NO321748B1 - Tokammers-patron for forstover - Google Patents
Tokammers-patron for forstover Download PDFInfo
- Publication number
- NO321748B1 NO321748B1 NO20011830A NO20011830A NO321748B1 NO 321748 B1 NO321748 B1 NO 321748B1 NO 20011830 A NO20011830 A NO 20011830A NO 20011830 A NO20011830 A NO 20011830A NO 321748 B1 NO321748 B1 NO 321748B1
- Authority
- NO
- Norway
- Prior art keywords
- chamber
- piston
- stated
- container
- opening
- Prior art date
Links
- 239000013543 active substance Substances 0.000 claims description 103
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 76
- 239000000203 mixture Substances 0.000 claims description 57
- 239000012141 concentrate Substances 0.000 claims description 47
- 239000002904 solvent Substances 0.000 claims description 47
- 239000000243 solution Substances 0.000 claims description 38
- 239000000725 suspension Substances 0.000 claims description 30
- 239000007788 liquid Substances 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims description 17
- 229960002848 formoterol Drugs 0.000 claims description 17
- 238000007789 sealing Methods 0.000 claims description 17
- 239000003814 drug Substances 0.000 claims description 15
- -1 sorbitan ester Chemical class 0.000 claims description 15
- 239000000126 substance Substances 0.000 claims description 15
- 229940079593 drug Drugs 0.000 claims description 14
- 238000003860 storage Methods 0.000 claims description 14
- 239000000443 aerosol Substances 0.000 claims description 11
- 239000011888 foil Substances 0.000 claims description 10
- 239000012266 salt solution Substances 0.000 claims description 10
- 238000005192 partition Methods 0.000 claims description 8
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 7
- 239000008139 complexing agent Substances 0.000 claims description 7
- 229960000257 tiotropium bromide Drugs 0.000 claims description 7
- 239000003755 preservative agent Substances 0.000 claims description 6
- 150000003431 steroids Chemical class 0.000 claims description 6
- 239000012928 buffer substance Substances 0.000 claims description 5
- 239000000808 adrenergic beta-agonist Substances 0.000 claims description 4
- 230000003266 anti-allergic effect Effects 0.000 claims description 4
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 230000003454 betamimetic effect Effects 0.000 claims description 4
- 239000000812 cholinergic antagonist Substances 0.000 claims description 4
- 238000002664 inhalation therapy Methods 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 239000005642 Oleic acid Substances 0.000 claims description 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000004147 Sorbitan trioleate Substances 0.000 claims description 3
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 3
- 239000000043 antiallergic agent Substances 0.000 claims description 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 3
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 235000019337 sorbitan trioleate Nutrition 0.000 claims description 3
- 229960000391 sorbitan trioleate Drugs 0.000 claims description 3
- 229940110309 tiotropium Drugs 0.000 claims description 3
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 2
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 2
- 239000013583 drug formulation Substances 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
- 235000010445 lecithin Nutrition 0.000 claims description 2
- 229940067606 lecithin Drugs 0.000 claims description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 2
- 229960002052 salbutamol Drugs 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 241001631457 Cannula Species 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 39
- 238000002360 preparation method Methods 0.000 description 34
- 239000003085 diluting agent Substances 0.000 description 17
- 239000000375 suspending agent Substances 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 239000000654 additive Substances 0.000 description 8
- 230000008901 benefit Effects 0.000 description 8
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 7
- 239000007789 gas Substances 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 239000006199 nebulizer Substances 0.000 description 6
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- 239000000825 pharmaceutical preparation Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000003380 propellant Substances 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 229960000686 benzalkonium chloride Drugs 0.000 description 4
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 239000001530 fumaric acid Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 229940126601 medicinal product Drugs 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
