NO315976B1 - Immunokonjugater, fremgangsmåte for fremstilling derav, farmasöytiske preparater som omfatter immunokonjugatene, samt anvendelse avimmunokonjugatene for fremstilling av legemidler mot tumorer - Google Patents
Immunokonjugater, fremgangsmåte for fremstilling derav, farmasöytiske preparater som omfatter immunokonjugatene, samt anvendelse avimmunokonjugatene for fremstilling av legemidler mot tumorer Download PDFInfo
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- NO315976B1 NO315976B1 NO19953650A NO953650A NO315976B1 NO 315976 B1 NO315976 B1 NO 315976B1 NO 19953650 A NO19953650 A NO 19953650A NO 953650 A NO953650 A NO 953650A NO 315976 B1 NO315976 B1 NO 315976B1
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- antibody
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- immunoconjugates
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94114572 | 1994-09-16 |
Publications (3)
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| NO953650D0 NO953650D0 (no) | 1995-09-15 |
| NO953650L NO953650L (no) | 1996-03-18 |
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| NO19953650A NO315976B1 (no) | 1994-09-16 | 1995-09-15 | Immunokonjugater, fremgangsmåte for fremstilling derav, farmasöytiske preparater som omfatter immunokonjugatene, samt anvendelse avimmunokonjugatene for fremstilling av legemidler mot tumorer |
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| EP (1) | EP0706799B1 (cs) |
| JP (2) | JP3865802B2 (cs) |
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| CN (1) | CN1123185A (cs) |
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| CA (1) | CA2158322C (cs) |
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| PT (1) | PT706799E (cs) |
| RU (1) | RU2157701C2 (cs) |
| SK (1) | SK282263B6 (cs) |
| UA (1) | UA40611C2 (cs) |
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| IL132596A0 (en) | 1997-06-04 | 2001-03-19 | Oxford Biomedica Ltd | Vector |
| US7635687B2 (en) * | 1997-06-04 | 2009-12-22 | Oxford Biomedica (Uk) Limited | Vector system |
| WO1999029732A2 (en) | 1997-12-08 | 1999-06-17 | Lexigen Pharmaceuticals Corporation | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
| US6562347B1 (en) | 1998-03-12 | 2003-05-13 | The United States Of America As Represented By The Department Of Health And Human Services | Chemokine-tumor antigen fusion proteins as cancer vaccines |
| NZ506877A (en) * | 1998-03-31 | 2002-04-26 | Tanabe Seiyaku Co | Benzenesulfonamide compounds useful in treating dysuria |
| DE69931908T2 (de) * | 1998-04-15 | 2007-01-11 | Lexigen Pharmaceuticals Corp., Lexington | Steigerung der antikörper-zytokin-fusionsproteinmediierten immunantwort durch mitverabreichung mit einem angiogeneseinhibitor |
| EP1071469A2 (en) * | 1998-04-17 | 2001-01-31 | Lexigen Pharmaceuticals Corp. | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with prostaglandin inhibitor |
| US6869606B1 (en) | 1999-02-22 | 2005-03-22 | Millennium Pharmaceuticals, Inc. | Biotinylated-chemokine antibody complexes |
| WO2000078334A1 (en) * | 1999-06-17 | 2000-12-28 | University Of Maryland Biotechnology Institute | Chimeric chemokine-antigen polypeptides and uses therefor |
| GB9915074D0 (en) * | 1999-06-28 | 1999-08-25 | Cortecs Plc | Ligand-binding composition |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| MXPA02001417A (es) | 1999-08-09 | 2002-08-12 | Lexigen Pharm Corp | Complejos multiples de citosina-anticuerpo. |
| JP2003515323A (ja) * | 1999-11-18 | 2003-05-07 | オックスフォード バイオメディカ（ユーケイ）リミテッド | 抗 体 |
