NO320182B1 - Fenylfenantridiner med PDE-IV inhiberende aktivitet, legemidler omfattende dem samt anvendelse av forbindelsene. - Google Patents
Fenylfenantridiner med PDE-IV inhiberende aktivitet, legemidler omfattende dem samt anvendelse av forbindelsene. Download PDFInfo
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- NO320182B1 NO320182B1 NO20013341A NO20013341A NO320182B1 NO 320182 B1 NO320182 B1 NO 320182B1 NO 20013341 A NO20013341 A NO 20013341A NO 20013341 A NO20013341 A NO 20013341A NO 320182 B1 NO320182 B1 NO 320182B1
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- hydrogen
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- methoxy
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Immunology (AREA)
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- Urology & Nephrology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100694 | 1999-01-15 | ||
| PCT/EP2000/000172 WO2000042020A1 (en) | 1999-01-15 | 2000-01-12 | Phenylphenanthridines with pde-iv inhibiting activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20013341D0 NO20013341D0 (no) | 2001-07-05 |
| NO20013341L NO20013341L (no) | 2001-09-17 |
| NO320182B1 true NO320182B1 (no) | 2005-11-07 |
Family
ID=8237351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20013341A NO320182B1 (no) | 1999-01-15 | 2001-07-05 | Fenylfenantridiner med PDE-IV inhiberende aktivitet, legemidler omfattende dem samt anvendelse av forbindelsene. |
Country Status (32)
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| EP (2) | EP1147089B1 (es) |
| JP (1) | JP4653314B2 (es) |
| KR (1) | KR100720906B1 (es) |
| CN (1) | CN1152864C (es) |
| AT (1) | ATE312081T1 (es) |
| AU (1) | AU774868B2 (es) |
| BG (1) | BG65126B1 (es) |
| BR (1) | BR0007527B1 (es) |
| CA (1) | CA2359440C (es) |
| CY (1) | CY1106436T1 (es) |
| CZ (1) | CZ300366B6 (es) |
| DE (1) | DE60024581T2 (es) |
| DK (1) | DK1147089T3 (es) |
| EA (1) | EA003780B1 (es) |
| EE (1) | EE05105B1 (es) |
| ES (1) | ES2254132T3 (es) |
| HK (1) | HK1040997B (es) |
| HR (1) | HRP20010578A2 (es) |
| HU (1) | HU227624B1 (es) |
| ID (1) | ID29070A (es) |
| IL (2) | IL144026A0 (es) |
| NO (1) | NO320182B1 (es) |
| NZ (1) | NZ512872A (es) |
| PL (1) | PL205670B1 (es) |
| RS (1) | RS50297B (es) |
| SI (1) | SI1147089T1 (es) |
| SK (1) | SK286946B6 (es) |
| TR (2) | TR200501553T2 (es) |
| UA (1) | UA69436C2 (es) |
| WO (1) | WO2000042020A1 (es) |
| ZA (1) | ZA200104864B (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001267589A1 (en) * | 2000-07-14 | 2002-01-30 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines |
| US20060116518A1 (en) * | 2002-08-17 | 2006-06-01 | Altana Pharma Ag | Novel phenanthridines |
| JP4587294B2 (ja) | 2002-08-29 | 2010-11-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン |
| US7423046B2 (en) * | 2002-08-29 | 2008-09-09 | Nycomed Gmbh | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| US6894061B2 (en) | 2002-12-04 | 2005-05-17 | Wyeth | Substituted dihydrophenanthridinesulfonamides |
| WO2005012252A1 (en) * | 2003-07-31 | 2005-02-10 | Altana Pharma Ag | Novel 6-phenylphenantridines |
| JP2007500686A (ja) * | 2003-07-31 | 2007-01-18 | アルタナ ファルマ アクチエンゲゼルシャフト | 新規の６−フェニルフェナントリジン |
| MXPA06002521A (es) * | 2003-09-05 | 2006-06-20 | Altana Pharma Ag | Uso de inhibidores de pde4 para el tratamiento de diabetes mellitus. |
