 IL IL14900700A patent/IL149007A0/xx active IP Right Grant
- 2000-10-12 JP JP2001530333A patent/JP3776799B2/ja not_active Expired - Lifetime
- 2000-10-12 EP EP00966445A patent/EP1221445B1/en not_active Expired - Lifetime
- 2000-10-12 AU AU76851/00A patent/AU774787B2/en not_active Ceased
- 2000-10-12 KR KR1020027004826A patent/KR100706566B1/ko not_active IP Right Cessation
- 2000-10-12 DK DK00966445T patent/DK1221445T3/da active
- 2000-10-13 TW TW089121432A patent/TWI225062B/zh not_active IP Right Cessation
- 2000-10-13 AR ARP000105381A patent/AR026026A1/es active IP Right Grant
-
2002
- 2002-04-04 IL IL149007A patent/IL149007A/en unknown
- 2002-04-05 ZA ZA200202696A patent/ZA200202696B/en unknown
- 2002-04-12 NO NO20021753A patent/NO328418B1/no not_active IP Right Cessation
- 2002-08-01 HK HK02105667.9A patent/HK1044000B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO20021753D0 (no) | 2002-04-12 |
CA2386772A1 (en) | 2001-04-19 |
HK1044000A1 (en) | 2002-10-04 |
EP1221445B1 (en) | 2008-08-20 |
EP1221445A4 (en) | 2003-05-28 |
RU2257387C2 (ru) | 2005-07-27 |
DK1221445T3 (da) | 2008-11-24 |
AU7685100A (en) | 2001-04-23 |
JP3776799B2 (ja) | 2006-05-17 |
ATE405569T1 (de) | 2008-09-15 |
TWI225062B (en) | 2004-12-11 |
KR20020035901A (ko) | 2002-05-15 |
IL149007A0 (en) | 2002-11-10 |
EP1221445A1 (en) | 2002-07-10 |
AU774787B2 (en) | 2004-07-08 |
NO20021753L (no) | 2002-06-12 |
NO328418B1 (no) | 2010-02-15 |
MY125378A (en) | 2006-07-31 |
CN1409714A (zh) | 2003-04-09 |
MXPA02003797A (es) | 2002-12-13 |
WO2001027115A1 (fr) | 2001-04-19 |
CA2386772C (en) | 2009-01-13 |
PT1221445E (pt) | 2008-10-08 |
HK1044000B (zh) | 2008-11-21 |
CN1203074C (zh) | 2005-05-25 |
DE60039998D1 (de) | 2008-10-02 |
ZA200202696B (en) | 2003-09-23 |
ES2311473T3 (es) | 2009-02-16 |
KR100706566B1 (ko) | 2007-04-13 |
IL149007A (en) | 2006-12-10 |
BR0014687A (pt) | 2002-11-19 |
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Legal Events
Date | Code | Title | Description |
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FG | Grant, registration |