| US6319675B1 (en) | 1999-11-24 | 2001-11-20 | Millennium Pharmaceuticals, Inc. | Methods for detecting and/or identifying agents which bind and/or modulate function of “bonzo” chemokine receptor |
| US7208152B2 (en) * | 1999-11-24 | 2007-04-24 | Millennium Pharmaceuticals, Inc. | Antibodies for “Bonzo” chemokine receptor and therapeutic uses thereof |
| EP1252192B1 (en) | 2000-02-11 | 2006-08-16 | MERCK PATENT GmbH | Enhancing the circulating half-life of antibody-based fusion proteins |
| DE10019157A1 (de) * | 2000-04-18 | 2001-11-15 | Stefan Duebel | Verfahren zum Einbringen von Liganden in lebende Zellen |
| US20040091485A1 (en) * | 2000-05-19 | 2004-05-13 | Ellis John Robert Maxwell | Humanised antibodies to the epidermal growth factor receptor |
| US7754676B2 (en) | 2000-09-15 | 2010-07-13 | The United States Of America As Represented By The Department Of Health And Human Services | Defensin-antigen fusion proteins |
| AU2001291050A1 (en) | 2000-09-15 | 2002-03-26 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Viral chemokine-tumur antigen fusion proteins |
| GB0029407D0 (en) * | 2000-12-01 | 2001-01-17 | Affitech As | Product |
| DK1366067T3 (da) | 2001-03-07 | 2012-10-22 | Merck Patent Gmbh | Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| BR0209177A (pt) | 2001-05-03 | 2004-10-05 | Merck Patent Gmbh | Anticorpo especìfico a tumor recombinante e uso do mesmo |
| EP1256354A1 (en) * | 2001-05-11 | 2002-11-13 | Schering Corporation | Methods for treating cancer |
| US20020193569A1 (en) * | 2001-06-04 | 2002-12-19 | Idec Pharmaceuticals Corporation | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| CN100497389C (zh) | 2001-06-13 | 2009-06-10 | 根马布股份公司 | 表皮生长因子受体(egfr)的人单克隆抗体 |
| WO2004003019A2 (en) * | 2002-06-28 | 2004-01-08 | Domantis Limited | Immunoglobin single variant antigen-binding domains and dual-specific constructs |
| EP1399484B1 (en) * | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
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| JP4212921B2 (ja) | 2002-03-29 | 2009-01-21 | 独立行政法人科学技術振興機構 | 抗体を提示するタンパク質中空ナノ粒子を用いる治療薬剤およびタンパク質中空ナノ粒子 |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| US20040110929A1 (en) * | 2002-07-12 | 2004-06-10 | Bjorn Soren E. | TF binding compound |
| RS20050300A (en) | 2002-10-16 | 2007-08-03 | Euro-Celtique S.A., | Antibodies that bind cell-associated ca 125/0772p and methods of use thereof |
| US7388079B2 (en) * | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
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| JP2006523090A (ja) * | 2002-12-27 | 2006-10-12 | ドマンティス リミテッド | リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体 |
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| EP1699822B1 (en) | 2003-12-30 | 2008-04-23 | MERCK PATENT GmbH | Il-7 fusion proteins with antibody portions, their preparation and their use |
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| US5470571A (en) * | 1988-01-27 | 1995-11-28 | The Wistar Institute | Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425 |
| IE63847B1 (en) * | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
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| US5314995A (en) * | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
| AU654811B2 (en) * | 1990-03-20 | 1994-11-24 | Trustees Of Columbia University In The City Of New York, The | Chimeric antibodies with receptor binding ligands in place of their constant region |
