NO326015B1 - Anti-inflammatoriske 17.beta.-karbotioatesterderivater av androstan med en cyklisk estergruppe i posisjon 17.alfa og anvendelse og fremstilling derav, samt farmasoytisk sammensetning og aerosolformulering - Google Patents
Anti-inflammatoriske 17.beta.-karbotioatesterderivater av androstan med en cyklisk estergruppe i posisjon 17.alfa og anvendelse og fremstilling derav, samt farmasoytisk sammensetning og aerosolformulering Download PDFInfo
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- NO326015B1 NO326015B1 NO20034708A NO20034708A NO326015B1 NO 326015 B1 NO326015 B1 NO 326015B1 NO 20034708 A NO20034708 A NO 20034708A NO 20034708 A NO20034708 A NO 20034708A NO 326015 B1 NO326015 B1 NO 326015B1
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- Prior art keywords
- methyl
- hydroxy
- compound
- oxy
- oxo
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P17/00—Drugs for dermatological disorders
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0110578A GB0110578D0 (en) | 2001-04-30 | 2001-04-30 | Novel compounds |
| GB0127988A GB0127988D0 (en) | 2001-11-22 | 2001-11-22 | Novel compounds |
| GB0202442A GB0202442D0 (en) | 2002-02-02 | 2002-02-02 | Novel compounds |
| GB0202637A GB0202637D0 (en) | 2002-02-05 | 2002-02-05 | Novel compounds |
| PCT/GB2002/001971 WO2002088167A1 (fr) | 2001-04-30 | 2002-04-30 | Derives anti-inflammatoires d'androstane 17.beta.-carbothioate ester avec un groupe cyclique en position 17.alpha |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20034708D0 NO20034708D0 (no) | 2003-10-21 |
| NO20034708L NO20034708L (no) | 2003-12-22 |
| NO326015B1 true NO326015B1 (no) | 2008-09-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20034708A NO326015B1 (no) | 2001-04-30 | 2003-10-21 | Anti-inflammatoriske 17.beta.-karbotioatesterderivater av androstan med en cyklisk estergruppe i posisjon 17.alfa og anvendelse og fremstilling derav, samt farmasoytisk sammensetning og aerosolformulering |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7291608B2 (fr) |
| EP (2) | EP1383786B1 (fr) |
| JP (1) | JP4446661B2 (fr) |
| KR (1) | KR100831534B1 (fr) |
| CN (1) | CN1302007C (fr) |
| AR (1) | AR033290A1 (fr) |
| AT (1) | ATE411334T1 (fr) |
| AU (2) | AU2002253342B2 (fr) |
| BR (1) | BR0209271A (fr) |
| CA (1) | CA2445839A1 (fr) |
| CZ (1) | CZ20032958A3 (fr) |
| DE (1) | DE60229372D1 (fr) |
| DK (1) | DK1383786T3 (fr) |
| ES (1) | ES2314052T3 (fr) |
| HK (1) | HK1062020A1 (fr) |
| HU (1) | HUP0400070A2 (fr) |
| IL (1) | IL158222A0 (fr) |
| MX (1) | MXPA03009940A (fr) |
| MY (1) | MY137522A (fr) |
| NO (1) | NO326015B1 (fr) |
| NZ (1) | NZ528888A (fr) |
| PL (1) | PL366937A1 (fr) |
| PT (1) | PT1383786E (fr) |
| SI (1) | SI1383786T1 (fr) |
| WO (1) | WO2002088167A1 (fr) |
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| AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| US6787532B2 (en) | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
| CN1302007C (zh) * | 2001-04-30 | 2007-02-28 | 葛兰素集团有限公司 | 具有抗炎性的在17.α位上具有环酯基的雄甾烷的17.β.－硫代羧酸酯衍生物 |
| AU2002356759A1 (en) * | 2001-12-01 | 2003-06-17 | Glaxo Group Limited | 17.alpha. -cyclic esters of 16-methylpregnan-3,20-dione as anti-inflammatory agents |