- 235000015165 citric acid Nutrition 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 229960000676 flunisolide Drugs 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 238000005304 joining Methods 0.000 description 3
- 150000007522 mineralic acids Chemical class 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 3
- 239000011877 solvent mixture Substances 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 2
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 2
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 150000002334 glycols Chemical class 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000012669 liquid formulation Substances 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- 239000011976 maleic acid Substances 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 235000019260 propionic acid Nutrition 0.000 description 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 239000004546 suspension concentrate Substances 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 1
- ILPBINAXDRFYPL-UHFFFAOYSA-N 2-octene Chemical compound CCCCCC=CC ILPBINAXDRFYPL-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- YYMCYJLIYNNOMK-UHFFFAOYSA-N N-normethyltropine Natural products C1C(O)CC2CCC1N2 YYMCYJLIYNNOMK-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- UKXSKSHDVLQNKG-UHFFFAOYSA-N benzilic acid Chemical compound C=1C=CC=CC=1C(O)(C(=O)O)C1=CC=CC=C1 UKXSKSHDVLQNKG-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- DMLFJMQTNDSRFU-UHFFFAOYSA-N chlordiazepoxide hydrochloride Chemical compound Cl.O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 DMLFJMQTNDSRFU-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 229960000265 cromoglicic acid Drugs 0.000 description 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 229960003449 epinastine Drugs 0.000 description 1
- WHWZLSFABNNENI-UHFFFAOYSA-N epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229960001361 ipratropium bromide Drugs 0.000 description 1
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960004398 nedocromil Drugs 0.000 description 1
- RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229960001609 oxitropium bromide Drugs 0.000 description 1
- LCELQERNWLBPSY-KHSTUMNDSA-M oxitropium bromide Chemical compound [Br-].C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)CC)=CC=CC=C1 LCELQERNWLBPSY-KHSTUMNDSA-M 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Package Specialized In Special Use (AREA)
- Closures For Containers (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Chemical Vapour Deposition (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Catching Or Destruction (AREA)
- Nozzles (AREA)
- Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19847968A DE19847968A1 (de) | 1998-10-17 | 1998-10-17 | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
DE19847970A DE19847970A1 (de) | 1998-10-17 | 1998-10-17 | Lagerfähige Wirkstoff-Formulierung |
US11238098P | 1998-12-14 | 1998-12-14 | |
PCT/EP1999/007589 WO2000023037A1 (fr) | 1998-10-17 | 1999-10-09 | Cartouche a deux chambres pour atomiseur |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20011830D0 NO20011830D0 (no) | 2001-04-10 |
NO20011830L NO20011830L (no) | 2001-06-18 |
NO321748B1 true NO321748B1 (no) | 2006-06-26 |
Family
ID=26049593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20011830A NO321748B1 (no) | 1998-10-17 | 2001-04-10 | Tokammers-patron for forstover |
Country Status (36)
Country | Link |
---|---|
US (4) | US6481435B2 (fr) |
EP (2) | EP1119334B1 (fr) |
JP (1) | JP2002527205A (fr) |
CN (1) | CN1197541C (fr) |
AR (1) | AR020831A1 (fr) |
AT (1) | ATE231715T1 (fr) |
AU (1) | AU761858B2 (fr) |
BG (1) | BG64523B1 (fr) |
BR (1) | BR9914608A (fr) |
CA (1) | CA2345675C (fr) |
CO (2) | CO5271681A1 (fr) |
CZ (1) | CZ300606B6 (fr) |
DE (2) | DE19847968A1 (fr) |
DK (1) | DK1119334T3 (fr) |
EA (1) | EA002581B1 (fr) |
EE (1) | EE04514B1 (fr) |
EG (1) | EG23069A (fr) |
ES (1) | ES2187202T3 (fr) |
HK (1) | HK1040049B (fr) |
HR (1) | HRP20010273B1 (fr) |
HU (1) | HU224244B1 (fr) |
ID (1) | ID28440A (fr) |
MY (1) | MY121789A (fr) |
NO (1) | NO321748B1 (fr) |
NZ (1) | NZ511646A (fr) |
PE (1) | PE20001000A1 (fr) |
PL (1) | PL194220B1 (fr) |
PT (1) | PT1119334E (fr) |
RS (1) | RS49724B (fr) |
SA (1) | SA99200701B1 (fr) |
SI (1) | SI1119334T1 (fr) |
SK (1) | SK286632B6 (fr) |
TR (1) | TR200101095T2 (fr) |
TW (1) | TW466111B (fr) |
UA (1) | UA71933C2 (fr) |
WO (1) | WO2000023037A1 (fr) |
Families Citing this family (171)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5823179A (en) | 1996-02-13 | 1998-10-20 | 1263152 Ontario Inc. | Nebulizer apparatus and method |
