NO326015B1 - Anti-inflammatoriske 17.beta.-karbotioatesterderivater av androstan med en cyklisk estergruppe i posisjon 17.alfa og anvendelse og fremstilling derav, samt farmasoytisk sammensetning og aerosolformulering - Google Patents
Anti-inflammatoriske 17.beta.-karbotioatesterderivater av androstan med en cyklisk estergruppe i posisjon 17.alfa og anvendelse og fremstilling derav, samt farmasoytisk sammensetning og aerosolformulering Download PDFInfo
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- NO326015B1 NO326015B1 NO20034708A NO20034708A NO326015B1 NO 326015 B1 NO326015 B1 NO 326015B1 NO 20034708 A NO20034708 A NO 20034708A NO 20034708 A NO20034708 A NO 20034708A NO 326015 B1 NO326015 B1 NO 326015B1
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- Prior art keywords
- methyl
- hydroxy
- compound
- oxy
- oxo
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0110578A GB0110578D0 (en) | 2001-04-30 | 2001-04-30 | Novel compounds |
| GB0127988A GB0127988D0 (en) | 2001-11-22 | 2001-11-22 | Novel compounds |
| GB0202442A GB0202442D0 (en) | 2002-02-02 | 2002-02-02 | Novel compounds |
| GB0202637A GB0202637D0 (en) | 2002-02-05 | 2002-02-05 | Novel compounds |
| PCT/GB2002/001971 WO2002088167A1 (en) | 2001-04-30 | 2002-04-30 | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20034708D0 NO20034708D0 (no) | 2003-10-21 |
| NO20034708L NO20034708L (no) | 2003-12-22 |
| NO326015B1 true NO326015B1 (no) | 2008-09-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20034708A NO326015B1 (no) | 2001-04-30 | 2003-10-21 | Anti-inflammatoriske 17.beta.-karbotioatesterderivater av androstan med en cyklisk estergruppe i posisjon 17.alfa og anvendelse og fremstilling derav, samt farmasoytisk sammensetning og aerosolformulering |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7291608B2 (ja) |
| EP (2) | EP2039700A2 (ja) |
| JP (1) | JP4446661B2 (ja) |
| KR (1) | KR100831534B1 (ja) |
| CN (1) | CN1302007C (ja) |
| AR (1) | AR033290A1 (ja) |
| AT (1) | ATE411334T1 (ja) |
| AU (2) | AU2002253342B2 (ja) |
| BR (1) | BR0209271A (ja) |
| CA (1) | CA2445839A1 (ja) |
| CZ (1) | CZ20032958A3 (ja) |
| DE (1) | DE60229372D1 (ja) |
| DK (1) | DK1383786T3 (ja) |
| ES (1) | ES2314052T3 (ja) |
| HK (1) | HK1062020A1 (ja) |
| HU (1) | HUP0400070A2 (ja) |
| IL (1) | IL158222A0 (ja) |
| MX (1) | MXPA03009940A (ja) |
| MY (1) | MY137522A (ja) |
| NO (1) | NO326015B1 (ja) |
| NZ (1) | NZ528888A (ja) |
| PL (1) | PL366937A1 (ja) |
| PT (1) | PT1383786E (ja) |
| SI (1) | SI1383786T1 (ja) |
| WO (1) | WO2002088167A1 (ja) |
Families Citing this family (128)
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| AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| US6787532B2 (en) | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
| EP2039700A2 (en) * | 2001-04-30 | 2009-03-25 | Glaxo Group Limited | Novel anti-inflammatory androstane derivatives |
| WO2003048181A1 (en) * | 2001-12-01 | 2003-06-12 | Glaxo Group Limited | 17.alpha. -cyclic esters of 16-methylpregnan-3,20-dione as anti-inflammatory agents |
| WO2003072592A1 (en) * | 2002-01-15 | 2003-09-04 | Glaxo Group Limited | 17.alpha-cycloalkyl/cycloylkenyl esters of alkyl-or haloalkyl-androst-4-en-3-on-11.beta.,17.alpha.-diol 17.beta.-carboxylates as anti-inflammatory agents |
| GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| ME00489B (me) * | 2002-11-27 | 2011-10-10 | Astrazeneca Ab | NOVA SINERGIČKA KOMBINACIJA KOJA UKLJUČUJE ROFLUMILAST l FERMOTEROL |
| PL214869B1 (pl) * | 2002-11-27 | 2013-09-30 | Nycomed Gmbh | Synergistyczna kombinacja zawierajaca roflumilast i (R, R)-formoterol |
| TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| GB0316290D0 (en) * | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| EP1921919B1 (en) | 2005-07-14 | 2012-04-04 | Lithera, Inc. | Sustained release enhanced lipolytic formulation for regional adipose tissue treatment |
