NO324251B1 - <Beta>-karbolinderivater, farmasoytisk preparat inneholdende samme, fremgangsmate for fremstilling av farmasoytisk preparat ved anvendelse av beta-karbolinderivater for fremstilling av medikament - Google Patents

<Beta>-karbolinderivater, farmasoytisk preparat inneholdende samme, fremgangsmate for fremstilling av farmasoytisk preparat ved anvendelse av beta-karbolinderivater for fremstilling av medikament

Info

Publication number
NO324251B1
NO324251B1 NO20025527A NO20025527A NO324251B1 NO 324251 B1 NO324251 B1 NO 324251B1 NO 20025527 A NO20025527 A NO 20025527A NO 20025527 A NO20025527 A NO 20025527A NO 324251 B1 NO324251 B1 NO 324251B1
Authority
NO
Norway
Prior art keywords
preparation
beta
carboline derivatives
pharmaceutical preparation
drugs
Prior art date
Application number
NO20025527A
Other languages
English (en)
Norwegian (no)
Other versions
NO20025527D0 (no
NO20025527L (no
Inventor
Mark J Macielag
Zhihua Sui
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of NO20025527D0 publication Critical patent/NO20025527D0/no
Publication of NO20025527L publication Critical patent/NO20025527L/no
Publication of NO324251B1 publication Critical patent/NO324251B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO20025527A 2000-05-17 2002-11-18 <Beta>-karbolinderivater, farmasoytisk preparat inneholdende samme, fremgangsmate for fremstilling av farmasoytisk preparat ved anvendelse av beta-karbolinderivater for fremstilling av medikament NO324251B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20466700P 2000-05-17 2000-05-17
PCT/US2001/014357 WO2001087038A2 (en) 2000-05-17 2001-05-03 β-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE

Publications (3)

Publication Number Publication Date
NO20025527D0 NO20025527D0 (no) 2002-11-18
NO20025527L NO20025527L (no) 2003-01-16
NO324251B1 true NO324251B1 (no) 2007-09-17

Family

ID=22758909

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20025527A NO324251B1 (no) 2000-05-17 2002-11-18 <Beta>-karbolinderivater, farmasoytisk preparat inneholdende samme, fremgangsmate for fremstilling av farmasoytisk preparat ved anvendelse av beta-karbolinderivater for fremstilling av medikament

Country Status (32)

