NO327752B1 - Legemiddel leveringsanordninger for vedvarende frigivelse - Google Patents
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- NO327752B1 NO327752B1 NO20000735A NO20000735A NO327752B1 NO 327752 B1 NO327752 B1 NO 327752B1 NO 20000735 A NO20000735 A NO 20000735A NO 20000735 A NO20000735 A NO 20000735A NO 327752 B1 NO327752 B1 NO 327752B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/919,221 US5902598A (en) | 1997-08-28 | 1997-08-28 | Sustained release drug delivery devices |
| PCT/US1998/017342 WO1999011244A1 (fr) | 1997-08-28 | 1998-08-28 | Dispositifs d'administration de medicament a degagement prolonge |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20000735D0 NO20000735D0 (no) | 2000-02-14 |
| NO20000735L NO20000735L (no) | 2000-04-28 |
| NO327752B1 true NO327752B1 (no) | 2009-09-14 |
Family
ID=25441727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20000735A NO327752B1 (no) | 1997-08-28 | 2000-02-14 | Legemiddel leveringsanordninger for vedvarende frigivelse |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5902598A (fr) |
| EP (1) | EP1009388B1 (fr) |
| JP (2) | JP4530531B2 (fr) |
| KR (1) | KR20010023358A (fr) |
| CN (2) | CN101327197A (fr) |
| AR (1) | AR017026A1 (fr) |
| AT (1) | ATE548029T1 (fr) |
| AU (1) | AU741846B2 (fr) |
| BR (1) | BR9811381A (fr) |
| CA (1) | CA2301685C (fr) |
| CZ (1) | CZ302339B6 (fr) |
| EA (1) | EA002162B1 (fr) |
| HK (1) | HK1035135A1 (fr) |
| HU (1) | HUP0002797A3 (fr) |
| IL (1) | IL134568A (fr) |
| ME (2) | ME00122B (fr) |
| NO (1) | NO327752B1 (fr) |
| NZ (2) | NZ502836A (fr) |
| PL (1) | PL344039A1 (fr) |
| RS (1) | RS52096B (fr) |
| SG (1) | SG121718A1 (fr) |
| TR (1) | TR200001029T2 (fr) |
| TW (1) | TWI222884B (fr) |
| UA (1) | UA71898C2 (fr) |
| WO (1) | WO1999011244A1 (fr) |
Families Citing this family (268)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060280774A1 (en) * | 1995-06-02 | 2006-12-14 | Allergan, Inc. | Compositions and methods for treating glaucoma |
| US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6117643A (en) * | 1997-11-25 | 2000-09-12 | Ut Battelle, Llc | Bioluminescent bioreporter integrated circuit |
| CA2358296A1 (fr) * | 1999-01-05 | 2000-07-13 | Anthony P. Adamis | Administration ciblee de medicament a liberation regulee vers la retine et la choroide a travers la sclerotique |
| US20040121014A1 (en) * | 1999-03-22 | 2004-06-24 | Control Delivery Systems, Inc. | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| US6217895B1 (en) | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| AU768400B2 (en) * | 1999-10-21 | 2003-12-11 | Alcon Inc. | Drug delivery device |
| US7943162B2 (en) * | 1999-10-21 | 2011-05-17 | Alcon, Inc. | Drug delivery device |
| US6413245B1 (en) | 1999-10-21 | 2002-07-02 | Alcon Universal Ltd. | Sub-tenon drug delivery |
| US6416777B1 (en) | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
| US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| US20040115268A1 (en) * | 2000-04-26 | 2004-06-17 | Control Delivery Systems, Inc. | Systemic delivery of antiviral agents |
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| US20040208910A1 (en) * | 2000-04-26 | 2004-10-21 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of adrenergic agents |
| US20040175410A1 (en) * | 2000-04-26 | 2004-09-09 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors |
| US6726918B1 (en) | 2000-07-05 | 2004-04-27 | Oculex Pharmaceuticals, Inc. | Methods for treating inflammation-mediated conditions of the eye |
| USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
| US7452964B2 (en) * | 2001-09-07 | 2008-11-18 | Board Of Regents, The University Of Texas System | Compositions and methods of use of targeting peptides against placenta and adipose tissues |
| US20050074747A1 (en) * | 2000-09-08 | 2005-04-07 | Wadih Arap | Biopanning and rapid analysis of selective interactive ligands (brasil) |
| US20040170955A1 (en) * | 2000-09-08 | 2004-09-02 | Wadih Arap | Human and mouse targeting peptides identified by phage display |
| US7420030B2 (en) | 2000-09-08 | 2008-09-02 | The Board Of Regents Of The University Of Texas System | Aminopeptidase A (APA) targeting peptides for the treatment of cancer |
| JP2004537495A (ja) * | 2000-11-03 | 2004-12-16 | コントロール・デリバリー・システムズ | 関節疾患を治療するための改善された装置及び方法 |
| AU3649502A (en) * | 2000-11-29 | 2002-06-11 | Oculex Pharm Inc | Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor |
| WO2002056863A2 (fr) | 2000-12-29 | 2002-07-25 | Bausch & Lomb Incorporated | Dispositif d'apport de medicaments en continu |
| CA2432225C (fr) * | 2001-01-03 | 2008-01-15 | Michael J. Brubaker | Dispositifs d'administration de medicament a liberation prolongee a tampons permeables prefabriques |
| EP1847255A3 (fr) * | 2001-01-03 | 2009-03-04 | Bausch & Lomb Incorporated | Dispositifs de livraison de médicaments à libération prolongée avec noyaux de médicaments recouverts |
| ES2294043T3 (es) * | 2001-01-03 | 2008-04-01 | BAUSCH & LOMB INCORPORATED | Dispositivos de liberacion prolongada de medicamentos que comprenden nucleos recubiertos de medicamentos. |
| ES2320533T3 (es) | 2001-01-03 | 2009-05-25 | BAUSCH & LOMB INCORPORATED | Dispositivos de administracion de farmacos de liberacion sostenida con multiples agentes. |
| US6991808B2 (en) * | 2001-01-26 | 2006-01-31 | Bausch & Lomb Inc. | Process for the production of sustained release drug delivery devices |
| US6713081B2 (en) * | 2001-03-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Ocular therapeutic agent delivery devices and methods for making and using such devices |
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| DE60239528D1 (de) * | 2001-05-01 | 2011-05-05 | Corium International Redwood City | Zweiphasige, wasserabsorbierende bioadhäsive zusammenstezung |