DE19615422A1 (de) * | 1996-04-19 | 1997-11-20 | Boehringer Ingelheim Kg | Zweikammer-Kartusche für treibgasfreie Dosieraerosole |
US20030215396A1 (en) | 1999-09-15 | 2003-11-20 | Boehringer Ingelheim Pharma Kg | Method for the production of propellant gas-free aerosols from aqueous medicament preparations |
US7963955B2 (en) | 1998-02-27 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Container for a medicinal liquid |
DE19847968A1 (de) | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
GB9902689D0 (en) * | 1999-02-08 | 1999-03-31 | Novartis Ag | Organic compounds |
DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
US20040002548A1 (en) * | 1999-05-12 | 2004-01-01 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
US20100197719A1 (en) * | 1999-05-12 | 2010-08-05 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
CA2826724C (fr) | 2000-04-11 | 2016-02-02 | Trudell Medical International | Appareil aerosol avec une capacite de pression expiratoire positive |
US20020035107A1 (en) * | 2000-06-20 | 2002-03-21 | Stefan Henke | Highly concentrated stable meloxicam solutions |
CN100396285C (zh) * | 2000-10-31 | 2008-06-25 | 贝林格尔英格海姆法玛两合公司 | 包含噻托铵盐溶液的可吸入制剂 |
US20020137764A1 (en) * | 2000-10-31 | 2002-09-26 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
AU2174102A (en) * | 2000-10-31 | 2002-05-15 | Boehringer Ingelheim Pharma | Inhalative solution formulation containing a tiotropium salt |
CA2441100C (fr) * | 2001-03-20 | 2013-05-21 | Trudell Medical International | Nebuliseur avec orifice ajustable pour l'emission d'un liquide aerololise |
ITMI20010741A1 (it) * | 2001-04-06 | 2002-10-06 | Tuttoespresso Spa | Metodo per l'apertura di contenitori sigillati per prodotti alimentari |
US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
US20030055026A1 (en) * | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
DE10161077A1 (de) * | 2001-12-12 | 2003-06-18 | Boehringer Ingelheim Vetmed | Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion |
US6994083B2 (en) | 2001-12-21 | 2006-02-07 | Trudell Medical International | Nebulizer apparatus and method |
US20030225089A1 (en) * | 2002-04-10 | 2003-12-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors |
US20040019073A1 (en) * | 2002-04-11 | 2004-01-29 | Boehringer Ingelheim Pharma Gmbh Co. Kg | Aerosol formulation for inhalation containing a tiotropium salt |
DE10216036A1 (de) * | 2002-04-11 | 2003-10-23 | Boehringer Ingelheim Pharma | Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz |
US20030205226A1 (en) | 2002-05-02 | 2003-11-06 | Pre Holding, Inc. | Aerosol medication inhalation system |
US6904908B2 (en) | 2002-05-21 | 2005-06-14 | Trudell Medical International | Visual indicator for an aerosol medication delivery apparatus and system |
WO2004004705A2 (fr) * | 2002-07-03 | 2004-01-15 | Shannon Biotechnology Ltd | Formulations pharmaceutiques |
DE60310730T2 (de) | 2002-07-09 | 2007-05-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege |
US20040058950A1 (en) * | 2002-07-09 | 2004-03-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
DE60309731T2 (de) * | 2002-08-21 | 2007-06-28 | Pharmacia Corp. | Injizierbare pharmazeutische suspension in einer phiole mit zwei kammern |
US8992980B2 (en) * | 2002-10-25 | 2015-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Water-soluble meloxicam granules |
TWI359675B (en) | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
US20050026948A1 (en) * | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a betamimetic |
AU2004262902B2 (en) | 2003-07-29 | 2009-07-30 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising betamimetics and an anticholinergic |
US7270123B2 (en) * | 2003-08-13 | 2007-09-18 | Trudell Medical International | Nebulizer apparatus and method |
US20050136118A1 (en) * | 2003-12-19 | 2005-06-23 | Wu Su-Syin S. | Distribution and preparation of germicidal compositions |
DE102004001451A1 (de) | 2004-01-08 | 2005-08-11 | Boehringer Ingelheim International Gmbh | Vorrichtung zum Haltern eines fluidischen Bauteiles |
EP1568369A1 (fr) * | 2004-02-23 | 2005-08-31 | Boehringer Ingelheim Vetmedica Gmbh | Utilisation du meloxicam pour le traitement de maladies respiratoires des porcs |
US7517568B2 (en) * | 2004-03-23 | 2009-04-14 | The Clorox Company | Packaging for dilute hypochlorite |
DE102004021281A1 (de) * | 2004-04-29 | 2005-11-24 | Boehringer Ingelheim Vetmedica Gmbh | Verwendung von Meloxicam-Formulierungen in der Veterinärmedizin |
ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
DE102004030409A1 (de) * | 2004-06-23 | 2006-01-26 | Boehringer Ingelheim Vetmedica Gmbh | Neue Verwendung von Meloxicam in der Veterinärmedizin |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