| AU2003202044A1 (en) * | 2002-01-15 | 2003-09-09 | Glaxo Group Limited | 17.alpha-cycloalkyl/cycloylkenyl esters of alkyl-or haloalkyl-androst-4-en-3-on-11.beta.,17.alpha.-diol 17.beta.-carboxylates as anti-inflammatory agents |
| GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| CN100346777C (zh) * | 2002-11-27 | 2007-11-07 | 奥坦纳医药公司 | 包括罗氟斯特和福莫特罗的新的协同组合 |
| JP2006508993A (ja) * | 2002-11-27 | 2006-03-16 | アルタナ ファルマ アクチエンゲゼルシャフト | ロフルミラスト及び（ｒ，ｒ）−ホルモテロールを含有する新規の相乗組合せ |
| AR044519A1 (es) | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| GB0316290D0 (en) * | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| ATE552032T1 (de) * | 2005-07-14 | 2012-04-15 | Lithera Inc | Verbesserte lipolytikum-formulierung mit hinhaltender wirkstofffreigabe für die arealbehandlung von fettgewebe |
| JP2009504624A (ja) | 2005-08-08 | 2009-02-05 | アージェンタ ディスカバリー リミテッド | ビシクロ［２．２．１］ヘプタ−７−イルアミン誘導体およびその使用 |
| GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
| TW200744612A (en) * | 2005-08-26 | 2007-12-16 | Astrazeneca Ab | New combination |
| KR20080049113A (ko) | 2005-10-21 | 2008-06-03 | 노파르티스 아게 | Ｉｌ-13에 대항한 인간 항체 및 치료적 용도 |
| GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| AR060536A1 (es) | 2006-04-20 | 2008-06-25 | Glaxo Group Ltd | Agonista del receptor de glucocorticoides y composiciones farmaceuticas |
| ES2440317T3 (es) | 2006-04-21 | 2014-01-28 | Novartis Ag | Derivados de purina para su uso como agonistas del receptor de adenosina A2A |
| GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
| MX2009000475A (es) | 2006-07-19 | 2009-07-10 | Astrazeneca Ab | Nuevos compuestos de espiropiperidina triciclicos, su sintesis y sus usos como moduladores de la actividad de los receptores de quimioquinas. |
| ATE502943T1 (de) | 2006-09-29 | 2011-04-15 | Novartis Ag | Pyrazolopyrimidine als pi3k-lipidkinasehemmer |
| AU2007313077B2 (en) * | 2006-10-17 | 2011-06-02 | Neothetics, Inc. | Methods, compositions, and formulations for the treatment of thyroid eye disease |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| ES2385681T3 (es) | 2006-12-19 | 2012-07-30 | Astrazeneca Ab | Derivados de quinuclidinol como antagonistas de receptores muscarínicos |
| MX2009007476A (es) | 2007-01-10 | 2009-07-22 | Irm Llc | Compuestos y composiciones como inhibidores de proteasa activadora de canal. |
| MX2009008493A (es) | 2007-02-09 | 2009-08-20 | Irm Llc | Compuestos y composiciones como inhibidores de la proteasa activadora de canal. |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| PE20090733A1 (es) | 2007-05-07 | 2009-07-17 | Novartis Ag | Derivados de pirazina como bloqueadores de los canales de sodio epitelial |
| US8048980B2 (en) * | 2007-09-17 | 2011-11-01 | Bezwada Biomedical, Llc | Hydrolysable linkers and cross-linkers for absorbable polymers |
| MX2010003698A (es) * | 2007-10-04 | 2010-04-21 | Astrazeneca Ab | Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide. |
| KR101578235B1 (ko) | 2007-12-10 | 2015-12-16 | 노파르티스 아게 | 유기 화합물 |
| WO2009087224A1 (fr) | 2008-01-11 | 2009-07-16 | Novartis Ag | Pyrimidines utilisés en tant qu'inhibiteurs de kinase |
| US8268834B2 (en) | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
| AU2008356409B2 (en) | 2008-05-13 | 2012-01-19 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic M3 receptor antagonists |