| US8541021B2 (en) * | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
| US20050215727A1 (en) * | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
| US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
| US8728445B2 (en) * | 2001-05-01 | 2014-05-20 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences | Hydrogel Compositions |
| US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
| US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
| EP1387671A1 (fr) | 2001-05-03 | 2004-02-11 | MASSACHUSETTS EYE & EAR INFIRMARY | Dispositif d'administration de medicament implantable et utilisation associee |
| EP2316394B1 (fr) | 2001-06-12 | 2016-11-23 | The Johns Hopkins University | Dispositif à réservoir pour administration intraoculaire de médicaments |
| WO2003007979A1 (fr) * | 2001-07-18 | 2003-01-30 | Board Of Regents, The University Of Texas System | Etat anti-angiogene chez les souris et les etres humains souffrant d'une degenerescence cellulaire du photorecepteur retinien |
| PT1409065E (pt) | 2001-07-23 | 2007-03-30 | Alcon Inc | Dispositivo de administração de fármacos oftálmicos |
| PT1385452E (pt) * | 2001-07-23 | 2006-12-29 | Alcon Inc | Dispositivo de administração de fármacos oftálmicos |
| US7749528B2 (en) * | 2001-08-29 | 2010-07-06 | Ricardo Azevedo Pontes De Carvalho | Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues |
| JP2005501602A (ja) | 2001-08-29 | 2005-01-20 | カルバーリョ、リカルド エイ．ピー． デ | 治療薬を組織に一方向送達するための封鎖可能な移殖型装置 |
| US7671010B2 (en) * | 2002-08-30 | 2010-03-02 | The Board Of Regents Of The University Of Texas System | Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer |
| US8507445B2 (en) * | 2001-09-07 | 2013-08-13 | Board Of Regents, The University Of Texas System | Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer |
| US20040048243A1 (en) * | 2001-09-07 | 2004-03-11 | Wadih Arap | Methods and compositions for in vitro targeting |
| US20030158598A1 (en) * | 2001-09-17 | 2003-08-21 | Control Delivery Systems, Inc. | System for sustained-release delivery of anti-inflammatory agents from a coated medical device |
| OA12764A (en) * | 2002-01-31 | 2006-07-04 | Vestergaard Framdsen As | Laminated insecticide dispenser. |
| AU2003216379A1 (en) * | 2002-02-22 | 2003-09-09 | Control Delivery Systems, Inc. | Method for treating otic disorders |
| EP2522319A3 (fr) * | 2002-03-11 | 2013-09-25 | Novartis AG | Système de distribution de médicament implantable |
| AU2003224087B2 (en) | 2002-04-18 | 2009-03-05 | Opko Pharmaceuticals, Llc. | Means and methods for the specific inhibition of genes in cells and tissue of the CNS and/or eye |
| WO2003092514A1 (fr) * | 2002-05-02 | 2003-11-13 | Control Delivery Systems, Inc. | Dispositif et procede pour traiter des etats d'une articulation |
| AU2003217531A1 (en) * | 2002-05-02 | 2003-11-17 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
| WO2003094888A1 (fr) * | 2002-05-07 | 2003-11-20 | Control Delivery Systems, Inc. | Procedes de fabrication d'un distributeur de medicaments |
| US8871241B2 (en) * | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
| EP1507826A4 (fr) | 2002-05-17 | 2007-11-07 | Othera Pharmaceuticals Inc | Amelioration de l'evolution des cataractes et d'autres maladies ophtalmiques |
| US20070184089A1 (en) * | 2002-07-15 | 2007-08-09 | Alcon, Inc. | Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use |
| BR0312635A (pt) * | 2002-07-15 | 2005-04-19 | Alcon Inc | Composições de implante farmacêutico lipofìlico não polimérico para uso intraocular |
| US7148342B2 (en) * | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| WO2004036182A2 (fr) * | 2002-10-17 | 2004-04-29 | Control Delivery Systems, Inc. | Procede de suivi de traitement de maladie |
| AU2003287666A1 (en) * | 2002-11-13 | 2004-06-03 | Control Delivery Systems, Inc. | Systemic delivery of antiviral agents |
| CA2729967C (fr) * | 2002-12-13 | 2018-01-16 | Schering-Plough Healthcare Products, Inc. | Utilisation d'un appareil de distribution d'ingredient transdermique ou transmucosique |
| AU2003301129A1 (en) * | 2002-12-20 | 2004-07-22 | Control Delivery Systems, Inc. | Steroid compositions for intraocular use |
| US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
| ATE477337T1 (de) | 2003-01-16 | 2010-08-15 | Univ Pennsylvania | Zusammensetzungen und verfahren zur sirna-hemmung von icam-1 |
| CN1741793A (zh) * | 2003-01-24 | 2006-03-01 | 控释给药系统公司 | 高可溶性药物的控制释放 |
| SI1592408T1 (sl) * | 2003-01-24 | 2010-01-29 | Psivida Inc | Naprava s podaljšanim sproščanjem in postopek za okularno dajanje adrenergičnih sredstev |
| WO2004066980A2 (fr) * | 2003-01-24 | 2004-08-12 | Control Delivery Systems, Inc. | Dispositif et procede a liberation prolongee pour l'administration oculaire d'inhibiteurs d'anhydrase carbonique |
| US20050019400A1 (en) * | 2003-01-27 | 2005-01-27 | Deveney Thomas William | Controlled-release drug delivery system |
| WO2004073551A2 (fr) * | 2003-02-18 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Dispositif d'administration transsclerale de medicament et procedes associes |
| US9445901B2 (en) * | 2003-03-12 | 2016-09-20 | Deger C. Tunc | Prosthesis with sustained release analgesic |
| US20050261668A1 (en) * | 2003-03-28 | 2005-11-24 | Bausch & Lomb Incorporated | Drug delivery device |
| US7037521B2 (en) * | 2003-03-28 | 2006-05-02 | Bausch & Lomb Incorporated | Using a laser for cutting a hole in a capsule for controlled drug delivery |
| US7589107B2 (en) | 2003-05-19 | 2009-09-15 | Othera Holding, Inc. | Amelioration of vitrectomy-induced cataracts |
| US7825134B2 (en) * | 2003-05-19 | 2010-11-02 | Othera Holding, Inc. | Amelioration of cataracts, macular degeneration and other ophthalmic diseases |