US20060210483A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections |
WO2006114379A1 (fr) * | 2005-04-23 | 2006-11-02 | Boehringer Ingelheim International Gmbh | Combinaison de medicaments a inhaler contenant un betamimetique et un steroide en plus d'un anticholinergique |
US20060239935A1 (en) * | 2005-04-23 | 2006-10-26 | Boehringer Ingelheim International Gmbh | Compositions for inhalation |
US9675109B2 (en) * | 2005-07-19 | 2017-06-13 | J. T. International Sa | Method and system for vaporization of a substance |
US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
DE102005035715A1 (de) | 2005-07-27 | 2007-02-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Überprüfung der Permeabilitätsrate eines geschlossenen Behälters |
DE102005038619A1 (de) | 2005-08-16 | 2007-02-22 | Pari GmbH Spezialisten für effektive Inhalation | Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments |
US20070045342A1 (en) * | 2005-08-29 | 2007-03-01 | Anthony Pigliacampo | Apparatus and methods for multi-fluid dispensing systems |
GB0518400D0 (en) * | 2005-09-09 | 2005-10-19 | Clinical Designs Ltd | Dispenser |
FR2890940B1 (fr) * | 2005-09-21 | 2007-10-26 | Fillon Investissement | Dispositif de remplissage en liquide de recipient aerosol, installation de remplissage apte a recevoir un tel dispositif et recipient aerosol equipe d'un tel dispositif de remplissage |
WO2007039417A1 (fr) * | 2005-09-30 | 2007-04-12 | Boehringer Ingelheim Vetmedica Gmbh | Préparation pharmaceutique qui contient du méloxicam |
DE102005057685A1 (de) * | 2005-12-01 | 2007-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator und Speicher für eine trockene Arzneimittelformulierung sowie diesbezügliche Verfahren und Verwendung |
AR058290A1 (es) * | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | Dispensador de medicamento |
TR201807714T4 (tr) * | 2006-02-10 | 2018-06-21 | Pari Pharma Gmbh | İnhalasyon tedavisine yönelik nebülize antibiyotikler. |
DE102006022002A1 (de) * | 2006-05-10 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Zerstäuber und Verfahren zur Zerstäubung von Fluid |
SE530232C2 (sv) * | 2006-08-11 | 2008-04-08 | Biomet Cementing Technologies | Vätskebehållare för bencementblandare |
SE530233C2 (sv) * | 2006-08-11 | 2008-04-08 | Biomet Cementing Technologies | Vätskebehållare för bencementblandare |
US20100095957A1 (en) * | 2007-03-02 | 2010-04-22 | Corbco, Inc. | Manually operated monodose nasal sprayer device |
US7789278B2 (en) * | 2007-04-12 | 2010-09-07 | The Clorox Company | Dual chamber aerosol container |
DE102007056462B4 (de) | 2007-11-23 | 2011-10-27 | Pari Pharma Gmbh | Einwegampulle für eine Vorrichtung zur Erzeugung von Aerosolen |
US8991402B2 (en) | 2007-12-18 | 2015-03-31 | Pax Labs, Inc. | Aerosol devices and methods for inhaling a substance and uses thereof |
EP2077132A1 (fr) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispositif distributeur, dispositif de stockage et procédé pour la distribution d'une formulation |
EP2100599A1 (fr) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques |
EP2100598A1 (fr) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques |
US20090261126A1 (en) * | 2008-04-17 | 2009-10-22 | Tai-Her Yang | Press-open type storage device with prestressed to open closure |
ES2905719T3 (es) | 2008-05-14 | 2022-04-11 | Biolyph Llc | Dispositivo de preparación y dispensación de mezclas de reactivos y métodos asociados |
WO2010112358A2 (fr) | 2009-03-31 | 2010-10-07 | Boehringer Ingelheim International Gmbh | Procédé de revêtement d'une surface d'un composant |
JP5763053B2 (ja) | 2009-05-18 | 2015-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アダプタ、吸入器具及びアトマイザ |
CN102647971B (zh) * | 2009-10-12 | 2016-03-16 | 贝林格尔.英格海姆维特梅迪卡有限公司 | 用于包含美洛昔康的组合物的容器 |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
EA026241B1 (ru) | 2009-11-25 | 2017-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Распылитель |
JP5658268B2 (ja) | 2009-11-25 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
WO2011107150A1 (fr) | 2010-03-03 | 2011-09-09 | Boehringer Ingelheim Vetmedica Gmbh | Utilisation de méloxicam pour le traitement à long terme de troubles musculo-squelettiques chez les chats |
US9795568B2 (en) | 2010-05-05 | 2017-10-24 | Boehringer Ingelheim Vetmedica Gmbh | Low concentration meloxicam tablets |
JP5874724B2 (ja) | 2010-06-24 | 2016-03-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
EP2588404B1 (fr) | 2010-06-29 | 2018-03-28 | Biolyph, Llc | Ensemble de préparation de réactif |
EP3147032B1 (fr) | 2010-11-18 | 2024-06-12 | Biolyph, Llc | Dispositif de préparation et de distribution de réactif |
WO2012130757A1 (fr) | 2011-04-01 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Appareil médical pourvu d'un récipient |