| AU2005212857B2 (en) * | 2004-02-18 | 2011-04-28 | Takeda Gmbh | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| RS53543B1 (en) | 2004-03-03 | 2015-02-27 | Takeda Gmbh | NEW HYDROXY-6-HETEROARYLPHENANTRIDINES AND THEIR USE AS PDE4 INHIBITORS |
| US20070191414A1 (en) * | 2004-03-09 | 2007-08-16 | Altana Pharma Ag | Novel isoamido-substituted hydroxy-6-phenylphenanthridines |
| CA2558391A1 (en) * | 2004-03-10 | 2005-09-22 | Altana Pharma Ag | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| BRPI0508473A (pt) * | 2004-03-10 | 2007-07-31 | Altana Pharma Ag | hidróxi-6-fenilfenantridinas contendo tiol e seu uso como inibidores de pde4 |
| EP1725532A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| US7589205B2 (en) * | 2004-09-08 | 2009-09-15 | Nycomed Gmbh | 3-thia-10-aza-phenanthrene derivatives |
| US7411093B2 (en) * | 2004-12-20 | 2008-08-12 | Hoffman-La Roche Inc. | Aminocycloalkanes as DPP-IV inhibitors |
| KR101421914B1 (ko) | 2005-03-02 | 2014-07-22 | 다케다 게엠베하 | 6-헤테로시클릴 치환된 헥사히드로페난트리딘 유도체의 신규한 염 |
| NZ560269A (en) | 2005-03-08 | 2010-12-24 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
| EP1858880A1 (en) * | 2005-03-09 | 2007-11-28 | Nycomed GmbH | Amido-substituted 6-phenylphenanthridines |
| KR101178674B1 (ko) | 2007-10-04 | 2012-08-30 | 에프. 호프만-라 로슈 아게 | 사이클로프로필 아릴 아마이드 유도체 및 이의 용도 |
| ES2649410T3 (es) | 2011-12-21 | 2018-01-11 | Novira Therapeutics Inc. | Agentes antivirales para la hepatitis B |
| AP2015008248A0 (en) | 2012-08-28 | 2015-02-28 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis B |
| ES2628953T3 (es) | 2013-02-28 | 2017-08-04 | Janssen Sciences Ireland Uc | Sulfamoilarilamidas y el uso de las mismas como medicamentos para el tratamiento de la hepatitis B |
| HUE033542T2 (en) | 2013-04-03 | 2017-12-28 | Janssen Sciences Ireland Uc | Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| AU2014267235B2 (en) | 2013-05-17 | 2017-10-05 | Janssen Sciences Ireland Uc | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| SI3024819T1 (en) | 2013-07-25 | 2018-06-29 | Janssen Sciences Ireland Uc | Glyoxamide-substituted pyrrolamide derivatives and their use as medicines for the treatment of hepatitis B |
| DK3060547T3 (en) | 2013-10-23 | 2018-01-15 | Janssen Sciences Ireland Uc | CARBOXAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATMENT OF HEPATITS B |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| ES2792848T3 (es) | 2014-02-05 | 2020-11-12 | Novira Therapeutics Inc | Politerapia para el tratamiento de infecciones por VHB |
| JP6495929B2 (ja) | 2014-02-06 | 2019-04-03 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | スルファモイルピロールアミド誘導体およびｂ型肝炎の治療のための医薬としてのその使用 |
| US9884831B2 (en) | 2015-03-19 | 2018-02-06 | Novira Therapeutics, Inc. | Azocane and azonane derivatives and methods of treating hepatitis B infections |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| CN108430971A (zh) | 2015-09-29 | 2018-08-21 | 诺维拉治疗公司 | 乙型肝炎抗病毒剂的晶体形式 |
| EP3442524A2 (en) | 2016-04-15 | 2019-02-20 | Novira Therapeutics Inc. | Combinations and methods comprising a capsid assembly inhibitor |
| US10973801B2 (en) | 2018-03-14 | 2021-04-13 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
| BR112021015618A2 (pt) | 2019-02-22 | 2021-10-05 | Janssen Sciences Ireland Unlimited Company | Derivados de amida úteis no tratamento da infecção pelo hbv ou doenças induzidas pelo hbv |