| US7553298B2 (en) * | 2003-12-19 | 2009-06-30 | Ethicon Endo-Surgery, Inc. | Implantable medical device with cover and method |
| US8715243B2 (en) * | 2003-06-16 | 2014-05-06 | Ethicon Endo-Surgery, Inc. | Injection port applier with downward force actuation |
| US7862546B2 (en) * | 2003-06-16 | 2011-01-04 | Ethicon Endo-Surgery, Inc. | Subcutaneous self attaching injection port with integral moveable retention members |
| US8790637B2 (en) * | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| PL1641914T3 (pl) | 2003-06-27 | 2017-01-31 | DePuy Synthes Products, Inc. | Komórki pochodzące z poporodowej tkanki łożyska oraz sposoby uzyskiwania i zastosowania tych komórek |
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
| US20050054586A1 (en) * | 2003-06-30 | 2005-03-10 | Bartels Stephen P. | Treatment of ophthalmic disorders |
| US20040265356A1 (en) * | 2003-06-30 | 2004-12-30 | Bausch & Lomb Incorporated | Drug delivery device |
| CA2530996C (fr) * | 2003-07-03 | 2013-05-07 | Corium International, Inc. | Pansement, dispositif d'administration d'ingredient et dispositif de fixation intraveineux et procede associe |
| CN1805719A (zh) * | 2003-07-10 | 2006-07-19 | 爱尔康公司 | 眼药输送装置 |
| CA2539324A1 (fr) * | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Administration transsclerale d'agents therapeutiques |
| DK1696822T3 (da) * | 2003-11-13 | 2010-05-17 | Psivida Inc | Injicerbart vedvarende frigørelsesimplantat, som har en bioeroderbar matrixkerne og en bioeroderbar hus |
| US20050130906A1 (en) * | 2003-11-20 | 2005-06-16 | Matier William L. | Amelioration of macular degeneration and other ophthalmic diseases |
| US8162897B2 (en) * | 2003-12-19 | 2012-04-24 | Ethicon Endo-Surgery, Inc. | Audible and tactile feedback |
| US20050148948A1 (en) * | 2003-12-19 | 2005-07-07 | Caputa Steven G. | Sutureless ophthalmic drug delivery system and method |
| DE10360185A1 (de) * | 2003-12-20 | 2005-08-04 | Max Wyssmann | Vorrichtung zur gezielten, steuerbaren Abgabe oder zum Ansaugen einer Flüssigkeit oder einer viskosen Masse |
| US20050158365A1 (en) | 2003-12-22 | 2005-07-21 | David Watson | Drug delivery device with mechanical locking mechanism |
| US20050136095A1 (en) * | 2003-12-22 | 2005-06-23 | Brian Levy | Drug delivery device with suture ring |
| US20050137538A1 (en) | 2003-12-22 | 2005-06-23 | Bausch & Lomb Incorporated | Drug delivery device |
| US7211272B2 (en) * | 2003-12-22 | 2007-05-01 | Bausch & Lomb Incorporated | Drug delivery device |
| WO2005070333A1 (fr) * | 2004-01-13 | 2005-08-04 | Orthobiologica, Inc. | Administration d'un medicament a une articulation |
| CN101018541A (zh) * | 2004-01-26 | 2007-08-15 | 普西维达公司 | 核酸基治疗药剂的受控和持续传输 |
| KR20070007299A (ko) | 2004-01-30 | 2007-01-15 | 코리움 인터네셔널, 인크. | 활성제의 전달을 위한 급속 용해 필름 |
| US20060018949A1 (en) * | 2004-04-07 | 2006-01-26 | Bausch & Lomb Incorporated | Injectable biodegradable drug delivery system |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| US20070254950A1 (en) * | 2004-05-25 | 2007-11-01 | Othera Pharmaceuticals, Inc. | Oculoselective Drugs and Prodrugs |
| CA2572223C (fr) | 2004-06-25 | 2014-08-12 | The Johns Hopkins University | Inhibiteurs d'angiogenese |
| US20060110428A1 (en) * | 2004-07-02 | 2006-05-25 | Eugene Dejuan | Methods and devices for the treatment of ocular conditions |
| EP3470108A1 (fr) | 2004-07-02 | 2019-04-17 | Mati Therapeutics Inc. | Dispositif de mise en place d'un moyen de traitement destinees a la mise en place dans l'oeil |
| CN103497713B (zh) * | 2004-08-05 | 2018-07-17 | 考里安国际公司 | 粘合剂组合物 |
| US20060068012A1 (en) * | 2004-09-29 | 2006-03-30 | Bausch & Lomb Incorporated | Process for preparing poly (vinyl alcohol) drug delivery devices with humidity control |
| US20060067978A1 (en) * | 2004-09-29 | 2006-03-30 | Bausch & Lomb Incorporated | Process for preparing poly(vinyl alcohol) drug delivery devices |
| US20060067979A1 (en) * | 2004-09-30 | 2006-03-30 | Bausch & Lomb Incorporated | Ophthalmic drug release device for multiple drug release |
| US20060067980A1 (en) * | 2004-09-30 | 2006-03-30 | Bausch & Lomb Incorporated | Capsule for encasing tablets for surgical insertion into the human body |
| US20060078592A1 (en) * | 2004-10-12 | 2006-04-13 | Bausch & Lomb Incorporated | Drug delivery systems |
| US20070276481A1 (en) * | 2004-12-08 | 2007-11-29 | Renner Steven B | Drug delivery device |
| US20060134162A1 (en) * | 2004-12-16 | 2006-06-22 | Larson Christopher W | Methods for fabricating a drug delivery device |
| US20060171930A1 (en) * | 2004-12-21 | 2006-08-03 | Agnieszka Seyda | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| US20060153815A1 (en) * | 2004-12-21 | 2006-07-13 | Agnieszka Seyda | Tissue engineering devices for the repair and regeneration of tissue |
| WO2006083394A2 (fr) * | 2004-12-21 | 2006-08-10 | Ethicon, Inc. | Cellules post-partum derivees de tissu placentaire et leurs procedes de production, de culture et d'utilisation |
| US20060134174A1 (en) * | 2004-12-22 | 2006-06-22 | Bausch & Lomb Incorporated | Pharmaceutical delivery system and method of use |
| US20060134175A1 (en) * | 2004-12-22 | 2006-06-22 | Stephen Bartels | Drug eluting pharmaceutical delivery system for treatment of ocular disease and method of use |
| US20060134176A1 (en) * | 2004-12-22 | 2006-06-22 | Bausch & Lomb Incorporated | Pharmaceutical delivery system and method of use |
| WO2006068898A1 (fr) * | 2004-12-22 | 2006-06-29 | Bausch & Lomb Incorporated | Dispositif de distribution de medicament reutilisable |
| ES2621847T3 (es) | 2004-12-23 | 2017-07-05 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas |
| PL1835924T3 (pl) | 2004-12-23 | 2014-01-31 | Ethicon Incorporated | Leczenie choroby Parkinsona i zaburzeń związanych z tą chorobą z użyciem komórek uzyskiwanych po porodzie |