EP2510928A1 (fr) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium pour l'amélioration du sommeil des patients avec des maldadies respiratoires |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
GB201111250D0 (en) * | 2011-07-01 | 2011-08-17 | Univ Central Lancashire | Method of producing a nebuliser composition |
EA037480B1 (ru) | 2011-08-16 | 2021-04-01 | Джуул Лэбз, Инк. | Низкотемпературное электронное устройство испарения |
EP2626317A1 (fr) * | 2012-02-13 | 2013-08-14 | de Schrijver, Aster | Systèmes d'emballage sous pression pour des adhésifs mono-composants et produits d'étanchéité |
WO2013152894A1 (fr) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Pulvérisateur comprenant des moyens de détrompage |
US10517530B2 (en) | 2012-08-28 | 2019-12-31 | Juul Labs, Inc. | Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances |
US20140202895A1 (en) * | 2013-01-22 | 2014-07-24 | Brian G. Larson | Multi-chamber container for storing and mixing liquids |
US10279934B2 (en) | 2013-03-15 | 2019-05-07 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
CA3208137A1 (fr) | 2013-05-06 | 2014-11-13 | Juul Labs, Inc. | Formulations de sel de nicotine pour des dispositifs de generation d'aerosol et methodes connexes |
RU2677011C2 (ru) * | 2013-05-17 | 2019-01-14 | Конинклейке Филипс Н.В. | Модуль доставки вещества |
CN105473012B (zh) | 2013-06-14 | 2020-06-19 | 尤尔实验室有限公司 | 电子汽化设备中的具有单独的可汽化材料的多个加热元件 |
EP2835146B1 (fr) | 2013-08-09 | 2020-09-30 | Boehringer Ingelheim International GmbH | Atomiseur |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US20150102061A1 (en) * | 2013-10-11 | 2015-04-16 | Solutions Biomed, Llc | Multi-chamber container for storing and mixing liquids |
JP6581506B2 (ja) * | 2013-11-29 | 2019-09-25 | 株式会社ダイゾー | 内容物収容容器、それを用いた内容物収容製品、吐出製品および吐出装置 |
KR102665932B1 (ko) | 2013-12-05 | 2024-05-13 | 쥴 랩스, 인크. | 에어로졸 장치를 위한 니코틴 액제 및 그 방법 |
USD825102S1 (en) | 2016-07-28 | 2018-08-07 | Juul Labs, Inc. | Vaporizer device with cartridge |
US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
US9549573B2 (en) | 2013-12-23 | 2017-01-24 | Pax Labs, Inc. | Vaporization device systems and methods |
USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
CN110664012A (zh) | 2013-12-23 | 2020-01-10 | 尤尔实验室有限公司 | 蒸发装置系统和方法 |
US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
CA2928678A1 (fr) * | 2013-12-31 | 2015-07-09 | Philip Morris Products S.A. | Dispositif de production d'aerosol et capsule destinee a un dispositif de production d'aerosol |
US20180104197A9 (en) | 2014-05-01 | 2018-04-19 | Sun Pharmaceutical Industries Limited | Extended release liquid compositions of metformin |
WO2015166473A1 (fr) | 2014-05-01 | 2015-11-05 | Sun Pharmaceutical Industries Limited | Compositions en suspension à libération prolongée |
US10258583B2 (en) | 2014-05-01 | 2019-04-16 | Sun Pharmaceutical Industries Limited | Extended release liquid compositions of guanfacine |
US9962336B2 (en) | 2014-05-01 | 2018-05-08 | Sun Pharmaceutical Industries Limited | Extended release suspension compositions |
DK3139979T3 (da) | 2014-05-07 | 2023-10-09 | Boehringer Ingelheim Int | Enhed, forstøver og fremgangsmåde |
EP3139984B1 (fr) | 2014-05-07 | 2021-04-28 | Boehringer Ingelheim International GmbH | Nébuliseur |
NZ724449A (en) | 2014-05-07 | 2022-01-28 | Boehringer Ingelheim Int | Nebulizer and container |
US11478021B2 (en) | 2014-05-16 | 2022-10-25 | Juul Labs, Inc. | Systems and methods for aerosolizing a vaporizable material |
MX2017001332A (es) * | 2014-07-30 | 2017-08-02 | Sun Pharmaceutical Ind Ltd | Envase con camara.doble. |
KR102574658B1 (ko) | 2014-12-05 | 2023-09-05 | 쥴 랩스, 인크. | 교정된 투여량 제어 |
EP3288518A4 (fr) * | 2015-05-01 | 2018-12-12 | Sun Pharmaceutical Industries Limited | Emballage à deux chambres pour compositions de suspension à libération prolongée |
JP6754924B2 (ja) * | 2015-05-10 | 2020-09-16 | 義夫 大山 | 全方向への使用を可能にした二液を内包する使い捨てのアンプルユニット及びアンプルユニットの使用方法並びにアンプルユニットを用いた超音波振動式ミスト発生装置 |
MX2017016551A (es) | 2015-06-16 | 2018-05-11 | Boehringer Ingelheim Vetmedica Gmbh | Sistema de conexion y de recipiente. |
HRP20231259T1 (hr) | 2015-06-16 | 2024-02-02 | Boehringer Ingelheim Vetmedica Gmbh | Sustav spajanja i spremnika s nagnutom lomljivom linijom |
EA202192380A1 (ru) | 2015-06-16 | 2021-12-31 | Бёрингер Ингельхайм Ветмедика Гмбх | Система емкостей и способ приготовления смеси веществ |
USD858868S1 (en) | 2016-02-08 | 2019-09-03 | Juul Labs, Inc. | Vaporizer cartridge |
SG10202108578XA (en) | 2016-02-11 | 2021-09-29 | Juul Labs Inc | Securely attaching cartridges for vaporizer devices |
UA125687C2 (uk) | 2016-02-11 | 2022-05-18 | Джуул Лебз, Інк. | Заповнювальний картридж випарного пристрою та способи його заповнення |