Country Link
US (2) US6492358B2 (pl)
EP (1) EP1289985B1 (pl)
JP (1) JP5014551B2 (pl)
KR (1) KR20030031482A (pl)
CN (1) CN1255403C (pl)
AR (1) AR028576A1 (pl)
AT (1) ATE256127T1 (pl)
AU (2) AU6116701A (pl)
BG (1) BG66141B1 (pl)
CA (1) CA2409715C (pl)
CZ (1) CZ20023934A3 (pl)
DE (1) DE60101479T2 (pl)
DK (1) DK1289985T3 (pl)
ES (1) ES2211806T3 (pl)
GE (1) GEP20053511B (pl)
HK (1) HK1051368A1 (pl)
HR (1) HRP20020910B1 (pl)
HU (1) HUP0302412A3 (pl)
IL (2) IL152873A0 (pl)
MX (1) MXPA02011426A (pl)
MY (1) MY128479A (pl)
NO (1) NO324251B1 (pl)
NZ (1) NZ522731A (pl)
PL (1) PL205507B1 (pl)
PT (1) PT1289985E (pl)
RU (1) RU2271358C2 (pl)
SK (1) SK16972002A3 (pl)
TR (1) TR200302309T4 (pl)
TW (1) TWI286553B (pl)
UA (1) UA74826C2 (pl)
WO (1) WO2001087038A2 (pl)
ZA (1) ZA200210111B (pl)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2241902T3 (es) * 2000-12-08 2005-11-01 Smithkline Beecham Corporation Compuestos antibacterianos.
US6900220B2 (en) * 2001-01-02 2005-05-31 Syntex (U.S.A.) Llc Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
US7122554B2 (en) * 2001-02-12 2006-10-17 Lilly Icos Llc. Carboline derivatives
MXPA03007140A (es) * 2001-02-12 2004-05-24 Lilly Icos Llc Derivados de carbolina.
DE60216745T2 (de) * 2001-04-25 2007-05-16 Lilly Icos Llc, Wilmington Chemische Verbindungen
EP1401835A1 (en) 2001-06-05 2004-03-31 Lilly Icos LLC Carboline derivatives as pde-5 inhibitors
ES2269679T3 (es) 2001-06-21 2007-04-01 Lilly Icos Llc Derivados de carbolina como inhibidores de pdev.
US6686349B2 (en) 2001-11-14 2004-02-03 Ortho-Mcneil Pharmaceutical, Inc. Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors
MXPA04007639A (es) * 2002-02-07 2005-07-13 Gtx Inc Tratamiento de hiperplasia benigna de la prostata con un modulador de receptor de androgeno selectivo (sarm).
DE60317684T4 (de) * 2002-06-19 2011-06-22 Janssen Pharmaceutica N.V., 2340 SUBSTITUIERTE 2,4-DIHYDROPYRROLOc3,4BÜCHINOLIN-9-ONDERIVATE, DIE SICH ALS PHOSPHODIESTERASEINHIBITOREN EIGNEN
JP4671123B2 (ja) * 2003-06-23 2011-04-13 小野薬品工業株式会社 新規三環性複素環化合物
JP2007518822A (ja) 2004-01-23 2007-07-12 カイロン コーポレイション 抗癌剤としてのテトラヒドロカルボリン化合物
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
SG151267A1 (en) * 2004-03-15 2009-04-30 Ptc Therapeutics Inc Carboline derivatives useful in the inhibition of angiogenesis
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
EP1829874B1 (en) * 2004-12-22 2014-02-12 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
GB2422828A (en) * 2005-02-03 2006-08-09 Hunter Fleming Ltd Tricyclic cytoprotective compounds comprising an indole residue
WO2007016361A2 (en) * 2005-07-29 2007-02-08 Concert Pharmaceuticals Inc. Novel pharmaceutical compounds
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
KR20090064418A (ko) * 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2178537A4 (en) * 2007-07-19 2011-08-17 Merck Sharp & Dohme BETA-CARBOLIN DERIVATIVES AS ANTIDIBLE COMPOUNDS
WO2009073534A2 (en) 2007-11-30 2009-06-11 Maxthera Inc. Bicyclic ppat inhibitors as antibacterial agents
EP2240481A1 (en) 2008-01-11 2010-10-20 Albany Molecular Research, Inc. (1-azinone) -substituted pyridoindoles as mch antagonists
CN102083830B (zh) 2008-03-24 2014-11-12 梅迪维新技术公司 吡啶并[3,4-b]吲哚和应用方法
MD4009C2 (ro) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20120135089A1 (en) * 2009-03-17 2012-05-31 Stockwell Brent R E3 ligase inhibitors
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003005A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
CA2775129A1 (en) * 2009-09-23 2011-03-31 Medivation Technologies, Inc. Pyrido[3,4-b]indoles and methods of use
RU2572818C2 (ru) 2010-07-06 2016-01-20 Оно Фармасьютикал Ко., Лтд. Производное тетрагидрокарболина
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
EP2687531B1 (en) 2011-03-18 2016-07-13 ONO Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107216327A (zh) * 2017-06-27 2017-09-29 山东大学 5型磷酸二酯酶抑制剂及其制备方法和用途
US20220402914A1 (en) * 2019-09-03 2022-12-22 The Regents Of The University Of Colorado, A Body Corporate Tryptoline-Based Benzothiazoles and their use as Antibiotics and Antibiotic Resistance-Modifying Agents
EP4011877A3 (en) * 2020-12-11 2023-01-11 Institut de Cardiologie de Montréal Method of treating elevated plasma cholesterol
EP4267578A1 (en) 2020-12-23 2023-11-01 Recurium IP Holdings, LLC Estrogen receptor modulators