| US8663639B2 (en) * | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| DK1848431T3 (en) * | 2005-02-09 | 2016-04-18 | Santen Pharmaceutical Co Ltd | LIQUID FORMULATIONS FOR TREATMENT OF DISEASES OR CONDITIONS |
| BRPI0609432A2 (pt) * | 2005-03-21 | 2010-04-06 | Macusight Inc | sistemas de distribuição de fármacos para tratamento de doenças ou condições |
| JP2008535847A (ja) * | 2005-04-08 | 2008-09-04 | サーモディクス，インコーポレイティド | 網膜下に送達するための持続放出インプラント |
| US20080312283A1 (en) * | 2005-05-26 | 2008-12-18 | Othera Pharmaceuticals, Inc. | Use of Hydroxylamine Derivates for Inhibiting Vitrectomy-Induced Cataracts |
| US7918844B2 (en) | 2005-06-24 | 2011-04-05 | Ethicon Endo-Surgery, Inc. | Applier for implantable medical device |
| US7651483B2 (en) * | 2005-06-24 | 2010-01-26 | Ethicon Endo-Surgery, Inc. | Injection port |
| US20060292202A1 (en) * | 2005-06-27 | 2006-12-28 | Bausch & Lomb Incorporated | Drug delivery device |
| WO2007014327A2 (fr) | 2005-07-27 | 2007-02-01 | University Of Florida Research Foundation, Inc. | Petits composes corrigeant un mauvais repliement des proteines et utilisations de ceux-ci |
| US20070212397A1 (en) * | 2005-09-15 | 2007-09-13 | Roth Daniel B | Pharmaceutical delivery device and method for providing ocular treatment |
| CA2631173A1 (fr) | 2005-11-29 | 2007-06-07 | Smithkline Beecham Corporation | Procede de traitement |
| EP1971681B1 (fr) * | 2005-12-16 | 2017-08-23 | DePuy Synthes Products, Inc. | Compositions et procedes d'inhibition d'une reponse immunitaire negative en transplantation avec defaut d'histocompatibilite |
| AU2006330409B2 (en) * | 2005-12-28 | 2012-07-19 | Ethicon, Incorporated | Treatment of peripheral vascular disease using postpartum-derived cells |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| US20070178138A1 (en) * | 2006-02-01 | 2007-08-02 | Allergan, Inc. | Biodegradable non-opthalmic implants and related methods |
| AU2007212271B2 (en) | 2006-02-09 | 2012-11-01 | Santen Pharmaceutical Co., Ltd. | Stable formulations, and methods of their preparation and use |
| US20070203190A1 (en) * | 2006-02-22 | 2007-08-30 | Ghanshyam Patil | Hydroxylamines and derivatives for the inhibition of complement activation |
| BRPI0709016A2 (pt) | 2006-03-23 | 2011-06-21 | Macusight Inc | formulações e métodos para doenças ou condições relacionadas com a permeabilidade vascular |
| CN103393483B (zh) | 2006-03-31 | 2016-08-24 | 玛提治疗有限公司 | 用于鼻泪系统的药物释放方法、结构及组合物 |
| US20090130212A1 (en) * | 2006-05-15 | 2009-05-21 | Physical Pharmaceutica, Llc | Composition and improved method for preparation of small particles |
| ES2390499T3 (es) | 2006-06-12 | 2012-11-13 | Opko Pharmaceuticals, Llc | Composiciones y métodos para la inhibición de la angiogénesis por sirna |
| US20070298073A1 (en) * | 2006-06-23 | 2007-12-27 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| US8802128B2 (en) * | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| BRPI0714815A2 (pt) | 2006-08-07 | 2013-05-21 | Bausch & Lomb | composiÇço, e, uso de um (a) agonista e (b) um agente anti-infeccioso |
| CN101528208A (zh) * | 2006-08-31 | 2009-09-09 | 博士伦公司 | 治疗或预防青光眼或其进展的组合物和方法 |
| US7872118B2 (en) * | 2006-09-08 | 2011-01-18 | Opko Ophthalmics, Llc | siRNA and methods of manufacture |
| US20110105559A1 (en) * | 2006-09-11 | 2011-05-05 | Rohrs Brian R | Compositions and Methods for Treating, Controlling, Reducing, Ameliorating, or Preventing Allergy |
| US20110104159A1 (en) * | 2006-09-11 | 2011-05-05 | Rohrs Brian R | Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy |
| KR20090050076A (ko) * | 2006-09-11 | 2009-05-19 | 보오슈 앤드 롬 인코포레이팃드 | 알레르기를 치료, 관리, 경감, 개선 또는 예방하기 위한 조성물 및 방법 |
| US20080145405A1 (en) * | 2006-12-15 | 2008-06-19 | Kunzler Jay F | Drug delivery devices |
| GB0713463D0 (en) | 2007-07-11 | 2007-08-22 | Btg Int Ltd | Modulators of hypoxia inducible factor-1 and related uses |
| EP2125716A2 (fr) | 2007-02-22 | 2009-12-02 | Othera Holding, Inc. | Composés d'hydroxylamine et leurs procédés d'utilisation |
| US20080265343A1 (en) * | 2007-04-26 | 2008-10-30 | International Business Machines Corporation | Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof |
| US20090042936A1 (en) * | 2007-08-10 | 2009-02-12 | Ward Keith W | Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation |
| US20090087443A1 (en) | 2007-09-27 | 2009-04-02 | Bartels Stephen P | Pharmacological Adjunctive Treatment Associated with Glaucoma Filtration Surgery |
| BRPI0818183A2 (pt) * | 2007-10-05 | 2019-07-16 | Ethicon Inc | reparo e regeneração do tecido renal usando células derivadas do tecido do cordão umbilical humano |
| US20100152646A1 (en) * | 2008-02-29 | 2010-06-17 | Reshma Girijavallabhan | Intravitreal injection device and method |
| US9023063B2 (en) | 2008-04-17 | 2015-05-05 | Apollo Endosurgery, Inc. | Implantable access port device having a safety cap |
| ES2537815T3 (es) | 2008-04-17 | 2015-06-12 | Apollo Endosurgery, Inc. | Dispositivo con puerto de acceso implantable y sistema de fijación |
| US20090291073A1 (en) * | 2008-05-20 | 2009-11-26 | Ward Keith W | Compositions Comprising PKC-theta and Methods for Treating or Controlling Ophthalmic Disorders Using Same |
| US20100121441A1 (en) * | 2008-11-10 | 2010-05-13 | Nabil Jabbour | Surgical implant and method |
| JP5832293B2 (ja) | 2008-12-04 | 2015-12-16 | オプコ ファーマシューティカルズ、エルエルシー | 血管新生促進ｖｅｇｆイソ型を選択的に抑制する組成物および方法 |
| WO2010077732A2 (fr) * | 2008-12-09 | 2010-07-08 | Aether Medical Llc | Analgésique implantable |
| US10179900B2 (en) * | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| CA2747794C (fr) | 2008-12-19 | 2018-10-30 | Advanced Technologies And Regenerative Medicine, Llc | Traitement des poumons et des maladies et troubles pulmonaires |