US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
US10369078B2 (en) | 2016-05-02 | 2019-08-06 | Sun Pharmaceutical Industries Limited | Dual-chamber pack for pharmaceutical compositions |
US10238803B2 (en) | 2016-05-02 | 2019-03-26 | Sun Pharmaceutical Industries Limited | Drug delivery device for pharmaceutical compositions |
EP3454817A4 (fr) * | 2016-05-12 | 2020-02-19 | Nextteq LLC | Dispositif permettant de tester l'ajustement de masques à gaz |
WO2017199215A1 (fr) | 2016-05-19 | 2017-11-23 | Trudell Medical International | Chambre de retenue à valve intelligente |
USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
USD848057S1 (en) | 2016-06-23 | 2019-05-07 | Pax Labs, Inc. | Lid for a vaporizer |
USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
US10786638B2 (en) | 2016-07-08 | 2020-09-29 | Trudell Medical International | Nebulizer apparatus and method |
US10881818B2 (en) | 2016-07-08 | 2021-01-05 | Trudell Medical International | Smart oscillating positive expiratory pressure device |
WO2018036860A1 (fr) * | 2016-08-25 | 2018-03-01 | Carebay Europe Ltd. | Indicateur d'orientation pour un dispositif d'administration de médicament, un dispositif d'administration de médicament comprenant l'indicateur d'orientation, et dispositif d'entraînement pour un dispositif d'administration de médicament, lequel dispositif d'administration de médicament comprend l'indicateur d'orientation |
US11660403B2 (en) | 2016-09-22 | 2023-05-30 | Juul Labs, Inc. | Leak-resistant vaporizer device |
MX2019004366A (es) * | 2016-10-14 | 2019-08-05 | Glenmark Specialty Sa | Composiciones nebulizables de tiotropio y formoterol. |
US10736359B2 (en) | 2016-12-02 | 2020-08-11 | VMR Products, LLC | Cartridge-based vaporizers |
CA3036631A1 (fr) | 2016-12-09 | 2018-06-14 | Trudell Medical International | Nebuliseur intelligent |
KR102327122B1 (ko) | 2016-12-12 | 2021-11-16 | 브이엠알 프로덕츠 엘엘씨 | 기화기 카트리지 |
USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
GB2566983A (en) * | 2017-09-29 | 2019-04-03 | Epsilon Pharmaceuticals Ltd | Captopril liquid dosage form and delivery system |
US11702274B2 (en) | 2017-11-06 | 2023-07-18 | Op-Hygiene Ip Gmbh | Fluid storage reservoir |
CA2984761A1 (fr) * | 2017-11-06 | 2019-05-06 | Op-Hygiene Ip Gmbh | Reservoir de stockage de fluide |
EP3735287A4 (fr) | 2018-01-04 | 2021-09-15 | Trudell Medical International | Dispositif intelligent à pression expiratoire positive oscillante |
EP3563894B1 (fr) | 2018-05-04 | 2021-12-22 | Boehringer Ingelheim International GmbH | Nébuliseur et récipient |
CN112261931B (zh) | 2018-06-05 | 2023-12-08 | 宝洁公司 | 透明清洁组合物 |
US20210268213A1 (en) | 2018-06-15 | 2021-09-02 | Boehringer Ingelheim International Gmbh | System, cartridge and process |
FR3083721B1 (fr) * | 2018-07-12 | 2020-12-18 | Aptar France Sas | Dispositif de distribution de produit fluide et son procede de remplissage et de bouchage. |
CN108904960B (zh) * | 2018-07-20 | 2020-12-01 | 江苏泰德医药有限公司 | 一种呼吸科用高效给药装置 |
CN211794315U (zh) | 2018-07-23 | 2020-10-30 | 尤尔实验室有限公司 | 用于蒸发器装置的料盒 |
CN109264210B (zh) * | 2018-09-21 | 2019-09-13 | 江苏师范大学 | 即配式生物质护肤液包装瓶 |
CN113365518A (zh) | 2018-11-05 | 2021-09-07 | 尤尔实验室有限公司 | 用于蒸发器装置的料筒 |
US11838997B2 (en) | 2018-11-05 | 2023-12-05 | Juul Labs, Inc. | Cartridges for vaporizer devices |
WO2020094761A1 (fr) * | 2018-11-09 | 2020-05-14 | Softhale Nv | Réservoir pour dispositif d'inhalation |
JP7328336B2 (ja) | 2018-12-14 | 2023-08-16 | ザ プロクター アンド ギャンブル カンパニー | シート状マイクロカプセルを含むシャンプー組成物 |
US11896689B2 (en) | 2019-06-28 | 2024-02-13 | The Procter & Gamble Company | Method of making a clear personal care comprising microcapsules |
US20210030978A1 (en) * | 2019-07-29 | 2021-02-04 | Cai Gu Huang | Cartridge with single-layer container and its nozzle-shaped cap for nebulization inhalation |
AU2020338979A1 (en) | 2019-08-27 | 2022-03-17 | Trudell Medical International Inc. | Smart oscillating positive expiratory pressure device |
USD943160S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Vaporizer device |
USD943159S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Component for a vaporizer cartridge |
USD943158S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Vaporizer cartridge |
USD943161S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Vaporizer device |
JP7453395B2 (ja) * | 2020-02-14 | 2024-03-19 | ザ プロクター アンド ギャンブル カンパニー | 中に懸濁された審美的設計を有する液体組成物の保管に適合されたボトル |
BR112022019264A2 (pt) * | 2020-03-31 | 2022-11-08 | Softhale Nv | Sistema de disposição de inalação |
GB2586301B (en) | 2020-04-07 | 2021-08-25 | Splash Tm Gmbh | Stable-Foam inhalation Device and Cartridge |