| EP1924553A1 (en) | 2005-08-08 | 2008-05-28 | Argenta Discovery Limited | Bicyclo[2.2.]hept-7-ylamine derivatives and their uses |
| GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
| TW200744612A (en) * | 2005-08-26 | 2007-12-16 | Astrazeneca Ab | New combination |
| AU2006303452B2 (en) | 2005-10-21 | 2011-06-09 | Novartis Ag | Human antibodies against IL13 and therapeutic uses |
| GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| US8178573B2 (en) | 2006-04-20 | 2012-05-15 | Glaxo Group Limited | Compounds |
| EP2322525B1 (en) | 2006-04-21 | 2013-09-18 | Novartis AG | Purine derivatives for use as adenosin A2A receptor agonists |
| GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
| BRPI0714463A2 (pt) | 2006-07-19 | 2013-04-02 | Astrazeneca Ab | compostos de espiropiperidina tricÍclicos, sua sÍntese e seus usos como moduladores de atividade receptora de quimiocina |
| AU2007302263A1 (en) | 2006-09-29 | 2008-04-03 | Novartis Ag | Pyrazolopyrimidines as P13K lipid kinase inhibitors |
| EP2077830B1 (en) * | 2006-10-17 | 2012-11-07 | Lithera, Inc. | Methods, compositions, and formulations for the treatment of thyroid eye disease |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| ES2385681T3 (es) | 2006-12-19 | 2012-07-30 | Astrazeneca Ab | Derivados de quinuclidinol como antagonistas de receptores muscarínicos |
| DE602007011670D1 (de) | 2007-01-10 | 2011-02-10 | Irm Llc | Verbindungen und zusammensetzungen als kanal-aktivierende proteasehemmer |
| CA2677485A1 (en) | 2007-02-09 | 2008-08-14 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| ES2361595T3 (es) | 2007-05-07 | 2011-06-20 | Novartis Ag | Compuestos orgánicos. |
| US8048980B2 (en) * | 2007-09-17 | 2011-11-01 | Bezwada Biomedical, Llc | Hydrolysable linkers and cross-linkers for absorbable polymers |
| JP2010540612A (ja) | 2007-10-04 | 2010-12-24 | アストラゼネカ・アクチエボラーグ | グルココルチコイド活性を有するステロイド［３，２−ｃ］ピラゾール化合物 |
| PL2444120T3 (pl) | 2007-12-10 | 2018-02-28 | Novartis Ag | Spirocyklicze analogi amiloridu jako blokery ENac |
| MX2010007604A (es) | 2008-01-11 | 2010-08-02 | Novartis Ag | Pirimidinas como inhibidores de cinasa. |
| US8268834B2 (en) | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
| US8329729B2 (en) | 2008-05-13 | 2012-12-11 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic M3 receptor antagonists |
| AU2009325091A1 (en) | 2008-05-23 | 2010-06-17 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein inhibitor |
| US8273774B2 (en) | 2008-05-27 | 2012-09-25 | Astrazeneca Ab | Phenoxypyridinylamide compounds |
| ES2566339T3 (es) | 2008-06-05 | 2016-04-12 | Glaxo Group Limited | Derivados de 4-carboxamida indazol útiles como inhibidores de PI3-quinasas |
| JP2011522860A (ja) | 2008-06-10 | 2011-08-04 | ノバルティス アーゲー | 上皮性ナトリウムチャネルブロッカーとしてのピラジン誘導体 |
| WO2010067102A1 (en) | 2008-12-09 | 2010-06-17 | Astrazeneca Ab | Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders |
| MX2011007036A (es) | 2008-12-30 | 2011-07-20 | Pulmagen Therapeutics Inflammation Ltd | Compuestos de sulfonamida para el tratamiento de trastornos respiratorios. |
| TW201031406A (en) | 2009-01-29 | 2010-09-01 | Novartis Ag | Substituted benzimidazoles for the treatment of astrocytomas |
| US8524751B2 (en) | 2009-03-09 | 2013-09-03 | GlaxoSmithKline Intellecutual Property Development | 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases |
| US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
| US20120058984A1 (en) | 2009-03-17 | 2012-03-08 | Catherine Mary Alder | Pyrimidine derivatives used as itk inhibitors |
| EP2408915A2 (en) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GATA BINDING PROTEIN 3 (GATA3) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20120035247A1 (en) | 2009-03-19 | 2012-02-09 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| CN102439151A (zh) | 2009-03-19 | 2012-05-02 | 默沙东公司 | 使用短干扰核酸（siNA）的RNA干扰介导的BTB和CNC同系物1，碱性亮氨酸拉链转录因子1（Bach1）基因表达的抑制 |