| US20110160249A1 (en) | 2008-05-23 | 2011-06-30 | Schaab Kevin Murray | 5-lipoxygenase-activating protein inhibitor |
| BRPI0912103A2 (pt) | 2008-05-27 | 2021-04-20 | Astrazeneca Ab | derivados de fenoxipiridinilamida e seu uso no tratamento de estados de doenças mediados por pde4 |
| EP2280946B1 (fr) | 2008-06-05 | 2016-02-10 | Glaxo Group Limited | Dérivés de 4-carboxamide indazole utiles en tant qu'inhibiteurs de p13 kinases |
| KR20110040818A (ko) | 2008-06-10 | 2011-04-20 | 노파르티스 아게 | 상피 나트륨 채널 차단제로서의 피라진 유도체 |
| WO2010067102A1 (fr) | 2008-12-09 | 2010-06-17 | Astrazeneca Ab | Dérivés de diazaspiro[5.5]undécane et composés associés utilisés comme antagonistes des récepteurs muscariniques et agonistes des récepteurs bêta adrénergiques dans le traitement des affections pulmonaires |
| ES2442343T3 (es) | 2008-12-30 | 2014-02-11 | Pulmagen Therapeutics (Inflammation) Limited | Compuestos de sulfonamida para el tratamiento de trastornos respiratorios |
| SI2391366T1 (sl) | 2009-01-29 | 2013-01-31 | Novartis Ag | Substituirani benzimidazoli za zdravljenje astrocitomov |
| WO2010102958A1 (fr) | 2009-03-09 | 2010-09-16 | Glaxo Group Limited | 4-oxadiazol-2-yl-indazoles en tant qu'inhibiteurs des p13 kinases |
| JP2012520257A (ja) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Ｉｋｋ２阻害剤としてのインドール誘導体 |
| WO2010106016A1 (fr) | 2009-03-17 | 2010-09-23 | Glaxo Group Limited | Dérivés de pyrimidine utilisés comme inhibiteurs de ltk |
| WO2010107952A2 (fr) | 2009-03-19 | 2010-09-23 | Merck Sharp & Dohme Corp. | Inhibition médiée par arn interférence de l'expression génique de facteur de croissance de tissu conjonctif (ctgf) en utilisant un acide nucléique interférant court (ansi) |
| EP2408458A1 (fr) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | INHIBITION INDUITE PAR ARN INTERFÉRENCE DE L'EXPRESSION DU GÈNE TRANSDUCTEUR DE SIGNAL ET ACTIVITATEUR DE TRANSCRIPTION 6 (STAT6) AU MOYEN D'UN ACIDE NUCLÉIQUE INTERFÉRENT COURT (ANsi) |
| US20120016010A1 (en) | 2009-03-19 | 2012-01-19 | Merck Sharp & Dohme Corp | RNA Interference Mediated Inhibition of BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| JP2012520685A (ja) | 2009-03-19 | 2012-09-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いたＧＡＴＡ結合タンパク質３（ＧＡＴＡ３）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| US20120022142A1 (en) | 2009-03-27 | 2012-01-26 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| US20120004281A1 (en) | 2009-03-27 | 2012-01-05 | Merck Sharp & Dohme Corp | RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| EP2411520A2 (fr) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | Inhibition à médiation par l'interférence arn de l'expression du gène de la lymphopoïétine stromale thymique (tslp) faisant appel à de courts acides nucléiques interférents (ansi) |
| EP2411516A1 (fr) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | Inhibition par interférence arn de l'expression du gène kinase 1 de régulation du signal d'apoptose (ask1) au moyen d'un acide nucléique interférent court (ansi) |
| EP2411517A2 (fr) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | Inhibition à médiation par l'interférence arn de l'expression du gène de la molécule d'adhésion intercellulaire 1 (icam-1) faisant appel à de courts acides nucléiques interférents (ansi) |