US11633072B2 (en) | 2021-02-12 | 2023-04-25 | The Procter & Gamble Company | Multi-phase shampoo composition with an aesthetic design |
US12053130B2 (en) | 2021-02-12 | 2024-08-06 | The Procter & Gamble Company | Container containing a shampoo composition with an aesthetic design formed by bubbles |
CN118043017A (zh) * | 2021-09-30 | 2024-05-14 | 康宁公司 | 用于储存药品组合物的玻璃容器 |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US648435A (en) * | 1899-10-26 | 1900-05-01 | Charles B Rider | Sectional glass cup. |
US2362103A (en) * | 1941-01-04 | 1944-11-07 | Arthur E Smith | Ampoule |
US2793776A (en) * | 1956-05-23 | 1957-05-28 | Lipari Michael | Container attachment for providing a compartmental dispensing receptacle |
US3172568A (en) * | 1959-03-27 | 1965-03-09 | Modern Lab Inc | Pressurized dispensing device |
US3354883A (en) * | 1965-03-08 | 1967-11-28 | Southerland Elizabeth Lee | Disposable syringe having frangible means for mixing plural medicaments |
US3674028A (en) * | 1969-06-04 | 1972-07-04 | Ims Ltd | Multi-mix |
US3858580A (en) * | 1969-06-04 | 1975-01-07 | Ims Ltd | Intravenous container mixing assembly |
US3655096A (en) * | 1969-10-22 | 1972-04-11 | Pillsbury Co | Container for diluting and dispensing material |
US3949751A (en) * | 1970-03-03 | 1976-04-13 | Fisons Limited | Method and device for dispensing medicament to the body |
DE2221101C3 (de) * | 1972-04-28 | 1975-05-15 | Wolf-Geraete Gmbh, 5240 Betzdorf | Flaschenartiger Mischbehälter |
US3946732A (en) * | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
US3924741A (en) * | 1975-03-04 | 1975-12-09 | Gibson Ass Inc | Two-compartment container |
US4174035A (en) * | 1975-09-04 | 1979-11-13 | Georg Wiegner | Two-component container and package |
US4177938A (en) * | 1977-06-30 | 1979-12-11 | Brina Guido J | Container with mixing cartridge |
US4195730A (en) * | 1978-06-20 | 1980-04-01 | General Foods Corporation | Container having separate storage facilities for two materials |
US4315570A (en) * | 1979-01-04 | 1982-02-16 | Jules Silver | Two-compartment container with means for dispersing contents of one compartment into the other compartment |
US4516967A (en) * | 1981-12-21 | 1985-05-14 | Kopfer Rudolph J | Wet-dry compartmental syringe |
US4515586A (en) * | 1982-11-30 | 1985-05-07 | Abbott Laboratories | Powder syringe mixing system |
IT1185850B (it) * | 1985-08-02 | 1987-11-18 | Zambon Spa | Tappo serbatoio contagocce per flaconi |
US4727985A (en) * | 1986-02-24 | 1988-03-01 | The Boc Group, Inc. | Mixing and dispensing apparatus |
DE3611690A1 (de) * | 1986-04-08 | 1987-10-15 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer mischmedien |
DE3837595A1 (de) * | 1988-04-14 | 1990-05-10 | Goldwell Gmbh | Doppelkammer-behaelter |
CA2006582A1 (fr) * | 1988-12-27 | 1990-06-27 | Gabriel Meyer | Flacon de stockage et de transfert concu pour stocker deux composants dune substance medicamenteuse |
US4979941A (en) * | 1989-12-05 | 1990-12-25 | International Medication Systems, Limited | Device suitable for mixing medication |
SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
US5352196A (en) * | 1990-11-19 | 1994-10-04 | Habley Medical Technology Corporation | Mixing vial |
CA2059461C (fr) * | 1991-01-25 | 1999-02-09 | Hiroaki Takimoto | Bride de fixation pour appareil de fabrication de connecteurs fibres optiques |
IT223172Z2 (it) * | 1991-04-09 | 1995-06-13 | Tecnomedica Ricerche Srl | Dispositivo per la somministrazione di farmaci, particolarmente farma-ci a due componenti |
US5246142A (en) * | 1991-09-26 | 1993-09-21 | Dipalma Elio | Device for storing two products separately and subsequently mixing them |
ATE177941T1 (de) * | 1992-12-09 | 1999-04-15 | Boehringer Ingelheim Pharma | Stabilisierte medizinische aerosollösungen |
ES2115201T3 (es) * | 1992-12-15 | 1998-06-16 | Sanofi Sa | Dispositivo para la preparacion de una solucion, de una suspension o de una emulsion de una sustancia medicinal. |
DE69412492T2 (de) * | 1993-09-07 | 1999-02-11 | Debiotech S.A., Lausanne | Spritzenvorrichtung zum mischen von zwei präparaten |
DE4428434A1 (de) | 1994-08-11 | 1996-02-15 | Boehringer Ingelheim Kg | Verschlußkappe und Verfahren zur gasblasenfreien Füllung von Behältern |
US5685846A (en) * | 1995-02-27 | 1997-11-11 | Schott Parenta Systems, Inc. | Dual chamber internal by-pass syringe assembly |
TW406214B (en) * | 1995-03-16 | 2000-09-21 | Hitachi Chemical Co Ltd | Production of color filter |
DK0835098T3 (da) | 1995-06-27 | 2002-10-07 | Boehringer Ingelheim Pharma | Stabilt lægemiddelpræparat til frembringlese af drivgasfrie aerosoler |
DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
ES2128220B1 (es) * | 1995-12-04 | 1999-12-16 | Cusi Lab | Envase farmaceutico de dos sustancias separadas, con dispositivo de mezcla, aplicacion dosificada y su proceso de montaje. |
