NO322475B1 - Tricykliske inhibitorer av poly(ADP-ribose)-polymeraser, anvendelser derav, samt et farmasoytisk materiale fremstilt derfra. - Google Patents

Tricykliske inhibitorer av poly(ADP-ribose)-polymeraser, anvendelser derav, samt et farmasoytisk materiale fremstilt derfra. Download PDF

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Publication number
NO322475B1
NO322475B1 NO20020421A NO20020421A NO322475B1 NO 322475 B1 NO322475 B1 NO 322475B1 NO 20020421 A NO20020421 A NO 20020421A NO 20020421 A NO20020421 A NO 20020421A NO 322475 B1 NO322475 B1 NO 322475B1
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NO
Norway
Prior art keywords
ring structure
fused ring
aromatic
alkyl
monocyclic
Prior art date
Application number
NO20020421A
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English (en)
Norwegian (no)
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NO20020421D0 (no
NO20020421L (no
Inventor
Stephen Evan Webber
Jayashree Girish Tikhe
Donald James Skalitzky
Robert Arnold Kumpf
Joseph Timothy Marakovits
Brian Walter Eastman
Original Assignee
Agouron Pharma
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Agouron Pharma, Cancer Rec Tech Ltd filed Critical Agouron Pharma
Publication of NO20020421D0 publication Critical patent/NO20020421D0/no
Publication of NO20020421L publication Critical patent/NO20020421L/no
Publication of NO322475B1 publication Critical patent/NO322475B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20020421A 1999-08-31 2002-01-28 Tricykliske inhibitorer av poly(ADP-ribose)-polymeraser, anvendelser derav, samt et farmasoytisk materiale fremstilt derfra. NO322475B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15214299P 1999-08-31 1999-08-31
PCT/US2000/023882 WO2001016136A2 (en) 1999-08-31 2000-08-31 Tricyclic inhibitors of poly(adp-ribose) polymerases

Publications (3)

Publication Number Publication Date
NO20020421D0 NO20020421D0 (no) 2002-01-28
NO20020421L NO20020421L (no) 2002-04-25
NO322475B1 true NO322475B1 (no) 2006-10-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020421A NO322475B1 (no) 1999-08-31 2002-01-28 Tricykliske inhibitorer av poly(ADP-ribose)-polymeraser, anvendelser derav, samt et farmasoytisk materiale fremstilt derfra.

Country Status (48)

Country Link
US (1) US6548494B1 (https=)
EP (1) EP1208104B1 (https=)
JP (1) JP4272375B2 (https=)
KR (1) KR20020038742A (https=)
CN (1) CN1384835A (https=)
AP (1) AP1553A (https=)
AR (1) AR035162A1 (https=)
AT (1) ATE287406T1 (https=)
AU (1) AU781826B2 (https=)
BG (1) BG106562A (https=)
BR (1) BR0015051A (https=)
CA (1) CA2382404C (https=)
CO (1) CO5200769A1 (https=)
CR (1) CR6577A (https=)
CZ (1) CZ2002613A3 (https=)
DE (1) DE60017575T2 (https=)
DK (1) DK1208104T3 (https=)
DO (1) DOP2000000069A (https=)
DZ (1) DZ3216A1 (https=)
EA (1) EA200200306A1 (https=)
EC (1) ECSP003637A (https=)
EE (1) EE200200100A (https=)
ES (1) ES2234657T3 (https=)
GE (1) GEP20043268B (https=)
GT (1) GT200000145A (https=)
HK (1) HK1045509B (https=)
HR (1) HRP20020271A2 (https=)
HU (1) HUP0202703A3 (https=)
IL (1) IL147863A0 (https=)
IS (1) IS6289A (https=)
MA (1) MA25876A1 (https=)
MX (1) MXPA02002138A (https=)
MY (1) MY135910A (https=)
NO (1) NO322475B1 (https=)
NZ (1) NZ516793A (https=)
OA (1) OA12016A (https=)
PA (1) PA8501801A1 (https=)
PE (1) PE20010538A1 (https=)
PL (1) PL354242A1 (https=)
PT (1) PT1208104E (https=)
SI (1) SI1208104T1 (https=)
SK (1) SK2592002A3 (https=)
SV (1) SV2003000162A (https=)
UA (1) UA73144C2 (https=)
UY (1) UY26323A1 (https=)
WO (1) WO2001016136A2 (https=)
YU (1) YU15102A (https=)
ZA (1) ZA200200830B (https=)

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CA2332279A1 (en) 1998-05-15 1999-11-25 Jia-He Li Carboxamide compounds, compositions, and methods for inhibiting parp activity

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