| EP2379089B1 (fr) * | 2008-12-19 | 2019-04-17 | DePuy Synthes Products, Inc. | Regeneration et reparation du tissu nerveux suite à une blessure |
| BRPI0923177A2 (pt) * | 2008-12-19 | 2020-08-25 | Advanced Technologies And Regenerative Medicine, Llc | usos de composições para tratar dor neuropática e espacidade, as referidas composições, e kit |
| WO2010083035A2 (fr) * | 2009-01-14 | 2010-07-22 | Corium International, Inc. | Administration transdermique de tamsulosine |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| CN104887389B (zh) | 2009-01-29 | 2017-06-23 | 弗赛特影像4股份有限公司 | 后段给药 |
| WO2010093945A2 (fr) | 2009-02-13 | 2010-08-19 | Glaukos Corporation | Implant médicamenteux uvéoscléral et ses procédés d'implantation |
| CA2756600C (fr) | 2009-03-26 | 2019-08-20 | Advanced Technologies And Regenerative Medicine, Llc | Cellules tissulaires du cordon ombilical humain utilisees comme therapie pour la maladie d'alzheimer |
| US20110077270A1 (en) * | 2009-04-21 | 2011-03-31 | Pfeffer Bruce A | Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure |
| US8372036B2 (en) * | 2009-05-06 | 2013-02-12 | Alcon Research, Ltd. | Multi-layer heat assembly for a drug delivery device |
| AU2010249683B2 (en) * | 2009-05-18 | 2015-06-25 | Dose Medical Corporation | Drug eluting ocular implant |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| WO2012071476A2 (fr) | 2010-11-24 | 2012-05-31 | David Haffner | Implant oculaire à élution de médicament |
| CA2764063C (fr) | 2009-06-03 | 2019-05-14 | Forsight Labs, Llc | Distribution de medicament de segment anterieur |
| IN2012DN00352A (fr) | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
| US8506532B2 (en) | 2009-08-26 | 2013-08-13 | Allergan, Inc. | System including access port and applicator tool |
| US8715158B2 (en) | 2009-08-26 | 2014-05-06 | Apollo Endosurgery, Inc. | Implantable bottom exit port |
| US8708979B2 (en) | 2009-08-26 | 2014-04-29 | Apollo Endosurgery, Inc. | Implantable coupling device |
| WO2011039648A1 (fr) | 2009-09-30 | 2011-04-07 | Glaxo Wellcome Manufacturing Pte Ltd. | Procédé d'administration et de traitement |
| CN102812126A (zh) * | 2009-12-04 | 2012-12-05 | 奥普科制药有限责任公司 | 用于抑制vegf的组合物和方法 |
| US8177747B2 (en) * | 2009-12-22 | 2012-05-15 | Alcon Research, Ltd. | Method and apparatus for drug delivery |
| US20110238036A1 (en) * | 2009-12-23 | 2011-09-29 | Psivida Us, Inc. | Sustained release delivery devices |
| US10166142B2 (en) | 2010-01-29 | 2019-01-01 | Forsight Vision4, Inc. | Small molecule delivery with implantable therapeutic device |
| US20110189174A1 (en) * | 2010-02-01 | 2011-08-04 | Afshin Shafiee | Compositions and methods for treating, reducing, ameliorating, alleviating, or inhibiting progression of, pathogenic ocular neovascularization |
| US8882728B2 (en) | 2010-02-10 | 2014-11-11 | Apollo Endosurgery, Inc. | Implantable injection port |
| US8992415B2 (en) | 2010-04-30 | 2015-03-31 | Apollo Endosurgery, Inc. | Implantable device to protect tubing from puncture |
| US20110270021A1 (en) | 2010-04-30 | 2011-11-03 | Allergan, Inc. | Electronically enhanced access port for a fluid filled implant |
| US20110270025A1 (en) | 2010-04-30 | 2011-11-03 | Allergan, Inc. | Remotely powered remotely adjustable gastric band system |
| CA2798084A1 (fr) * | 2010-05-17 | 2011-11-24 | Aerie Pharmaceuticals, Inc. | Dispositifs d'administration de medicament pour administration d'agents therapeutiques oculaires |
| WO2011163560A1 (fr) | 2010-06-25 | 2011-12-29 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Méthodes de traitement utilisant l'acide sterculique |
| AU2011285548B2 (en) | 2010-08-05 | 2014-02-06 | Forsight Vision4, Inc. | Combined drug delivery methods and apparatus |
| SI2600930T1 (sl) | 2010-08-05 | 2021-08-31 | Forsight Vision4, Inc. | Injekcijska naprava za dajanje zdravila |
| HUE057267T2 (hu) | 2010-08-05 | 2022-05-28 | Forsight Vision4 Inc | Berendezés szem kezelésére |
| US20120041258A1 (en) | 2010-08-16 | 2012-02-16 | Allergan, Inc. | Implantable access port system |
| US20120065460A1 (en) | 2010-09-14 | 2012-03-15 | Greg Nitka | Implantable access port system |
| WO2012068549A2 (fr) | 2010-11-19 | 2012-05-24 | Forsight Vision4, Inc. | Formulations d'agents thérapeutiques pour des dispositifs implantés |
| WO2012080833A2 (fr) | 2010-12-13 | 2012-06-21 | Purdue Pharma L.P. | Formes pharmaceutiques permettant une libération contrôlée |
| US8821373B2 (en) | 2011-05-10 | 2014-09-02 | Apollo Endosurgery, Inc. | Directionless (orientation independent) needle injection port |
| US20120316199A1 (en) | 2011-06-07 | 2012-12-13 | Ward Keith W | Compositions and methods for treating, controlling, reducing, or ameliorating inflammatory pain |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| BR112013032199A2 (pt) | 2011-06-14 | 2017-12-12 | Bikam Pharmaceuticals Inc | ligantes de ligação à opsina, composições e métodos de utilização |
| EP2726016B1 (fr) | 2011-06-28 | 2023-07-19 | ForSight Vision4, Inc. | Un appareil pour collecter un échantillon de fluide à partir d'une chambre réservoir d'un dispositif thérapeutique pour l'oeil |
| US8801597B2 (en) | 2011-08-25 | 2014-08-12 | Apollo Endosurgery, Inc. | Implantable access port with mesh attachment rivets |
| JP6100782B2 (ja) | 2011-08-29 | 2017-03-22 | キューエルティー インコーポレイテッド | 緑内障および高眼圧症を治療するための活性剤の徐放送達 |
| US9974685B2 (en) | 2011-08-29 | 2018-05-22 | Mati Therapeutics | Drug delivery system and methods of treating open angle glaucoma and ocular hypertension |
| CN106073986B (zh) | 2011-09-14 | 2019-01-11 | 弗赛特影像5股份有限公司 | 治疗患者的眼睛的装置 |
| US9883968B2 (en) | 2011-09-16 | 2018-02-06 | Forsight Vision4, Inc. | Fluid exchange apparatus and methods |