| AU660297B2 (en) * | 1990-11-09 | 1995-06-22 | Stephen D. Gillies | Cytokine immunoconjugates |
| CZ282603B6 (cs) * | 1991-03-06 | 1997-08-13 | Merck Patent Gesellschaft Mit Beschränkter Haftun G | Humanizované a chimerické monoklonální protilátky |
| EP0603194A4 (en) * | 1991-07-05 | 1994-12-07 | Seragen Inc | TO THE RECEPTOR OF THE EPIDERMAL GROWTH FACTOR TARGETED MOLECULES FOR TREATING INFLAMMABLE ARTHRITIS. |
| ES2144440T3 (es) * | 1992-08-18 | 2000-06-16 | Centro Inmunologia Molecular | Anticuerpos monoclonales que reconocen el receptor del factor de crecimiento epidermico, celulas y metodos para su produccion y compuestos que los contienen. |
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1995
- 1995-09-06 DK DK95113956T patent/DK0706799T3/da active
- 1995-09-06 AT AT95113956T patent/ATE208633T1/de not_active IP Right Cessation
- 1995-09-06 ES ES95113956T patent/ES2167391T3/es not_active Expired - Lifetime
- 1995-09-06 DE DE69523857T patent/DE69523857T2/de not_active Expired - Fee Related
- 1995-09-06 EP EP95113956A patent/EP0706799B1/en not_active Expired - Lifetime
- 1995-09-06 PT PT95113956T patent/PT706799E/pt unknown
- 1995-09-08 AU AU30533/95A patent/AU702184B2/en not_active Ceased
- 1995-09-11 JP JP23283295A patent/JP3865802B2/ja not_active Expired - Fee Related
- 1995-09-13 SK SK1145-95A patent/SK282263B6/sk unknown
- 1995-09-14 UA UA95094164A patent/UA40611C2/uk unknown
- 1995-09-14 CA CA002158322A patent/CA2158322C/en not_active Expired - Fee Related
- 1995-09-14 CZ CZ19952375A patent/CZ289641B6/cs not_active IP Right Cessation
- 1995-09-14 CN CN95116279A patent/CN1123185A/zh active Pending
- 1995-09-15 KR KR1019950030385A patent/KR100386171B1/ko not_active IP Right Cessation
- 1995-09-15 RU RU95115976/14A patent/RU2157701C2/ru not_active IP Right Cessation
- 1995-09-15 PL PL95310493A patent/PL182636B1/pl not_active IP Right Cessation
- 1995-09-15 HU HU9502711A patent/HU221989B1/hu not_active IP Right Cessation
- 1995-09-15 ZA ZA957808A patent/ZA957808B/xx unknown
- 1995-09-15 NO NO19953650A patent/NO315976B1/no not_active IP Right Cessation
- 1995-09-15 US US08/528,523 patent/US5824782A/en not_active Expired - Fee Related
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2005
- 2005-11-17 JP JP2005332965A patent/JP2006117684A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR960010023A (ko) | 1996-04-20 |
| PL182636B1 (pl) | 2002-02-28 |
| CA2158322A1 (en) | 1996-03-17 |
| CZ237595A3 (en) | 1996-04-17 |
| JP2006117684A (ja) | 2006-05-11 |
| ES2167391T3 (es) | 2002-05-16 |
| KR100386171B1 (ko) | 2003-08-21 |
| SK282263B6 (sk) | 2001-12-03 |
| EP0706799A3 (en) | 1996-12-04 |
| UA40611C2 (uk) | 2001-08-15 |
| AU702184B2 (en) | 1999-02-18 |
| CN1123185A (zh) | 1996-05-29 |
| RU2157701C2 (ru) | 2000-10-20 |
| SK114595A3 (en) | 1997-03-05 |
| US5824782A (en) | 1998-10-20 |
| NO953650L (no) | 1996-03-18 |
| ATE208633T1 (de) | 2001-11-15 |
| DE69523857T2 (de) | 2002-06-13 |
| EP0706799A2 (en) | 1996-04-17 |
| DE69523857D1 (de) | 2001-12-20 |
| HUT75836A (en) | 1997-05-28 |
| NO953650D0 (no) | 1995-09-15 |
| ZA957808B (en) | 1996-05-07 |
| EP0706799B1 (en) | 2001-11-14 |
| PT706799E (pt) | 2002-05-31 |
| CA2158322C (en) | 2009-06-16 |
| PL310493A1 (en) | 1996-03-18 |
| AU3053395A (en) | 1996-03-28 |
| HU9502711D0 (en) | 1995-11-28 |
| DK0706799T3 (da) | 2002-02-25 |
| JPH0899901A (ja) | 1996-04-16 |
| CZ289641B6 (cs) | 2002-03-13 |
| JP3865802B2 (ja) | 2007-01-10 |
| HU221989B1 (hu) | 2003-03-28 |
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