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1055203A (en) 1964-09-16 1967-01-18 Ici Ltd -ß-carboline derivatives, a process for their manufacture, and compositions containing them
US4228168A (en) 1978-11-22 1980-10-14 Tanabe Seiyaku Co., Ltd. Azepino [1,2,3-lm]-β-carboline compounds and pharmaceutical composition thereof
NZ194747A (en) 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
WO1988002751A1 (en) 1986-10-13 1988-04-21 Asahi Kasei Kogyo Kabushiki Kaisha Pyridine derivatives
CS262100B1 (cs) * 1987-07-17 1989-02-10 Protiva Miroslav 1-substituované 2- [ (4-methyl-l-piperazinyl)acetyl ] -2,3,4,9- -tetrahydro-lH-pyrido( 3,4-b)indoly a jejich hydrochloridy
ATE136032T1 (de) 1987-07-20 1996-04-15 Duphar Int Res 8,9-anellierte 1,2,3,4-tetrahydro-beta-carbolin- derivate
FR2619112B1 (fr) * 1987-08-07 1989-11-17 Synthelabo Derives de (piperidinyl-4)methyl-2 benzo(b)furo(2,3-c) pyridines, leur preparation et leur application en therapeutique
US4971974A (en) 1988-06-16 1990-11-20 Neurex Corporation Benzothiophenes as appetite suppressants
WO1990001483A1 (en) 1988-08-11 1990-02-22 Asahi Kasei Kogyo Kabushiki Kaisha Tetrahydropyridine derivatives
US5250534A (en) * 1990-06-20 1993-10-05 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
FR2663935A1 (fr) 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
GB9301192D0 (en) 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
GB9401090D0 (en) 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
US5403851A (en) 1994-04-05 1995-04-04 Interneuron Pharmaceuticals, Inc. Substituted tryptamines, phenalkylamines and related compounds
ATE247114T1 (de) * 1994-09-12 2003-08-15 Lilly Co Eli Serotonergische modulatoren
FR2724384B1 (fr) 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament
DE4436190A1 (de) 1994-10-10 1996-04-11 Gerhard Prof Dr Bringmann Halogenierte ß-Carbolin-Derivate, Verfahren zu ihrer Herstellung und Verwendung dieser Substanzen zur Hemmung der Atmungskette
DE4436509A1 (de) 1994-10-13 1996-04-18 Hoechst Schering Agrevo Gmbh Substituierte Spiroalkylamino- und alkoxy-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
GB9423911D0 (en) 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
GB9423910D0 (en) 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
US5968910A (en) * 1994-11-30 1999-10-19 Jan M. R. Balzarini Compositions containing two or three inhibitors of different HIV reverse transcriptases
GB9514464D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
FR2748026B1 (fr) 1996-04-26 1998-06-05 Adir Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SK154498A3 (en) 1996-05-10 2000-01-18 Icos Corp Carboline derivatives, process for the preparation thereof, pharmaceutical compositions containing same and use of mentioned derivatives as drugs
ATE236156T1 (de) 1996-05-31 2003-04-15 Mochida Pharm Co Ltd Pyridocarbazol derivate die einen cgmp-pde inhibilierenden effekt haben
EP0973778A1 (en) 1997-03-07 2000-01-26 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO 3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
US6043252A (en) 1997-05-05 2000-03-28 Icos Corporation Carboline derivatives
WO2000002878A1 (en) 1998-07-11 2000-01-20 University Of Bristol Compounds having activity at imidazoline receptors
FR2796644B1 (fr) * 1999-07-23 2001-09-07 Adir Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ATE256127T1 (de) 2003-12-15
HUP0302412A3 (en) 2007-02-28
CN1255403C (zh) 2006-05-10
ES2211806T3 (es) 2004-07-16
CZ20023934A3 (cs) 2003-10-15
PL205507B1 (pl) 2010-04-30
EP1289985B1 (en) 2003-12-10
HK1051368A1 (en) 2003-08-01
WO2001087038A2 (en) 2001-11-22
AU2001261167B2 (en) 2006-10-05
PT1289985E (pt) 2004-03-31
US20020010189A1 (en) 2002-01-24
KR20030031482A (ko) 2003-04-21
PL365445A1 (pl) 2005-01-10
GEP20053511B (en) 2005-05-10
BG66141B1 (bg) 2011-07-29
CN1446217A (zh) 2003-10-01
NZ522731A (en) 2004-09-24
NO20025527D0 (no) 2002-11-18
SK16972002A3 (sk) 2003-11-04
MXPA02011426A (es) 2004-09-06
IL152873A (en) 2012-01-31
BG107285A (bg) 2003-07-31
TR200302309T4 (tr) 2004-02-23
IL152873A0 (en) 2003-06-24
CA2409715C (en) 2010-09-14
DK1289985T3 (da) 2004-04-05
UA74826C2 (en) 2006-02-15
JP5014551B2 (ja) 2012-08-29
DE60101479T2 (de) 2005-04-28
TWI286553B (en) 2007-09-11
NO20025527L (no) 2003-01-16
AU6116701A (en) 2001-11-26
HRP20020910A2 (en) 2004-12-31
MY128479A (en) 2007-02-28
HUP0302412A2 (hu) 2003-11-28
US20030166641A1 (en) 2003-09-04
JP2003533453A (ja) 2003-11-11
DE60101479D1 (en) 2004-01-22
EP1289985A2 (en) 2003-03-12
CA2409715A1 (en) 2001-11-22
US6864253B2 (en) 2005-03-08
US6492358B2 (en) 2002-12-10
WO2001087038A3 (en) 2002-05-16
HRP20020910B1 (en) 2011-02-28
AR028576A1 (es) 2003-05-14
RU2271358C2 (ru) 2006-03-10
ZA200210111B (en) 2004-03-12

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