| AU2012325341B2 (en) | 2011-10-19 | 2017-01-05 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
| US9199069B2 (en) | 2011-10-20 | 2015-12-01 | Apollo Endosurgery, Inc. | Implantable injection port |
| US8858421B2 (en) | 2011-11-15 | 2014-10-14 | Apollo Endosurgery, Inc. | Interior needle stick guard stems for tubes |
| US9089395B2 (en) | 2011-11-16 | 2015-07-28 | Appolo Endosurgery, Inc. | Pre-loaded septum for use with an access port |
| US9353063B2 (en) | 2011-11-30 | 2016-05-31 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
| JP6322142B2 (ja) | 2011-12-01 | 2018-05-09 | ビカム ファーマスーティカルス，インコーポレイテッド | オプシン結合性リガンド、組成物、及び使用方法 |
| ES2676556T3 (es) | 2011-12-23 | 2018-07-20 | Depuy Synthes Products Llc | Detección de células derivadas de tejido del cordón umbilical humano |
| US10080648B2 (en) | 2012-01-24 | 2018-09-25 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
| US10028824B2 (en) | 2012-01-24 | 2018-07-24 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
| JP6270739B2 (ja) | 2012-01-24 | 2018-01-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド, ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate | モジュール式眼内レンズの設計および方法 |
| US9364316B1 (en) * | 2012-01-24 | 2016-06-14 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
| WO2013116061A1 (fr) | 2012-02-03 | 2013-08-08 | Forsight Vision4, Inc. | Procédés et instrument pour l'insertion et le retrait de dispositifs thérapeutiques |
| KR101969594B1 (ko) * | 2012-05-11 | 2019-04-16 | 서강대학교산학협력단 | 안내 약물 전달 임플란트 |
| WO2014066775A1 (fr) | 2012-10-26 | 2014-05-01 | Forsight Vision5, Inc. | Système ophtalmique pour la libération prolongée de médicament dans l'œil |
| WO2014164703A1 (fr) | 2013-03-11 | 2014-10-09 | University Of Florida Research Foundation, Inc. | Délivrance d'une protéine card en tant que thérapie pour inflammation oculaire |
| WO2014152959A1 (fr) | 2013-03-14 | 2014-09-25 | Forsight Vision4, Inc. | Systèmes pour l'administration intra-oculaire entretenue de composés à faible solubilité provenant d'un implant de système de pose d'orifice |
| US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
| EP4302736A3 (fr) | 2013-03-28 | 2024-04-03 | ForSight Vision4, Inc. | Implant ophtalmique pour l'administration de substances thérapeutiques |
| JP6340673B2 (ja) | 2013-05-02 | 2018-06-13 | レティナ ファウンデーション オブ ザ サウスウエストＲｅｔｉｎａ Ｆｏｕｎｄａｔｉｏｎ Ｏｆ Ｔｈｅ Ｓｏｕｔｈｗｅｓｔ | 二層型眼用インプラント |
| ES2864274T3 (es) * | 2013-11-14 | 2021-10-13 | Eyed Pharma | Dispositivo ocular |
| JP2016538050A (ja) * | 2013-11-15 | 2016-12-08 | グローコス コーポレーション | 安定な薬物製剤を貯蔵及び放出するように構成された眼内インプラント |
| EP4215159A1 (fr) | 2014-02-18 | 2023-07-26 | Alcon Inc. | Conceptions de lentille intraoculaire modulaire, outils et procédés associés |
| WO2015184173A1 (fr) | 2014-05-29 | 2015-12-03 | Dose Medical Corporation | Implants à caractéristiques de libération contrôlée de médicament et leurs procédés d'utilisation |
| US9580896B2 (en) | 2014-07-05 | 2017-02-28 | John David Hopkins | Apparatus and method for prolonged active agent in aqueous systems |
| KR102416726B1 (ko) | 2014-07-15 | 2022-07-05 | 포사이트 비젼4, 인크. | 안구 이식물 전달 디바이스 및 방법 |
| WO2016022750A1 (fr) | 2014-08-08 | 2016-02-11 | Forsight Vision4, Inc. | Formulations stables et solubles d'inhibiteurs de la tyrosine kinase de récepteurs, et procédés de préparation de ces dernières |
| US10500091B2 (en) | 2014-11-10 | 2019-12-10 | Forsight Vision4, Inc. | Expandable drug delivery devices and methods of use |
| JP7002331B2 (ja) | 2015-01-30 | 2022-01-20 | クラービスタ メディカル，インコーポレイテッド | 眼内挿入用に構成された装置 |
| US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
| US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| US11564833B2 (en) | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| US11458041B2 (en) | 2015-10-08 | 2022-10-04 | Ocular Therapeutix, Inc. | Punctal plug and bioadhesives |
| AU2016349363B2 (en) | 2015-11-04 | 2022-01-27 | Alcon Inc. | Modular intraocular lens designs, tools and methods |
| AU2016355345A1 (en) | 2015-11-20 | 2018-05-31 | Forsight Vision4, Inc. | Porous structures for extended release drug delivery devices |
| CN109195556B (zh) | 2016-04-05 | 2021-03-26 | 弗赛特影像4股份有限公司 | 可植入眼睛药物递送装置 |
| CN109937025B (zh) | 2016-04-20 | 2022-07-29 | 多斯医学公司 | 生物可吸收眼部药物的递送装置 |
| US11045309B2 (en) | 2016-05-05 | 2021-06-29 | The Regents Of The University Of Colorado | Intraocular lens designs for improved stability |
| EP3481405A1 (fr) | 2016-07-05 | 2019-05-15 | Janssen Biotech, Inc. | Traitement d'une maladie vasculaire rétinienne utilisant des cellules progénitrices |
| US11382736B2 (en) | 2017-06-27 | 2022-07-12 | Alcon Inc. | Injector, intraocular lens system, and related methods |
| US11103460B2 (en) | 2017-08-07 | 2021-08-31 | Board Of Regents, The University Of Texas System | Fabrication methods for nanodelivery systems for long term controlled delivery of active pharmaceutical ingredients |
| WO2019103906A1 (fr) | 2017-11-21 | 2019-05-31 | Forsight Vision4, Inc. | Appareil d'échange de fluide pour système d'administration à port extensible et méthodes d'utilisation |
| US11689849B2 (en) | 2018-05-24 | 2023-06-27 | Nureva, Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| CN111971026A (zh) | 2018-05-24 | 2020-11-20 | 塞拉尼斯伊娃高性能聚合物公司 | 用于持续释放大分子药物化合物的可植入器件 |
| AU2019275409B2 (en) | 2018-05-24 | 2024-08-15 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
| US11779739B2 (en) * | 2018-12-21 | 2023-10-10 | Perfect Ip, Llc | Drug delivery system and method |
| AU2021215929A1 (en) | 2020-02-06 | 2022-08-04 | Ocular Therapeutix, Inc. | Compositions and methods for treating ocular diseases |
| WO2021195163A1 (fr) | 2020-03-25 | 2021-09-30 | Ocular Therapeutix, Inc. | Implant oculaire contenant un inhibiteur de tyrosine kinase |