| EP2408916A2 (en) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| JP2012521762A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いた神経成長因子β鎖（ＮＧＦβ）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| JP2012521760A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いたアポトーシスシグナル調節キナーゼ１（ＡＳＫ１）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| KR20110138223A (ko) | 2009-03-27 | 2011-12-26 | 머크 샤프 앤드 돔 코포레이션 | 짧은 간섭 핵산 (ｓｉＮＡ)을 사용한 세포간 부착 분자 1 (ＩＣＡＭ-1) 유전자 발현의 ＲＮＡ 간섭 매개 억제 |
| US20120022143A1 (en) | 2009-03-27 | 2012-01-26 | Merck Sharp & Dohme Corp | RNA Interference Mediated Inhibition of the Thymic Stromal Lymphopoietin (TSLP) Gene Expression Using Short Interfering Nucliec Acid (siNA) |
| WO2010111471A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| UY32525A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| UY32520A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
| UY32523A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| UY32521A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Combinación para emplear en el tratamiento de enfermedades respiratorias |
| JP2012524754A (ja) | 2009-04-24 | 2012-10-18 | グラクソ グループ リミテッド | Ｃｒａｃチャネル阻害剤としてのピラゾールおよびトリアゾ−ルカルボキサミド |
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| DE10237739A1 (de) | 2002-08-17 | 2004-02-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalative Arzneimittel enthaltend ein neues Anticholinergikum in Kombination mit Corticosteroiden und Betamimetika |
| WO2004041793A1 (en) * | 2002-11-08 | 2004-05-21 | Warner-Lambert Company Llc | Phenylalkyl and pyridylalkyl piperazine derivatives |
| GB0526419D0 (en) | 2005-12-23 | 2006-02-08 | Cyclacel Ltd | Formulation |
-
2002
- 2002-04-30 EP EP08157256A patent/EP2039700A2/en not_active Withdrawn
- 2002-04-30 CZ CZ20032958A patent/CZ20032958A3/cs unknown
- 2002-04-30 EP EP02722463A patent/EP1383786B1/en not_active Expired - Lifetime
- 2002-04-30 KR KR1020037014199A patent/KR100831534B1/ko not_active IP Right Cessation
- 2002-04-30 JP JP2002585465A patent/JP4446661B2/ja not_active Expired - Fee Related
- 2002-04-30 NZ NZ528888A patent/NZ528888A/en unknown
- 2002-04-30 BR BR0209271-9A patent/BR0209271A/pt not_active IP Right Cessation
- 2002-04-30 SI SI200230765T patent/SI1383786T1/sl unknown
- 2002-04-30 ES ES02722463T patent/ES2314052T3/es not_active Expired - Lifetime
- 2002-04-30 CN CNB028112121A patent/CN1302007C/zh not_active Expired - Fee Related
- 2002-04-30 WO PCT/GB2002/001971 patent/WO2002088167A1/en active IP Right Grant
- 2002-04-30 DK DK02722463T patent/DK1383786T3/da active
- 2002-04-30 MY MYPI20021593A patent/MY137522A/en unknown
- 2002-04-30 IL IL15822202A patent/IL158222A0/xx unknown
- 2002-04-30 HU HU0400070A patent/HUP0400070A2/hu unknown
- 2002-04-30 AR ARP020101587A patent/AR033290A1/es unknown
- 2002-04-30 PT PT02722463T patent/PT1383786E/pt unknown
- 2002-04-30 AT AT02722463T patent/ATE411334T1/de not_active IP Right Cessation
- 2002-04-30 AU AU2002253342A patent/AU2002253342B2/en not_active Ceased
- 2002-04-30 US US10/478,893 patent/US7291608B2/en not_active Expired - Fee Related
- 2002-04-30 DE DE60229372T patent/DE60229372D1/de not_active Expired - Lifetime
- 2002-04-30 CA CA002445839A patent/CA2445839A1/en not_active Abandoned
- 2002-04-30 PL PL02366937A patent/PL366937A1/xx unknown
- 2002-04-30 MX MXPA03009940A patent/MXPA03009940A/es active IP Right Grant
-
2003
- 2003-10-21 NO NO20034708A patent/NO326015B1/no unknown
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2004
- 2004-07-13 HK HK04105110.0A patent/HK1062020A1/xx not_active IP Right Cessation
-
2007
- 2007-04-04 AU AU2007201491A patent/AU2007201491A1/en not_active Abandoned
- 2007-09-06 US US11/851,125 patent/US20070297989A1/en not_active Abandoned
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