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| UA77656C2 (en) | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
| CN1302007C (zh) * | 2001-04-30 | 2007-02-28 | 葛兰素集团有限公司 | 具有抗炎性的在17.α位上具有环酯基的雄甾烷的17.β.－硫代羧酸酯衍生物 |
| US20030018019A1 (en) * | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| US6787593B2 (en) * | 2002-03-27 | 2004-09-07 | Lear Corporation | Sound-deadening composites of metallocene copolymers for use in vehicle applications |
| JP3691459B2 (ja) | 2002-06-14 | 2005-09-07 | 久光メディカル株式会社 | 粉末状吸入剤組成物 |
| US7244742B2 (en) * | 2002-08-17 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic |
| DE10237739A1 (de) | 2002-08-17 | 2004-02-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalative Arzneimittel enthaltend ein neues Anticholinergikum in Kombination mit Corticosteroiden und Betamimetika |
| JP2006508101A (ja) * | 2002-11-08 | 2006-03-09 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | フェニルアルキルおよびピリジルアルキルピペラジン誘導体 |
| GB0526419D0 (en) | 2005-12-23 | 2006-02-08 | Cyclacel Ltd | Formulation |
-
2002
- 2002-04-30 CN CNB028112121A patent/CN1302007C/zh not_active Expired - Fee Related
- 2002-04-30 DK DK02722463T patent/DK1383786T3/da active
- 2002-04-30 NZ NZ528888A patent/NZ528888A/en unknown
- 2002-04-30 ES ES02722463T patent/ES2314052T3/es not_active Expired - Lifetime
- 2002-04-30 HU HU0400070A patent/HUP0400070A2/hu unknown
- 2002-04-30 CZ CZ20032958A patent/CZ20032958A3/cs unknown
- 2002-04-30 EP EP02722463A patent/EP1383786B1/fr not_active Expired - Lifetime
- 2002-04-30 DE DE60229372T patent/DE60229372D1/de not_active Expired - Lifetime
- 2002-04-30 AT AT02722463T patent/ATE411334T1/de not_active IP Right Cessation
- 2002-04-30 SI SI200230765T patent/SI1383786T1/sl unknown
- 2002-04-30 JP JP2002585465A patent/JP4446661B2/ja not_active Expired - Fee Related
- 2002-04-30 WO PCT/GB2002/001971 patent/WO2002088167A1/fr active IP Right Grant
- 2002-04-30 AR ARP020101587A patent/AR033290A1/es unknown
- 2002-04-30 US US10/478,893 patent/US7291608B2/en not_active Expired - Fee Related
- 2002-04-30 KR KR1020037014199A patent/KR100831534B1/ko not_active IP Right Cessation
- 2002-04-30 MX MXPA03009940A patent/MXPA03009940A/es active IP Right Grant
- 2002-04-30 PL PL02366937A patent/PL366937A1/xx unknown
- 2002-04-30 IL IL15822202A patent/IL158222A0/xx unknown
- 2002-04-30 PT PT02722463T patent/PT1383786E/pt unknown
- 2002-04-30 CA CA002445839A patent/CA2445839A1/fr not_active Abandoned
- 2002-04-30 EP EP08157256A patent/EP2039700A2/fr not_active Withdrawn
- 2002-04-30 BR BR0209271-9A patent/BR0209271A/pt not_active IP Right Cessation
- 2002-04-30 AU AU2002253342A patent/AU2002253342B2/en not_active Ceased
- 2002-04-30 MY MYPI20021593A patent/MY137522A/en unknown
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2003
- 2003-10-21 NO NO20034708A patent/NO326015B1/no unknown
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2004
- 2004-07-13 HK HK04105110.0A patent/HK1062020A1/xx not_active IP Right Cessation
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2007
- 2007-04-04 AU AU2007201491A patent/AU2007201491A1/en not_active Abandoned
- 2007-09-06 US US11/851,125 patent/US20070297989A1/en not_active Abandoned
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