| BR112023004378A2 (pt) | 2020-09-24 | 2023-04-04 | Ocular Therapeutix Inc | Insertos intracanaliculares biodegradáveis de liberação sustentada que compreendem um hidrogel e uma ciclosporina |
| US11357620B1 (en) | 2021-09-10 | 2022-06-14 | California LASIK & Eye, Inc. | Exchangeable optics and therapeutics |
| USD1033637S1 (en) | 2022-01-24 | 2024-07-02 | Forsight Vision4, Inc. | Fluid exchange device |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2961629A (en) * | 1957-02-12 | 1960-11-22 | Lawrence J Kamm | Electrical connector for flexible cable |
| US3416530A (en) * | 1966-03-02 | 1968-12-17 | Richard A. Ness | Eyeball medication dispensing tablet |
| US3896819A (en) * | 1969-04-01 | 1975-07-29 | Alejandro Zaffaroni | IUD having a replenishing drug reservoir |
| US3618604A (en) * | 1969-06-09 | 1971-11-09 | Alza Corp | Ocular insert |
| US3630200A (en) * | 1969-06-09 | 1971-12-28 | Alza Corp | Ocular insert |
| US3632739A (en) * | 1969-12-29 | 1972-01-04 | Sandoz Ag | Solid sustained release pharmaceutical preparation |
| US3980463A (en) * | 1970-11-16 | 1976-09-14 | Sumitomo Chemical Company, Limited | Process for producing granular composition for use in agriculture and horticulture |
| US3993071A (en) * | 1971-09-09 | 1976-11-23 | Alza Corporation | Bioerodible ocular device |
| US4036227A (en) * | 1973-04-25 | 1977-07-19 | Alza Corporation | Osmotic releasing device having a plurality of release rate patterns |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US3961628A (en) * | 1974-04-10 | 1976-06-08 | Alza Corporation | Ocular drug dispensing system |
| US4142526A (en) * | 1974-12-23 | 1979-03-06 | Alza Corporation | Osmotic releasing system with means for changing release therefrom |
| US4014335A (en) * | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
| US3977404A (en) * | 1975-09-08 | 1976-08-31 | Alza Corporation | Osmotic device having microporous reservoir |
| US4034758A (en) * | 1975-09-08 | 1977-07-12 | Alza Corporation | Osmotic therapeutic system for administering medicament |
| US4077407A (en) * | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
| US4014334A (en) * | 1976-02-02 | 1977-03-29 | Alza Corporation | Laminated osmotic system for dispensing beneficial agent |
| US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4247498A (en) * | 1976-08-30 | 1981-01-27 | Akzona Incorporated | Methods for making microporous products |
| US4111203A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system with means for improving delivery kinetics of system |
| US4111201A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for delivering selected beneficial agents having varying degrees of solubility |
| US4256108A (en) * | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4519909A (en) * | 1977-07-11 | 1985-05-28 | Akzona Incorporated | Microporous products |
| US4186184A (en) * | 1977-12-27 | 1980-01-29 | Alza Corporation | Selective administration of drug with ocular therapeutic system |
| JPS54119021A (en) * | 1978-03-06 | 1979-09-14 | Nippon Kayaku Co Ltd | Carcinostatic agent |
| US4290426A (en) * | 1978-05-04 | 1981-09-22 | Alza Corporation | Dispenser for dispensing beneficial agent |
| US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
| US4326525A (en) * | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| US4730013A (en) * | 1981-10-08 | 1988-03-08 | Merck & Co., Inc. | Biosoluble ocular insert |
| US4439196A (en) * | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| DK90883A (da) * | 1982-03-18 | 1983-09-19 | Merck & Co Inc | Beholder til osmotisk afgivelse af et stof eller en stofblanding |
| US4475916A (en) * | 1982-03-18 | 1984-10-09 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4432965A (en) * | 1982-07-09 | 1984-02-21 | Key Pharmaceuticals, Inc. | Quinidine sustained release dosage formulation |
| US4519801A (en) * | 1982-07-12 | 1985-05-28 | Alza Corporation | Osmotic device with wall comprising cellulose ether and permeability enhancer |
| US4522625A (en) * | 1982-09-29 | 1985-06-11 | Alza Corporation | Drug dispenser comprising wall formed of semipermeable member and enteric member |
| US4673405A (en) * | 1983-03-04 | 1987-06-16 | Alza Corporation | Osmotic system with instant drug availability |
| US4627850A (en) * | 1983-11-02 | 1986-12-09 | Alza Corporation | Osmotic capsule |
| JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4777049A (en) * | 1983-12-01 | 1988-10-11 | Alza Corporation | Constant release system with pulsed release |
| EP0147780A3 (fr) * | 1984-01-03 | 1987-03-11 | Merck & Co. Inc. | Dispositif pour la libération d'un médicament |
| IT1206166B (it) * | 1984-07-26 | 1989-04-14 | Sigma Tau Ind Farmaceuti | Dispositivo per rilasciare una sostanza in un fluido di dissoluzione con cinetica di ordine zero e procedimento per la sua preparazione |
| US4692336A (en) * | 1984-03-19 | 1987-09-08 | Alza Corporation | Self controlled release device for administering beneficial agent to recipient |
| US4716031A (en) * | 1984-03-21 | 1987-12-29 | Alza Corporation | Drug dispenser comprising a multiplicity of members acting together for successfully dispensing drug |
| US4615698A (en) * | 1984-03-23 | 1986-10-07 | Alza Corporation | Total agent osmotic delivery system |
| US4657543A (en) * | 1984-07-23 | 1987-04-14 | Massachusetts Institute Of Technology | Ultrasonically modulated polymeric devices for delivering compositions |
| US4927687A (en) * | 1984-10-01 | 1990-05-22 | Biotek, Inc. | Sustained release transdermal drug delivery composition |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US4913906B1 (en) * | 1985-02-28 | 2000-06-06 | Yissum Res Dev Co | Controlled release dosage form of valproic acid |
| US4693886A (en) * | 1985-04-22 | 1987-09-15 | Alza Corporation | Osmotic device with inert core |
| US4609374A (en) * | 1985-04-22 | 1986-09-02 | Alza Corporation | Osmotic device comprising means for governing initial time of agent release therefrom |
| US4624847A (en) * | 1985-04-22 | 1986-11-25 | Alza Corporation | Drug delivery device for programmed delivery of beneficial drug |
| US4720384A (en) * | 1985-05-03 | 1988-01-19 | E. I. Du Pont De Nemours And Company | Manufacture of hollow fine tubular drug delivery systems |
| US4898733A (en) * | 1985-11-04 | 1990-02-06 | International Minerals & Chemical Corp. | Layered, compression molded device for the sustained release of a beneficial agent |
| US4717567A (en) * | 1985-11-25 | 1988-01-05 | Eastman Kodak Company | Rumen-stable pellets |
| IT1188212B (it) * | 1985-12-20 | 1988-01-07 | Paolo Colombo | Sistema per il rilascio a velocita' controllata di sostanze attive |
| US5141752A (en) * | 1986-05-09 | 1992-08-25 | Alza Corporation | Delayed drug delivery device |
| US4832957A (en) * | 1987-12-11 | 1989-05-23 | Merck & Co., Inc. | Controlled release combination of carbidopa/levodopa |
| US4786500A (en) * | 1986-06-26 | 1988-11-22 | Alza Corporation | Programmable agent delivery system |
| JPH0794384B2 (ja) * | 1986-09-01 | 1995-10-11 | 帝国製薬株式会社 | 徐放性口腔内用製剤 |
| US4806382A (en) * | 1987-04-10 | 1989-02-21 | University Of Florida | Ocular implants and methods for their manufacture |
| US4861627A (en) * | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
| US4891223A (en) * | 1987-09-03 | 1990-01-02 | Air Products And Chemicals, Inc. | Controlled release delivery coating formulation for bioactive substances |
| US4994273A (en) * | 1987-11-02 | 1991-02-19 | Merck & Co., Inc. | Solubility modulated drug delivery device |
| IT1223150B (it) * | 1987-11-18 | 1990-09-12 | Ubaldo Conte | Compressa per uso oftalmico e rilascio controllato della sostanza attiva |
| US4877618A (en) * | 1988-03-18 | 1989-10-31 | Reed Jr Fred D | Transdermal drug delivery device |
| US4882150A (en) * | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US4865846A (en) * | 1988-06-03 | 1989-09-12 | Kaufman Herbert E | Drug delivery system |
| US5360611A (en) * | 1988-10-03 | 1994-11-01 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation |
| US5098443A (en) * | 1989-03-23 | 1992-03-24 | University Of Miami | Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents |
| US5028435A (en) * | 1989-05-22 | 1991-07-02 | Advanced Polymer Systems, Inc. | System and method for transdermal drug delivery |
| AU651084B2 (en) * | 1990-01-30 | 1994-07-14 | Akzo N.V. | Article for the controlled delivery of an active substance, comprising a hollow space fully enclosed by a wall and filled in full or in part with one or more active substances |
| US5091185A (en) * | 1990-06-20 | 1992-02-25 | Monsanto Company | Coated veterinary implants |
| US5525601A (en) * | 1990-09-07 | 1996-06-11 | Universidad De Alicante | Composition for treating ocular pain |
| IS3778A7 (is) * | 1990-10-31 | 1992-05-02 | Amgen Inc. | Aðferð til að gefa dýrum vaxtarhormón, þar sem gefnu magni er stýrt |
| US5378475A (en) * | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| US5435998A (en) * | 1994-08-03 | 1995-07-25 | Abelson; Mark B. | Treatment of low-tension glaucoma by topical administration of calcium channel blocking agents |
-
1997
- 1997-08-28 US US08/919,221 patent/US5902598A/en not_active Expired - Lifetime
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1998
- 1998-08-27 TW TW087114137A patent/TWI222884B/zh not_active IP Right Cessation
- 1998-08-28 ME MEP-2008-200A patent/ME00122B/me unknown
- 1998-08-28 BR BR9811381-0A patent/BR9811381A/pt not_active Application Discontinuation
- 1998-08-28 AR ARP980104323A patent/AR017026A1/es not_active Application Discontinuation
- 1998-08-28 WO PCT/US1998/017342 patent/WO1999011244A1/fr active Application Filing
- 1998-08-28 NZ NZ502836A patent/NZ502836A/xx unknown
- 1998-08-28 AT AT98942180T patent/ATE548029T1/de active
- 1998-08-28 KR KR1020007001996A patent/KR20010023358A/ko not_active Application Discontinuation
- 1998-08-28 AU AU90291/98A patent/AU741846B2/en not_active Ceased
- 1998-08-28 PL PL98344039A patent/PL344039A1/xx unknown
- 1998-08-28 EP EP98942180A patent/EP1009388B1/fr not_active Expired - Lifetime
- 1998-08-28 CN CNA2007101933400A patent/CN101327197A/zh active Pending
- 1998-08-28 RS YU11100A patent/RS52096B/sr unknown
- 1998-08-28 SG SG200203462A patent/SG121718A1/en unknown
- 1998-08-28 CA CA002301685A patent/CA2301685C/fr not_active Expired - Fee Related
- 1998-08-28 ME MEP-200/08A patent/MEP20008A/xx unknown
- 1998-08-28 IL IL13456898A patent/IL134568A/xx not_active IP Right Cessation
- 1998-08-28 CN CNB988103753A patent/CN100453074C/zh not_active Expired - Fee Related
- 1998-08-28 UA UA2000031729A patent/UA71898C2/uk unknown
- 1998-08-28 CZ CZ20000604A patent/CZ302339B6/cs not_active IP Right Cessation
- 1998-08-28 EA EA200000267A patent/EA002162B1/ru not_active IP Right Cessation
- 1998-08-28 JP JP2000508347A patent/JP4530531B2/ja not_active Expired - Fee Related
- 1998-08-28 HU HU0002797A patent/HUP0002797A3/hu unknown
- 1998-08-28 TR TR2000/01029T patent/TR200001029T2/xx unknown
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2000
- 2000-02-14 NO NO20000735A patent/NO327752B1/no not_active IP Right Cessation
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2001
- 2001-08-13 HK HK01105631.3A patent/HK1035135A1/xx not_active IP Right Cessation
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2002
- 2002-03-11 NZ NZ517736A patent/NZ517736A/en not_active IP Right Cessation
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2010
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