| AU2020269897A1 (en) | 2019-05-06 | 2021-10-14 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899494A (en) | 1970-05-13 | 1975-08-12 | Sandoz Ltd | Substituted 6-phenyl benzo-naphthyridines |
| DE59709437D1 (de) | 1996-01-31 | 2003-04-10 | Altana Pharma Ag | Neue phenanthridine |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| DE59708265D1 (de) * | 1996-03-26 | 2002-10-24 | Altana Pharma Ag | Neue in 6-position substituierte phenanthridine |
| US6008215A (en) * | 1996-11-11 | 1999-12-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridines as bronchial therapeutics |
| US6143759A (en) | 1997-03-07 | 2000-11-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tetrazoles |
| WO1998055481A1 (en) | 1997-06-03 | 1998-12-10 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine |
| CZ296064B6 (cs) * | 1997-07-25 | 2006-01-11 | Altana Pharma Ag | 6-Fenylfenanthridinové deriváty a farmaceutický prostredek |
| ES2217575T3 (es) * | 1997-07-25 | 2004-11-01 | Altana Pharma Ag | Nuevos derivados de tetrazol. |
| AU2107700A (en) * | 1999-01-15 | 2000-08-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridine-n-oxides with pde-iv inhibiting activity |
| DE60019894T2 (de) * | 1999-01-15 | 2006-01-12 | Altana Pharma Ag | Phenantrhridin-n-oxides mit pde-iv hemmender wirkung |
| ATE315029T1 (de) * | 1999-01-15 | 2006-02-15 | Altana Pharma Ag | 6-arylphenanthridine mit pde-iv hemmender wirkung |
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- 2000-01-12 PL PL348925A patent/PL205670B1/pl unknown
- 2000-01-12 CZ CZ20012248A patent/CZ300366B6/cs not_active IP Right Cessation
- 2000-01-12 BR BRPI0007527-2A patent/BR0007527B1/pt not_active IP Right Cessation
- 2000-01-12 EP EP05108689A patent/EP1650193A3/en not_active Withdrawn
- 2000-01-12 EA EA200100731A patent/EA003780B1/ru not_active IP Right Cessation
- 2000-01-12 CN CNB008027951A patent/CN1152864C/zh not_active Expired - Fee Related
- 2000-01-12 TR TR2005/01553T patent/TR200501553T2/xx unknown
- 2000-01-12 ID IDW00200101411A patent/ID29070A/id unknown
- 2000-01-12 AT AT00901534T patent/ATE312081T1/de active
- 2000-01-12 TR TR2001/01938T patent/TR200101938T2/xx unknown
- 2000-01-12 WO PCT/EP2000/000172 patent/WO2000042020A1/en not_active Application Discontinuation
- 2000-01-12 KR KR1020017008670A patent/KR100720906B1/ko not_active IP Right Cessation
- 2000-01-12 EE EEP200100350A patent/EE05105B1/xx not_active IP Right Cessation
- 2000-01-12 SI SI200030806T patent/SI1147089T1/sl unknown
- 2000-01-12 AU AU22896/00A patent/AU774868B2/en not_active Ceased
- 2000-01-12 IL IL14402600A patent/IL144026A0/xx active IP Right Grant
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- 2000-01-12 JP JP2000593588A patent/JP4653314B2/ja not_active Expired - Fee Related
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- 2000-01-12 DE DE60024581T patent/DE60024581T2/de not_active Expired - Lifetime
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2001
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- 2001-06-14 ZA ZA200104864A patent/ZA200104864B/en unknown
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2002
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- 2006-02-14 CY CY20061100209T patent/CY1106436T1/el unknown
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