DE19615422A1 (de) | 1996-04-19 | 1997-11-20 | Boehringer Ingelheim Kg | Zweikammer-Kartusche für treibgasfreie Dosieraerosole |
DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
JP3940455B2 (ja) * | 1997-01-30 | 2007-07-04 | 武田薬品工業株式会社 | 2室式容器兼用注射器 |
JPH1147274A (ja) * | 1997-06-03 | 1999-02-23 | Takeda Chem Ind Ltd | 2室型注射器及び2室型注射器用接続具 |
IT1293005B1 (it) * | 1997-06-10 | 1999-02-11 | Bernardino Parise | Contenitore per sostanze concentrate in polvere o liquide da porre in soluzione entro un involucro al momento dell'uso |
US5902298A (en) * | 1997-11-07 | 1999-05-11 | Bracco Research Usa | Medicament container stopper with integral spike access means |
US6267154B1 (en) * | 1998-06-05 | 2001-07-31 | Abbott Laboratories | System for storing mixing and administering a drug |
DE19847968A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
US6152296A (en) * | 1998-11-06 | 2000-11-28 | Shih; Kuang-Sheng | Additive holder for a pet bottle |
-
1998
- 1998-10-17 DE DE19847968A patent/DE19847968A1/de not_active Withdrawn
-
1999
- 1999-09-10 UA UA2001053341A patent/UA71933C2/uk unknown
- 1999-10-09 SI SI9930253T patent/SI1119334T1/xx unknown
- 1999-10-09 TR TR2001/01095T patent/TR200101095T2/xx unknown
- 1999-10-09 ID IDW20010840A patent/ID28440A/id unknown
- 1999-10-09 BR BR9914608-8A patent/BR9914608A/pt active Search and Examination
- 1999-10-09 HU HU0103888A patent/HU224244B1/hu not_active IP Right Cessation
- 1999-10-09 CA CA002345675A patent/CA2345675C/fr not_active Expired - Fee Related
- 1999-10-09 EE EEP200100225A patent/EE04514B1/xx not_active IP Right Cessation
- 1999-10-09 JP JP2000576814A patent/JP2002527205A/ja active Pending
- 1999-10-09 ES ES99950688T patent/ES2187202T3/es not_active Expired - Lifetime
- 1999-10-09 SK SK495-2001A patent/SK286632B6/sk not_active IP Right Cessation
- 1999-10-09 CN CNB99812222XA patent/CN1197541C/zh not_active Expired - Fee Related
- 1999-10-09 PL PL99347365A patent/PL194220B1/pl unknown
- 1999-10-09 EP EP99950688A patent/EP1119334B1/fr not_active Expired - Lifetime
- 1999-10-09 CZ CZ20011363A patent/CZ300606B6/cs not_active IP Right Cessation
- 1999-10-09 WO PCT/EP1999/007589 patent/WO2000023037A1/fr active IP Right Grant
- 1999-10-09 AU AU63370/99A patent/AU761858B2/en not_active Ceased
- 1999-10-09 EA EA200100438A patent/EA002581B1/ru not_active IP Right Cessation
- 1999-10-09 DK DK99950688T patent/DK1119334T3/da active
- 1999-10-09 DE DE59904187T patent/DE59904187D1/de not_active Expired - Lifetime
- 1999-10-09 EP EP02014579A patent/EP1291013A3/fr not_active Withdrawn
- 1999-10-09 RS YUP-266/01A patent/RS49724B/sr unknown
- 1999-10-09 AT AT99950688T patent/ATE231715T1/de active
- 1999-10-09 NZ NZ511646A patent/NZ511646A/xx not_active IP Right Cessation
- 1999-10-09 PT PT99950688T patent/PT1119334E/pt unknown
- 1999-10-14 MY MYPI99004452A patent/MY121789A/en unknown
- 1999-10-14 CO CO99065440A patent/CO5271681A1/es not_active Application Discontinuation
- 1999-10-14 CO CO99065440D patent/CO5271682A1/es unknown
- 1999-10-14 EG EG128599A patent/EG23069A/xx active
- 1999-10-15 AR ARP990105228A patent/AR020831A1/es active Pending
- 1999-10-15 PE PE1999001044A patent/PE20001000A1/es not_active Application Discontinuation
- 1999-10-15 TW TW088117882A patent/TW466111B/zh not_active IP Right Cessation
- 1999-10-24 SA SA99200701A patent/SA99200701B1/ar unknown
-
2001
- 2001-03-29 BG BG105390A patent/BG64523B1/bg active Active
- 2001-04-10 NO NO20011830A patent/NO321748B1/no not_active IP Right Cessation
- 2001-04-12 HR HR20010273A patent/HRP20010273B1/xx not_active IP Right Cessation
- 2001-05-31 US US09/871,500 patent/US6481435B2/en not_active Expired - Lifetime
-
2002
- 2002-02-25 HK HK02101406.4A patent/HK1040049B/zh not_active IP Right Cessation
- 2002-09-27 US US10/256,781 patent/US6986346B2/en not_active Expired - Lifetime
-
2005
- 2005-03-11 US US11/077,681 patent/US7040311B2/en not_active Expired - Lifetime
-
2006
- 2006-05-02 US US11/415,752 patent/US20060196500A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO321748B1 (no) | Tokammers-patron for forstover | |
CA2251828C (fr) | Cartouche a deux chambres pour distribuer des aerosols de facon dosee sans gaz propulseur | |
AU2011316124B2 (en) | Nasal spray device | |
MX2009001553A (es) | Formulacion en aerosol que contienen beta-agonistas y esteroides. | |
JPH0984855A (ja) | 直腸または膣への薬物投与用のエアゾール製剤 | |
KR100627592B1 (ko) | 분무기용 2챔버 카트리지 | |
US12005185B2 (en) | Medical counter measures including dry powder formulations and associated methods | |
MXPA01003698A (en) | Two chamber cartridge for atomizers |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |